Evidence-based medicine and progress in the medical sciences

The question what scientific progress means for a particular domain such as medicine seems importantly different from the question what scientific progress is in general. While the latter question received ample treatment in the philosophical literature, the former question is hardly discussed. I argue that it is nonetheless important to think about this question in view of the methodological choices we make. I raise specific questions that should be tackled regarding scientific progress in the medical sciences and demonstrate their importance by means of an analysis of what evidence-based medicine (EBM) has, and has not, to offer in terms of progress. I show how critically thinking about EBM from the point of view of progress can help us in putting EBM and its favoured methodologies in the right perspective. My conclusion will be that blindly favouring certain methods because of their immediately tangible short-term benefits implies that we parry the important question of how best to advance progress in the long run. This leads us to losing sight of our general goals in doing research in the medical sciences

Reconstruction of heavy quark current correlators at O(\alpha_s^3)

We construct approximate formulas for the O(\alpha_s^3) QCD contributions to vector, axial-vector, scalar and pseudo-scalar quark current correlators, which are valid for arbitrary values of momenta and masses. The derivation is based on conformal mapping and the Pade approximation procedure and incorporates known expansions in the low energy, threshold and high energy regions. We use our results to estimate additional terms in these expansions.Comment: 24 pages, 4 figure

Design Principles for Plasmonic Nanoparticle Devices

For all applications of plasmonics to technology it is required to tailor the resonance to the optical system in question. This chapter gives an understanding of the design considerations for nanoparticles needed to tune the resonance. First the basic concepts of plasmonics are reviewed with a focus on the physics of nanoparticles. An introduction to the finite element method is given with emphasis on the suitability of the method to nanoplasmonic device simulation. The effects of nanoparticle shape on the spectral position and lineshape of the plasmonic resonance are discussed including retardation and surface curvature effects. The most technologically important plasmonic materials are assessed for device applicability and the importance of substrates in light scattering is explained. Finally the application of plasmonic nanoparticles to photovoltaic devices is discussed.Comment: 29 pages, 15 figures, part of an edited book: "Linear and Non-Linear Nanoplasmonics

Five-loop renormalization-group expansions for the three-dimensional n-vector cubic model and critical exponents for impure Ising systems

The renormalization-group (RG) functions for the three-dimensional n-vector cubic model are calculated in the five-loop approximation. High-precision numerical estimates for the asymptotic critical exponents of the three-dimensional impure Ising systems are extracted from the five-loop RG series by means of the Pade-Borel-Leroy resummation under n = 0. These exponents are found to be: \gamma = 1.325 +/- 0.003, \eta = 0.025 +/- 0.01, \nu = 0.671 +/- 0.005, \alpha = - 0.0125 +/- 0.008, \beta = 0.344 +/- 0.006. For the correction-to-scaling exponent, the less accurate estimate \omega = 0.32 +/- 0.06 is obtained.Comment: 11 pages, LaTeX, no figures, published versio

zCOSMOS 20k: Satellite galaxies are the main drivers of environmental effects in the galaxy population at least to z~0.7

We explore the role of environment in the evolution of galaxies over 0.1<z<0.7 using the final zCOSMOS-bright data set. Using the red fraction of galaxies as a proxy for the quenched population, we find that the fraction of red galaxies increases with the environmental overdensity and with the stellar mass, consistent with previous works. As at lower redshift, the red fraction appears to be separable in mass and environment, suggesting the action of two processes: mass and environmental quenching. The parameters describing these appear to be essentially the same at z~0.7 as locally. We explore the relation between red fraction, mass and environment also for the central and satellite galaxies separately, paying close attention to the effects of impurities in the central-satellite classification and using carefully constructed samples matched in stellar mass. There is little evidence for a dependence of the red fraction of centrals on overdensity. Satellites are consistently redder at all overdensities, and the satellite quenching efficiency increases with overdensity at 0.1<z<0.4. This is less marked at higher redshift, but both are nevertheless consistent with the equivalent local measurements. At a given stellar mass, the fraction of galaxies that are satellites also increases with the overdensity. At a given overdensity and mass, the obtained relation between the environmental quenching and the satellite fraction agrees well with the satellite quenching efficiency, demonstrating that the environmental quenching in the overall population is consistent with being entirely produced through the satellite quenching process at least up to z=0.7. However, despite the unprecedented size of our high redshift samples, the associated statistical uncertainties are still significant and our statements should be understood as approximations to physical reality, rather than physically exact formulae.Comment: 22 pages, 19 figures, submitted to MNRA

Extreme emission-line galaxies out to z∼\sim1 in zCOSMOS. I. Sample and characterization of global properties

We present a thorough characterization of a large sample of 183 extreme emission-line galaxies (EELGs) at redshift 0.11 < z < 0.93 selected from the 20k zCOSMOS Bright Survey because of their unusually large emission line equivalent widths. We use multiwavelength COSMOS photometry, HST-ACS I-band imaging and optical zCOSMOS spectroscopy to derive the main global properties of EELGs, such as sizes, masses, SFRs, reliable metallicities from both "direct" and "strong-line" methods. The EELGs are compact (R_50 ~ 1.3 kpc), low-mass (log(M*/Msol)~7-10) galaxies forming stars at unusually high specific SFR (log(sSFR/yr) up to ~ -7) compared to main sequence SFGs of the same stellar mass and redshift. At UV wavelengths, the EELGs are luminous and show high surface brightness and include strong Ly$\alpha$ emitters, as revealed by GALEX spectroscopy. We show that zCOSMOS EELGs are high-ionization, low-metallicity systems, with median 12+log(O/H)=8.16, including a handful of extremely metal-deficient galaxies (<10% solar). While ~80% of the EELGs show non-axisymmetric morphologies, including clumpy and tadpole galaxies, we find that ~29% of them show additional low surface-brightness features, which strongly suggest recent or ongoing interactions. As star-forming dwarfs in the local Universe, EELGs are most often found in relative isolation. While only very few EELGs belong to compact groups, almost one third of them are found in spectroscopically confirmed loose pairs or triplets. We conclude that EELGs are galaxies caught in a transient and probably early period of their evolution, where they are efficiently building-up a significant fraction of their present-day stellar mass in an ongoing galaxy-wide starburst. Therefore, the EELGs constitute an ideal benchmark for comparison studies between low- and high-redshift low-mass star-forming galaxies.Comment: Accepted in A&A. Final replacement to match the version in press. It includes a minor change in the title and a new figur

Spectrophotometric properties of galaxies at intermediate redshifts (z ~ 0.2--1.0) I. Sample description, photometric properties and spectral measurements

We present the spectrophotometric properties of a sample of 141 emission-line galaxies at redshifts in the range $0.2<z<1.0$ with a peak around $z\in[0.2,0.4]$. The analysis is based on medium resolution ($R\_{\mathrm{s}}=500-600$), optical spectra obtained at VLT and Keck. The targets are mostly {} "Canada-France Redshift Survey" emission-line galaxies, with the addition of field galaxies randomly selected behind lensing clusters. We complement this sample with galaxy spectra from the {} "Gemini Deep Deep Survey" public data release. We have computed absolute magnitudes of the galaxies and measured the line fluxes and equivalent widths of the main emission/absorption lines. The last two have been measured after careful subtraction of the fitted stellar continuum using the \texttt{platefit} software originally developed for the SDSS and adapted to our data. We present a careful comparison of this software with the results of manual measurements. The pipeline has also been tested on lower resolution spectra, typical of the {} "VIMOS/VLT Deep Survey" ($R\_{\mathrm{s}}=250$), by resampling our medium resolution spectra. We show that we can successfully deblend the most important strong emission lines. These data are primarily used to perform a spectral classification of the galaxies in order to distinguish star-forming galaxies from AGNs. Among the initial sample of 141 emission-line galaxies, we find 7 Seyfert 2 (narrow-line AGN), 115 star-forming galaxies and 16 {} "candidate" star-forming galaxies. Scientific analysis of these data, in terms of chemical abundances, stellar populations, etc, will be presented in subsequent papers of this serie.Comment: 24 pages. Accepted for publication in A&A; reference added; bug corrected: flux scaled by (1+z

Spectral classification of emission-line galaxies from the Sloan Digital Sky Survey. II. A supplementary diagnostic for AGNs using the Dn(4000) index

In this paper we present a classification of emission-line galaxies at intermediate and high redshifts (0.52.5 for near-infrared spectra), using the Dn(4000) index as a supplementary diagnostic. Our goal is to complement the diagnostic based only on emission-line ratios from the blue part of the spectra, which suffer from some limitations for the classification of Seyfert 2 and composite galaxies. We used a sample of 89 379 galaxies with a good signal-to-noise ratio from the Sloan Digital Sky Survey (data release 7). Using the classification scheme presented in Paper I, we classified these galaxies with a diagnostic diagram involving the [Oiii]5007 /Hbeta and [Oii]3726+3729 /Hbeta emission-line ratios. Then we derived a supplementary diagnostic involving Dn(4000) to improve this classification, in the regions where objects of different types are mixed. To show the validity of our spectral classification we established success-rate and contamination charts, then we compared our results to those obtained with the reference classification that was scheme obtained also using Halpha, [Nii]6584, and [Sii]6717+6731 emission lines. We show that our supplementary classification based on the Dn(4000) index allows to separate unambiguously star-forming galaxies from Seyfert 2 in the region where they were mixed in Paper I. It also significantly reduces the region where star-forming galaxies are mixed with composites.Comment: accepted for publication in A\&A, 10 pages corrected bug in LateX file for equations 7 and

The mass-metallicity relation of zCOSMOS galaxies at z ~ 0.7, its dependence on SFR, and the existence of massive low-metallicity galaxies

(Abridged) The knowledge of the number and of the physical nature of low-metallicity massive galaxies is crucial for the determination and interpretation of the mass-metallicity relation (MZR). Using VLT-ISAAC near-infrared (NIR) spectroscopy of 39 zCOSMOS z~0.7 galaxies, we have measured Halpha and [NII] emission line fluxes for galaxies with [OII], Hbeta and [OIII] available from VIMOS optical spectroscopy. The NIR spectroscopy enables us to break the degeneracy of the R23 method to derive unambiguously O/H gas metallicities, and also SFRs from extinction corrected Halpha. Using, as a benchmark, the position in the D4000 vs. [OIII]/Hbeta diagram of galaxies with reliable O/Hs from NIR spectroscopy, we were able to break the lower/upper branch R23 degeneracy of additional 900 zCOSMOS z~0.7 galaxies. Additionally, the Halpha-based SFR measurements were used to find the best SFR calibration based on [OII] for the zCOSMOS z~0.7 galaxies without Halpha measurements. We find a fraction of 19% of lower mass 9.5<logM/Msun<10.3 zCOSMOS galaxies which shows a larger evolution of the MZR relation, compared to higher mass galaxies, being more metal poor at a given mass by a factor of 2-3 compared to SDSS. This indicates that the low-mass MZR slope is getting steeper at z~0.7 compared to local galaxies. The existence of these metal-poor galaxies at z~0.7 can be interpreted as the chemical version of galaxy downsizing. Moreover, the sample of zCOSMOS galaxies shows direct evidence that SFR influences the MZR at these redshifts. The comparison of the measured metallicities for the zCOSMOS sample with the values expected for a non-evolving fundamental metallicity relation (FMR) shows broadly agreement, and reveals that also galaxies with lower metallicities and typically higher (specific) SFRs, as found in our zCOSMOS sample at z~0.7, are in agreement with the predictions of a non-evolving Z(M,SFR).Comment: Accepted for publication in A&A; clarifying Appendix adde