LP-VIcode: a program to compute a suite of variational chaos indicators

An important point in analysing the dynamics of a given stellar or planetary system is the reliable identification of the chaotic or regular behaviour of its orbits. We introduce here the program LP-VIcode, a fully operational code which efficiently computes a suite of ten variational chaos indicators for dynamical systems in any number of dimensions. The user may choose to simultaneously compute any number of chaos indicators among the following: the Lyapunov Exponents, the Mean Exponential Growth factor of Nearby Orbits, the Slope Estimation of the largest Lyapunov Characteristic Exponent, the Smaller ALignment Index, the Generalized ALignment Index, the Fast Lyapunov Indicator, the Othogonal Fast Lyapunov Indicator, the dynamical Spectra of Stretching Numbers, the Spectral Distance, and the Relative Lyapunov Indicator. They are combined in an efficient way, allowing the sharing of differential equations whenever this is possible, and the individual stopping of their computation when any of them saturates.Comment: 26 pages, 9 black-and-white figures. Accepted for publication in Astronomy and Computing (Elsevier

On the relevance of chaos for halo stars in the solar neighbourhood II

In a previous paper based on dark matter only simulations we show that, in the approximation of an analytic and static potential describing the strongly triaxial and cuspy shape of Milky Way-sized haloes, diffusion due to chaotic mixing in the neighbourhood of the Sun does not efficiently erase phase space signatures of past accretion events. In this second paper we further explore the effect of chaotic mixing using multicomponent Galactic potential models and solar neighbourhood-like volumes extracted from fully cosmological hydrodynamic simulations, thus naturally accounting for the gravitational potential associated with baryonic components, such as the bulge and disc. Despite the strong change in the global Galactic potentials with respect to those obtained in dark matter only simulations, our results confirm that a large fraction of halo particles evolving on chaotic orbits exhibit their chaotic behaviour after periods of time significantly larger than a Hubble time. In addition, significant diffusion in phase space is not observed on those particles that do exhibit chaotic behaviour within a Hubble time

Hematopoietic Stem/Progenitor Cells Express Functional Mitochondrial Energy-Dependent Cystic Fibrosis Transmembrane Conductance Regulator

Bone marrow-derived hematopoietic stem/progenitor cells (HSPCs) encompass a wide array of cell subsets with different capacities of engraftment and injured tissue-regenerating potential. The characterization/isolation of the stem cell subpopulations represents a major challenge to improve the efficacy of transplantation protocols used in regenerative medicine. Cystic fibrosis (CF) is one of the diseases whose hope of cure relies on the successful application of cell-based gene therapy. This study was aimed at characterizing murine HSPCs on the basis of their bioenergetic competence and CF transmembrane conductance regulator (CFTR) expression. Positively immunoselected Sca-1(+) HSPCs encompassed 2 populations distinguished by their different size, Sca-1 expression and mitochondrial content. The smaller were the cells, the higher was Sca-1 expression and the lower was the intracellular density of functional mitochondria. Reverse transcription-polymerase chain reaction and western blotting revealed that HSPCs expressed CFTR mRNA and protein, which was also functional, as assessed by spectrofluorimetric and patch-clamp techniques. Inhibition of mitochondrial oxidative phosphorylation by oligomycin resulted in a 70% decrease of both the intracelluar adenosine triphosphate content and CFTR-mediated channel activity. Finally, HSPCs with lower Sca-1 expression and higher mitochondrial content displayed higher CFTR levels. Our findings identify 2 subpopulations in HSPCs and unveil a so-far unappreciated relationship between bioenergetic metabolism and CFTR in HSPC biology

A tidally induced global corrugation pattern in an external disk galaxy similar to the milky way

We study the two-dimensional (2D) line-of-sight velocity (Vlos) field of the low-inclination, late-type galaxy VV304a. The resulting 2D kinematic map reveals a global, coherent, and extended perturbation that is likely associated with a recent interaction with the massive companion VV304b. We use multiband imaging and a suite of test-particle simulations to quantify the plausible strength of in-plane flows due to nonaxisymmetric perturbations and show that the observed velocity flows are much too large to be driven either by a spiral structure or by a bar. We use fully cosmological hydrodynamical simulations to characterize the contribution from in- and off-plane velocity flows to the Vlos field of recently interacting galaxy pairs like the VV304 system. We show that, for recently perturbed low-inclination galactic disks, the structure of the residual velocity field, after subtraction of an axisymmetric rotation model, can be dominated by vertical flows. Our results indicate that the Vlos perturbations in VV304a are consistent with a corrugation pattern. Its Vlos map suggests the presence of a structure similar to the Monoceros ring seen in the Milky Way. Our study highlights the possibility of addressing important questions regarding the nature and origin of vertical perturbations by measuring the line-of-sight velocities in low-inclination nearby galaxies

Tectonic evolution and paleogeography of the Kırşehir Block and the Central Anatolian Ophiolites, Turkey

In Central and Western Anatolia two continent-derived massifs simultaneously underthrusted an oceanic lithosphere in the Cretaceous and ended up with very contrasting metamorphic grades: high pressure, low temperature in the Tavsanli zone and the low pressure, high temperature in the Kirsehir Block. To assess why, we reconstruct the Cretaceous paleogeography and plate configuration of Central Anatolia using structural, metamorphic, and geochronological constraints and Africa-Europe plate reconstructions. We review and provide new Ar-40/Ar-39 and U/Pb ages from Central Anatolian metamorphic and magmatic rocks and ophiolites and show new paleomagnetic data on the paleo-ridge orientation in a Central Anatolian Ophiolite. Intraoceanic subduction that formed within the Neotethys around 100-90 Ma along connected N-S and E-W striking segments was followed by overriding oceanic plate extension. Already during suprasubduction zone ocean spreading, continental subduction started. We show that the complex geology of central and southern Turkey can at first order be explained by a foreland-propagating thrusting of upper crustal nappes derived from a downgoing, dominantly continental lithosphere: the Kirsehir Block and Tavsanli zone accreted around 85 Ma, the Afyon zone around 65 Ma, and Taurides accretion continued until after the middle Eocene. We find no argument for Late Cretaceous subduction initiation within a conceptual "Inner Tauride Ocean" between the Kirsehir Block and the Afyon zone as widely inferred. We propose that the major contrast in metamorphic grade between the Kirsehir Block and the Tavsanli zone primarily results from a major contrast in subduction obliquity and the associated burial rates, higher temperature being reached upon higher subduction obliquity.European Research Council ; Netherlands Organization for Scientific Research (NWO

Simulating cosmological substructure in the solar neighbourhood

We explore the predictive power of cosmological, hydrodynamical simulations for stellar phase-space substructure and velocity correlations with the auriga simulations and aurigaia mock Gaia catalogues. We show that at the solar circle the auriga simulations commonly host phase-space structures in the stellar component that have constant orbital energies and arise from accreted subhaloes. These structures can persist for a few Gyr, even after coherent streams in position space have been erased. We also explore velocity two-point correlation functions and find this diagnostic is not deterministic for particular clustering patterns in phase space. Finally, we explore these structure diagnostics with the aurigaia catalogues and show that current catalogues have the ability to recover some structures in phase space but careful consideration is required to separate physical structures from numerical structures arising from catalogue generation methods

Intraperitoneal drain placement and outcomes after elective colorectal surgery: international matched, prospective, cohort study

Despite current guidelines, intraperitoneal drain placement after elective colorectal surgery remains widespread. Drains were not associated with earlier detection of intraperitoneal collections, but were associated with prolonged hospital stay and increased risk of surgical-site infections.Background Many surgeons routinely place intraperitoneal drains after elective colorectal surgery. However, enhanced recovery after surgery guidelines recommend against their routine use owing to a lack of clear clinical benefit. This study aimed to describe international variation in intraperitoneal drain placement and the safety of this practice. Methods COMPASS (COMPlicAted intra-abdominal collectionS after colorectal Surgery) was a prospective, international, cohort study which enrolled consecutive adults undergoing elective colorectal surgery (February to March 2020). The primary outcome was the rate of intraperitoneal drain placement. Secondary outcomes included: rate and time to diagnosis of postoperative intraperitoneal collections; rate of surgical site infections (SSIs); time to discharge; and 30-day major postoperative complications (Clavien-Dindo grade at least III). After propensity score matching, multivariable logistic regression and Cox proportional hazards regression were used to estimate the independent association of the secondary outcomes with drain placement. Results Overall, 1805 patients from 22 countries were included (798 women, 44.2 per cent; median age 67.0 years). The drain insertion rate was 51.9 per cent (937 patients). After matching, drains were not associated with reduced rates (odds ratio (OR) 1.33, 95 per cent c.i. 0.79 to 2.23; P = 0.287) or earlier detection (hazard ratio (HR) 0.87, 0.33 to 2.31; P = 0.780) of collections. Although not associated with worse major postoperative complications (OR 1.09, 0.68 to 1.75; P = 0.709), drains were associated with delayed hospital discharge (HR 0.58, 0.52 to 0.66; P < 0.001) and an increased risk of SSIs (OR 2.47, 1.50 to 4.05; P < 0.001). Conclusion Intraperitoneal drain placement after elective colorectal surgery is not associated with earlier detection of postoperative collections, but prolongs hospital stay and increases SSI risk

A record of spontaneous subduction initiation in the Izu–Bonin–Mariana arc

The initiation of tectonic plate subduction into the mantle is poorly understood. If subduction is induced by the push of a distant mid-ocean ridge or subducted slab pull, we expect compression and uplift of the overriding plate. In contrast, spontaneous subduction initiation, driven by subsidence of dense lithosphere along faults adjacent to buoyant lithosphere, would result in extension and magmatism. The rock record of subduction initiation is typically obscured by younger deposits, so evaluating these possibilities has proved elusive. Here we analyse the geochemical characteristics of igneous basement rocks and overlying sediments, sampled from the Amami Sankaku Basin in the northwest Philippine Sea. The uppermost basement rocks are areally widespread and supplied via dykes. They are similar in composition and age—as constrained by the biostratigraphy of the overlying sediments—to the 52–48-million-year-old basalts in the adjacent Izu–Bonin–Mariana fore-arc. The geochemical characteristics of the basement lavas indicate that a component of subducted lithosphere was involved in their genesis, and the lavas were derived from mantle source rocks that were more melt-depleted than those tapped at mid-ocean ridges. We propose that the basement lavas formed during the inception of Izu–Bonin–Mariana subduction in a mode consistent with the spontaneous initiation of subduction

Tectonic Reconstructions of the Southernmost Andes and the Scotia Sea During the Opening of the Drake Passage

Study of the tectonic development of the Scotia Sea region started with basic lithological and structural studies of outcrop geology in Tierra del Fuego and the Antarctic Peninsula. To nineteenth- and early twentieth-century geologists, the results of these studies suggested the presence of a submerged orocline running around the margins of the Scotia Sea. Subsequent increases in detailed knowledge about the fragmentary outcrop geology from islands distributed around the margins of the Scotia Sea, and later their interpretation in the light of the plate tectonic paradigm led to large modifications in the hypothesis such that by the present day the concept of oroclinal bending in the region persists only in vestigial form. Of the early comparative lithostratigraphic work in the region, only the likenesses between Jurassic–Cretaceous basin floor and fill sequences in South Georgia and Tierra del Fuego are regarded as strong enough to be useful in plate kinematic reconstruction by permitting the interpretation of those regions’ contiguity in mid-Mesozoic times. Marine and satellite geophysical data sets reveal features of the remaining, submerged, 98 % of the Scotia Sea region between the outcrops. These data enable a more detailed and quantitative approach to the region’s plate kinematics. In contrast to long-used interpretations of the outcrop geology, these data do not prescribe the proximity of South Georgia to Tierra del Fuego in any past period. It is, however, possible to reinterpret the geology of those two regions in terms of the plate kinematic history that the seafloor has preserved