The State of Knowledge of CCA Diversity in the Caribbean Coral Reefs

Crustose coralline algae (CCA) are a diverse and ecologically important species found in most of the world’s oceans. The current lack of taxonomic knowledge and relative abundance compromises our ability to predict species diversity numbers and, thus, their ecological roles and impacts on coral reefs. To gather a better understanding of the state of knowledge of crustose coralline algae taxonomy in the Caribbean, 107 different research papers, and other primary and secondary literature were studied; any source with taxonomical information, species identification, or genetic markers for identification was recorded. All Genebank codes were collected and sorted by supposed species marker and then ran through the National Center of Biotechnology Information. The location these genetic markers were gathered from was compared to the natural habitat range of the species, based on the Algaebank habitat description. Of the supposed 83 described species of crustose algae in the Caribbean, based on morphological characteristics, only 24 total were confirmed by DNA markers. This leaves at least 59 species of CCA to be confirmed in the Caribbean Sea with molecular markers. This indicates the importance of DNA barcode survey studies to assess the accurate diversity of this group in the region. With this limited knowledge apparent, it should be seen that a CCAs phylogenetic and taxonomical review must be done. An in-depth assessment should be conducted on CCA collections to identify the Caribbean species correctly and thus know their biodiversity in local habitats

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.

Funder: Funder: Fundación bancaria ‘La Caixa’ Number: LCF/PR/PR16/51110003 Funder: Grifols SA Number: LCF/PR/PR16/51110003 Funder: European Union/EFPIA Innovative Medicines Initiative Joint Number: 115975 Funder: JPco-fuND FP-829-029 Number: 733051061Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Proyecto de inversión para el mejoramiento de la calidad de servicio del proceso de docencia de pregrado, en la facultad de ciencias humanísticas y económicas (iche) de la escuela superíor politécnica del litoral (ESPOL)

Este documento hace referencia a la calidad del proceso de docencia de pregrado de la Facultad de Ciencias Humanísticas y Económicas (ICHE) de la Escuela Superior Politécnica del Litoral (ESPOL), hace referencia a la misión de la Facultad y a la calidad de servicio que debe brindar a sus estudiantes. El proceso de docencia de pregrado juega un papel supremamente importante, lo que implica que todos los actores vinculados a la educación superior sea un proceso permanente, participativo y se constituya en una práctica común. Iniciamos el proceso determinando dos etapas de investigación, la primera que se realizó fue la Investigación Exploratoria con datos provenientes de fuentes de control de calidad, tales como el CENACAD, departamento de calidad del ICHE y la ESPOL, buzón de sugerencias de los estudiantes, encuestas en línea, entre otros, y la segunda parte fue la investigación de mercado que se efectuó mediante una entrevista a los expertos en este tema (método de Delphi), las mismas que ayudaron a obtener un análisis preliminar de la situación de la Facultad ICHE, en cuanto al proceso de docencia de pregrado se refiere. En esta etapa se pudo descubrir información no identificada previamente y dio como resultado las áreas donde existen No conformidades por parte de los estudiantes; aplicando el criterio de Pareto y mediante la investigación concluyente se pudo validar la información obtenida en la investigación exploratoria, por medio de la evaluación, escala de valoración para cada área siendo así; 1: mayor importancia y 4: menor importancia, por tal motivo la sumatoria de menor valor es la que indica el mayor grado de incidencia en dicho problema; y así se pudo determinar los problemas de mayor incidencia. Luego se realizó el debido Plan de Mejora de las áreas afectadas(Laboratorios, Servicio al Cliente y Profesores), mencionadas y analizadas anteriormente, en las que se detalla las actividades a realizar para alcanzar dichas metas planteadas, con el fin de contribuir a la mejora continua del Sistema de Gestión de Calidad de la Facultad ICHE. En el área del personal Docente (profesores), se detectaron problemas básicamente en la parte pedagógica, por lo cual se propuso el respectivo Plan de Capacitación semestral, especialmente dirigida a profesores con baja calificación por parte de los estudiantes. En lo que respecta a los laboratorios, se realizaron dos propuestas la primera crear un nuevo laboratorio de computación, y así evitar futuras no conformidades que representarían un gasto para la Facultad; la segunda propuesta fue realizar reposición de computadoras a los actuales laboratorios, con la donación de máquinas de varias empresas de prestigio del país con intercambio de publicidad para las mismas. Análisis Beneficio/Costo la razón es de 1.89, lo que hace que el proyecto sea factible y viable, se lo ajustó al análisis de sensibilidad concluyendo, que el proyecto posee baja sensibilidad respecto a las variaciones de la TMAR. El análisis de sensibilidad, con respecto a los beneficios (mantener constante la TMAR, los costos y variando los beneficios), nos demuestra, hasta donde pueden disminuir, y en este caso solo puede hasta el 52% que equivale a 0,98 El análisis con respecto a los costos (mantener constante la TMAR, los beneficios y variando los costos) nos refleja hasta donde los costos pueden aumentar, y en este caso solo puede hasta el 90% que equivale a 0,99

Dropped in the ocean – 87Sr/86Sr as a provenance tool for ice-rafted Arctic driftwood

Provenance and age determinations of driftwood provide insights into Holocene Arctic Ocean surface currents and sea ice dynamics, with detailed reconstructions requiring a provenance methodology with fine temporal and spatial resolution. Determination of wood geographical provenance by genus data is limited by its spatially coarse resolution, while provenance by dendrochronological crossdating is reliant on available boreal forest reference chronologies which are abundant for recent centuries but more sparse for older periods of the Holocene. We present the development of novel techniques to refine the provenance of driftwood through radiogenic isotopic analysis (87Sr/86Sr). The use of geochemical techniques addresses limitations of current methods and opens the possibility of defining the role of atmospheric and oceanic circulation in sea ice and climatic changes throughout the Holocene at a finer spatial resolution than currently possible. This study investigates and develops geochemical 87Sr/86Sr fingerprinting of Arctic driftwood. To this end, it analyses driftwood samples from northern Svalbard and compares this technique with provenance regions obtained through dendrochronology, and with modelled and measured global 87Sr/86Sr reference databases. We conclude that the utilisation of 87Sr/86Sr ratios to establish provenance for Arctic driftwood has some potential, but identify important limitations in the method, concerning both the signal in samples and reference values required for provenance. Increased sample populations and source samples for calibration, as well as methodological improvements that address the likely overprinting linked to driftwood transport, are recommended to build upon this work. We conclude that at present dendro-provenancing continues to be the most powerful method to study sea ice dynamics from Arctic driftwood and suggest that given the high spatial granularity of 87Sr/86Sr across the boreal forest, this technique might only be usable in combination with previously developed provenance tools and reconstructions. This study provides a first step in the use of radiogenic isotopic analysis in a multi-proxy reconstruction of Holocene driftwood incursion onto high Arctic shorelines