The SIMBAD astronomical database

Simbad is the reference database for identification and bibliography of astronomical objects. It contains identifications, `basic data', bibliography, and selected observational measurements for several million astronomical objects. Simbad is developed and maintained by CDS, Strasbourg. Building the database contents is achieved with the help of several contributing institutes. Scanning the bibliography is the result of the collaboration of CDS with bibliographers in Observatoire de Paris (DASGAL), Institut d'Astrophysique de Paris, and Observatoire de Bordeaux. When selecting catalogues and tables for inclusion, priority is given to optimal multi-wavelength coverage of the database, and to support of research developments linked to large projects. In parallel, the systematic scanning of the bibliography reflects the diversity and general trends of astronomical research. A WWW interface to Simbad is available at: http://simbad.u-strasbg.fr/SimbadComment: 14 pages, 5 Postscript figures; to be published in A&A

Which fetal growth charts should be used in France? Position of the French College of Obstetricians and Gynecologists (CNGOF)

Objective: To assess which fetal growth charts best describe intrauterine growth in France defined as the ability to classify 10% of fetuses below the 10th percentile (small for gestational age [SGA]) and above the 90th percentile (large for gestational age [LGA]) in the second and third trimesters. Methods: We analyzed five studies on fetal ultrasound measurements using three French data sources. Two studies used second and third trimester ultrasound data from a nationwide birth cohort in 2011 (the ELFE study, N = 13 197 and N = 7747); one study used third trimester ultrasound data from on a nationwide cross-sectional study (the 2016 French National Perinatal Survey, N = 9940); and the last two studies were from the “Flash study” 2014 which prospectively collected ultrasound data from routine visits in the second and third trimesters (N = 4858 and N = 3522). For each study, we reported the percentage of measurements below the 10th percentile or above the 90th percentile, using French, Hadlock's, WHO and Intergrowth (IG) charts. Results: WHO classified 4.7% and 16.3% of fetuses as having an estimated fetal weight (EFW) 90th percentiles in the second trimester compared to 3.3% and 34.7% with IG. The percentage of fetuses in the third trimester with an EFW 90th percentiles, ranged from 9.1% to 9.4% and from 8.0% to 11.1%, respectively, for WHO, and from 3.9% to 4.1% and from 17.3% to 21.6%, respectively, for IG. The WHO and IG charts for head circumference were very similar and performed well. Compared to the WHO charts, the French and Hadlock's charts deviated more frequently from the target percentiles values for EFW and biometric measures. Conclusion: It is recommended to use the WHO charts for the assessment of EFW and ultrasound biometric measurements in France (strong recommendation; low quality of evidence)

Genome-wide association study of lung function decline in adults with and without asthma

Background: Genome-wide association studies have identified determinants of chronic obstructive pulmonary disease, asthma, and lung function level; however, none have addressed decline in lung function. Objective: We conducted the first genome-wide association study on the age-related decrease in FEV1 and its ratio to forced vital capacity (FVC) stratified a priori by asthma status. Methods: Discovery cohorts included adults of European ancestry (1,441 asthmatic and 2,677 nonasthmatic participants: the Epidemiological Study on the Genetics and Environment of Asthma, the Swiss Cohort Study on Air Pollution and Lung and Heart Disease in Adults, and the European Community Respiratory Health Survey). The associations of FEV1 and FEV1/FVC ratio decrease with 2.5 million single nucleotide polymorphisms (SNPs) were estimated. Thirty loci were followed up by in silico replication (1,160 asthmatic and 10,858 nonasthmatic participants: Atherosclerosis Risk in Communities, the Framingham Heart Study, the British 1958 Birth Cohort, and the Dutch Asthma Study). Results: Main signals identified differed between asthmatic and nonasthmatic participants. None of the SNPs reached genome-wide significance. The association between the height-related gene DLEU7 and FEV1 decrease suggested for nonasthmatic participants in the discovery phase was replicated (discovery, P = 4.8 x 10(-6); replication, P = .03), and additional sensitivity analyses point to a relation to growth. The top ranking signal, TUSC3, which is associated with FEV1/FVC ratio decrease in asthmatic participants (P = 5.3 x 10(-8)), did not replicate. SNPs previously associated with cross-sectional lung function were not prominently associated with decline. Conclusions: Genetic heterogeneity of lung function might be extensive. Our results suggest that genetic determinants of longitudinal and cross-sectional lung function differ and vary by asthma status. (J Allergy Clin Immunol 2012;129:1218-28.

Genome-wide association study of lung function decline in adults with and without asthma

Background: Genome-wide association studies have identified determinants of chronic obstructive pulmonary disease, asthma, and lung function level; however, none have addressed decline in lung function. Objective: We conducted the first genome-wide association study on the age-related decrease in FEV1 and its ratio to forced vital capacity (FVC) stratified a priori by asthma status. Methods: Discovery cohorts included adults of European ancestry (1,441 asthmatic and 2,677 nonasthmatic participants: the Epidemiological Study on the Genetics and Environment of Asthma, the Swiss Cohort Study on Air Pollution and Lung and Heart Disease in Adults, and the European Community Respiratory Health Survey). The associations of FEV1 and FEV1/FVC ratio decrease with 2.5 million single nucleotide polymorphisms (SNPs) were estimated. Thirty loci were followed up by in silico replication (1,160 asthmatic and 10,858 nonasthmatic participants: Atherosclerosis Risk in Communities, the Framingham Heart Study, the British 1958 Birth Cohort, and the Dutch Asthma Study). Results: Main signals identified differed between asthmatic and nonasthmatic participants. None of the SNPs reached genome-wide significance. The association between the height-related gene DLEU7 and FEV1 decrease suggested for nonasthmatic participants in the discovery phase was replicated (discovery, P = 4.8 x 10(-6); replication, P = .03), and additional sensitivity analyses point to a relation to growth. The top ranking signal, TUSC3, which is associated with FEV1/FVC ratio decrease in asthmatic participants (P = 5.3 x 10(-8)), did not replicate. SNPs previously associated with cross-sectional lung function were not prominently associated with decline. Conclusions: Genetic heterogeneity of lung function might be extensive. Our results suggest that genetic determinants of longitudinal and cross-sectional lung function differ and vary by asthma status. (J Allergy Clin Immunol 2012;129:1218-28.)

Mediatization of a (non-) preservation: the relations of society, journalism and the internet on the demolition of Monroe Palace

Tem sido uma constante no campo patrimonial a exortação de que as políticas do patrimônio precisam se aproximar dos anseios preservacionistas da população. Este artigo procura discutir essa máxima, analisando as razões para a demanda pró-preservação de não especialistas do Palácio Monroe, obra de arquitetura erigida pelo governo brasileiro em 1904, nos EUA, remontada no Brasil, em 1906, e demolida em 1976. Como forma de entender a percepção da sociedade sobre o patrimônio, procura-se mostrar como o processo de demolição do Monroe mobilizou a sociedade carioca. O objetivo é compreender a produção de memória e da história do Rio por pessoas que não pertencem às agências oficiais do patrimônio e que podem, como resultado, permitir que o circuito social da arquitetura seja incorporado às discussões do campo do patrimônio.Many scholars have pointed that the preservation policies should contemplate the society desires. This article discusses this maximum analyzing the reasons that produced demands from non-specialists about the preservation of the Monroe Palace. This building, that originally was built by the Brazilian government in 1904, in the US, was reassembled in Rio de Janeiro in 1906 and demolished in 1976. In order to understand the perception of society about this building, this paper seeks to show how the Monroe’s demolition mobilized Rio society. Taking this episode about the (non-) preservation of this architecture, we developed some reflections on the role of the journalism, blogs and websites, framed by one methodological preoccupation. The goal is to comprehend the production of the Rio’s memory and history by people that do not belong to official agencies of heritage in that city and, as result, to allow the discussion about the social circuit of the architecture within the heritage field