A study of adsorption from solution by titanium dioxide using a flow micro-calorimeter

The flow microcalorimeter, as developed by Messrs. Groszek & Templer was the first commercially available dynamic calorimeter. It was soon recognised by the Paint Research Station, Teddington, BS a potential tool to further studios in surface chemistry. [Continues.

Probing the dynamics of plasmon-excited hexanethiol-capped gold nanoparticles by picosecond X-ray absorption spectroscopy

Picosecond X-ray absorption spectroscopy (XAS) is used to investigate the electronic and structural dynamics initiated by plasmon excitation of 1.8 nm diameter Au nanoparticles (NPs) functionalised with 1-hexanethiol. We show that 100 ps after photoexcitation the transient XAS spectrum is consistent with an 8% expansion of the Au-Au bond length and a large increase in disorder associated with melting of the NPs. Recovery of the ground state occurs with a time constant of ∼1.8 ns, arising from thermalisation with the environment. Simulations reveal that the transient spectrum exhibits no signature of charge separation at 100 ps and allows us to estimate an upper limit for the quantum yield (QY) of this process to be <0.1

Stellar structure and compact objects before 1940: Towards relativistic astrophysics

Since the mid-1920s, different strands of research used stars as "physics laboratories" for investigating the nature of matter under extreme densities and pressures, impossible to realize on Earth. To trace this process this paper is following the evolution of the concept of a dense core in stars, which was important both for an understanding of stellar evolution and as a testing ground for the fast-evolving field of nuclear physics. In spite of the divide between physicists and astrophysicists, some key actors working in the cross-fertilized soil of overlapping but different scientific cultures formulated models and tentative theories that gradually evolved into more realistic and structured astrophysical objects. These investigations culminated in the first contact with general relativity in 1939, when J. Robert Oppenheimer and his students George Volkoff and Hartland Snyder systematically applied the theory to the dense core of a collapsing neutron star. This pioneering application of Einstein's theory to an astrophysical compact object can be regarded as a milestone in the path eventually leading to the emergence of relativistic astrophysics in the early 1960s.Comment: 83 pages, 4 figures, submitted to the European Physical Journal

The price of rapid exit in venture capital-backed IPOs

This paper proposes an explanation for two empirical puzzles surrounding initial public offerings (IPOs). Firstly, it is well documented that IPO underpricing increases during “hot issue” periods. Secondly, venture capital (VC) backed IPOs are less underpriced than non-venture capital backed IPOs during normal periods of activity, but the reverse is true during hot issue periods: VC backed IPOs are more underpriced than non-VC backed ones. This paper shows that when IPOs are driven by the initial investor’s desire to exit from an existing investment in order to finance a new venture, both the value of the new venture and the value of the existing firm to be sold in the IPO drive the investor’s choice of price and fraction of shares sold in the IPO. When this is the case, the availability of attractive new ventures increases equilibrium underpricing, which is what we observe during hot issue periods. Moreover, I show that underpricing is affected by the severity of the moral hazard problem between an investor and the firm’s manager. In the presence of a moral hazard problem the degree of equilibrium underpricing is more sensitive to changes in the value of the new venture. This can explain why venture capitalists, who often finance firms with more severe moral hazard problems, underprice IPOs less in normal periods, but underprice more strongly during hot issue periods. Further empirical implications relating the fraction of shares sold and the degree of underpricing are presented

Rotating inclined cylinder and the effect of the tilt angle on vortices

We study numerically some possible vortex configurations in a rotating cylinder that is tilted with respect to the rotation axis and where different numbers of vortices can be present at given rotation velocity. In a long cylinder at small tilt angles the vortices tend to align along the cylinder axis and not along the rotation axis. We also show that the axial flow along the cylinder axis, caused by the tilt, will result in the Ostermeier-Glaberson instability above some critical tilt angle. When the vortices become unstable the final state often appears to be a dynamical steady state, which may contain turbulent regions where new vortices are constantly created. These new vortices push other vortices in regions with laminar flow towards the top and bottom ends of the cylinder where they finally annihilate. Experimentally the inclined cylinder could be a convenient environment to create long lasting turbulence with a polarization which can be adjusted with the tilt angle.Comment: 10 pages, 10 figure

The blood metabolome of incident kidney cancer: A case-control study nested within the MetKid consortium.

BackgroundExcess bodyweight and related metabolic perturbations have been implicated in kidney cancer aetiology, but the specific molecular mechanisms underlying these relationships are poorly understood. In this study, we sought to identify circulating metabolites that predispose kidney cancer and to evaluate the extent to which they are influenced by body mass index (BMI).Methods and findingsWe assessed the association between circulating levels of 1,416 metabolites and incident kidney cancer using pre-diagnostic blood samples from up to 1,305 kidney cancer case-control pairs from 5 prospective cohort studies. Cases were diagnosed on average 8 years after blood collection. We found 25 metabolites robustly associated with kidney cancer risk. In particular, 14 glycerophospholipids (GPLs) were inversely associated with risk, including 8 phosphatidylcholines (PCs) and 2 plasmalogens. The PC with the strongest association was PC ae C34:3 with an odds ratio (OR) for 1 standard deviation (SD) increment of 0.75 (95% confidence interval [CI]: 0.68 to 0.83, p = 2.6 × 10-8). In contrast, 4 amino acids, including glutamate (OR for 1 SD = 1.39, 95% CI: 1.20 to 1.60, p = 1.6 × 10-5), were positively associated with risk. Adjusting for BMI partly attenuated the risk association for some-but not all-metabolites, whereas other known risk factors of kidney cancer, such as smoking and alcohol consumption, had minimal impact on the observed associations. A mendelian randomisation (MR) analysis of the influence of BMI on the blood metabolome highlighted that some metabolites associated with kidney cancer risk are influenced by BMI. Specifically, elevated BMI appeared to decrease levels of several GPLs that were also found inversely associated with kidney cancer risk (e.g., -0.17 SD change [ßBMI] in 1-(1-enyl-palmitoyl)-2-linoleoyl-GPC (P-16:0/18:2) levels per SD change in BMI, p = 3.4 × 10-5). BMI was also associated with increased levels of glutamate (ßBMI: 0.12, p = 1.5 × 10-3). While our results were robust across the participating studies, they were limited to study participants of European descent, and it will, therefore, be important to evaluate if our findings can be generalised to populations with different genetic backgrounds.ConclusionsThis study suggests a potentially important role of the blood metabolome in kidney cancer aetiology by highlighting a wide range of metabolites associated with the risk of developing kidney cancer and the extent to which changes in levels of these metabolites are driven by BMI-the principal modifiable risk factor of kidney cancer

FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium

Background:Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium. Methods:Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression. Results:Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in FGFR3; the estimated per-allele odds ratio was 1.05 (95 confidence interval=1.02-1.09, P=0.0020), which is substantially lower than that observed for SNPs in FGFR2. Conclusion:Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for FGFR2. © 2014 Cancer Research UK

Implications of H.E.S.S. observations of pulsar wind nebulae

In this review paper on pulsar wind nebulae (PWN) we discuss the properties of such nebulae within the context of containment against cross-field diffusion (versus normal advection), the effect of reverse shocks on the evolution of offset ``Vela-like'' PWN, constraints on maximum particle energetics, magnetic field strength estimates based on spectral and spatial properties, and the implication of such field estimates on the composition of the wind. A significant part of the discussion is based on the High Energy Stereoscopic System ({\it H.E.S.S.} or {\it HESS}) detection of the two evolved pulsar wind nebulae Vela X (cocoon) and HESS J1825-137. In the case of Vela X (cocoon) we also review evidence of a hadronic versus a leptonic interpretation, showing that a leptonic interpretation is favored for the {\it HESS} signal. The constraints discussed in this review paper sets a general framework for the interpretation of a number of offset, filled-center nebulae seen by {\it HESS}. These sources are found along the galactic plane with galactic latitudes $|b|\sim 0$, where significant amounts of molecular gas is found. In these regions, we find that the interstellar medium is inhomogeneous, which has an effect on the morphology of supernova shock expansion. One consequence of this effect is the formation of offset pulsar wind nebulae as observed.Comment: to appear in Springer Lecture Notes on Neutron Stars and Pulsars: 40 years after their discovery, eds. W. Becke

Mapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum

Falciparum malaria is clinically heterogeneous and the relative contribution of parasite and host in shaping disease severity remains unclear. We explored the interaction between inflammation and parasite variant surface antigen (VSA) expression, asking whether this relationship underpins the variation observed in controlled human malaria infection (CHMI). We uncovered marked heterogeneity in the host response to blood challenge; some volunteers remained quiescent, others triggered interferon-stimulated inflammation and some showed transcriptional evidence of myeloid cell suppression. Significantly, only inflammatory volunteers experienced hallmark symptoms of malaria. When we tracked temporal changes in parasite VSA expression to ask whether variants associated with severe disease rapidly expand in naive hosts, we found no transcriptional evidence to support this hypothesis. These data indicate that parasite variants that dominate severe malaria do not have an intrinsic growth or survival advantage; instead, they presumably rely upon infection-induced changes in their within-host environment for selection

Prominence seismology using small amplitude oscillations

Quiescent prominences are thin slabs of cold, dense plasma embedded in the much hotter and rarer solar corona. Although their global shape is rather irregular, they are often characterised by an internal structure consisting of a large number of thin, parallel threads piled together. Prominences often display periodic disturbances mostly observed in the Doppler displacement of spectral lines and with an amplitude typically of the order of or smaller than 2--3 km s$^{-1}$, a value which seems to be much smaller than the characteristic speeds of the prominence plasma (namely the Alfv\'en and sound velocities). Two particular features of these small amplitude prominence oscillations is that they seem to damp in a few periods and that they seem not to affect the whole prominence structure. In addition, in high spatial resolution observations, in which threads can be discerned, small amplitude oscillations appear to be clearly associated to these fine structure constituents. Prominence seismology tries to bring together the results from these observations (e.g. periods, wavelengths, damping times) and their theoretical modeling (by means of the magnetohydrodynamic theory) to gain insight into physical properties of prominences that cannot be derived from direct observation. In this paper we discuss works that have not been described in previous reviews, namely the first seismological application to solar prominences and theoretical advances on the attenuation of prominence oscillations