Characterization of size-sorted particulated matter collected on solid substrates by laser-ionization mass spectrometry and laser-induced breakdown spectrometry

Resumen de trabajos realizados mediante excitación láser de material particulado y su posterior análisis mediante espectroscopía óptica de emisión o ionización.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Invasion of the dark false mussel in shrimp farms in Venezuela: species identification and genetic analysis

An inspection was carried out at shrimp farms located South West of Lake Maracaibo (Zulia State, Venezuela), with high incidences of mussel bivalve. Morphological and genetic analysis helped to identify the species as the dark false mussel Mytilopsis leucophaeata Conrad, 1831, and this is the first record of the species from tropical waters of northern South America. The highest incidences of mussels were detected in ponds and channels but no live mussels were observed in the coastal intertidal area surrounding the entrances of the farms, although empty shells were detected there, suggesting their former presence. The environmental conditions of the artificial system of shrimp culture, is a niche suitable for the proliferation of the bivalve. The consequences of the presence of this bivalve in the production of shrimp are discussed.S

«Momias. Biografías en 3D». Una nueva mirada a los restos humanos momificados de la población prehispánica de Gran Canaria

The «Mummies. 3D Biographies» project is a bet of El Museo Canario on coming together research and diffusion based on new information and communication technologies (ICT). In order to achieve this objective, a multidisciplinary team was set up, integrated by specialist on bioarchaeology, archaeology and digitalization of cultural heritage. The project addresses a review of the historic meaning of the prehispanic mummies of Gran Canaria in the light of the data showed by recent archaeological excavations in aboriginal cemeteries. These works call into question the mummification as funerary ritual differentiated from the rest of the mortuary practices among the canarians. The current study also included a biographic perspective of three mummies by analysing their bones, teeth and shrouds, which are interpreted as a result of their social and cultural system: that of the ancient canarians. It was considered that the new knowledge would need dynamic, interactive and direct tools of learning. Three-dimensional modeling of the mummies was therefore the resource adopted to optimize the purpose of divulgation. The great interest that people had shown in the different diffusion actions developed in this project, enhance the need –in the Social Sciences research field– of improving tools that grab the attention of public towards the new historic information.El proyecto «Momias. Biografías en 3D» representa una apuesta emprendida desde El Museo Canario por aunar investigación científica y difusión desde las nuevas tecnologías de la información y la comunicación (TIC). Para ello se configuró un equipo de carácter multidisciplinar en el que participaran especialistas en el ámbito de la bioantropología, de la arqueología, así como de la digitalización del patrimonio cultural. El trabajo aborda una relectura del significado histórico de las momias aborígenes de Gran Canaria a la luz de los datos aportados por las recientes intervenciones arqueológicas en espacios sepulcrales, que cuestionan la momificación como ritual funerario diferenciado de las demás prácticas mortuorias. A tal fin se desarrolló el estudio de los restos óseos, dentales, así como de las mortajas de una selección de momias, reconstruyendo la biografía de cada una de ellas en tanto que reflejo de un sistema social y cultural concreto: el de los antiguos canarios. La socialización del nuevo conocimiento histórico producido requería contar con unas herramientas de aprendizaje dinámicas, ágiles y directas, razón por la que se optó por la modelización tridimensional de las momias estudiadas. El interés y la respuesta que las acciones de difusión emprendidas en torno a este proyecto han despertado en la sociedad ponen de manifiesto la necesidad de que los trabajos de investigación en el ámbito de las ciencias sociales se doten de herramientas que propicien y capten la atención del público hacia la nueva información histórica

DISEÑO DE OSCILADORES CAÓTICOS DE CHUA EN MATLAB, MULTISIM Y DSP-BUILDER (DESIGN OF A CHAOTIC OSCILLATORS OF CHUA IN MATLAB, MULTISIM AND DSP-BUILDER)

ResumenEste artículo presenta la metodología de diseño del sistema caótico de Chua, en los programas de software Matlab, Multisim y DSP-Builder. La simulación del circuito caótico en Multisim va acompañada del cálculo de cada uno de los componentes electrónicos y las conexiones correspondientes. También se hace uso del software Matlab/Simulink para recrear las ecuaciones diferenciales que representan del sistema de Chua, creando un programa mediante el que se pueden obtener las salidas del sistema, visualizarlas gráficamente y comparar los resultados. De la misma manera se muestran los resultados de la implementación en DSP-FPGA específicamente en un DSP-FPGA Cyclone III Edition de Altera, visualizándose las secuencias y los enrollamientos resultantes en un osciloscopio.Palabras Clave: Caos, DSP-Builder, Matlab, Multisim, Oscilador de Chua. AbstractThis article presents the design methodology of a Chua chaotic system, using the software programs Matlab, Multisim and DSP-Builder. The simulation of the chaotic circuit on Multisim is accompanied by the calculation of each of the electronic components and the corresponding connections. Matlab/Simulink software is also used to represent the differential equations that describe the Chua system, generating a program through the outputs signals can be obtained, graphically visualized and compared the results. In the same way the results of implementation into an DSP-FPGA Cyclone III Edition, Altera, visualizing the output sequences and scrolls.Keywords: Chaos, Chua oscillator, DSP-Builder, Matlab, Multisim

Severe manifestations of SARS-CoV-2 in children and adolescents: from COVID-19 pneumonia to multisystem inflammatory syndrome: a multicentre study in pediatric intensive care units in Spain

Background Multisystem inflammatory syndrome temporally associated with COVID-19 (MIS-C) has been described as a novel and often severe presentation of SARS-CoV-2 infection in children. We aimed to describe the characteristics of children admitted to Pediatric Intensive Care Units (PICUs) presenting with MIS-C in comparison with those admitted with SARS-CoV-2 infection with other features such as COVID-19 pneumonia. Methods A multicentric prospective national registry including 47 PICUs was carried out. Data from children admitted with confirmed SARS-CoV-2 infection or fulfilling MIS-C criteria (with or without SARS-CoV-2 PCR confirmation) were collected. Clinical, laboratory and therapeutic features between MIS-C and non-MIS-C patients were compared. Results Seventy-four children were recruited. Sixty-one percent met MIS-C definition. MIS-C patients were older than non-MIS-C patients (p = 0.002): 9.4 years (IQR 5.5-11.8) vs 3.4 years (IQR 0.4-9.4). A higher proportion of them had no previous medical history of interest (88.2% vs 51.7%, p = 0.005). Non-MIS-C patients presented more frequently with respiratory distress (60.7% vs 13.3%, p < 0.001). MIS-C patients showed higher prevalence of fever (95.6% vs 64.3%, p < 0.001), diarrhea (66.7% vs 11.5%, p < 0.001), vomits (71.1% vs 23.1%, p = 0.001), fatigue (65.9% vs 36%, p = 0.016), shock (84.4% vs 13.8%, p < 0.001) and cardiac dysfunction (53.3% vs 10.3%, p = 0.001). MIS-C group had a lower lymphocyte count (p < 0.001) and LDH (p = 0.001) but higher neutrophil count (p = 0.045), neutrophil/lymphocyte ratio (p < 0.001), C-reactive protein (p < 0.001) and procalcitonin (p < 0.001). Patients in the MIS-C group were less likely to receive invasive ventilation (13.3% vs 41.4%, p = 0.005) but were more often treated with vasoactive drugs (66.7% vs 24.1%, p < 0.001), corticosteroids (80% vs 44.8%, p = 0.003) and immunoglobulins (51.1% vs 6.9%, p < 0.001). Most patients were discharged from PICU by the end of data collection with a median length of stay of 5 days (IQR 2.5-8 days) in the MIS-C group. Three patients died, none of them belonged to the MIS-C group. Conclusions MIS-C seems to be the most frequent presentation among critically ill children with SARS-CoV-2 infection. MIS-C patients are older and usually healthy. They show a higher prevalence of gastrointestinal symptoms and shock and are more likely to receive vasoactive drugs and immunomodulators and less likely to need mechanical ventilation than non-MIS-C patients

La enseñanza en el máster de abogacía a través del análisis de casos reales de carácter multidisciplinar. Aprendizaje "a partir del estudio de razonamientos parciales temáticos"

Generar blog para publicaciones de alumnos del Máster Abogacía, con "entradas" dirigidas. Habría análisis desde varias disciplinas añadiéndose estudios con enfoque basado en otras áreas de conocimiento, generando interdisciplinariedad

NGS-Based Molecular Karyotyping of Multiple Myeloma: Results from the GEM12 Clinical Trial

Simple Summary Multiple Myeloma (MM) is considered an incurable chronic disease, which prognosis depends on the presence of different genomic alterations. To accomplish a complete molecular diagnosis in a single essay, we have designed and validated a capture-based NGS approach to reliably identify pathogenic mutations (SNVs and indels), genomic alterations (CNVs and chromosomic translocations), and IGH rearrangements. We have observed a good correlation of the results obtained using our capture panel with data obtained by both FISH and WES techniques. In this study, the molecular classification performed using our approach was significantly associated with the stratification and outcome of MM patients. Additionally, this panel has been proven to detect specific IGH rearrangements that could be used as biomarkers in patient follow-ups through minimal residual disease (MRD) assays. In conclusion, we think that MM patients could benefit from the use of this capture-based NGS approach with a more accurate, single-essay molecular diagnosis. Next-generation sequencing (NGS) has greatly improved our ability to detect the genomic aberrations occurring in multiple myeloma (MM); however, its transfer to routine clinical labs and its validation in clinical trials remains to be established. We designed a capture-based NGS targeted panel to identify, in a single assay, known genetic alterations for the prognostic stratification of MM. The NGS panel was designed for the simultaneous study of single nucleotide and copy number variations, insertions and deletions, chromosomal translocations and V(D)J rearrangements. The panel was validated using a cohort of 149 MM patients enrolled in the GEM2012MENOS65 clinical trial. The results showed great global accuracy, with positive and negative predictive values close to 90% when compared with available data from fluorescence in situ hybridization and whole-exome sequencing. While the treatments used in the clinical trial showed high efficacy, patients defined as high-risk by the panel had shorter progression-free survival (p = 0.0015). As expected, the mutational status of TP53 was significant in predicting patient outcomes (p = 0.021). The NGS panel also efficiently detected clonal IGH rearrangements in 81% of patients. In conclusion, molecular karyotyping using a targeted NGS panel can identify relevant prognostic chromosomal abnormalities and translocations for the clinical management of MM patients