Influence of Blood Contamination on Bond Strength of a Self-Etching System

OBJECTIVES: To detect the influence of blood contamination (BC) on the bond strength (BS) of a self-etching bonding system (SES) to enamel and dentine. METHODS: 25 human molars were longitudinally sectioned on the mesio-distal axis in order to obtain 50 specimens, which were embedded in acrylic resin. At first, the specimens were ground to expose a flat surface of enamel, and a bond strength test was performed. Afterwards, the samples were ground again in order to obtain a flat surface of dentine. Ten groups (total: n=100) were assigned according to substrate (enamel and dentine), step in the bonding sequence when contamination occurred (before the acidic primer and after the bonding resin), and contamination treatment (dry or rinse and dry procedure). Fresh human blood was introduced either before or after SES application (Clearfil SE Bond) and treated with air drying, or by rinsing and drying following application. Composite resin (Filtek Z-250,3M ESPE) was applied as inverted, truncated cured cones that were debonded in tension. RESULTS: The mean tensile BS values (MPa) for enamel/dentine were 19.4/23.0 and 17.1/10.0 for rinse-and-dry treatment (contamination before and after SES, respectively); while the measurements for the dry treatment, 16.2/23.3 and 0.0/0.0 contamination before and after SES, respectively. CONCLUSIONS: It was determined that blood contamination impaired adhesion to enamel and dentine when it occurred after bond light curing. Among the tested contamination treatments, the rinse-and-dry treatment produced the highest bond strength with BC after SES application, but it was not sufficient to recover the BS in the contamination-free group

ATUAÇÃO DOS SERVIDORES DA FUNDAÇÃO UNIVERSIDADE FEDERAL DE RONDÔNIA (UNIR) EM CACOAL – RO NA IMPLEMENTAÇÃO DA CULTURA DE ACESSO À INFORMAÇÃO POR MEIO DO SISTEMA ELETRÔNICO DO SERVIÇO DE INFORMAÇÕES AO CIDADÃO (E-SIC)

Constitui objeto desse estudo, identificar o grau de conhecimento dos servidores públicos ativos da UNIR no Campus de Cacoal sobre o e-SIC, o qual constitui um sistema que permite que qualquer pessoa, física ou jurídica, solicite e obtenha informações dos órgãos e entidades do Executivo no Brasil, a partir de um cadastro eletrônico. Dada a importância do tema elaborou-se a seguinte questão problema: os servidores públicos ativos da UNIR lotados no Campus em Cacoal – RO, atuam como agentes de mudança na implementação de uma cultura de acesso à informação por meio do e-SIC? Para isso foi necessário, primeiramente, classificar o perfil de conhecimento apresentado pelos referidos servidores sobre o e-SIC para, em seguida, caracterizar o perfil de uso do e-SIC dos mesmos, por meio de uma pesquisa survey. O instrumento utilizado foi o questionário fechado e aplicado junto a uma população de 76 (setenta e seis) servidores entre técnicos e docentes e a amostra de 100%. Os resultados apontaram que os servidores da UNIR em Cacoal – RO não estão atuando, ainda, como agentes de mudança na implementação da cultura de acesso à informação por meio do e-SIC em razão de apenas 3,2% declararem que conhecem bem o sistema enquadrando-se em um grau de conhecimento muito baixo

EVIDENCIAÇÃO DAS DEMONSTRAÇÕES CONTÁBEIS DOS MUNICÍPIOS DO ESTADO DE RONDÔNIA: UMA ANÁLISE SOB O PRISMA DA CONVERGÊNCIA DAS NORMAS DE CONTABILIDADE PÚBLICA BRASILEIRA ÀS NORMAS INTERNACIONAIS

O presente artigo diligenciou realizar um estudo sobre o processo de convergência das normas de contabilidade públicas brasileiras de acordo com os padrões internacionais. O objetivo geral da pesquisa consistiu-se em verificar o nível de evidenciação das Demonstrações Contábeis dos Municípios do Estado de Rondônia em consonância com a convergência das normas. Assim, esta pesquisa qualitativa, de objetivos exploratórios e descritivos, e de procedimentos bibliográficos e documental, utilizou-se para verificar o nível de evidenciação das demonstrações contábeis das entidades públicas uma métrica composta por 8 unidades e 51 categorias de análise. Quanto a amostra de pesquisa, foram considerados os municípios rondonienses que publicaram seus demonstrativos contábeis consolidados nos anos de 2013 e 2014, nos quais foram identificados 7 municípios no total. Desta forma, quanto ao nível de evidenciação, verificou-se que a pontuação mais alta (maior nível de evidenciação) obtida foi alcançada pelo município de Ji-Paraná em ambos os anos de pesquisa, que evidenciou 46 itens (90,19%); e de forma geral foi constatado um baixo nível de evidenciação pelos municípios rondonienses no ano de 2013 – 19 pontos em média dos municípios, de 51 possíveis – e uma melhora para o ano de 2014, sendo caracterizada a maioria dos municípios com o nível médio ou alto – 31 pontos em média, de 51 possíveis

SUSTENTABILIDADE NAS INSTITUIÇÕES DE ENSINO SUPERIOR: UM ESTUDO NO MUNICÍPIO DE CACOAL - RO

O objetivo desta pesquisa consiste em apontar quais os procedimentos das Instituições de Ensino Superior do município de Cacoal- RO que denotam as ações praticadas no âmbito da Sustentabilidade, haja vista a necessidade de se conhecer as práticas sustentáveis e o incentivo ao desenvolvimento sustentável nas referidas instituições,uma vez que estas fomentam a economia local, geram forte movimentação financeira na cidade e contribuem para a formação de futuros profissionais. Realizou-se uma pesquisa exploratória descritiva, com abordagem qualitativa por meio do método dedutivo, mediante adoção de procedimentos de pesquisa bibliográfica, de campo e documental. A técnica de pesquisa empregada foi a de entrevistas com apoio de formulário pré-elaborado, com gestores de instituições de ensino superior presenciais do município de Cacoal, uma vez que são responsáveis por controlar, organizar e alocar os recursos, além de solucionar possíveis problemas de conformidade das mesmas. Os dados foram verificados, interpretados e confrontados, utilizando-se figuras com o auxílio de recursos do Microsoft Word

DESENVOLVIMENTO SUSTENTÁVEL: UMA PERSPECTIVA INTEGRADA PARA GARANTIR SAÚDE PLANETÁRIA E A SOBERANIA ALIMENTAR

This article is about the interconnection between sustainable development with regard to ensuring planetary health and food sovereignty. In this context, planetary health is understood based on the paradigm shift proposed by the degradation of the environment during the decades preceding the current situation. In the meantime, it can be said that, in addition to excess production towards agribusiness, there is also the formation of the process of food insecurity and disrespect for the cultures of each society, through the violence proposed by the colonial idea of enrichment through economic capital. To this end, this summary studies the interconnection between sustainable development, planetary health and Food Sovereignty, in order to clarify the implications intrinsic to each concept and intertwined with each other. In this sense, secondary sources were chosen, through books, articles and texts that were related to the objective. Thus, as an exclusion criterion, all texts that did not express a strict relationship and were on the margins of the debate were discarded. On the other hand, for inclusion, we sought to collect texts that discuss the topic in a way corresponding to the discussion. Thus, food sovereignty is the right of people to define their own agricultural and food policies according to their needs and cultures, which recognizes the importance of autonomy in the production and access to healthy and sustainable food. Food sovereignty values ​​family farming, fair trade and the preservation of natural resources. In turn, planetary health presents itself as an essential approach to sustainable development and promoting human well-being. Thus, the search for planetary health, sustainable development and food sovereignty is a collective and continuous effort that requires concrete actions at a global, national and individual level. Therefore, the protection and preservation of the environment, the promotion of sustainable agricultural practices, especially within the family, and the guarantee of equitable access to healthy food are essential elements for a healthy and sustainable future for all, so that by recognizing interdependence Between health, the environment and healthy eating, we can talk about sustainable development.O presente artigo versa sobre a interconexão entre o desenvolvimento sustentável no que diz respeito à garantia da saúde planetária e da soberania alimentar. Nesse contexto, a saúde planetária é compreendida a partir da mudança de paradigma proposta pela degradação do meio ambiente durante os decênios que precedem o quadro atual. Nesse ínterim, pode-se dizer que, além do excesso de produção em direção ao agronegócio, tem-se, outrossim, a formação do processo de insegurança alimentar e do desrespeito às culturas de cada sociedade, por meio da violência proposta pela ideia colonial do enriquecimento através do capital econômico. Para tanto, este resumo estuda a interconexão entre desenvolvimento sustentável, saúde planetária e Soberania Alimentar, de forma a clarificar as implicações intrínsecas a cada conceito e entrelaçadas entre si. Nesse sentido, optou-se por fontes secundárias, através de livros, artigos e textos que tivessem relação com o objetivo. Assim, como critério de exclusão, foram descartados todos os textos que não expressassem relação estrita e estivessem à margem do debate. Por outro lado, para inclusão, procurou-se coletar os textos que discutem a temática de forma correspondente à discussão. Destarte, a soberania alimentar é o direito dos povos de definirem suas próprias políticas agrícolas e alimentares de acordo com suas necessidades e culturas que reconhecem a importância da autonomia na produção e no acesso a alimentos saudáveis e sustentáveis. A soberania alimentar valoriza a agricultura familiar, o comércio justo e a preservação dos recursos naturais. Por sua vez, a saúde planetária apresenta-se como abordagem imprescindível no desenvolvimento sustentável e na promoção ao bem-estar do ser humano. Assim, a busca pela saúde planetária, o desenvolvimento sustentável e a soberania alimentar trata-se de um esforço coletivo e contínuo que requer ações concretas em nível global, nacional e individual. Desse modo, a proteção e preservação do meio ambiente, a promoção de práticas agrícolas sustentáveis, mormente no âmbito familiar, a garantia de acesso equitativo a alimentos saudáveis são elementos essenciais para um futuro saudável e sustentável para todos, de forma que ao reconhecer a interdependência entre saúde, meio ambiente e a alimentação saudável, pode-se falar em desenvolvimento sustentável

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum TimeCourse

Introduction: Increased cardiovascular (CV) morbidity and mortality is observed in inflammatory joint diseases (IJDs) such as rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis. However, the management of CV disease in these conditions is far from being well established.Areas covered: This review summarizes the main epidemiologic, pathophysiological, and clinical risk factors of CV disease associated with IJDs. Less common aspects on early diagnosis and risk stratification of the CV disease in these conditions are also discussed. In Europe, the most commonly used risk algorithm in patients with IJDs is the modified SCORE index based on the revised recommendations proposed by the EULAR task force in 2017.Expert opinion: Early identification of IJD patients at high risk of CV disease is essential. It should include the use of complementary noninvasive imaging techniques. A multidisciplinary approach aimed to improve heart-healthy habits, including strict control of classic CV risk factors is crucial. Adequate management of the underlying IJD is also of main importance since the reduction of disease activity decreases the risk of CV events. Non-steroidal anti-inflammatory drugs may have a lesser harmful effect in IJD than in the general population, due to their anti-inflammatory effects along with other potential beneficial effects.This research was partially funded by FOREUM—Foundation for Research in Rheumatolog

Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients

Data on convalescent plasma (CP) treatment in COVID-19 outpatients are scarce. We aimed to assess whether CP administered during the first week of symptoms reduced the disease progression or risk of hospitalization of outpatients. Two multicenter, double-blind randomized trials (NCT04621123, NCT04589949) were merged with data pooling starting when = 50 years and symptomatic for <= 7days were included. The intervention consisted of 200-300mL of CP with a predefined minimum level of antibodies. Primary endpoints were a 5-point disease severity scale and a composite of hospitalization or death by 28 days. Amongst the 797 patients included, 390 received CP and 392 placebo; they had a median age of 58 years, 1 comorbidity, 5 days symptoms and 93% had negative IgG antibody-test. Seventy-four patients were hospitalized, 6 required mechanical ventilation and 3 died. The odds ratio (OR) of CP for improved disease severity scale was 0.936 (credible interval (CI) 0.667-1.311); OR for hospitalization or death was 0.919 (CI 0.592-1.416). CP effect on hospital admission or death was largest in patients with <= 5 days of symptoms (OR 0.658, 95%CI 0.394-1.085). CP did not decrease the time to full symptom resolution

Neuropsychiatric manifestations and sleep disturbances with dolutegravir-based antiretroviral therapy versus standard of care in children and adolescents: a secondary analysis of the ODYSSEY trial

BACKGROUND: Cohort studies in adults with HIV showed that dolutegravir was associated with neuropsychiatric adverse events and sleep problems, yet data are scarce in children and adolescents. We aimed to evaluate neuropsychiatric manifestations in children and adolescents treated with dolutegravir-based treatment versus alternative antiretroviral therapy. METHODS: This is a secondary analysis of ODYSSEY, an open-label, multicentre, randomised, non-inferiority trial, in which adolescents and children initiating first-line or second-line antiretroviral therapy were randomly assigned 1:1 to dolutegravir-based treatment or standard-of-care treatment. We assessed neuropsychiatric adverse events (reported by clinicians) and responses to the mood and sleep questionnaires (reported by the participant or their carer) in both groups. We compared the proportions of patients with neuropsychiatric adverse events (neurological, psychiatric, and total), time to first neuropsychiatric adverse event, and participant-reported responses to questionnaires capturing issues with mood, suicidal thoughts, and sleep problems. FINDINGS: Between Sept 20, 2016, and June 22, 2018, 707 participants were enrolled, of whom 345 (49%) were female and 362 (51%) were male, and 623 (88%) were Black-African. Of 707 participants, 350 (50%) were randomly assigned to dolutegravir-based antiretroviral therapy and 357 (50%) to non-dolutegravir-based standard-of-care. 311 (44%) of 707 participants started first-line antiretroviral therapy (ODYSSEY-A; 145 [92%] of 157 participants had efavirenz-based therapy in the standard-of-care group), and 396 (56%) of 707 started second-line therapy (ODYSSEY-B; 195 [98%] of 200 had protease inhibitor-based therapy in the standard-of-care group). During follow-up (median 142 weeks, IQR 124–159), 23 participants had 31 neuropsychiatric adverse events (15 in the dolutegravir group and eight in the standard-of-care group; difference in proportion of participants with ≥1 event p=0·13). 11 participants had one or more neurological events (six and five; p=0·74) and 14 participants had one or more psychiatric events (ten and four; p=0·097). Among 14 participants with psychiatric events, eight participants in the dolutegravir group and four in standard-of-care group had suicidal ideation or behaviour. More participants in the dolutegravir group than the standard-of-care group reported symptoms of self-harm (eight vs one; p=0·025), life not worth living (17 vs five; p=0·0091), or suicidal thoughts (13 vs none; p=0·0006) at one or more follow-up visits. Most reports were transient. There were no differences by treatment group in low mood or feeling sad, problems concentrating, feeling worried or feeling angry or aggressive, sleep problems, or sleep quality. INTERPRETATION: The numbers of neuropsychiatric adverse events and reported neuropsychiatric symptoms were low. However, numerically more participants had psychiatric events and reported suicidality ideation in the dolutegravir group than the standard-of-care group. These differences should be interpreted with caution in an open-label trial. Clinicians and policy makers should consider including suicidality screening of children or adolescents receiving dolutegravir