The muon anomalous magnetic moment and a new light gauge boson

It is shown that the 2.6 $\sigma$ discrepancy between the predicted and recently measured value of the anomalous magnetic moment of positive muons could be explained by the existence of a new light gauge boson X with a mass $M_X \leq O(5) GeV$. Phenomenological bounds on the X coupling are discussed.Comment: 7 pages, version to appear in PL

Targeted Gene Expression Profiling Predicts Meningioma Outcomes and Radiotherapy Responses

Surgery is the mainstay of treatment for meningioma, the most common primary intracranial tumor, but improvements in meningioma risk stratification are needed and indications for postoperative radiotherapy are controversial. Here we develop a targeted gene expression biomarker that predicts meningioma outcomes and radiotherapy responses. Using a discovery cohort of 173 meningiomas, we developed a 34-gene expression risk score and performed clinical and analytical validation of this biomarker on independent meningiomas from 12 institutions across 3 continents (N = 1,856), including 103 meningiomas from a prospective clinical trial. The gene expression biomarker improved discrimination of outcomes compared with all other systems tested (N = 9) in the clinical validation cohort for local recurrence (5-year area under the curve (AUC) 0.81) and overall survival (5-year AUC 0.80). The increase in AUC compared with the standard of care, World Health Organization 2021 grade, was 0.11 for local recurrence (95% confidence interval 0.07 to 0.17, P \u3c 0.001). The gene expression biomarker identified meningiomas benefiting from postoperative radiotherapy (hazard ratio 0.54, 95% confidence interval 0.37 to 0.78, P = 0.0001) and suggested postoperative management could be refined for 29.8% of patients. In sum, our results identify a targeted gene expression biomarker that improves discrimination of meningioma outcomes, including prediction of postoperative radiotherapy responses

Personalized early detection and prevention of breast cancer: ENVISION consensus statement

Abstract: The European Collaborative on Personalized Early Detection and Prevention of Breast Cancer (ENVISION) brings together several international research consortia working on different aspects of the personalized early detection and prevention of breast cancer. In a consensus conference held in 2019, the members of this network identified research areas requiring development to enable evidence-based personalized interventions that might improve the benefits and reduce the harms of existing breast cancer screening and prevention programmes. The priority areas identified were: 1) breast cancer subtype-specific risk assessment tools applicable to women of all ancestries; 2) intermediate surrogate markers of response to preventive measures; 3) novel non-surgical preventive measures to reduce the incidence of breast cancer of poor prognosis; and 4) hybrid effectiveness–implementation research combined with modelling studies to evaluate the long-term population outcomes of risk-based early detection strategies. The implementation of such programmes would require health-care systems to be open to learning and adapting, the engagement of a diverse range of stakeholders and tailoring to societal norms and values, while also addressing the ethical and legal issues. In this Consensus Statement, we discuss the current state of breast cancer risk prediction, risk-stratified prevention and early detection strategies, and their implementation. Throughout, we highlight priorities for advancing each of these areas

Interculturalism: Europe and Its Muslims in Search of Sound Societal Models. CEPS Paperbacks. June 2011

The simmering debate in Europe about multiculturalism versus assimilation has now come to a boil. The German Chancellor, Angela Merkel, famously stated in October 2010 that “multiculturalism in Germany (Multikulti) had failed, completely failed”. In February 2011, both Prime Minister David Cameron and President Nicholas Sarkozy could also be heard declaring that multiculturalism was a failure, although only the French President endorsed assimilation as the alternative. Others argue that both assimilation and multiculturalism have failed. These dramatic statements represent the challenge of interpretation and policy analysis to which this book is addressed. If these single words can identify a failure of society and of the policies of government, then there has to be a better model, concept and policy. This study tries to work towards a better solution, and uses the term ‘interculturalism’ to represent that solution