24 research outputs found
Sleep and immune function
- Author
- A Cava La
- A Grakoui
- A Zager
- AC Griffin
- AI Esquifino
- AI Esquifino
- AN Vgontzas
- AN Vgontzas
- AN Vgontzas
- BL Spangelo
- BS McEwen
- C Benedict
- C Benedict
- C Bierwolf
- C Dodt
- C Franceschi
- C Simon
- CA Everson
- CA Everson
- CA Ottaway
- CJ Fox
- CV Clevenger
- D Kioussis
- D Lucas
- D Luna-Moreno
- DA Kaminski
- DD Taub
- DE Blask
- DL Drazen
- DM Nance
- DP Cardinali
- DP Cardinali
- E Cauter Van
- E Haus
- E Spath-Schwalbe
- ES Reis
- F Geissmann
- F Halberg
- F Kapsimalis
- F Radogna
- FS Dhabhar
- GJ Maestroni
- GM Lord
- HK Meier-Ewert
- HO Besedovsky
- HO Besedovsky
- I Wilhelm
- IC Chikanza
- IJ Elenkov
- J Born
- J Born
- J Westermann
- Jan Born
- JB Dickstein
- JB Dickstein
- JD Scheff
- JH Cox
- JM Krueger
- JM Krueger
- JM Krueger
- JM Mullington
- JM Mullington
- JP Campbell
- JR Stephenson
- K Spiegel
- K Spiegel
- K Spiegel
- K Spiegel
- K Viswanathan
- K Viswanathan
- KB Renegar
- KB Renegar
- KW Kelley
- L Capuron
- L Chen
- L Pavon
- LA Toth
- Luciana Besedovsky
- M Haack
- M Haack
- M Haack
- M Hayashi
- M Irwin
- M Keller
- M Mellado
- M Schwartz
- MA Cooper
- MG Bonacho
- MG Strainic
- MH Bonnet
- ML Dustin
- N Hattori
- N Petrovsky
- N Ron-Harel
- NP Walsh
- O Suchanek
- P Cano
- P Meerlo
- P Saint-Mezard
- PA Bryant
- R Brown
- RA Warnock
- RH Straub
- RH Straub
- RJ Benschop
- RM Ransohoff
- RR Gala
- S Cohen
- S Diekelmann
- S Dimitrov
- S Dimitrov
- S Dimitrov
- S Dimitrov
- S Dimitrov
- S Gallucci
- S Mendez-Ferrer
- S Smaniotto
- S Suzuki
- SA Jones
- T Bollinger
- T Bollinger
- T Lange
- T Lange
- T Lange
- T Lange
- Tanja Lange
- WT Shearer
- Y Matsumoto
- YJ Liu
- Z Grossman
- Z Guan
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2011
- Field of study
Sleep and the circadian system exert a strong regulatory influence on immune functions. Investigations of the normal sleep–wake cycle showed that immune parameters like numbers of undifferentiated naïve T cells and the production of pro-inflammatory cytokines exhibit peaks during early nocturnal sleep whereas circulating numbers of immune cells with immediate effector functions, like cytotoxic natural killer cells, as well as anti-inflammatory cytokine activity peak during daytime wakefulness. Although it is difficult to entirely dissect the influence of sleep from that of the circadian rhythm, comparisons of the effects of nocturnal sleep with those of 24-h periods of wakefulness suggest that sleep facilitates the extravasation of T cells and their possible redistribution to lymph nodes. Moreover, such studies revealed a selectively enhancing influence of sleep on cytokines promoting the interaction between antigen presenting cells and T helper cells, like interleukin-12. Sleep on the night after experimental vaccinations against hepatitis A produced a strong and persistent increase in the number of antigen-specific Th cells and antibody titres. Together these findings indicate a specific role of sleep in the formation of immunological memory. This role appears to be associated in particular with the stage of slow wave sleep and the accompanying pro-inflammatory endocrine milieu that is hallmarked by high growth hormone and prolactin levels and low cortisol and catecholamine concentrations
Pharmacological Strategies for the Management of Levodopa-Induced Dyskinesia in Patients with Parkinson’s Disease
- Author
- A Alachkar
- A Antonini
- A Berthet
- A Jahangirvand
- A Lees
- A Lieberman
- A Lopez
- A Molina-Hernandez
- A Mori
- A Munoz
- A Munoz
- A Nadjar
- A Nahimi
- A Schrag
- A Thomas
- AH Rajput
- AH Rajput
- AH Schapira
- AJ Manson
- AJ Manson
- AJ Manson
- AJ Manson
- AM Murray
- Andrea Pilotto
- AR Carta
- AR Troiano
- B Henry
- B Henry
- B Lavoie
- B Ossola
- B Ouattara
- B Picconi
- B Picconi
- BE Jones
- BJ Snow
- BY Zeng
- C Fiorentini
- C Fiorentini
- C Guigoni
- C Kobylecki
- C Kobylecki
- C Konradi
- C Marin
- C Moine Le
- C Moreau
- C Sampaio
- C Winkler
- CA Braz
- CA Lieu
- CA Lieu
- CB Carroll
- CG Goetz
- CG Goetz
- CG Goetz
- CH Waters
- CH Waters
- CJ Barnum
- CL Xie
- CR Gerfen
- CR Gerfen
- CR Gerfen
- CW Olanow
- CW Olanow
- CW Olanow
- D Berg
- D Mango
- D Nilsson
- D Rylander
- D Rylander
- D Xiao
- D Zhang
- DA Monte Di
- Daniela Berg
- DJ Brooks
- DM Herz
- DW Miller
- E Bezard
- E Bezard
- E Dupont
- E Luginger
- E Moreno
- E Pourcher
- E Santini
- E Santini
- E Santini
- E Wolf
- EC Maratos
- EC Maratos
- EC Wolters
- ED Abercrombie
- Eva Schaeffer
- F Bibbiani
- F Calon
- F Calon
- F Durif
- F Fornai
- F Fulceri
- F Gardoni
- F Grandas
- F Mela
- F Ory-Magne
- F Stocchi
- F Stocchi
- F Stocchi
- F Stocchi
- FM Zhou
- G Block
- G Fabbrini
- G Fenelon
- G Gerdeman
- G Hasko
- G Lera
- GA Ordway
- H Baas
- H Kase
- H Prast
- H Reichmann
- H Sawada
- H Tanaka
- H Yamada
- HA Hanagasi
- HS Lindgren
- HS Lindgren
- HY Park
- I Ahmed
- I Aubert
- I Aubert
- I Mahmood
- I Shoulson
- J Bronzova
- J Gomez-Ramirez
- J Grenhoff
- J Jankovic
- J Jankovic
- JC Moller
- JD Oh
- JE Ahlskog
- JE Ahlskog
- JE Westin
- JE Westin
- JG Nutt
- JG Nutt
- JG Nutt
- JI Sage
- JJ Ferreira
- JL Koranda
- JL Montastruc
- JM Brotchie
- JM Loftis
- JM Savola
- JS Schneider
- JY Hong
- K Eggert
- K Eggert
- K Kannari
- K Kannari
- K Tayarani-Binazir
- K Venderova
- KA Sieradzan
- KA Stockwell
- KE Ohlin
- KK Wong
- KL Eskow
- KS Raevskii
- L Gregoire
- LA Smith
- LA Smith
- LC Johnston
- LV Metman
- LV Metman
- M Andersson
- M Carta
- M Carta
- M Carta
- M Carta
- M Carta
- M Contin
- M Emre
- M Lundblad
- M Lundblad
- M Merello
- M Morelli
- M Murata
- M Politis
- M Stacy
- M Wolz
- M Zappia
- MA Cenci
- MA Cenci
- MA Cenci
- MA Hely
- MA Silverdale
- MC Kurth
- MF Lew
- MJ Guerra
- MJ Hurley
- MK Tamim
- MM Bucheler
- MM Iravani
- MM Mouradian
- MP Hill
- MP Hill
- N Blercom Van
- N Morin
- N Pavese
- N Pavon
- NP Visanji
- O Rascol
- O Rascol
- O Rascol
- O Rascol
- O Rascol
- O Rascol
- ODP Rascol
- P Barone
- P Calabresi
- P Dotto Del
- P Garcao
- P Gaspar
- P Hagell
- P Huot
- P Jenner
- P Jenner
- P Mailleux
- P Piccini
- P Stathis
- PA Lewitt
- PA LeWitt
- PA LeWitt
- PA LeWitt
- PA Price
- PJ Bedard
- PJ Blanchet
- PJ Hallett
- PJ Hallett
- PM Becker
- R Arai
- R Arai
- R Borgohain
- R Borgohain
- R Djaldetti
- R Fuente-Fernandez de la
- R Grondin
- R Inzelberg
- R Katzenschlager
- R Katzenschlager
- R Pahwa
- R Pons
- R Stowe
- R Talati
- RA Hauser
- RA Hauser
- RA Hauser
- RA Hodgson
- RG Holloway
- RH Wessell
- RJ Mones
- RL Watts
- RM Cohen
- RTC Pahwa
- S Boyce
- S Boyce
- S Darmopil
- S Duty
- S Fahn
- S Fahn
- S Ferre
- S Fox
- S Konitsiotis
- S Navailles
- S Pietracupa
- S Reddy
- S Robelet
- S Uhlen
- S Varanese
- SA Factor
- SA Factor
- SH Fox
- SH Fox
- SJ Cragg
- SL Foote
- SN Schiffmann
- T Bordia
- T Carlsson
- T Carlsson
- T Foltynie
- T Klockgether
- T Maeda
- T Muller
- TDB-JW Dimitrova
- TH Johnston
- TH Johnston
- TN Chase
- TOC Müller
- TS Gertler
- V Marzo Di
- V Sgambato-Faure
- V Sossi
- W Bara-Jimenez
- W Bara-Jimenez
- W Maetzler
- W Zhang
- WC Koller
- WG Ondo
- WH Poewe
- WH Poewe
- WJ Hwang
- XA Perez
- Y Mizuno
- Y Mizuno
- Y Mizuno
- Y Tani
- Y Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
- Author
- Abdallah J
- Abdul Ghani R
- Abdul Kadir K
- Abdullah R
- Abejuela Z
- Abouglila K
- Abraham O
- Abrahamsen I
- Abraira Munoz Ld
- Abramowitz M
- Abusnana S
- Accini Mendoza Jl
- Acosta I
- Agafyina A
- Agarwal R
- Agarwal Rajiv
- Aggarwal N
- Agra J
- Ahmed F
- Ahuad Guerrero Ra
- Aiello J
- Ainsworth P
- Aizenberg D
- Akiyama H
- Akright L
- Akyea-Djamson A
- Al-Karadsheh A
- Alamartine E
- Alappan R
- Albisu Jp
- Ali N
- Ali Z
- Alicic R
- Allison Dc
- Alvarez Garcia P
- Alvarisqueta A
- Alves da Costa Fa
- Amerena J
- Amigo A
- Amodeo C
- Andreeva V
- Andreotti Turatti La
- Angelescu Lm
- Angelova A
- Anghel V
- Antic S
- Aoki H
- Aquitania G
- Arauz-Pacheco C
- Arcos E
- Arfeen S
- Arif A
- Aronson R
- Arutchelvam V
- Arvind M
- Asano A
- Asmarats Mercadal L
- Atray N
- August P
- Avendano J
- Avram Ri
- Awad A
- Babikova J
- Badat A
- Bajaj H
- Baker J
- Bakris G
- Bakris George
- Barbarash O
- Barna O
- Barnard M
- Barnhill P
- Barranco E
- Barrera C
- Barrios C
- Bartaskova D
- Bartolacci I
- Barton P
- Barysheva O
- Beacom M
- Behara V
- Bellary S
- Belo D
- Belobradkova J
- Bentley-Lewis R
- Benusova O
- Berenguer R
- Berli Ma
- Bermudez L
- Bernardo M
- Bhushan Rs
- Bijata-Bronisz R
- Bilyk Sd
- Bin Shudim Ss
- Biscoveanu M
- Bompoint Severine
- Bonadonna R
- Bordonava A
- Borot S
- Botsyurko V
- Bowman-Stroud C
- Brandon D
- Breedt J
- Bregman R
- Brenner Barry M
- Brenner Bm
- Brusco O
- Buganova I
- Bull Scott
- Burst V
- Busch R
- Busegeanu Mm
- Calella P
- Camelo Sanches Fc
- Canaan Y
- Canani Lh
- Cannon Christopher P
- Cannon Cp
- Cantero Mc
- Capuano George
- Caringal C
- Cariou B
- Cartasegna Lr
- Castellino P
- Cercos E
- Cereto Castro F
- Ceriello A
- Chacra Ar
- Chae Dw
- Chang Ct
- Chang T
- Chapin L
- Charytan David M
- Charytan Dm
- Che Yusof Md
- Cheifetz A
- Chen E
- Chen N
- Chen Q
- Cherney D 3rd
- Chertow G
- Cheung Nw
- Chilito A
- Chiovato L
- Chizhov D
- Cho Ym
- Chouinard G
- Christensen T
- Christiano C
- Christofides E
- Chu Pei-Ling
- Chuang Lm
- Chuateco C
- Cif A
- Cigarran Guldris S
- Coffee L
- Cohen K
- Cohen R
- Cohen S
- Cohen-Stein D
- Coloma Gc
- Colombo H
- Comia Rs
- Commendatore V
- Conway J
- Cook C
- Correa Rotter Jr
- Cosma D
- Cournoyer S
- Coyne D
- Crisan C
- Cruz Jb
- Csecsei G
- Csiky B
- Cuadrado J
- Culak J
- Cuneo Ca
- Cunha Borges Jl
- Cunha V\ueancio Sa
- Cusumano Am
- D'Avila D
- da Silva Franco Rj
- Daboul N
- Danos P
- Daroza G
- Darwish R
- Daswani A
- David C
- Davies E
- Davies M
- Davies S
- Dawson A
- De Brouwer K
- de Carvalho Contieri Fl
- De Cosmo S
- De Nicola L
- De Serres S
- de Souza Portes E
- de Souza P
- de Zeeuw D
- de Zeeuw Dick
- Deak L
- Deboni Lm
- Deck K
- Deepak D
- Delos Santos L
- Demian Ld
- Derosa G
- Desouza C
- Destree M
- Dev D
- Dhillon M
- Di Carlo A
- Di Cianni G
- Diaz Escalante T
- Diaz Ruiz Jea
- Dimitrov S
- Distiller L
- Distiller L
- Djordjevic M
- Dobronravov V
- Dohnalova L
- Dominquez Lopez M
- Douthat Wg
- Dran Rd
- Drasnar T
- Dreval A
- Droste C
- Dua S
- Dub\ue9 F
- Dudar I
- Dudas M
- Dussol B
- Dzupina A
- Dzuponova J
- Eder F
- Edwards Robert
- Edwin Fm
- Egido de Los Rios J
- El Kossi M
- El-Shahawy M
- Elosegui Am
- English P
- Enriquez Sosa Fe
- Ervin J
- Esquenazi A
- Evans J
- Faghih M
- Farias E
- Faulmann G
- Fauvel Jp
- Ferariu Ie
- Ferkl R
- Fern\ue1ndez Montenegro Ma
- Fernandez Fresnedo G
- Fernandez Mf
- Feuerstein J
- Filho Ff
- Finkelstein H
- Fishbane S
- Flores Lozano F
- Flota Cervera Lf
- Fragale G
- Frasc\ue0 G
- Fraser D
- Fraser I
- Frenk Baron P
- Fretes Jo
- Frias J
- Fuiano G
- Fulcher G
- Fulop P
- Fushtey I
- G\uf3rriz Jl
- Gaglia J
- Galan Serrano A
- Galindo-Ramos E
- Galphin C
- Gambaro G
- Gan Cl
- Gan S
- Garcia Ballesteros C
- Garcia Ortiz Lh
- Garcia I
- Garcia Nh
- Garibotto G
- Gastaldi A
- Gaupsiene E
- Gelersztein E
- Geloneze Neto B
- Genadieva V
- Genova-Hristova G
- George S
- Ghazi A
- Giorda C
- Glenny Ja
- Glinkina I
- Gnudi L
- Godlevska O
- Godoy Jorquera Jg
- Goldenberg R
- Golovchenko O
- Gomes M
- Gomez Rangel Jd
- Gomez O
- Gonzalez Colaso Pdc
- Gonzalez Martinez Fj
- Gonzalez Orellana Ra
- Gonzalez A
- Gonzalez E
- Gonzalez Jp
- Gopalakrishnan N
- Gorelick P
- Gorson D
- Gourdy P
- Govender R
- Govender V
- Gowda A
- Goycoa C
- Goykhman S
- Gracious N
- Greco B
- Greene T
- Greene Tom
- Greloni Gc
- Grineva E
- Grubb S
- Guinsburg A
- Gulati R
- Gunstone A
- Gupta A
- Gupta M
- Gyrina O
- Haase Fp
- Hadjadj S
- Halciakova K
- Hall T
- Haller H
- Halmagyi I
- Hammoud J
- Hancu N
- Handelsman S
- Hanif W
- Hansraj A
- Harcsa E
- Harris R
- Hartman I
- Hawley C
- Heerspink Hiddo J L
- Heerspink Hjl
- Henein S
- Hermida S
- Hernandez Triana E
- Herrera Jimenez Le
- Hershon K
- Hettiarachchi M
- Higuera Jd
- Hillis G
- Hiser D
- Holman R
- Home P
- Hon G
- Hotlos L
- Hristozov K
- Hsia Tl
- Hsieh Ch
- Hudson M
- Hufert K
- Hwang Sj
- Ignjatovic J
- Iitsuka T
- Ilavska A
- Irizar Santana Ss
- Ismail M
- Jackson A
- Jacob R
- Jaffer S
- Jaime M
- Jain D
- Jamal A
- Januszewicz A
- Januzzi J
- Jardine M
- Jardine Meg J
- Jardine Mj
- Jeong Ik
- Jerwan-Keim R
- Jha V
- Ji L
- Jimenez Florez F
- Jimeno C
- Jodar Gimeno Je
- Johnson A
- Johnson D
- Joseph F
- Joshi M
- Juncos Li
- Jurgens J
- Kaczmarek B
- Kajiyama S
- Kamenov Z
- Kaminska A
- Kashine S
- Kasner S
- Kaupke C
- Kawada T
- Kazmirchuk A
- Keightley G
- Keitel E
- Keltai K
- Kendereski A
- Keresztesi S
- Kern E
- Kerr Saraiva Jf
- Keshavamurthy Cb
- Khandwala H
- Khanna R
- Khirmanov V
- Khitan Z
- Khullar D
- Kim S
- Kim Sg
- Kim Yh
- Kiss K
- Kissela B
- Klein A
- Klokocnikova V
- Klyver Mi
- Kodera T
- Kohara Sk
- Koizumi M
- Kolansky D
- Kolesnyk I
- Kolesnyk M
- Kolmakova E
- Komisarenko I
- Kong Wy
- Kong Y
- Kono H
- Konyves L
- Koppolu D
- Kopyt N
- Koroleva T
- Korzh O
- Koundurdjiev A
- Kovar R
- Kovesdy C
- Koyama K
- Kozloviene D
- Kraft F
- Krane V
- Kravchun N
- Krishna G
- Krishnan S
- Kropp J
- Krynski F
- Kumar A
- Kumar J
- Kumar N
- Kumeda Y
- Kumwenda M
- Kurtz Lisboa Hr
- Kusnir J
- Kvitkova L
- Kwon Hs
- Kwon Mj
- Lalic K
- Lalic N
- Lam Sw
- Lanchiotti Pv
- Lane W
- Lastuvka J
- Latiff G
- Laviada Molina H
- Lawrence M
- Lazuka L
- Le Meur Y
- Lee Bw
- Lee J
- Lee Ly
- Lee Mk
- Legun O
- Lehrner L
- Leia C
- Leiter L
- Lentz J
- Leon de la Fuente Ra
- Levin A
- Levin Adeera
- Levinson D
- Lewis D
- Li D
- Li N
- Li W
- Li X
- Lim Sk
- Lim-Abrahan Ma
- Limos A
- Lin Cc
- Lin G
- Lin H
- Lin P
- Lindley R
- Liss K
- Liu J
- Loh Cl
- Lombard L
- Lozanov L
- Lu W
- Lu Yc
- Lukac M
- Luna Ceballos Ri
- Macdougall I
- Maddux A
- Madej A
- Madore F
- Mah Pm
- Mahaffey Kenneth W.
- Mahaffey Kw
- Maheshwari H
- Major L
- Malaver N
- Malberti F
- Malek Marin T
- Mandayam S
- Mandreoli M
- Manisha S
- Mankovskyy B
- Mannucci E
- Manocha Ab
- Mao H
- Marar I
- Marasaev V
- Marchetta N
- Margaritov V
- Martin Del Camp Blanco B
- Martinka E
- Martynyuk L
- Mascaro D
- Maxeiner S
- Mazur S
- Mcguire Dk
- Mcmahon A
- Medina Fari\uf1a M
- Mehta B
- Meininger G
- Meininger Gary
- Mele P
- Middleton J
- Milagres R
- Mileder M
- Miyauchi S
- Mizuyama K
- Mkrtumyan A
- Mlodawska-Choluj D
- Molina de Salazar Di
- Molnar M
- Montenegro Junior R
- Mookadam M
- Morales Franco G
- Morales Portillo C
- Mordujovich J
- Moreda R
- Moreira de Brito C
- Moreira Diaz Jp
- Moreno Loza Ot
- Morren F
- Morugova T
- Mostovoy Y
- Moustafa M
- Mu\uf1oz Lopez Mendoza M
- Mu\uf1oz Torres M
- Mucsi J
- Muirhead N
- Mujica Trenche S
- Munar Vila Ma
- Munteanu M
- Mustieles Rocha C
- Nagibovich G
- Nagibovich O
- Nam Ms
- Narayanan M
- Narvarte J
- Nassar T
- Navickas A
- Nazario Sabbag \uc2r
- Nazzer Hissa M
- Neal B
- Neal Bruce
- Nedogoda S
- Negru D
- Newman G
- Ng Ks
- Ngcakani N
- Nichol B
- Nicholls K
- Nicol P
- Nicolai S
- Nieto Iglesias J
- Niiya T
- Nik Ahmad Nnf
- Nisnisan J
- Nixon P
- Nonchev B
- Noonan P
- Noronha I
- Nortje H
- Nossuli Ak
- Novoa Pa
- Nowicki M
- Nowicki M
- O'Hare J
- O'Shaughnessy A
- Obialo C
- Obrador Vera G
- Obrador G
- Ochodnicka Z
- Oh Kh
- Oishi H
- Olelewe S
- Oliver M
- Onaca Ag
- Oosthuizen H
- Orio Si
- Orlowska-Kowalik G
- Oroszlan T
- Orozco Castellanos R
- Orsi E
- Ory I
- Osipova I
- Ota S
- Otreras F
- Ounadjela S
- Oviedo A
- Packham D
- Padron J
- Panarotto D
- Pankhaniya R
- Pantoja Perez J
- Paragh G
- Parfrey P
- Park Cy
- Park Sh
- Parker R
- Paschen B
- Pashkovska N
- Patel D
- Patel G
- Patel N
- Pavon H
- Pecoits Filho R
- Pecoits-Filho R
- Pella D
- Penfornis A
- Peralta Calcaneo J
- Pereira Ma
- Pererva L
- Perez Vera M
- Perez A
- Perez C
- Peringat J
- Perkovic V
- Perkovic Vlado
- Perlman A
- Pertseva T
- Pesickova S
- Peterfai E
- Peterka K
- Petrica L
- Petro G
- Pettis K
- Pharr W
- Philip S
- Phillips A
- Piatti P
- Pichette V
- Pillay-Ramaya L
- Plassmann G
- Plaza Mv
- Pollock C
- Pollock Carol
- Popa Ar
- Popenda G
- Popovic-Radinovic V
- Portoles Perez Jm
- Prasad N
- Proietto J
- Prozesky H
- Pumprla J
- Purighalla R
- Quesada Sim\uf3n Ma
- Quesada-Suarez L
- Rabasa-Lhoret R
- Raduan Ra
- Raffaele P
- Railey M
- Ramirez Roca La
- Ramos Jc
- Ramtoola S
- Ranetti Ae
- Rangelov R
- Ranjan R
- Raskina T
- Rastogi S
- Ratnasingam V
- Reddy J
- Reddy J
- Ren Y
- Rendell M
- Resk Jh
- Revesz K
- Rewerska B
- Reyes Rosano Ma
- Rheeder P
- Rich L
- Rista L
- Roberts A
- Robinson M
- Rodriguez Papini N
- Rodriguez Pattzi H
- Rodriguez H
- Roger S
- Rosas Guzman J
- Rosas S
- Rose L
- Rosero R
- Rosivall L
- Roussel R
- Rucker Joerg Ie
- Rychl\uedk I
- Rychlik I
- S\ue1nchez Arenales Ja
- Saaveddra Sanchez Sb
- Saavedra Gajardo V
- Saba F
- Sakakibara T
- Sala J
- Salazar Ma
- Samoylov O
- Samoylova Y
- Sanchez Mijangos Jh
- Sanchez Polo Jv
- Sankaram R
- Santoro D
- Santos F
- Santos Jc
- Saporito W
- Sarin R
- Sasso Fc
- Satyanarayana Rk
- Saudek F
- Saulnier Pj
- Saxena M
- Sazonova O
- Scharfstein D
- Schiavi Lb
- Schiller A
- Schmidt M
- Schreiman R
- Schuch T
- Scott D
- Scott R
- Scotton As
- Seeber M
- Sekkarie M
- Sennik D
- Sensenbrenner J
- Serafinceanu C
- Serrano Sanson P
- Serviddio G
- Sessa H
- Shahinfar S
- Shakeel M
- Shamkhalova M
- Shanik M
- Shaw S
- Sheth S
- Sheu Wh
- Shinkov A
- Shutemova E
- Shwartz Y
- Sim\uf5es de Almeida R
- Simo Canonge R
- Simon G
- Singh B
- Sinha Ad
- Slompo Ramos C
- Smatanova I
- Smirnov I
- Smith Casabella T
- Smith S
- Soares Fel\uedcio J
- Solomon R
- Song W
- Sood V
- Soto Gonzalez A
- Soto Mb
- Sowinski D
- Sprague A
- Spry L
- Sreedhar R
- Sreelatha M
- Starzec A
- Steele A
- Stella A
- Stephens J
- Strzelecka A
- Suchinda P
- Sudhakar B
- Sultan S
- Sun J
- Sun L
- Surampudi P
- Sussman S
- Svyshchenko Y
- Symonds R
- Takacs R
- Takai M
- Tamayo Y Orozco JA
- Tan A
- Tan G
- Tangri N
- Tellez Chavez E
- Temelkova M
- Terns Riera M
- Terrelonge A
- Terront Lozano Ma
- Tesar V
- Thervet E
- Thimmaiah R
- Thom\ue9 F
- Thompson M
- Tibes Hachmann Jc
- Tinahones Madueno Fj
- Toarba C
- Tolentino M
- Tomashkevych H
- Tomonaga O
- Topchii I
- Torshizi A
- Travis K
- Trespalacios F
- Trevisan R
- Trippe B
- Trueba P
- Tryshchuk N
- Tsang V
- Tseluyko V
- Tsujimoto M
- Tu P
- Turchin A
- Turcios Juarez E
- Turner W
- Twahirwa M
- Ulla Mr
- Updegrove J
- Urbanaviciene E
- Uriasyev O
- Valderrama Cometa L
- Valdes Depeda A
- Valdez M
- Valenzuela A
- Valis M
- Vallejos A
- Van Buren P
- Vangel S
- Vannorsdall M
- Vargas Alonso Rd
- Varghese F
- Vasas S
- Vazelov E
- Vejar M
- Velasquez-Mieyer P
- Velichkova E
- Venegas Carrillo L
- Vengadasalam P
- Ventrapragada S
- Veronelli Am
- Villagordoa Mesa J
- Villarino A
- Villegas I
- Visco Ve
- Vizir V
- Vlasenko M
- von Ingersleben G
- Vorobyev S
- Vukotic G
- Vyasam Rc
- Wada T
- Wadud K
- Wahba M
- Wakasugi M
- Wakeling J
- Wakida Y
- Walker R
- Wang G
- Wang H
- Warren M
- Wassermann A
- Watanabe T
- Watson E
- Watson H
- Watts R
- Weiner D
- Weiner P
- Welker J
- Welsh J
- Wheeler D
- Wheeler David C
- Wheeler Dc
- Williams M
- Williams S
- Winocour P
- Wong Ac
- Woo V
- Yakov A
- Yamada M
- Yamada S
- Yanagida K
- Yanase T
- Yang J
- Yao C
- Yap Ye
- Yavin Yshai
- Ygpuara Mdl
- Yin A
- Yoiti Hayashida C
- Yoon Kh
- Yost L
- Young S
- Yu X
- Yumita W
- Yupanqui H
- Zaidman Cj
- Zalunardo N
- Zamarripa Escobedo R
- Zanata Petry Tb
- Zanella Mt
- Zaniewski-Singh M.
- Zanoli L
- Zaoui P
- Zateyshchikova A
- Zateyshshikov D
- Zaviriukha V
- Zemek S
- Zhang H
- Zhang Hong
- Zhao M
- Zheng H
- Zinman B
- Zinman Bernard
- Zlova T
- Zsom M
- Zub L
- Zykova T
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to 300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m 2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
Canagliflozin and renal outcomes in type 2 diabetes and nephropathy
- Author
- A Kaldun Nossuli
- Aamir Jamal
- Adalbert Schiller
- Adam Cheifetz
- Adarsh Daswani
- Adeera Levin
- Adline Ghazi
- Adrian Guinsburg
- Adriana Cif
- Adriana Gabriela Onaca
- Adriana Ilavska
- Adriana Villarino
- Agarwal R.
- Agnieszka Starzec
- Ahmed Arif
- Ahmed Awad
- Aiping Yin
- Akimichi Asano
- Alan Jackson
- Alan McMahon
- Alan Perlman
- Alberto Di Carlo
- Alberto Esquenazi
- Alejandra Oviedo
- Alejandro Valdes Depeda
- Aleksandra Kendereski
- Alex Valenzuela
- Alexander Dreval
- Alexander Gonzalez
- Alexander Shinkov
- Alexander Turchin
- Alexandre Klein
- Alfonso Soto Gonzalez
- Alfred Penfornis
- Alfredo Chew Wong
- Alfredo Wassermann
- Ali Torshizi
- Alicia Chilito
- Alina Agafyina
- Alison Dawson
- Alva Hansraj
- Amer Al-Karadsheh
- Amorin Remus Popa
- Amrendra Kumar
- Amy Sprague
- Ana Limos
- Ana Maria Cusumano
- Ana Maria Elosegui
- Anabella Amigo
- Anatoliy Kazmirchuk
- Andrea Phillips
- Andrea Stella
- Andreas Maddux
- Andrej Dzupina
- Andres Alvarisqueta
- Andrew Johnson
- Andrew O'Shaughnessy
- Andrew Steele
- Andrian Yakov
- Andrzej Januszewicz
- Andrzej Madej
- Angelina Angelova
- Anibal Gastaldi
- Anil Gupta
- Anita Bhajan Manocha
- Anjanette Tan
- Anna Kaminska
- Anna Maria Veronelli
- Anna Strzelecka
- Anna Zateyshchikova
- Anselmo Bordonava
- Antanas Navickas
- Anthony Gunstone
- Anthony Roberts
- Antonio Ceriello
- Antonio Galan Serrano
- Antonio Scafuto Scotton
- Antonio Terrelonge
- Antônio Roberto Chacra
- Anupama Gowda
- Arjun D Sinha
- Armando Perez
- Ashot Mkrtumyan
- Atanas Koundurdjiev
- Augusto Vallejos
- Aurelian-Emil Ranetti
- Ayim Akyea-Djamson
- Aysha Badat
- Bakris G.
- Baldev Singh
- Barbara Greco
- Barbara Kaczmarek
- Barbara Rewerska
- Barry M Brenner
- Belia Martin Del Camp Blanco
- Bernard Zinman
- Bertrand Cariou
- Bertrand Dussol
- Bhasker Mehta
- Bhimavarapu Sudhakar
- Björn Paschen
- Bompoint S.
- Borys Mankovskyy
- Botond Csiky
- Boyan Nonchev
- Brenner B. M.
- Brett Kissela
- Brian Nichol
- Bruce Neal
- Bruce Trippe
- Bruno Geloneze Neto
- Bull S.
- Byung-Wan Lee
- C B Keshavamurthy
- Cannon C. P.
- Capuano G.
- Carlo Giorda
- Carlos Alberto Cuneo
- Carlos Arauz-Pacheco
- Carlos Barrera
- Carlos Perez
- Carmel Hawley
- Carmen Crisan
- Carol Pollock
- Carolyn Droste
- Caroucel Chuateco
- Caryl David
- Cecilia Garcia Ballesteros
- Cecilia Jimeno
- Celso Amodeo
- Cesar Javier Zaidman
- Cesar Yoiti Hayashida
- Chamberlain Obialo
- Chang-Hsun Hsieh
- Charles Cook
- Charles Kaupke
- Charytan D. M.
- Chek Loong Loh
- Chen Leia
- Cheol-Young Park
- Chih-Ching Lin
- Christopher P Cannon
- Christy Yao
- Chu P. -L.
- Chwen-Tzuei Chang
- Chye Lee Gan
- Clara Barrios
- Claude Galphin
- Claudia Goycoa
- Claudia Moreira de Brito
- Clodoaido Caringal
- Cristian Serafinceanu
- Cristina Toarba
- Cristobal Morales Portillo
- Csaba Kovesdy
- Cynthia Bowman-Stroud
- Cynthia Christiano
- Cynthia Mustieles Rocha
- Cyrus Desouza
- Cássio Slompo Ramos
- Dagmar Bartaskova
- Dale Crawford Allison
- Dalia Kozloviene
- Dan Scharfstein
- Dana Cosma
- Daniel Coyne
- Daniel Hiser
- Daniel Kolansky
- Daniel Panarotto
- Daniel Pella
- Daniel Weiner
- Daniil Chizhov
- Dariusz Sowinski
- Darren K McGuire
- Davesh Sennik
- David C Wheeler
- David Cherney 3rd
- David Gorson
- David Johnson
- David M Charytan
- David Packham
- David Scott
- David Wheeler
- De Zeeuw D.
- Debbie Cohen-Stein
- Debbie Mascaro
- Deepak Koppolu
- Dennis Levinson
- Derek Lewis
- Detian Li
- Devasmita Dev
- Devesh Patel
- Dewan Deepak
- Dick de Zeeuw
- Diego Aizenberg
- Dinesh Jain
- Dinesh Khullar
- Diogo Belo
- Dmitry Zateyshshikov
- Domenico Santoro
- Domingos d'Avila
- Donald Brandon
- Donald Fraser
- Dong-Wan Chae
- Dora Inés Molina de Salazar
- Dorota Mlodawska-Choluj
- Doru Negru
- Edgar Arcos
- Edoardo Mannucci
- Eduardo Farias
- Edward Watson
- Edwards R.
- Egle Gaupsiene
- Egle Urbanaviciene
- Ekaterina Velichkova
- Elena Christofides
- Elena Grineva
- Elena Kolmakova
- Elena Shutemova
- Eleonora Harcsa
- Elizabeth Barranco
- Elizabeth Gelersztein
- Elizabeth Kern
- Elizete Keitel
- Eloisa Tellez Chavez
- Emanuela Orsi
- Emil Martinka
- Emyr Davies
- Enrique Gonzalez
- Eric Alamartine
- Eric Hernandez Triana
- Eric Thervet
- Erick Turcios Juarez
- Esteban Cercos
- Eugenia Galindo-Ramos
- Eva Peterfai
- Evaly Chen
- Evandro de Souza Portes
- Evgueniy Vazelov
- Fabian Otreras
- Fabiana Loss de Carvalho Contieri
- Fabio Malberti
- Fadi Saba
- Fadlo Fraige Filho
- Favio Edmundo Enriquez Sosa
- Fayzal Ahmed
- Ferdinando Carlo Sasso
- Fernanco Augusto Alves da Costa
- Fernanda Cristina Camelo Sanches
- Fernando Cereto Castro
- Fernando Flores Lozano
- Fernando Jimenez Florez
- Fernando Krynski
- Fernando M Edwin
- Fernando Thomé
- Fernando Trespalacios
- Florence Santos
- Florencia Kraft
- Fracisco Javier Gonzalez Martinez
- Fran Morren
- Franciso Jose Tinahones Madueno
- Frank Eder
- Franklin Joseph
- Franklin Paul Haase
- Frantisek Saudek
- François Dubé
- François Madore
- Freemu Varghese
- Gabriela Cecilia Coloma
- Gabriela Genova-Hristova
- Gabriele von Ingersleben
- Gaetano Serviddio
- Galina Nagibovich
- Gary Meininger
- Gema Fernandez Fresnedo
- Georg Plassmann
- George Bakris
- George Hon
- George Newman
- Gerald DaRoza
- Gerald Keightley
- Gerry Tan
- Giacomo Garibotto
- Giorgio Fuiano
- Giovanni Frascà
- Giovanni Gambaro
- Giuseppe Derosa
- Gizella Petro
- Glenn Chertow
- Gnyandev Patel
- Godwin Simon
- Goga Vukotic
- Gopal Krishna
- Grace Aquitania
- Grace Lin
- Graham Hillis
- Graziano Di Cianni
- Grazyna Orlowska-Kowalik
- Grazyna Popenda
- Greene T.
- Greg Fulcher
- Gregorio Obrador
- Gregorio Obrador Vera
- Grit Faulmann
- Guadalupe Morales Franco
- Guillermo Fragale
- Guixia Wang
- Gulam Latiff
- Gustavo Cristian Greloni
- Guy Chouinard
- Gyongyi Csecsei
- Gyorgy Paragh
- Halyna Tomashkevych
- Hans Prozesky
- Harpreet Bajaj
- Hasnain Khandwala
- Hector Rodriguez
- Heerspink H. J. L.
- Helena Oosthuizen
- Hendrik Nortje
- Henry Watson
- Hermann Haller
- Hernan Finkelstein
- Hernan Yupanqui
- Hiddo J L Heerspink
- Hiralal Maheshwari
- Hiroko Oishi
- Hiromi Aoki
- Hiromi Rodriguez Pattzi
- Hiroshi Kono
- Hitoshi Akiyama
- Holly Wang
- Hong Mao
- Hong Zhang
- Hongguang Zheng
- Hongli Lin
- Horacio Sessa
- Hugo Colombo
- Hugo Laviada Molina
- Hugo Roberto Kurtz Lisboa
- Humberto Pavon
- Hyuk-Sang Kwon
- Iain MacDougall
- Ian Fraser
- Idalia Acosta
- Ildiko Halmagyi
- In-Kyung Jeong
- Ines Bartolacci
- Ingrid Abrahamsen
- Ingrid Buganova
- Inna Kolesnyk
- Ioana Emilia Ferariu
- Irene Noronha
- Irina Glinkina
- Irina Osipova
- Iryna Dudar
- Isabel Erika Rucker Joerg
- Isabel Garcia
- Isam Marar
- Israel Hartman
- Iuliia Komisarenko
- Ivan Fushtey
- Ivan Ory
- Ivan Rychlik
- Ivan Rychlík
- Ivan Smirnov
- Ivan Topchii
- Ivan Villegas
- Iveta Smatanova
- Jaco Jurgens
- Jakkidi Reddy
- Jamal Hammoud
- James Conway
- James Januzzi
- James Welker
- Jan Culak
- Jana Babikova
- Jana Belobradkova
- Jana Dzuponova
- Janos Mucsi
- Jardine M. J.
- Jason Gaglia
- Javier Narvarte
- Javier Nieto Iglesias
- Jayameena Peringat
- Jayant Kumar
- Jean Carlo Tibes Hachmann
- Jean Welsh
- Jean-Pierre Fauvel
- Jeevren Reddy
- Jeffrey Kropp
- Jeffrey Stephens
- Jeimeen Agra
- Jelena Ignjatovic
- Jesus Cuadrado
- Jesus Egido de Los Rios
- Jian Liu
- Jiao Sun
- Jinkui Yang
- Jiri Lastuvka
- Jiri Pumprla
- Joaquin Pablo Gonzalez
- Johannes Breedt
- John Amerena
- John Baker
- John Ervin
- John Evans
- John Lentz
- John Middleton
- John Padron
- John Sensenbrenner
- John Updegrove
- John Wakeling
- Jonay Pantoja Perez
- Jorge Archibaldo Glenny
- Jorge Avendano
- Jorge Ernesto Andres Diaz Ruiz
- Jorge Hector Resk
- Jorge Kusnir
- Jorge Mordujovich
- Jorgelina Sala
- Jose Antonio Sánchez Arenales
- Jose Chevaile Ramos
- Jose David Gomez Rangel
- Jose Esteban Jodar Gimeno
- Jose Francisco Kerr Saraiva
- Jose Hector Sanchez Mijangos
- Jose L Górriz
- Jose Luis Accini Mendoza
- Jose Ma Portoles Perez
- Jose Osvaldo Fretes
- Jose Ricardo Correa Rotter
- Joseph Abdallah
- Joseph Aiello
- Joseph Feuerstein
- Joseph O'Hare
- Joseph Proietto
- Josier Nisnisan
- José Vicente Sanchez Polo
- João Lindolfo Cunha Borges
- João Soares Felício
- Juan Alfredo Tamayo Y Orozco
- Juan Baas Cruz
- Juan Carlos Santos
- Juan Diego Higuera
- Juan Frias
- Juan Gonzalo Godoy Jorquera
- Juan Pablo Albisu
- Juan Pablo Moreira Diaz
- Juan Peralta Calcaneo
- Juan Rosas Guzman
- Juan Villagordoa Mesa
- JungEun Lee
- Kamal Abouglila
- Karel Peterka
- Karina Hufert
- Karlton Pettis
- Katalin Keltai
- Katalin Revesz
- Katarina Halciakova
- Katarina Lalic
- Kathy Nicholls
- Kati De Brouwer
- Kazuhiro Yanagida
- Kazunori Koyama
- Kazuyuki Mizuyama
- Kee Sing Ng
- Kenneth Cohen
- Kenneth Deck
- Kenneth Hershon
- Kenneth Liss
- Kenneth W Mahaffey
- Khalid Abdul Kadir
- Khurram Wadud
- Kim Travis
- Kiril Hristozov
- Kook-Hwan Oh
- Krisztian Kiss
- Kun Ho Yoon
- Lachezar Lozanov
- Lajos Major
- Lalaine Delos Santos
- Landman Lombard
- Larisha Pillay-Ramaya
- Larry Distiller
- Larysa Pererva
- Laszlo Deak
- Laszlo Konyves
- Laura Akright
- Laura Coffee
- Lawrence Distiller
- Lawrence Lehrner
- Lawrence Leiter
- Lech Lazuka
- Lee-Ming Chuang
- Lenka Dohnalova
- Leslie Spry
- Levin A.
- Li Yuan Lee
- Lidia Bermudez
- Ligia Petrica
- Lilia Beatriz Schiavi
- Liliana Monica Angelescu
- Liliia Zub
- Liliya Martynyuk
- Lin Sun
- Lincoln Chapin
- Linong Ji
- Lisa Rich
- Liudmila Kvitkova
- Lori Yost
- Luca Chiovato
- Luca De Nicola
- Luca Zanoli
- Lucas Rista
- Luciane Mônica Deboni
- Lucyna Hotlos
- Ludger Rose
- Luigi Gnudi
- Luis Alberto Ramirez Roca
- Luis Asmarats Mercadal
- Luis David Abraira Munoz
- Luis Enrique Herrera Jimenez
- Luis Fernando Flota Cervera
- Luis Henrique Canani
- Luis Hernando Garcia Ortiz
- Luis Isaias Juncos
- Luis Quesada-Suarez
- Luis Rodolfo Cartasegna
- Luis Valderrama Cometa
- Luis Venegas Carrillo
- Luiz Alberto Andreotti Turatti
- Luiza Despina Demian
- László Rosivall
- Ma Dovie Lallaine Ygpuara
- Mahaffey K. W.
- Manel Terns Riera
- Manish Saxena
- Manthi Hettiarachchi
- Manuel Muñoz Lopez Mendoza
- Manuel Muñoz Torres
- Manuela Schmidt
- Marc Rendell
- Marcel Twahirwa
- Marcelo Medina Fariña
- Marcora Mandreoli
- Marcus Gomes
- Margarita Temelkova
- Margarita Vejar
- Margit Mileder
- Margo Hudson
- Maria Antonia Munar Vila
- Maria Barnard
- Maria Cecilia Cantero
- Maria Florencia Fernandez
- Maria Isabel Klyver
- Maria Jaime
- Maria Rosa Ulla
- Maria Teresa Zanella
- Maria Valdez
- Marializa Bernardo
- Marianna Zsom
- Mario Alberto Berli
- Mario Burgos Soto
- Mark Davies
- Mark Vannorsdall
- Mark Warren
- Markus Faghih
- Marsha Tolentino
- Marta Dominquez Lopez
- Marta Molnar
- Martin Lukac
- Martin Valis
- Martine Destree
- Mary Anne Lim-Abrahan
- Mary Lawrence
- Mary Seeber
- Maryna Vlasenko
- María Alicia Fernández Montenegro
- María Angustias Quesada Simón
- Masahiko Takai
- Masahiro Koizumi
- Masakiyo Wakasugi
- Masayo Yamada
- Mastura Ismail
- Matthew Abramowitz
- Matthew Beacom
- Meg J Jardine
- Meg Jardine
- Meininger G.
- Melchor Alpizar Salazar
- Melemadathil Sreelatha
- Merce Perez Vera
- Mercedes Velo Plaza
- Michael Oliver
- Michael Robinson
- Michael Shanik
- Michael Thompson
- Michael Williams
- Michal Nowicki
- Michał Nowicki
- Michelle Zaniewski-Singh
- Mick Kumwenda
- Miguel Nazzer Hissa
- Migues Angel Reyes Rosano
- Mihaela Biscoveanu
- Mihaela-Magdalena Busegeanu
- Mihaly Dudas
- Milan Gupta
- Min Jeong Kwon
- Minara Shamkhalova
- Minghui Zhao
- Miodrag Djordjevic
- Mircea Munteanu
- Mitsuru Tsujimoto
- Mohamed El-Shahawy
- Mohamed Mookadam
- Mohamed Railey
- Mohamed Sekkarie
- Mohanram Narayanan
- Mohd Daud Che Yusof
- Mohsen El Kossi
- Mona Wahba
- Monica Alexandra Terront Lozano
- Monika Dhillon
- Moogali Arvind
- Moon-Kyu Lee
- Moon-Suk Nam
- Moustafa Moustafa
- Muhammad Shakeel
- Mukesh Joshi
- Mykola Kolesnyk
- Márcio Antônio Pereira
- Nadia Zalunardo
- Nadiya Tryshchuk
- Nan Chen
- Narayan Prasad
- Naresh Aggarwal
- Natalia Malaver
- Nataliia Pashkovska
- Natarajan Gopalakrishnan
- Navdeep Tangri
- Naveen Atray
- Neal B.
- Nebojsa Lalic
- Neil Kumar
- Nelson Kopyt
- Nelson Rodriguez Papini
- Nestor Horacio Garcia
- Ngai Wah Cheung
- Nicolae Hancu
- Nicole Li
- Nik Nur Fatnoon Nik Ahmad
- Nina Patel
- Nizar Daboul
- Noble Gracious
- Nomangesi Ngcakani
- Nonna Kravchun
- Nora Marchetta
- Norman Muirhead
- Norsiah Ali
- Oleg Legun
- Oleg Nagibovich
- Oleg Uriasyev
- Oleksandr Golovchenko
- Oleksandr Samoylov
- Oleksii Korzh
- Olga Barbarash
- Olga Barna
- Olga Barysheva
- Olga Benusova
- Olga Godlevska
- Olga Gyrina
- Olga Sazonova
- Olivert Gomez
- Oomman Abraham
- Osamu Tomonaga
- Oscar Tarsicio Moreno Loza
- Osvaldo Brusco
- Pablo Antonio Novoa
- Pablo Mele
- Pablo Raffaele
- Pablo Serrano Sanson
- Paranthaman Vengadasalam
- Patricia Del Carmen Gonzalez Colaso
- Patrick English
- Patrick Parfrey
- Paul Ainsworth
- Paul Frenk Baron
- Paul Nixon
- Paul Noonan
- Paul Rheeder
- Paulina Virginia Lanchiotti
- Pavel Weiner
- Peak Mann Mah
- Pedro Calella
- Pedro de Souza
- Pedro Velasquez-Mieyer
- Peggy Barnhill
- Peggy Lin
- Pere Alvarez Garcia
- Perkovic V.
- Peter Danos
- Peter Fulop
- Peter Van Buren
- Peter Winocour
- Petr Barton
- Philip Gorelick
- Philip Home
- Philip Nicol
- Philippe Zaoui
- Phyllis August
- Piermarco Piatti
- Pierre Gourdy
- Pierre-Jean Saulnier
- Pietro Castellino
- Pilar Trueba
- Ping Tu
- Pollock C.
- Prasanth Surampudi
- Pusadee Suchinda
- Qinkai Chen
- Rachel Bregman
- Radica Alicic
- Radu Jacob
- Rafael Simo Canonge
- Raied Abdullah
- Rajendran Alappan
- Rajiv Agarwal
- Rajiv Ranjan
- Raju Sree Bhushan
- Rakesh Gulati
- Rakhi Khanna
- Rallabhandi Sankaram
- Raman Purighalla
- Ramesh Chandra Vyasam
- Ramesh Thimmaiah
- Ramon Berenguer
- Ramon Moreda
- Rangel Rangelov
- Rao K Satyanarayana
- Ravendran Govender
- Ravi Sarin
- Reddy Sreedhar
- Reginald Parker
- Rehan Symonds
- Reinhold Jerwan-Keim
- Remi Rabasa-Lhoret
- Renan Montenegro Junior
- Renata Bijata-Bronisz
- Rhea Severina Comia
- Rhonda Bentley-Lewis
- Riad Darwish
- Ricardo Alfonso Leon de la Fuente
- Ricardo Dario Dran
- Ricardo Rosero
- Riccardo Bonadonna
- Richard Ferkl
- Richard Kovar
- Richard Lindley
- Richard Orozco Castellanos
- Richard Solomon
- Robert Busch
- Robert Cohen
- Robert Schreiman
- Robert Takacs
- Robert Walker
- Roberto Abrão Raduan
- Roberto Jorge da Silva Franco
- Roberto Pecoits Filho
- Roberto Pecoits-Filho
- Roberto Simões de Almeida
- Roberto Trevisan
- Rodica-Ioana Avram
- Rodolfo Andres Ahuad Guerrero
- Rohana Abdul Ghani
- Rohit Pankhaniya
- Rolando Zamarripa Escobedo
- Ronald Goldenberg
- Ronald Harris
- Ronald Watts
- Ronaldo Arturo Gonzalez Orellana
- Ronan Roussel
- Ronnie Aronson
- Rosa Isela Luna Ceballos
- Rosângela Milagres
- Ruben Dario Vargas Alonso
- Rury Holman
- Russell Scott
- Sacha De Serres
- Sahay Manisha
- Saiful Shahrizal Bin Shudim
- Sailaja Ventrapragada
- Salah Abusnana
- Salvatore De Cosmo
- Sam Henein
- Sam Philip
- Samuel Cohen
- Samuel Mujica Trenche
- Samy Hadjadj
- Sandor Keresztesi
- Sandor Vangel
- Sandra Berenice Saaveddra Sanchez
- Sanjeev Rastogi
- Sara Jaffer
- Sarah Olelewe
- Satoshi Ota
- Satu Pesickova
- Scott Kasner
- Secundino Cigarran Guldris
- Senan Sultan
- Serge Cournoyer
- Sergei Nedogoda
- Sergey Vorobyev
- Sergio Saul Irizar Santana
- Shahabul Arfeen
- Shahnaz Shahinfar
- Shang-Jyh Hwang
- Shelley Williams
- Shenaz Ramtoola
- Shenglian Gan
- Sherry Sussman
- Shizuo Kajiyama
- Shozo Miyauchi
- Silvia Ines Orio
- Silvia Nicolai
- Simon Davies
- Simon Roger
- Simon Young
- Sin Gon Kim
- Singhan Krishnan
- Sini George
- Slobodan Antic
- Sohan Dua
- Sonia Hermida
- Soo Kun Lim
- Sophie Borot
- Souhila Ounadjela
- Sreedhar Mandayam
- Srikanth Bellary
- Stanislav Zemek
- Stanislaw Mazur
- Stefan Dimitrov
- Stephan Maxeiner
- Stephen Grubb
- Stephen Smith
- Steven Fishbane
- Stuart Handelsman
- Suely Keiko Kohara
- Sun Kim
- Sun-Hee Park
- Sunil Sheth
- Susumu Kashine
- Svetlana Goykhman
- Svitlana D Bilyk
- Swee Win Lam
- Sylvia Rosas
- Sylvia Shaw
- Szilard Vasas
- Sérgio Alberto Cunha Vêncio
- Sérgio Yamada
- Tadashi Iitsuka
- Takamoto Kodera
- Takashi Wada
- Takayuki Watanabe
- Tamara Malek Marin
- Tamas Oroszlan
- Tara Chang
- Tareq Nassar
- Tarissa Beatrice Zanata Petry
- Tatiana Koroleva
- Tatiana Morugova
- Tatiana Raskina
- Tatyana Zykova
- Te-Lin Hsia
- Terue Sakakibara
- Tetiana Zlova
- Tetsuji Niiya
- Tetyana Pertseva
- Tiago Schuch
- Timothy Hall
- Tom Christensen
- Tom Greene
- Tomas Drasnar
- Tomas Smith Casabella
- Tonatiu Diaz Escalante
- Toshihiko Yanase
- Toshio Kawada
- Vadym Vizir
- Vanassa Ratnasingam
- Venessa Tsang
- Venkata Behara
- Vera Klokocnikova
- Vera Krane
- Veronica Anghel
- Veselka Genadieva
- Vesna Popovic-Radinovic
- Viacheslav Marasaev
- Victor Commendatore
- Victor Saavedra Gajardo
- Vijayaraman Arutchelvam
- Viktor Margaritov
- Viktor Zaviriukha
- Viktoria Andreeva
- Vimladhevi Govender
- Vincent Pichette
- Vincent Woo
- Vira Tseluyko
- Virginia Esther Visco
- Vivek Sood
- Vivekan Jha
- Vladimir Dobronravov
- Vladimir Khirmanov
- Vladimir Tesar
- Vlado Perkovic
- Volker Burst
- Volodymyr Botsyurko
- Walter Guillermo Douthat
- Walter Pharr
- Wasim Hanif
- Wataru Yumita
- Wayne H-H Sheu
- Wayne Turner
- Wei Yen Kong
- Weihong Song
- Weiping Lu
- Wendy Lane
- Wenge Li
- Wheeler D. C.
- Wladmir Saporito
- Xuemei Li
- Xueqing Yu
- Yamil Canaan
- Yan Ren
- Yannick Le Meur
- Yaozhong Kong
- Yasuro Kumeda
- Yasushi Wakida
- Yavin Y.
- Yeong Hoon Kim
- Yevgeniya Svyshchenko
- Young Min Cho
- Yulia Samoylova
- Yung-Chuan Lu
- Yuriy Mostovoy
- Yuriy Shwartz
- Yvette Ethel Yap
- Zaynab Abejuela
- Zdravko Kamenov
- Zeid Khitan
- Zhang H.
- Zinman B.
- Zishan Ali
- Zuzana Ochodnicka
- Ângela Regina Nazario Sabbag
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
Use of anticoagulants and antiplatelet agents in stable outpatients with coronary artery disease and atrial fibrillation. International CLARIFY registry
- Author
- A. L. R. Ng
- Abardia Oliva F. J.
- Abdel Malak S.
- Abdel Wahab H.
- Abdul Kareem B. B.
- Abdul Manap H.
- Abdul Rahim A. A.
- Abdulkader F.
- Abdulla A. H. K.
- AbdulWahab M. Z.
- Abduvalieva V.
- Abele S.
- Aboyans V.
- Abreu P. E.
- Adam-Blanpain M.
- Adamaszek K.
- Adamczyk-Kot D.
- Adamkiewicz-Piejko A.
- Adda M.
- Aftab A.
- Agrawal A.
- Aguiar C.
- Ahuad Guerrero A.
- Ahuja R.
- Ai F.
- Aimouch N.
- Aiyegbayo O.
- Ajani A.
- Akbar M.
- Aksyutina N.
- Al Dhanki M.
- Al Ghool S.
- Al Kandari F.
- Al Lawati A.
- Al Mahmeed W.
- Al Radaideh G.
- Al Rashdan I.
- Al Sousi A.
- Al Suwaidi J.
- Al Tamimi F.
- Al Wahshi Y.
- Al Yazeedi J.
- Al Zaibag M.
- Al-Baker H.
- Al-Faleh H.
- Al-Hersi A.
- Al-Khalidi B.
- Al-Shamiri M.
- Al-Zaibag M.
- Alam A.
- Alanazy M.
- Alanbaei M.
- Albero Martinez V.
- Alberto Ramirez Reyes H.
- Albuquerque A.
- Alcaravela J.
- Alcocer Gamba M.
- Alegret Colomer J. M.
- Alegria Ezquerra E.
- Alekseenko V.
- Alekseeva T.
- Alexanderson E.
- Alexopoulos I.
- Alford K.
- Alitto F.
- Alizon F.
- Allcock A.
- Almeida Fernandez C. A.
- Altevogt B. -M.
- Altmann U.
- Alvarenga Recalde N.
- Alvarez Aunon A.
- Alvarez Garcia P.
- Alvarez Gil J.
- Alvarez Ramires F. J.
- Alves Costa M.
- Alves C.
- Amiel Oster Sauvinet G.
- Amini R.
- Amlaiky A.
- Amo Fernandez C.
- Amor R.
- Amoretti R.
- Amoros Galito C.
- Anastasiou E.
- Ancin Viguiristi R.
- Ancliff H.
- Andersen L. K.
- Andreev E.
- Andreicheva E.
- Andrews M.
- Ang C. C.
- Angela R.
- Anghel M.
- Ansalone G.
- Antia V.
- Antona Makoshi J.
- Antonelli G.
- Antoniadis G. A.
- Antonicelli R.
- Antunes J.
- Aparici Feal M.
- Apinyasawat S.
- Apitamsuntorn S.
- Appeltants H.
- Arabadzhi N.
- Arden C.
- Ardiaca Capell A.
- Ardill J.
- Ardouin L.
- Arenas Leon J. L.
- Arfaras V.
- Arias Mendoza A.
- Arkhipova Y.
- Arnau Vives M. A.
- Arnedillo Pardo J.
- Arquero Garcia G.
- Arrarte Esteban V.
- Arroja I.
- Arsenescu Georgescu C.
- Arsentieva T.
- Ashford A.
- Ashmak K.
- Ashton T. H.
- Asplanato M.
- Assouline S.
- Astrakhantseva P.
- Astridge P.
- Atamanchuk N.
- Attia G.
- Atueva K.
- Aubry J.
- Audibert H.
- Augarde R.
- Auhser F.
- Aumjaud A.
- Avgerinos C.
- Avlonitis S.
- Ayche M.
- Aylward P.
- Azar Manzur F.
- Azzolini P.
- Baar M.
- Babes K.
- Baboshina N.
- Bachmann B.
- Badariene J.
- Badorff C.
- Badr-Eslam R.
- Bahal A.
- Baika A.
- Bailey A.
- Bajcsi E.
- Bakbak A. I.
- Balai R.
- Balbi M.
- Baldev S.
- Baleeva L.
- Baleon R.
- Balice-Pasquinelli M. A.
- Ballet A.
- Balogh G.
- Banach J.
- Banham S.
- Banikova A.
- Banu M.
- Baptista S.
- Baquero Alonso M.
- Bar J. -P.
- Barahona Perez P.
- Baranes C.
- Baranova O.
- Barauskiene G.
- Bardachenko L.
- Bardaji Mayor J. L.
- Bariaud M.
- Baril J. F.
- Barjhoux C.
- Baroudi R.
- Barrera Bustillos M.
- Barriales Alvarez V.
- Barron G.
- Basara M.
- Bashkirtcev O.
- Baslaib F.
- Bastian B.
- Basto L.
- Batalla Celorio A.
- Bateman A.
- Bates F.
- Bath P. S.
- Batushkin V.
- Baurenski L.
- Bautista G.
- Baverstock M.
- Bayakhchan L.
- Baylac Domengetroy F.
- Bazargani N.
- Bdeir M.
- Beacock D.
- Beaurain C.
- Beckers J.
- Beinhauer A.
- Belanger A.
- Belcastro F.
- Belisle P.
- Bell J.
- Beltrame J. F.
- Benacka J.
- Benett I.
- Bennouna M. A.
- Berdnik K.
- Berezhna T.
- Bergen J. -M.
- Berkenboom G.
- Berlingieri J.
- Bernard A.
- Bernard X.
- Bernardeau C.
- Bernasconi F.
- Berrisch-Rahmel S.
- Berry P.
- Bertarini J. A.
- Berthezene P.
- Berube J.
- Better N.
- Beyer R.
- Bhaskaran R. K. M.
- Bhatt J. S.
- Bhayat J.
- Biausque F.
- Bierge Valero D.
- Bietzk R.
- Bilous N.
- Binet D.
- Birkenhagen A.
- Biryukova N.
- Bishop P.
- Bizyaeva N.
- Blanc E.
- Blanco Castineiras J.
- Blase I.
- Blaszczak P.
- Blignaut S.
- Blindt R.
- Blum-Decary I.
- Bode G.
- Bodur G.
- Boesch C.
- Bogdanski P.
- Boikova L.
- Bokuchava N.
- Bolidai A.
- Bolotova N.
- Bonal J.
- Bondarenko B.
- Bongo A. S.
- Bonhomme R.
- Bonnaud X.
- Bonnet J. L.
- Bonnet P.
- Bonny A.
- Boonyapisit W.
- Boonyasirinant T.
- Borbola J.
- Bories J.
- Borodina N.
- Bosa Ojeda F.
- Bosch R.
- Botana Penas C.
- Bouchaya T.
- Bourachot M. L.
- Bouranasompop C.
- Bourazanis I.
- Boureux C.
- Bourgeois G.
- Bourgeois J. M.
- Bousquet P.
- Boutros G.
- Boutsikos P.
- Bouvy T.
- Boyrazian H. A.
- Bozkova J.
- Bradley J.
- Bradshaw C.
- Braganca G.
- Brand N.
- Bratishko I.
- Brattstrom A.
- Bratu I.
- Breuer H. -H.
- Brice E.
- Briki R.
- Brindle P.
- Briseno J. L.
- Brisson G.
- Brodzicki P.
- Brottier L.
- Brouillette G.
- Brown B.
- Brown C.
- Brown G.
- Brown M.
- Brownlie R.
- Brscic E.
- Brufau Redondo H.
- Bruguera Cortada J.
- Brumelot F.
- Brunehaut Petaut M.
- Brunner H.
- Brunschwig C.
- Bryl W.
- Buakhamsri A.
- Budanova I.
- Buffet P.
- Bui C. M. A.
- Bui L.
- Bui T. T. H.
- Bukanina E.
- Bulakhova E.
- Bumbu A.
- Bundy C.
- Burgess L.
- Burlakova L.
- Burns R.
- Butkuviene I.
- Buttl A.
- Bykovskaya S.
- Cabau Rubies J.
- Cabrera Sole R.
- Cahill T.
- Cai B.
- Calaca J.
- Calder J.
- Caldwell I.
- Calmettes P.
- Calvo Iglesias F.
- Camossa C.
- Campbell J.
- Cantabrana Miguel S.
- Cao L.
- Capalneanu R.
- Capuano N.
- Carda J.
- Caridi G.
- Carpentier L.
- Carpinteiro L.
- Carrillo Calvillo J.
- Carrillo Cardoso R.
- Carvalho De Moura B.
- Carvalho J.
- Carvalho R.
- Casanovas Pie M.
- Casas Gimenez P.
- Castellari M.
- Castillo Luena E.
- Castillo Moreno J. A.
- Castillo Orive M.
- Castro A.
- Castrucci M.
- Catarino Carvalho M.
- Cattan S.
- Cavert B.
- Cazenave C.
- Ceng Q.
- Centa I.
- Ceraulo C.
- Cerda Rojas J.
- Cernetti C.
- Cernic-Suligoj N.
- Cervenak R.
- Cesar L. M.
- Ch&apos
- Ch&apos
- Cha J. Y. -M.
- Cha T. J.
- Chae I. H.
- Chaithiraphan V.
- Chalkiadakis E.
- Challenor V.
- Cham Y. L.
- Chambel De Aguiar J.
- Chamou K.
- Chan B.
- Chan R.
- Chan Y. K.
- Chandra S.
- Chandran K.
- Chang B. C.
- Chantrarat T.
- Charikova O.
- Charles H.
- Chartier B.
- Chatterjee S. S.
- Chatzioakim G.
- Chau N. H.
- Chauhan N.
- Chavez Paez J.
- Che C.
- Cheah Y. W.
- Chee K. H.
- Chee T. S.
- Chehayeb R.
- Chemin P.
- Chen B.
- Chen C.
- Chen F.
- Chen G.
- Chen H.
- Chen J.
- Chen K.
- Chen L.
- Chen M.
- Chen P.
- Chen W.
- Chen X.
- Chen Y.
- Chen Z.
- Cheng J.
- Chenniappan M. S.
- Chernozemova A.
- Cherry J. M.
- Chetelat C. A.
- Chioncel O. D.
- Chirivella Gonzalez A.
- Chiscaneanu T.
- Chiu S.
- Chlewicka I.
- Choi H.
- Chometon F.
- Chonkar N. S.
- Choo G. H.
- Choor C. K.
- Chopo Alcubilla J. M.
- Choudhury P.
- Chouinard G.
- Christodorescu R.
- Christoforidis C.
- Chua S. K.
- Chuang H. H.
- Chukwu A.
- Chung A.
- Chung E.
- Chushak S.
- Chyrek R.
- Ciaroni S.
- Cicek-Hartvig S.
- Cierpka R.
- Cieza Lara T. A.
- Cindea Nica N.
- Cinteza M.
- Cisowska-Drozd E.
- Claeys M.
- Claus M.
- Clavette P. F.
- Cleron S.
- Clifford A.
- Climent Paya V.
- Cobos Gil M. A.
- Coetzee K.
- Cohen J.
- Coimbra S. R.
- Colin R.
- Collette R. S.
- Colomer Martin J. L.
- Colquhoun D. M.
- Coman S.
- Compson L.
- Concepcion Clemente A.
- Cong H.
- Conradie A.
- Constance C.
- Constantinescu M.
- Correia A.
- Cortes Sanchez R.
- Cosgrave J.
- Costa J.
- Costello P.
- Cotroneo J.
- Cottin Y.
- Counsell J. T.
- Cox S.
- Craiu E.
- Crawford L.
- Cremer Luengo D.
- Crespo F.
- Cromarty I.
- Cross D.
- Cue Carpio R.
- Cullen I.
- Cunliffe G.
- Custodio M. H.
- Cygler J.
- Czarnecka M.
- Czarnecki W.
- Cziraki A.
- Czuriga I.
- d&apos
- D. B. Vu
- D. T. Le
- da Costa Pereira A.
- Dabboura A.
- Dai M.
- Dalal J.
- Dalampyras P.
- Dalrymple J.
- Dalton G.
- Daly K.
- Dan A.
- Dan D. C.
- Dan G. A.
- Danchin N.
- Danchin N.
- Dang L.
- Dang V. D.
- Dang V. P.
- Daniel R.
- Daniels E.
- Darnes Soler S.
- Dasbiswas A.
- Dascotte Y.
- Dau H.
- David C. M.
- David F.
- Davies E.
- Davies R.
- Davies S.
- Davin L.
- Davis R.
- Davydova N.
- Day B.
- Dayani A.
- Dayasagar Rao V.
- de Andres Novales J.
- De Backer T.
- de Brito Vianna C.
- De Castro Aritmendiz R.
- De Geeter G.
- de Jeus Rivera Arellano J.
- de Jeus Zuniga Sedano y America Alvarez J.
- De Keyser F.
- De Meester A.
- De Ridder S.
- de Sauvage Nolting P. R. W.
- Deb J.
- Dechoux E.
- Dedkova S.
- Dehayes P.
- Deissner M.
- Delcoulx E.
- Delgado Prieto J. L.
- Delhomme C.
- Dematteo P.
- Demianiuk B.
- Demina O.
- Dendale P.
- Denef K.
- Deng X.
- Deng Z.
- Deren M.
- Dernedde C.
- Detienne J. P.
- Dezsi C. A.
- Dhesi A.
- Dhondt E.
- Di Pasquale P.
- Diaz Diaz J. L.
- Diaz R.
- Dibon O.
- Didier M.
- Dinh H. N.
- Dixon C.
- Dixon S.
- Dmitrieva N.
- Dmitrieva T.
- Doan V. B.
- Dodemant P.
- Domine F.
- Donetti J.
- Dong J.
- Dong M.
- Dong S.
- Dong W.
- Dongo A.
- Doohan M. M.
- Dookie T.
- Dorian P.
- Dormagen V.
- Dorobantu M.
- Doronzo B.
- Doucet B.
- Doucet J.
- Dougall H.
- Drexler M.
- Dreycopp H.
- Dreyfus X.
- Drijfhout M.
- Drozd J.
- Drzewiecka A.
- Du Plooy J.
- Du N.
- Du W.
- Du Z.
- Dubinina E.
- Dubinskaya R.
- Dubois J. M.
- Dubrava J.
- Dubs J. P.
- Duchowska R.
- Duclos F.
- Ducoudre M.
- Dufka A.
- Dunn J.
- Duprez O.
- Durand E.
- Durand P.
- Dutoya T.
- Dutsadeevettakul S.
- Dymova D.
- Dzenkeviciute V.
- Dzhkha O.
- Dzien A.
- Eavis P.
- Eccleston D. S.
- Ecina V.
- Edes I.
- Edwards D.
- Ege M.
- Eggeling T.
- Egido J.
- Egloff P.
- Egstrup K.
- Eidelman S.
- Eisele G.
- El Menyar A.
- El-Shaer F.
- Elias R.
- Eliseeva N.
- Elizondo Sifuentes L. A.
- Elkohen M.
- Elkrail A.
- Elliott V.
- Ellis R.
- Elsby K.
- Emonts M.
- Enayat D.
- Engel R.
- Ennouchi D.
- Erglis A.
- Erofeev S.
- Escande M.
- Escobar Cervantes C.
- Escobedo de la Pena J.
- Escourrou Berdou M. C.
- Esenokova A.
- Esna Ashari G.
- Esperon G. L.
- Espiga De Macedo M.
- Estrella J.
- Estriga A.
- Etcheverry B.
- Evequoz D.
- Everton Biglow C.
- Evtukhova L.
- Ezcurdia Sasieta J.
- Ezekiel D.
- Facila Rubio L.
- Fagan M.
- Falces Salvador C.
- Falconer H.
- Fallacher M. H.
- Farcas D.
- Farges J. L.
- Faria A.
- Fathi R.
- Fauchier L.
- Fauchier L.
- Faudon B.
- Favarato D.
- Fayez Al-Habib K.
- Fazekas F.
- Fazil M. A.
- Federico Zaragoza P.
- Fedorova N.
- Fedoskin V.
- Felbermayer M.
- Feldmann I.
- Feldner-Busztin M.
- Felice Castro Issa A.
- Felis S.
- Fellous F.
- Feng L.
- Fernandes De Sousa F.
- Fernandes A.
- Fernandes F.
- Fernandes J.
- Fernandez Alvarez R.
- Fernandez de la Cigona F.
- Fernandez Lazaro L. A.
- Fernandez Leoz L. C.
- Fernandez Mouzo R.
- Fernandez Valadez E.
- Fernandez-Valls Gomez M.
- Ferrante R.
- Ferrao E Vasconcelos M. F.
- Ferrari R.
- Ferrari R.
- Ferreira Dos Santos J.
- Ferreira J.
- Ferreira P.
- Ferreiro Rodriguez B.
- Ferreyra Solorio C.
- Ferrieres J.
- Fesenko T.
- Fic M.
- Fikker K.
- Filip W.
- Filippova E.
- Fillet R.
- Fillipova O.
- Finlayson J.
- Firastrau V.
- Fitzgerald B.
- Fleming S.
- Flores J.
- Florescu C.
- Fochterle J.
- Foldi A.
- Foltzer E.
- Fong A. Y. Y.
- Fonseca P. F.
- Fontanet B.
- Forclaz A.
- Ford I.
- Ford J. C.
- Forge B. H. R.
- Forster T.
- Forte De Carvalho J.
- Foster E.
- Fouquet G.
- Fourchard V.
- Fournier J. B.
- Fox K. M.
- Fraboulet J. Y.
- Franco Aranda C.
- Frank U.
- Frankiewicz A.
- Franklin P.
- Franskyavichene L.
- Fras Z.
- Fras Z.
- Freeman V.
- Freire Corzo J.
- Freitas J.
- Fressonnet R.
- Frickel S.
- Fridrich J.
- Frost L.
- Fu Q.
- Fu Z.
- Fuertes Alonso J.
- Fuertes Beneitez J.
- Fullerton G. M.
- Furtak R.
- Gabriilidis S.
- Gadzinski W.
- Galeeva Z.
- Galehr E.
- Galinier M.
- Galuszka-Bilinska A.
- Galve Basilio E.
- Gamba M. A.
- Gamboa M. C.
- Gamzatov E.
- Ganguly K.
- Gao H.
- Gao J.
- Gao W.
- Gao X.
- Garadah T.
- Garandeau M.
- Garaud Y.
- Garban T.
- Garcia Garcia C.
- Garcia Gonzalez M. J.
- Garcia Ortego S.
- Garcia Saavedra V.
- Garcia D.
- Garcia-Moll Marimon J.
- Gareeva L.
- Garg S.
- Garofalo D.
- Gascuena Rubia R.
- Gaspar L.
- Gaxiola E.
- Gdalia J.
- Geffroy S.
- Gendreau R.
- Geneves M.
- Gentille Lorente D.
- George E.
- George S. K.
- Geraedts J. T. M.
- Gerasimova T.
- Gerges G.
- Gervas Pavon H.
- Gessner S.
- Getman M.
- Ghaly I.
- Ghapar A. K.
- Ghicu A.
- Ghose T.
- Giacomantonio N.
- Giacomazzi F.
- Gibbs M.
- Gil V.
- Gilabert Gomez R.
- Gilbert T.
- Gillam S.
- Gillet A.
- Gillet T.
- Gilmour I.
- Ginzburg V.
- Giokoglu K.
- Giordano J.
- Giorgadze M.
- Girao A.
- Giuca A.
- Giusti Rossi E.
- Gkinis T.
- Glanowska G.
- Gleizes J. L.
- Gmehling J.
- Gmur W.
- Gnadinger M.
- Godart S.
- Goethals M.
- Goh C. W.
- Gold J.
- Goldie C.
- Golovina G.
- Golub M.
- Golubeva O.
- Gomaa M. M.
- Gomez Alvarez E.
- Gomez Barrado J. J.
- Gomez Doblas J. J.
- Gomez Martinez M. J.
- Gong L.
- Gonos I.
- Gonzaga A.
- Gonzalez Juanatey C.
- Gonzalez Romero S.
- Gonzalez Toda V.
- Gonzalvez Ortega M.
- Goodwin D.
- Goralski M.
- Gordillo Higuero E.
- Gori P.
- Gorlova I.
- Gorodilova I.
- Gorshkova L.
- Goss F.
- Gosse P.
- Goudev A.
- Gough D.
- Gouli O.
- Govender S.
- Gowdak L. H.
- Goyal B. K.
- Gratia P.
- Grechishkina O.
- Greenlaw N.
- Gregoire J. -M.
- Greiner O.
- Grekhova L.
- Grewal R. S.
- Grieco A.
- Grigoriu R.
- Grigoryan S.
- Gritsch W.
- Grobety M.
- Grocutt M. S.
- Grogono R.
- Grollier G.
- Grooterhorst P.
- Grover A.
- Gruchala M.
- Grudtsina I.
- Grupi C. J.
- Grushetskaya I.
- Gruznykh L.
- Gu F.
- Guan T.
- Guan X.
- Guardigli G.
- Guenoun M.
- Guerard S.
- Gueusquin A.
- Guiu E.
- Gukov O.
- Guo J.
- Guo Y.
- Gupta A.
- Gupta R.
- Gupte A.
- Gureeva O.
- Gurianova N.
- Gusev O.
- Guy J. M.
- Guyetand C.
- Gwon H. C.
- Gysan D. B.
- Habab M.
- Haberl R.
- Haddad S.
- Hadjiivanov V.
- Haerer W.
- Haghfelt T.
- Haiba M.
- Haimes P.
- Haine E.
- Halcox J.
- Haldane N.
- Hamer A.
- Hamilton-Craig I.
- Hand C.
- Hang J.
- Hansone S.
- Haralambus P.
- Harinasuta J.
- Harlos H. E.
- Hart C.
- Hassager C.
- Hassler jun N.
- Hatalova K.
- Hay D.
- Hay L.
- Hayne S.
- He L.
- Healley W.
- Heap A.
- Hechtenthal N.
- Heddle W.
- Heinemann S.
- Hellermann J.
- Henne Otero O.
- Hennebelle V.
- Heno P.
- Henpin Yue Cesena F.
- Henry R.
- Henry R.
- Henschel F.
- Herbots T.
- Herdade A.
- Hermellin B.
- Hernandez Afonso J.
- Herrera Fernandez D.
- Herrmann R.
- Higgins S.
- Hilario Jimenez Orozco J.
- Hildebrant P.
- Hilti P.
- Hinrichsen M.
- Hiremath M. S.
- Hoang V. S.
- Hockings B.
- Hodac T.
- Hofer W.
- Hoffer E.
- Hofmeister A.
- Hoh G.
- Holden L. A.
- Holt G.
- Homs Espinach E.
- Hong S. K.
- Hong T. J.
- Honorat S.
- Honsig T.
- Hood S.
- Horrigan M.
- Horstkotte E.
- Hou M. K.
- Hourany A.
- Howie F.
- Howlett R.
- Hu D.
- Hu H.
- Hu Y.
- Hua G.
- Huang Q.
- Huo Y.
- Hur S. H.
- Hurlock-Clarke L.
- Hutayanon P.
- Hutse W. H. J.
- Huttin O.
- Huynh T. K.
- Hwang J. Y.
- I. T. Ly
- Idoate Gastearena A.
- Idrissi-Sbai A.
- Ignatieva T.
- Ihonor A.
- Il&apos
- Illushechkin I.
- Ilyukhina A.
- Ingham J.
- Ionescu D. A.
- Ionescu D. D.
- Iosipescu L. C.
- Iovescu D.
- Irurita Latasa M.
- Isaeva L.
- Ishmael R.
- Ismail O.
- Ivan M. V.
- Ivaschenko T.
- Izquierdo Gonzalez R.
- J. H. Zo
- Jaafar A. H.
- Jacquier P.
- Jagathesan R.
- Jager F.
- Jamaluddin A. N.
- Jamaluddin A. N.
- Jamiel A.
- Janes J.
- Jang Y.
- Jankauskiene E.
- Jankowska A.
- Jankowska L.
- Janody D.
- Janosi A.
- Janssen J.
- Jaquet Herter M.
- Jarmuzek P.
- Jarosinski G.
- Jarvis I.
- Jasinkevica I.
- Jaussi A.
- Jaussi A.
- Jayasinghe S. R.
- Jean S.
- Jeannerat P. A.
- Jelinek V. M. J.
- Jeon D. W.
- Jeong M. H.
- Jeremiasz R.
- Jerjes Sanchez C.
- Jerzykowska O.
- Jeserich M.
- Jezewska M.
- Jheeta B. S.
- Jiang F.
- Jiang H.
- Jiang J.
- Jiang Q.
- Jin D. K.
- Jin Q.
- Jiraroj-ungkun W.
- Jirmar R.
- Jobic Y.
- Johnson P.
- Jones H.
- Jordan R.
- Joseph K. L.
- Joseph M.
- Joubert S.
- Joulie V.
- Jourdain P.
- Jouve V.
- Juneja L. M.
- Junejo S.
- Jung K. T.
- Junior J. F.
- Jurgaitiene R.
- K. B. Do
- K. C. Vu
- K. H. Ng
- K. S. Ng
- Kaab S.
- Kacorzyk R.
- Kadleckova A.
- Kalampalikis A.
- Kalaras P.
- Kaliska G.
- Kalra P.
- Kalra P.
- Kamensky G.
- Kamensky G.
- Kanagaratnam L.
- Kang D. H.
- Kang S. M.
- Kanic V.
- Kanner J. P.
- Kanumilli N.
- Kapustina L.
- Karachaliou M.
- Karaseva T.
- Karastanev K.
- Kardashevskaya L.
- Karlicek M.
- Karnaukhova N.
- Karner K. H.
- Karnik R.
- Karnot V.
- Kaserbacher R.
- Kassab A.
- Kassianos G.
- Kaul U.
- Kauthaman M.
- Kazachkova V.
- Kazakovtseva M.
- Kazmierczak E.
- Ke Y.
- Keelan P.
- Keil U.
- Kellam G. W.
- Keller P.
- Kelly K.
- Kennedy A.
- Kennedy D. R.
- Kepa W.
- Kerbev M.
- Kero D.
- Ketelers R.
- Khalifa A.
- Khan I. A.
- Khan M. S. H.
- Khanoyan P.
- Khartova N.
- Khaznadar G.
- Kheliya T.
- Khera P.
- Khishova N.
- Khmelevskikh N.
- Khodanov A.
- Khong N. H.
- Khoury V.
- Khripun A.
- Khudina I.
- Kiernan T.
- Kilaberiya O.
- Killat H.
- Killeen C.
- Kim D. S.
- Kim H.
- Kim S. H.
- Kim T. B.
- Kim W.
- Kim Y. J.
- Kimmel S.
- Kindel M.
- Kindler P.
- King Wong S.
- Kinloch D.
- Kirmond P.
- Kiseleva I.
- Kisiel L.
- Kisjos B.
- Kittipovanonth M.
- Kiver T.
- Kleemann L.
- Kleta S.
- Knyazeva V.
- Kochurov E.
- Kohan P.
- Kohler P.
- Kojeliene J.
- Kokis A.
- Kolesnikov V.
- Kolesova O.
- Kolevatova L.
- Kolios G.
- Koller R.
- Kondratovica A.
- Konemann J.
- Konig K.
- Konstantinidis I.
- Koo B. K.
- Koo C. C.
- Kornienko S.
- Korotich T.
- Kosachek E.
- Kosareva L.
- Kositsina G.
- Kossowska U.
- Kostomarova S.
- Kotova E.
- Kotsalos A.
- Koujan B.
- Koutsimpanis G.
- Koval V.
- Kovar F.
- Kovyrshyna O.
- Kozhelenko Y.
- Kozlov D.
- Kozlowski A.
- Krajnc I.
- Krasnoslobodskaya O.
- Krasucki C.
- Kraus M.
- Krause-Allmendinger H.
- Krechunova T.
- Krolak A.
- Krolicka K.
- Kronberg K.
- Kruck I.
- Kruglova I.
- Krupicka J.
- Kryvenkova E.
- Kuanprasert S.
- Kuchar J.
- Kucheryava L.
- Kudryavtsev L.
- Kukaleva V.
- Kulig W.
- Kulik V.
- Kulikova Y.
- Kulinich S.
- Kulygina V.
- Kumbla D. K.
- Kunhali K.
- Kupstyte N.
- Kurekhyan A.
- Kurochkina S.
- Kushner A. M.
- Kutuzova S.
- Kuzmicheva M.
- Kuzmina T.
- Kuzyakina M.
- Kwok S.
- Kwon H. M.
- Kycina P.
- Kyd K.
- La Greca R.
- La Hay B.
- La Rosa C.
- Lacche A.
- Lacroix A.
- Ladha K.
- Lafarenko V.
- Lafontaine P.
- Lafrance G.
- Lagares Carballo M.
- Lagioia H.
- Lago N.
- Lai K.
- Lai L.
- Lai V. M.
- Lai Y. C.
- Laizane I.
- Lalla C.
- Lalljie G.
- Lammens B.
- Lancellotti P.
- Landragin I.
- Lang C.
- Lang I.
- Lang P.
- Langridge S.
- Lapanun W.
- Larina O.
- Lasalle L.
- Lastra Galan J. A.
- Latkovskis G.
- Latyntseva L.
- Laucevicius A.
- Laucevicius A.
- Lavicka C.
- Lavicka V.
- Lavoie J. P.
- Lawrence M.
- Lawton D.
- Lazaro M.
- Le Bouthillier P.
- Le Moal E.
- Leandri M.
- Lebedev S.
- Lebischak G.
- Leclair M.
- Lee K.
- Lee S.
- Lee S. H.
- Lefebvre P.
- Leherissier A.
- Lema L.
- Lemiere Y.
- Lenartowska L.
- Leong J. C. S.
- Leontaridis I.
- Lertnantakul M.
- Leshchuk O.
- Leso J.
- Lesseliers H.
- Levesque G.
- Lew R.
- Leyva Pons J. L.
- Li A.
- Li D.
- Li F.
- Li G.
- Li H.
- Li J.
- Li L.
- Li W.
- Li Y.
- Li Z.
- Liandrat S.
- Liang L.
- Liang Q.
- Liatas C.
- Liautard M.
- Liew H. B.
- Lighezan D.
- Likhobabina O.
- Lillo A.
- Lim B. A.
- Lim P.
- Limeres Gonzalez B.
- Lin L.
- Lindsay A.
- Ling K.
- Lins E.
- Lippai J.
- Liqui-Lung A.
- Liston A.
- Liu E.
- Liu F.
- Liu J.
- Liu P.
- Liu Q.
- Liu R.
- Liu X.
- Liu Y.
- Liu Z.
- Logan D.
- Loheac P.
- London E.
- Lopes Antunes L.
- Lopez Aranda M. A.
- Lopez Barreiro L.
- Lopez Cabanillas N.
- Lopez Gomez D.
- Lopez Granados A.
- Lopez Martinez M.
- Lopez Mourino V.
- Lopez
- Lopez-Sendon J. L.
- Lorenc J.
- Lorenc Z.
- Lotocka E.
- Louchart J. C.
- Lourenco A.
- Lousada N.
- Low L. P.
- Lozano A.
- Lu Q.
- Lubelsky B. J.
- Lugin A.
- Lugowski T.
- Luke B.
- Lukina Y.
- Luo L.
- Luong H. D.
- Luqman H. N.
- Luquez H.
- Lutai M.
- Luu T. Q.
- Lv J.
- Lv S.
- Lv Y.
- Lysunets O.
- M&apos
- M. C. Ta
- M. P. Vo
- M. S. C. Ho
- Ma F.
- Ma S.
- Maamar R.
- Macarie C.
- MacCarthy N.
- MacCowan H.
- Macedo L.
- Machado Cesar L.
- Mackow M.
- Mackrell J.
- MacNamara F.
- Maes F.
- Magheru S.
- Magherusan M.
- Magliari F.
- Magnus P.
- Maguire B.
- Maheas Morlet S.
- Maheu B.
- Mahler Mioto B.
- Mahr A.
- Mai N.
- Mai T. L.
- Mainar Latorre L.
- Mak K. H.
- Makarenkova K.
- Makhieva T.
- Malaterre H. R.
- Malden M.
- Malgina M.
- Maliszewski M.
- Malkocs Z.
- Mallamaci V.
- Malysheva A.
- Mamez B.
- Manautou L. E.
- Manchet G.
- Manlay W.
- Mannl V.
- Mantcheva M.
- Mantoux J.
- Manyari D. E.
- Manzi D.
- Mao J.
- Marachli M.
- Maragoni G.
- Marchenko B.
- Marchionni N.
- Marin Araez E.
- Marin Ortuno F.
- Marinescu S. M.
- Markenvard J.
- Maroun M.
- Marozsan I.
- Martin Santana A.
- Martin A.
- Martina-Hooi B.
- Martinez Florez J.
- Martinez Gonzalez J.
- Martinez Redding J.
- Martinez Rivero J. F.
- Martinez Sanchez C.
- Martinez C.
- Martinho V.
- Martins Oliveira M.
- Martins V.
- Marullo L.
- Marzal Martin D.
- Massabie R.
- Massari F.
- Massay R.
- Masszi G.
- Matheson H. B.
- Matias F.
- Matos Dias P.
- Matos J.
- Matos M. A.
- Matta W.
- Matthews P.
- Mattos M. A.
- Matuszewska G.
- Maxia P.
- Maximchuk N.
- Maximovitch A.
- Maxwell T.
- Mayr H.
- Mayr K.
- Mays C.
- Mazutavicius R.
- Mazzanti Mignaqui G. F.
- McAlavey P.
- McCansh G.
- McCracken A.
- McLaren G.
- McManus R.
- McNaught P.
- McNeilly R.
- McPherson J.
- Meddah D.
- Mehta A.
- Meinel A.
- Melainis
- Melero Pita A.
- Melnikova
- Mendonca M. I.
- Meneveau N.
- Mentz G.
- Merian B.
- Meriaux F. X.
- Merkely B.
- Merkely B.
- Merkhi A.
- Mescharekova D.
- Messali P.
- Messas E.
- Mestre-Fernandes C.
- Meyer-Michael E.
- Meyssonnier P.
- Miao W.
- Mibach F.
- Micheals M.
- Micko M.
- Miedema K.
- Migliore M.
- Mihailova I.
- Mika R.
- Mikhailova E.
- Milewski J.
- Millauer M. G.
- Miller C.
- Millet J. F.
- Milligan H.
- Mimoso J.
- Mincheva V.
- Mineeva E.
- Mingalaeva S.
- Mingam S.
- Minkin S.
- Minsafina A.
- Mintale I.
- Mitropoulos D.
- Moberik A.
- Mochkina P.
- Modi S.
- Modzelewska K.
- Moh d. Amin N. A.
- Mohamed Yusof A. K.
- Mohammed H.
- Mohr S.
- Moksyuta E.
- Molina Laborda E.
- Moller S.
- Molotyagina S.
- Monnier P.
- Monteiro Ferreira J. F.
- Monteiro P.
- Montero Gaspar M. A.
- Moolman J.
- Moore J.
- Mora Robles J.
- Morais J.
- Morais J.
- Morales Gonzalez J.
- Moreau Y.
- Moreira Pinto F.
- Moreira J.
- Moreno Arribas J.
- Moreno Casquete M. T.
- Moretti M.
- Morgado P. C.
- Morgan D.
- Moro Lopez J. A.
- Morra P.
- Morrell J.
- Morrison G.
- Morton C.
- Morz-Proszowski B.
- Moser E.
- Mospan M.
- Mossuti E.
- Motoc A. C.
- Motyer R. A.
- Mougeolle J. L.
- Mouhat T.
- Mouquet F.
- Moya Lopez C.
- Moyal J.
- Mozerova E.
- Mpompoth P.
- Mukhtar A.
- Mularek-Kubzdela T.
- Muller J. J.
- Mulvihill N.
- Murga Eizagaechevarria N.
- Murin J.
- Musetescu R.
- Musigchai C.
- Muth S.
- Muthu A.
- Myburgh J. L.
- Myhailiv I.
- Myint M.
- N. H. Vu
- N. T. H. Tu
- Naberezhnova N.
- Nacht C. A.
- Nagy A.
- Nagy K.
- Nagy L.
- Naidoo D. P.
- Naidoo D. P.
- Nair V. P.
- Naisseh M.
- Narayan A.
- Narro Garcia F.
- Nasser-Sharif F. J.
- Nastari L.
- Natarajan S.
- Navarro Manchon J.
- Navas Navas C.
- Navratil P.
- Nazar Luqman H.
- Nazeyrollas P.
- Nazir M.
- Nehrig K.
- Nelbock-Huber E.
- Nethononda R.
- Nevolina N.
- Ngamjanyaporn P.
- Ngo K. A.
- Ngo M. H.
- Nguyen A. K.
- Nguyen B. K.
- Nguyen H. K. N.
- Nguyen L. V.
- Nguyen L. V.
- Nguyen N. Q.
- Nguyen T. A.
- Nguyen T. H.
- Nguyen T. K. L.
- Nguyen T. N.
- Nguyen T. P.
- Nguyen T. T.
- Nguyen T. T. C.
- Nguyen T. T. H.
- Nguyen V. T.
- Nicolino A.
- Niederberger C.
- Nikishina S.
- Nikodemska I.
- Nikolaeva I.
- Nikolaeva L.
- Nisker W.
- Nkombua L.
- Noble M.
- Nobre Dos santos J.
- Nocon P.
- Noel J. -F.
- Noor Hasni H.
- Nosova N.
- Nourallah R.
- Noury A. I.
- Novikova M.
- Novo Garcia E.
- Nowicka E.
- Nowowiejska-Wiewiora A.
- Nunez Gamero J. A.
- Nurgalieva S.
- O&apos
- O&apos
- O&apos
- O&apos
- O&apos
- O&apos
- O&apos
- Odent G.
- Odin de los Rios Ibarra M.
- Oganov R.
- Ogorodnichuk A.
- Ohlmeyer D.
- Okawabata C.
- Oleinikova N.
- Oleksandr
- Oliveira L.
- Oliver R.
- Olszewski A.
- Omar H.
- Omardeen F.
- Omelchenko M.
- Ong T. K.
- Ong T. T. L.
- Onger D.
- Orazi S.
- Orban M.
- Ordonez Espana A.
- Orenstein-Lyall T. L.
- Orestis I.
- Ormiston P.
- Orpen I.
- Ortiz de Murua Lopez J. A.
- Orts Soler E.
- Orzechowski K.
- Osadchuk E.
- Otero Chulian E.
- Ou X.
- Ou Y.
- Ouguoujil A.
- Ovize M.
- Ozkan-Rashed Z.
- P. A. Do
- Paganelli F.
- Page E.
- Paget S. E.
- Paillard F.
- Painsipp P.
- Pal R.
- Paliulioniene R.
- Pallie S.
- Pan G.
- Pan J.
- Pan X.
- Panajatovic M.
- Pandey R. K.
- Panetta F.
- Panisois K.
- Panova E.
- Panpunnung S.
- Papathanasioy A.
- Pappas C.
- Pareathumby K.
- Paris D.
- Parkar W.
- Parker I.
- Parkin R.
- Partington M.
- Pasechnaya N.
- Pashentseva I.
- Pasquet A.
- Pastor Torres L.
- Patel R.
- Patel R. P.
- Pattison I.
- Paul C.
- Paul N.
- Paule Sanchez A. J.
- Paulus C. -P.
- Pavlova Y.
- Payot L.
- Paz Bermejo M. A.
- Pearce J.
- Pedretti R.
- Pego G.
- Pei H.
- Pei X.
- Pelicano N.
- Pelier F.
- Pella D.
- Pellerin F.
- Pena Perez G.
- Peneva Y.
- Peng C.
- Peng J.
- Peng Y.
- Peperstraete B.
- Perea Egido J. A.
- Pereira A.
- Perez de Isla L.
- Perez Ibiricu S.
- Perez Martinez M. A.
- Perez Paredes M.
- Perger T.
- Perings S.
- Peris Domingo E.
- Perna B.
- Perna G.
- Pernat A.
- Pernice V.
- Perreault F.
- Perry M.
- Pes G.
- Pesant Y.
- Petersen Aranguren F.
- Petit A.
- Petitjean F.
- Petoin Peuch L.
- Petrillo M. E.
- Petrochenko N.
- Petropoulos I.
- Petrova I.
- Petrova N.
- Pham H. T.
- Pham M. H.
- Pham N. H.
- Pham N. S.
- Pham N. V.
- Pham T. H. T.
- Pham T. S.
- Pham T. T. H.
- Pham T. T. N.
- Phan D. P.
- Phan H. H.
- Phillips K.
- Phrommintikul A.
- Pinar Sopena J.
- Pinch E.
- Pindado Rodriguez C.
- Pinero Ramirez C.
- Pinilla Lozano M. J.
- Pinto Vaz M. J.
- Pinzani A.
- Pires Pereira R.
- Pitella F.
- Pitsch T.
- Piyayotai D.
- Pjontek J.
- Placke J.
- Pladys A.
- Plastiras V.
- Playford D. A.
- Pleskof A.
- Pogrebna O.
- Poinson P.
- Pokrovskaya I.
- Poles J.
- Polkina L.
- Poluyanova G.
- Polyaeva L.
- Polyanskaya Y.
- Pons G.
- Pontaga N.
- Pontikakis N.
- Popova L.
- Poprawa B.
- Pornin M.
- Porras Ramos Y.
- Potapova E.
- Potapska L.
- Potter A.
- Pouderou P.
- Poujois J. N.
- Poulard J. E.
- Pournaras G.
- Pouwels S.
- Povolna P.
- Prada E.
- Pradhan R.
- Prasad B.
- Prevot J. L.
- Priftis C.
- Prikolota O.
- Primot P.
- Probst V.
- Proenca G.
- Proietti F.
- Prokop A.
- Provvidenza M.
- Prunier F.
- Prunier L.
- Pu Y.
- Pucheu A.
- Puel V.
- Puente Barragan A.
- Purnode P.
- Pustovit S.
- Q. H. Do
- Qian J.
- Qian Z.
- Quek S. S. S.
- Quinn L. P.
- Radwan Arafah M.
- Raffelsberger R.
- Rafter A.
- Rahali A.
- Rahman A.
- Rahman S.
- Rainbird A.
- Raisova L.
- Rajendran S.
- Ramachandran R.
- Ramadan F. B.
- Ramanaidu S.
- Ramesh S. S.
- Ramos Ariznabarreta F.
- Ramoutar P.
- Ramphall S.
- Ranjith N.
- Raska P.
- Raters C.
- Ratovskaya O.
- Rau M.
- Ravlyk V.
- Ravoala P.
- Rawal J.
- Ray N.
- Raymond P.
- Rayo Gutierrez M.
- Razzaq N.
- Rebelo L.
- Rechtman D.
- Redding Escalante F.
- Reddy G.
- Refsgaard J.
- Regulska A.
- Reid C.
- Reifart N.
- Reis Monteiro S.
- Relange D.
- Ren N.
- Ren W.
- Rennert R.
- Reviene S.
- Reyes Cisneros F. A.
- Reymond S.
- Rhew J. Y.
- Ribeiro A.
- Riccioni G.
- Richmond D.
- Rickli H.
- Rickli H.
- Rijavec B.
- Rink A.
- Rinkuniene E.
- Riou Y.
- Robb J.
- Robert J.
- Robert J. F.
- Roca Catalan J. M.
- Rocha De Almeida A.
- Rocha de Lorenzo A.
- Roche C.
- Rodenas P.
- Rodina O.
- Rodrigues C.
- Rodrigues O.
- Rodriguez Almodovar A.
- Rodriguez Briones I.
- Rodriguez Collado J.
- Rodriguez Fernandez A.
- Rodriguez Fernandez J. A.
- Rodriguez Hernandez J. A.
- Rodriguez Marrero I.
- Rodriguez Tejero I.
- Rodriguez E.
- Rogers J.
- Rogowsky A.
- Rogozhyna V.
- Rojas G.
- Romanov S.
- Romeo Castillejo I.
- Romero Alvira D.
- Romero Hinojosa J. A.
- Romero Maldonado M. A.
- Romero Menor C.
- Romo Santana J. R.
- Rosa Pais J.
- Rosado Soares R.
- Rosenstein H.
- Ross S.
- Rosseel M.
- Rossi Sevillano P.
- Rostik S.
- Rotaru L.
- Rotenberger V.
- Roul G.
- Rouse D.
- Rousson D.
- Rowe P.
- Roy A.
- Roy B.
- Roy T.
- Rozkova N.
- Rueda Calle E. C.
- Rueda Soriano J.
- Ruiz Esparza M. E.
- Ruiz Perez P.
- Rundell T.
- Rus H.
- Rybak K.
- Ryu J. K.
- Ryzhkova V.
- S. J. Oh
- S. K. Ma
- S. K. Oh
- Saade M.
- Sabe-Affaki G.
- Sadauskiene E.
- Sadiq A.
- Sadlowski R.
- Sadykova I.
- Safonova L.
- Sagastagoitia Gorostiza T.
- Sahar A. S.
- Sainz Hidalgo I.
- Salah T.
- Salakhova A.
- Salas Z.
- Salaun B.
- Salecker I.
- Saleh B.
- Salembier J. -P.
- Salimova S.
- Salustri A.
- Samakhovets V.
- Samal M. P.
- Samama P.
- Samothrakitis A.
- Sampson P.
- Sandalian A.
- Sander M.
- Sandin Rollan M.
- Sandoval S.
- Sanfins V.
- Sang Z.
- Santaolalla Rodriguez S.
- Santas Olmeda E.
- Santos Iglesias J. L.
- Santos R.
- Sanz Rodriguez M. L.
- Saporito F.
- Saran R. K.
- Sardon M.
- Sargento L.
- Sattar F.
- Saul P.
- Saulnier D.
- Saunders P.
- Savard D.
- Sawhney J. P. S.
- Scalia G.
- Sceats G.
- Schena R. G.
- Schenowitz A.
- Scherbak M.
- Schermaul K. -H.
- Schindler J.
- Schlesingerova S.
- Schlueter L.
- Schmidt E.
- Schmied C.
- Schmitz K. -H.
- Schneider J.
- Schon N.
- Schroder T.
- Schultz R.
- Schwarz R.
- Scott G.
- Seabra Gomes R.
- Seal P.
- Searles G. R.
- Sebastian M.
- See O.
- Segre C. A. W.
- Segura Laborda I.
- Semedo L.
- Semenova N.
- Sen I.
- Sengupta G.
- Seo H. S.
- Sepp G.
- Sepulcri F.
- Sequeira A.
- Serazhim A.
- Sereg M.
- Serrano Garcia S.
- Serrano-Garcia A.
- Servi S. D.
- Sevilla Toral B.
- Sewell R.
- Shah R. P.
- Shaikh I.
- Shalnova S.
- Shamsutdinova O.
- Shamsuzzaman M.
- Shan G.
- Shanina I.
- Shao C.
- Sharapova N.
- Sharapova Y.
- Sharif M.
- Sharp D.
- Shaw R.
- Sheahan R.
- Shein K.
- Shekhar Pandey A.
- Shelomova N.
- Sheringham P.
- Shetty K.
- Shetty S. R.
- Shiels P.
- Shimonenko S.
- Shin J. H.
- Shmakova N.
- Shokina T.
- Shuang D.
- Shukla D.
- Sia K. K.
- Sidor M.
- Sievers B.
- Sikorska-Buczkowska B.
- Silva Alves G.
- Silva E Sa J.
- Silva Melchor L.
- Silvestre A.
- Silvestri F.
- Silvestri R.
- Sim K. H.
- Simarro Martin-Ambrioso E.
- Simkova I.
- Simoes L.
- Simon M.
- Simper H.
- Sinclair D.
- Singal A.
- Singer P.
- Singh B.
- Singh G.
- Singh J.
- Singh L.
- Singh M. M.
- Singh P. P.
- Singh R. R.
- Sinicropi G.
- Sinnadurai J.
- Sinotova T.
- Sinyukova O.
- Sirazov I.
- Sirbu O.
- Skoczylas I.
- Skonieczny M.
- Slaboszewska J.
- Slapikas R.
- Slapikiene O. B.
- Smirnova E.
- Smirnova O.
- Smith A.
- Smrckova E.
- Snikyte R.
- Soares L.
- Sobczyk D.
- Soin I.
- Sokn F. J.
- Sola Casado R.
- Solache G.
- Soleille H.
- Soltysiak M.
- Somsen G. A.
- Son W. K.
- Song L.
- Soosiwala I.
- Sopia R.
- Soriano Navarro C.
- Sorodoc L.
- Soskin P.
- Sosner P.
- Sosnova Y.
- Soto Ruiz M. I.
- Soward A.
- Spengler U.
- Spensieri D.
- Speth-Nitschke M.
- Spink D. R.
- Spinu C. M.
- Spitsina T.
- Sprott V.
- Sreenivasa Murthy L.
- Srinivasa Reddy K.
- Sriratanasathavorn C.
- Srivastava P.
- Srtumilenko N.
- Stadler P.
- Stanciulescu G.
- Stankevicius R.
- Stanley M.
- Starostina N.
- Stasiuk T.
- Stasuk O.
- Statescu C.
- Steeds R.
- Steg G.
- Steg P. G.
- Stelmakh I.
- Stepinska J.
- Steponeniene R.
- Stergiou D.
- Sternthal P.
- Steurer G.
- Stevens A.
- Stevens L.
- Stikhurova M.
- Stordeur J. M.
- Strange S.
- Strathmore N. F.
- Streb W.
- Stumpp A.
- Stursova H.
- Suarez G.
- Sudnik J.
- Sudre A.
- Suglobova E.
- Suithichaiyakul T.
- Sukhanova L.
- Sulaiman K. J.
- Suliman I.
- Sullivan B.
- Sullivan H.
- Sun A.
- Sun L.
- Suntinger A.
- Surmont P.
- Surovtseva I.
- Svolis K.
- Syed A. B.
- Sykulski R.
- Sylivris S.
- Sytilina N.
- Szabo E.
- Szabo S.
- Szalkowski P.
- Szentivanyi M.
- Sziegl Z.
- Szpak A.
- Szto G.
- Szulc M.
- T. B. Le
- T. C. Do
- T. L. To
- T. N. Vo
- T. Q. Do
- T. T. H. Ta
- Tabet S.
- Tabone X.
- Tadeu Munhoz R.
- Taggeselle J.
- Tahir A. R.
- Takacs I.
- Takhar J.
- Talavera Calle P.
- Talbot P.
- Tamburino C.
- Tamimi M. Y.
- Tamm A.
- Tan E. H. M.
- Tan H.
- Tan S. K.
- Tang Y.
- Tangcharoen T.
- Tanielian P.
- Tantillo S.
- Tantisiriwat W.
- Tardif J. -C.
- Tardy M.
- Tarenidis P.
- Tasneeyapant S.
- Tavares E Taveira A.
- Tavazzi L.
- Tavlueva E.
- Tay M. H.
- Taylor A.
- Taylor H.
- Taylor N.
- Teleky U.
- Tendera M.
- Tennekoon M.
- Tereshko S.
- Terrosu P.
- Testa R.
- Thelemann A.
- Thelemann C.
- Theodorakis G.
- Thermol P.
- Theron H. D.
- Thillai Vallal S.
- Thoin F.
- Thomas H.
- Thomas L.
- Thomas-Richard F.
- Thomson A.
- Thummel H.
- Thurston S.
- Tian Z.
- Tikhonov Y.
- Tikhonova S.
- Till R.
- Tilluckdharry R.
- Tito Martins J.
- Tkachenko L.
- Tkhorzhevskaya L.
- Tolpygina S.
- Tomatti A.
- Tonet L.
- Topf H.
- Toplak J.
- Toringhibel M.
- Torres Diaz P. L.
- Toth K.
- Touzet P.
- Trambitas R.
- Tran A. C.
- Tran H.
- Tran L. U. P.
- Tran N. P. H.
- Tran Q. H.
- Tran T. H.
- Tran T. T. T.
- Tran V. D.
- Travill C.
- Tricoire J.
- Tricot C.
- Trivedi A. K.
- Trocan N.
- Troncoso Gil A.
- Troup D.
- Trujillo Berraquero F.
- Truong B.
- Truong P. H.
- Truong Q. B.
- Tsamopoulos I.
- Tsaryabina L.
- Tsui W. W. H.
- Tsygankov O.
- Tu C.
- Tucker A.
- Tudose A.
- Tuktarova F.
- Tulevski I. I.
- Tulevski I. I.
- Tumarov F.
- Tuong T. V. A.
- Turek P.
- Turi P.
- Turiel M.
- Turner C.
- Uerojanaungkul P.
- Ulecia Martinez M. A.
- Umaran Sanchez J.
- Unger G.
- Upton J.
- Ushakov O.
- Usoltseva E.
- Utech A.
- V. C. Do
- V. T. Le
- Vadavi A.
- Vaisvila T.
- Vallis M.
- Van de Walle S.
- Van den Branden F.
- Van den Branden F.
- Vance A.
- Vandeplas A. M. F.
- Vandergoten P.
- Vanhauwaert B. G.
- Vanneste L.
- Vaquette B.
- Varaldi J.
- Vardas P.
- Vardhani M.
- Varezhnikova O.
- Variava E.
- Varma S.
- Varughese S.
- Vasconcelos J.
- Vasylenko V.
- Vaticon Herreros C.
- Vaughan C.
- Vavougios J.
- Vawda G. H. M.
- Vaz G. F.
- Vazhdaeva Z.
- Vazquez Garcia A.
- Vechtomova N.
- Vega Barbado J. L.
- Velasco Espejo-Saavedra E.
- Verbrugge E.
- Vercammen J.
- Verleyen D.
- Vermander D.
- Verret G.
- Vertes G. E.
- Vervoort G.
- Veternik A.
- Veth V.
- Vial H.
- Vicente Amato R.
- Vicente Vera T.
- Vicentini A.
- Victory J.
- Vida Gutierrez M.
- Vieyra G.
- Vijayaraghavan G.
- Villar Mariscal C.
- Villasenor F. M.
- Vinereanu D.
- Vinhas H.
- Vites N.
- Vivekaphirat V.
- Vives Bonato G.
- Vizel S.
- Vlasuk Z.
- Vogel M.
- Volmar J.
- Voloshko Y.
- Voloshyna L.
- Voronina N.
- Voronina V.
- Voronova T.
- Vuille C.
- Vymetal P.
- Vyshnevaya N.
- W. K. Ng
- Walawski G.
- Walch J. M.
- Walcher K.
- Walczewska J.
- Waldman A.
- Walker D. M.
- Wallace A.
- Wang D.
- Wang H.
- Wang J.
- Wang L.
- Wang R.
- Wang S.
- Wang T.
- Wang W.
- Wang X.
- Wang Y.
- Warden D.
- Wassef A.
- Wasuwat A.
- Watkins N.
- Watson A.
- Wauer B.
- Wazana M.
- Weatherhead M.
- Weatherup A.
- Weber F.
- Weglarz M.
- Wehr G.
- Wei J.
- Weingrod M.
- Weinrich L.
- Weinrich R.
- Wellenkamp E.
- Wernham C.
- West P.
- Wettstein T.
- Weytjens C.
- Whetstone S.
- Widimsky P.
- Wiggers P.
- Wilkinson I.
- Williams H.
- Williams S.
- Wilson G.
- Windstetter U.
- Winter M.
- Wirtz J. H.
- Wittekoek J. E.
- Wittlich N.
- Wong A. P. T.
- Wong D. S.
- Wong P.
- Wongcharoen W.
- Woodall A.
- Woollard K.
- Wrebiak-Trznadel M.
- Wright S.
- Wu Amen L.
- Wu D.
- Wu G.
- Wu J.
- Wu K.
- Wu S.
- Wu Y.
- Wysocki R.
- Xiao J.
- Xie J.
- Xie X.
- Xie Y.
- Xing Y.
- Xiong C.
- Xiong L.
- Xu D.
- Xu M.
- Xu W.
- Xu Z.
- Xue H.
- Xue M.
- Yakimova N.
- Yakovenko E.
- Yakovova S.
- Yan J.
- Yan X.
- Yanes Bowden G.
- Yanez Wonenburger J. C.
- Yang F.
- Yang H.
- Yang K.
- Yang M.
- Yang Q.
- Yang X.
- Yang Y.
- Yanina Y.
- Yanni N.
- Yao E.
- Yao X.
- Yao Y.
- Yared K.
- Yeo C. K.
- Yeung M. M. M.
- Yip T.
- Yordanova V.
- Yu A.
- Yu B.
- Yu G.
- Yu M.
- Yu X.
- Yuan C.
- Yusuf A.
- Yusufali A.
- Yvorra S.
- Zaca F.
- Zachos V.
- Zagozen P.
- Zagreanu M.
- Zakirova V.
- Zakopoulos C.
- Zalewska D.
- Zamorano Gomez J. L.
- Zamorano J. L.
- Zaoral L.
- Zarauza Navarro J.
- Zarechnova S.
- Zaronskiene D.
- Zatsarina E.
- Zdrojewska J.
- Zeitouni R.
- Zhabina L.
- Zhang A.
- Zhang C.
- Zhang G.
- Zhang H.
- Zhang J.
- Zhang L.
- Zhang M.
- Zhang S.
- Zhang X.
- Zhang Y.
- Zhao G.
- Zhao H.
- Zhao R.
- Zhao S.
- Zhao Y.
- Zharikova L.
- Zheng S.
- Zheng X.
- Zheng Y.
- Zherebtsova A.
- Zherlitsyna E.
- Zhou G.
- Zhou S.
- Zhou X.
- Zhou Y.
- Zhou Z.
- Zhu B.
- Zhu J.
- Zhu M.
- Zhu S.
- Ziak E.
- Ziccarelli C.
- Ziehn P.
- Zimolag R.
- Zundorf P.
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2015
- Field of study
Orbitofrontal cortex 5-HT2A receptor mediates chronic stress-induced depressive-like behaviors and alterations of spine density and Kalirin7
- Author
- Aghajanian
- Agustin-Pavon
- Albert
- Alvarez
- Amargos-Bosch
- Anisman
- Artigas
- Boyko
- Campos
- Chang Xu
- Chen
- Cotter
- Cowen
- Cryan
- de Souza Moreno
- Demuyser
- Der-Avakian
- Desmyter
- Fenelon
- Frechilla
- Ge
- Geracioti
- Gilabert-Juan
- Goldwater
- Gourley
- Gutierrez-Rojas
- Hadamitzky
- Himichi
- Hui Qiao
- Hui-Bin Chen
- Jiang-Xie
- Jones
- Konopaske
- Laugeray
- Licznerski
- Liston
- Liu
- Liu
- Lucassen
- Luo
- Ma
- Ma
- Ma
- Marek
- Meng-He Zhou
- Messa
- Millon
- Millon
- Mogha
- Mychasiuk
- Niu
- Pandey
- Pazini
- Placidi
- Popko
- Qiao
- Qiao
- Radley
- Rajkowska
- Rush
- Santana
- Scheuerecker
- Sekiguchi
- Sharp
- Sheline
- Shu-Cheng An
- Sinclair
- Sumislawski
- Surget
- Vazquez-Borsetti
- Venzala
- Visser
- Volpicelli
- Wang
- Weisstaub
- Wesolowska
- WHO
- Willner
- Willner
- Willner
- Xie
- Xie
- Xin-Ming Ma
- Yalcin
- Yan
- Yoshida
- Zaniewska
- Zhang
- Zhao
- Zhao
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Characterization of Carriage Isolates of Neisseria meningitidis in the Adolescents and Young Adults Population of Bogota (Colombia)
- Author
- A von Gottberg
- AJ Beddek
- Ana Belén Ibarz-Pavon
- C Sorhouet-Pereira
- Carolina Duarte
- Caroline L Trotter
- CI Agudelo
- CL Trotter
- CL Trotter
- DA Ala'aldeen
- DA Caugant
- DA Caugant
- DA Caugant
- E Urra
- E Wedege
- H Christensen
- H Claus
- H Claus
- H Pinzón-Redondo
- J Leimkugel
- J MacLennan
- Jaime Moreno
- Jean Marc Gabastou
- LE Espinosa de los Monteros
- LH Harrison
- M Soriano-Gabarró
- M Taha
- M Taha
- MA Sáfadi
- MC Lourenço
- MC Maiden
- Melissa Hidalgo
- Olga Sanabria
- OO Bilukha
- P Araya
- P Rodriguez
- PA Kristiansen
- Q Chang
- R Abad
- R Abad
- RC Read
- RE Stanwell-Smith
- S Esposito
- SC Tayal
- SP Yazdankhah
- U Jounio
- Y Climent
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Higher versus lower blood pressure targets in adults with shock
- Author
- Alberti
- Amado
- Anderson
- Andreis
- Annane
- Antonelli
- Arnemann
- Asfar
- Awad
- Backer
- Badin
- Balogh
- Beesley
- Belletti
- Belletti
- Beloncle
- Bourgoin
- Brok
- Brok
- Brown
- Bulkley
- Carlotti
- Castellini
- Cecconi
- Cecconi
- Cotton
- D'Aragon
- Dave
- DeMets
- DerSimonian
- Dubin
- Dünser
- Dünser
- Egger
- Elbourne
- Esteban
- Fisher
- Frazee
- Gamper
- Gartlehner
- Genderen
- Gluud
- Golan
- Goldberg
- Greenwood
- Guyatt
- Hands
- Harbord
- Hessler
- Higgins
- Higgins
- Hjortrup
- Holler
- Hollis
- Jakobsen
- Jeppesen
- Kato
- Katzung
- Kjaergard
- Kobayashi
- Krausz
- Lamontagne
- Lamontagne
- LeDoux
- Levy
- Lewis
- Lundh
- Ma
- Marik
- McIntyre
- McMahon
- Moher
- Moranville
- Moreno
- Myburgh
- Møller
- Nduka
- Nielsen
- Pavon
- Pawlik
- Perel
- Pogue
- Post
- Quenot
- Rhodes
- Richards
- Rivers
- Rochwerg
- Rossaint
- Roth
- Russell
- Sakr
- Savović
- Schmittinger
- Shah
- Siegel
- Singer
- Starling
- Strandgaard
- Student
- Szopinski
- Thooft
- Thorlund
- Turner
- Varpula
- Venkatesh
- Vincent
- Weil
- Wetterslev
- Wetterslev
- Wetterslev
- Wo
- Wood
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Reduced plasmodium parasite burden associates with CD38(+) CD4(+) T cells displaying cytolytic potential and impaired IFN-gamma production
- Author
- A Funaro
- A Moreno
- AH Guse
- AK McElroy
- B Douradinha
- CB Wilson
- CJ Montoya
- CR Engwerda
- D Grogg
- Denise L. Doolan
- DJ Pombo
- DL Doolan
- DM Brown
- DM Zhao
- DR Green
- DT Patton
- DZ Soghoian
- DZ Soghoian
- E Amyes
- EJ Pavon
- EM Bijker
- EN Chini
- G Sconocchia
- H Cheroutre
- HZ Qui
- J Langhorne
- James S. McCarthy
- JD Miller
- JJ Zaunders
- JS McCarthy
- JS Tsang
- Julie G. Burel
- JV Falvo
- JX Lin
- K Eshima
- K Scalzo-Inguanti
- KB Nguyen
- Kerenaftali Klein
- KJ Livak
- L Frasca
- LC Platanias
- LE Kallal
- M Roestenberg
- M Tsuji
- MA Caligiuri
- Mary M. Stevenson
- MB McCall
- MH Kaplan
- MM Stevenson
- N Obeng-Adjei
- PD Crompton
- Penny L. Groves
- PO Krutzik
- R Mallone
- R Testi
- RJ Rockett
- RW Sauerwein
- S Agarwal
- S Crotty
- S Deaglio
- S Partida-Sanchez
- S Read
- Simon H. Apte
- SL Hoffman
- SL Swain
- TM Wilkinson
- V Appay
- V Appay
- V Groh
- V Kumar
- V Ryg-Cornejo
- WF Ng
- YD Mahnke
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2016
- Field of study
Using a unique resource of samples from a controlled human malaria infection ( CHMI) study, we identified a novel population of CD4(+) T cells whose frequency in the peripheral blood was inversely correlated with parasite burden following P. falciparum infection. These CD4(+) T cells expressed the multifunctional ectoenzyme CD38 and had unique features that distinguished them from other CD4(+) T cells. Specifically, their phenotype was associated with proliferation, activation and cytotoxic potential as well as significantly impaired production of IFN-gamma and other cytokines and reduced basal levels of activated STAT1. A CD38(+) CD4(+) T cell population with similar features was identified in healthy uninfected individuals, at lower frequency. CD38(+) CD4(+) T cells could be generated in vitro from CD38(-) CD4(+) T cells after antigenic or mitogenic stimulation. This is the first report of a population of CD38(+) CD4(+) T cells with a cytotoxic phenotype and markedly impaired IFN-gamma capacity in humans. The expansion of this CD38(+) CD4(+) T population following infection and its significant association with reduced blood-stage parasite burden is consistent with an important functional role for these cells in protective immunity to malaria in humans. Their ubiquitous presence in humans suggests that they may have a broad role in host-pathogen defense
Reduced Plasmodium Parasite Burden Associates with CD38+ CD4+ T Cells Displaying Cytolytic Potential and Impaired IFN-γ Production
- Author
- A Funaro
- A Moreno
- AH Guse
- AK McElroy
- B Douradinha
- CB Wilson
- CJ Montoya
- CR Engwerda
- D Grogg
- Denise L. Doolan
- DJ Pombo
- DL Doolan
- DM Brown
- DM Zhao
- DR Green
- DT Patton
- DZ Soghoian
- DZ Soghoian
- E Amyes
- EJ Pavon
- EM Bijker
- EN Chini
- G Sconocchia
- H Cheroutre
- HZ Qui
- J Langhorne
- James S. McCarthy
- JD Miller
- JJ Zaunders
- JS McCarthy
- JS Tsang
- Julie G. Burel
- JV Falvo
- JX Lin
- K Eshima
- K Scalzo-Inguanti
- KB Nguyen
- Kerenaftali Klein
- KJ Livak
- L Frasca
- LC Platanias
- LE Kallal
- M Roestenberg
- M Tsuji
- MA Caligiuri
- Mary M. Stevenson
- MB McCall
- MH Kaplan
- MM Stevenson
- N Obeng-Adjei
- PD Crompton
- Penny L. Groves
- PO Krutzik
- R Mallone
- R Testi
- RJ Rockett
- RW Sauerwein
- S Agarwal
- S Crotty
- S Deaglio
- S Partida-Sanchez
- S Read
- Simon H. Apte
- SL Hoffman
- SL Swain
- TM Wilkinson
- V Appay
- V Appay
- V Groh
- V Kumar
- V Ryg-Cornejo
- WF Ng
- YD Mahnke
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study