COMPUTATIONAL STUDY OF SIC HALIDE CHEMICAL VAPOR DEPOSITION SYSTEM

ABSTRACT Halide CVD (HCVD) is recently employed to grow SiC epitaxial layers using SiCl 4 /C 3 H 8 /H 2 mixtures in an effort to achieve high deposition rates. The introduction of the chlorinated species allows the formation of more stable species SiCl 2 while maintaining high surface reactivity, thus avoiding the silicon gas phase nucleation that has been widely reported in conventional CVD process using SiH 4 /C 3 H 8 /H 2 . However, the difficulties in reducing defect density and controlling the electrical properties of the material present a significant technical obstacle for HCVD of SiC. In experimental growth, the electrical properties, defect densities and the growth rate of as-deposited SiC epitaxial films are, to a large extent, determined by processing parameters including temperature, pressure, flow rates of precursors and carrier gas. Optimization of growth conditions provides the opportunity to engineer films with desired film properties and qualities at high deposition rate but requires in-depth understanding the deposition process. In this study, we performed computational study to investigate the effects of main processing parameters in HCVD process on film growth. Numerical experiments were performed over a wide range of operational parameters to provide information on distributions of gas velocity, temperature, and chemical species' concentrations in the reactor as well as the deposition rates on the substrate surface. Simulations were also carried out to address hot zone design and operational conditions

Immunotherapy of lung cancer: An update

In Germany lung cancer is the leading cause of cancer-associated death in men. Surgery, chemotherapy and radiation may enhance survival of patients suffering from lung cancer but the enhancement is typically transient and mostly absent with advanced disease; eventually more than 90% of lung cancer patients will die of disease. New approaches to the treatment of lung cancer are urgently needed. Immunotherapy may represent one new approach with low toxicity and high specificity but implementation has been a challenge because of the poor antigenic characterization of these tumors and their ability to escape immune responses. Several different immunotherapeutic treatment strategies have been developed. This review examines the current state of development and recent advances with respect to non-specific immune stimulation, cellular immunotherapy ( specific and non-specific), therapeutic cancer vaccines and gene therapy for lung cancer. The focus is primarily placed on immunotherapeutic cancer treatments that are already in clinical trial or well progressed in preclinical studies. Although there seems to be a promising future for immunotherapy in lung cancer, presently there is not standard immunotherapy available for clinical routine

Body Surface Area and Baseline Blood Pressure Predict Subclinical Anthracycline Cardiotoxicity in Women Treated for Early Breast Cancer

This work was supported by the United Kingdom Department of Health under the Pharmacogenetics Research programme (grant number PHGX23A).Background and aims: Anthracyclines are highly effective chemotherapeutic agents which may cause long-term cardiac damage (chronic anthracycline cardiotoxicity) and heart failure. The pathogenesis of anthracycline cardiotoxicity remains incompletely understood and individual susceptibility difficult to predict. We sought clinical features which might contribute to improved risk assessment. Methods: Subjects were women with early breast cancer, free of pre-existing cardiac disease. Left ventricular ejection fraction was measured using cardiovascular magnetic resonance before and >12 months after anthracycline-based chemotherapy (>3 months post-Trastuzumab). Variables associated with subclinical cardiotoxicity (defined as a fall in left ventricular ejection fraction of ≥5%) were identified by logistic regression. Results: One hundred and sixty-five women (mean age 48.3 years at enrollment) completed the study 21.7 months [IQR 18.0-26.8] after starting chemotherapy. All received anthracyclines (98.8% epirubicin, cumulative dose 400 [300-450] mg/m2); 18% Trastuzumab. Baseline blood pressure was elevated (≥140/90mmHg, mean 147.3/86.1mmHg) in 18 subjects. Thirty-four subjects (20.7%) were identified with subclinical cardiotoxicity, independent predictors of which were the number of anthracycline cycles (odds ratio, OR 1.64 [1.17-2.30] per cycle), blood pressure ≥140/90mmHg (OR 5.36 [1.73-17.61]), body surface area (OR 2.08 [1.36-3.20] per standard deviation (0.16m2) increase), and Trastuzumab therapy (OR 3.35 [1.18-9.51]). The resultant predictive-model had an area under the receiver operating characteristics curve of 0.78 [0.70-0.86]. Conclusions: We found subclinical cardiotoxicity to be common even within this low risk cohort. Risk of cardiotoxicity was associated with modestly elevated baseline blood pressure-indicating that close attention should be paid to blood pressure in patients considered for anthracycline based chemotherapy. The association with higher body surface area suggests that indexing of anthracycline doses to surface area may not be appropriate for all, and points to the need for additional research in this area

The Parametric Inverse Problem in Transient Scattering

Scattering problems in many areas of applied physics are governed by the wave equation. In the most usual situation, we are given the incident wave (input) and the scatterer(s) and attempt, through analytical, experimental, or numerical methods, to produce the scattered waves (output). Such procedures can be carried out in either the frequency domain or the time domain and are categorized under the general heading of “forward problems.” In a less usual, but no less important situation, we are given the incident wave (input) and the scattered waves (output) and attempt to find the scatterer(s) that produced the output. In this case, we call the procedures “inverse” problems

Alpha-particle-induced complex chromosome exchanges transmitted through extra-thymic lymphopoiesis in vitro show evidence of emerging genomic instability

Human exposure to high-linear energy transfer α-particles includes environmental (e.g. radon gas and its decay progeny), medical (e.g. radiopharmaceuticals) and occupational (nuclear industry) sources. The associated health risks of α-particle exposure for lung cancer are well documented however the risk estimates for leukaemia remain uncertain. To further our understanding of α-particle effects in target cells for leukaemogenesis and also to seek general markers of individual exposure to α-particles, this study assessed the transmission of chromosomal damage initially-induced in human haemopoietic stem and progenitor cells after exposure to high-LET α-particles. Cells surviving exposure were differentiated into mature T-cells by extra-thymic T-cell differentiation in vitro. Multiplex fluorescence in situ hybridisation (M-FISH) analysis of naïve T-cell populations showed the occurrence of stable (clonal) complex chromosome aberrations consistent with those that are characteristically induced in spherical cells by the traversal of a single α-particle track. Additionally, complex chromosome exchanges were observed in the progeny of irradiated mature T-cell populations. In addition to this, newly arising de novo chromosome aberrations were detected in cells which possessed clonal markers of α-particle exposure and also in cells which did not show any evidence of previous exposure, suggesting ongoing genomic instability in these populations. Our findings support the usefulness and reliability of employing complex chromosome exchanges as indicators of past or ongoing exposure to high-LET radiation and demonstrate the potential applicability to evaluate health risks associated with α-particle exposure.This work was supported by the Department of Health, UK. Contract RRX95 (RMA NSDTG)

Water vapor in the starburst galaxy NGC 253: A new nuclear maser?

22 GHz water vapor emission was observed toward the central region of the spiral starburst galaxy NGC 253. Monitoring observations with the 100-m telescope at Effelsberg and measurements with the BnC array of the VLA reveal three distinct velocity components, all of them blueshifted with respect to the systemic velocity. The main component arises from a region close to the dynamical center and is displaced by <1 arcsec from the putative nuclear continuum source. The bulk of this maser component is spread over an area not larger than 70 x 50 mas. Its radial velocity may be explained by masing gas that is part of a nuclear accretion disk or of a counterrotating kinematical subsystem or by gas that is entrained by the nuclear superwind or by an expanding supernova shell. A weaker feature, located 5 arcsec to the northeast, is likely related to an optically obscured site of massive star formation.Comment: 6 pages, 4 Postscript figures, A&A Main Journa

The 3.4 micron absorption feature towards three obscured active galactic nuclei

The results of 3-4 $\mu$m spectroscopy towards the nuclei of NGC 3094, NGC 7172, and NGC 7479 are reported. In ground-based 8-13 $\mu$m spectra, all the sources have strong absorption-like features at $\sim$10 $\mu$m, but they do not have detectable polycyclic aromatic hydrocarbon (PAH) emission features. The 3.4 $\mu$m carbonaceous dust absorption features are detected towards all nuclei. NGC 3094 shows a detectable 3.3 $\mu$m PAH emission feature, while NGC 7172 and NGC 7479 do not. Nuclear emission whose spectrum shows dust absorption features but no PAH emission features is thought to dominated by highly obscured active galactic nuclei (AGNs) activity. For NGC 7172, NGC 7479, and three other such nuclei in the literature, we investigate the optical depth ratios between the 3.4 $\mu$m carbonaceous dust and 9.7 $\mu$m silicate dust absorption ($\tau_{3.4}$/$\tau_{9.7}$). The $\tau_{3.4}$/$\tau_{9.7}$ ratios towards three highly obscured AGNs with face-on host galaxies are systematically larger than the ratios in the Galactic diffuse interstellar medium or the ratios for two highly obscured AGNs with edge-on host galaxies. We suggest that the larger ratios can be explained if the obscuring dust is so close to the central AGNs that a temperature gradient occurs in it. If this idea is correct, our results may provide spectroscopic evidence for the presence of the putative ``dusty tori'' in the close vicinity of AGNs.Comment: 9 pages, 3 figures, mn.sty, Accepted for publication in MNRA

Nitrogen uptake and internal recycling in Zostera marina exposed to oyster farming: eelgrass potential as a natural biofilter

Oyster farming in estuaries and coastal lagoons frequently overlaps with the distribution of seagrass meadows, yet there are few studies on how this aquaculture practice affects seagrass physiology. We compared in situ nitrogen uptake and the productivity of Zostera marina shoots growing near off-bottom longlines and at a site not affected by oyster farming in San Quintin Bay, a coastal lagoon in Baja California, Mexico. We used benthic chambers to measure leaf NH4 (+) uptake capacities by pulse labeling with (NH4)-N-15 (+) and plant photosynthesis and respiration. The internal N-15 resorption/recycling was measured in shoots 2 weeks after incubations. The natural isotopic composition of eelgrass tissues and vegetative descriptors were also examined. Plants growing at the oyster farming site showed a higher leaf NH4 (+) uptake rate (33.1 mmol NH4 (+) m(-2) day(-1)) relative to those not exposed to oyster cultures (25.6 mmol NH4 (+) m(-2) day(-1)). We calculated that an eelgrass meadow of 15-16 ha (which represents only about 3-4 % of the subtidal eelgrass meadow cover in the western arm of the lagoon) can potentially incorporate the total amount of NH4 (+) excreted by oysters (similar to 5.2 x 10(6) mmol NH4 (+) day(-1)). This highlights the potential of eelgrass to act as a natural biofilter for the NH4 (+) produced by oyster farming. Shoots exposed to oysters were more efficient in re-utilizing the internal N-15 into the growth of new leaf tissues or to translocate it to belowground tissues. Photosynthetic rates were greater in shoots exposed to oysters, which is consistent with higher NH4 (+) uptake and less negative delta C-13 values. Vegetative production (shoot size, leaf growth) was also higher in these shoots. Aboveground/belowground biomass ratio was lower in eelgrass beds not directly influenced by oyster farms, likely related to the higher investment in belowground biomass to incorporate sedimentary nutrients