1,318 research outputs found
Floristic composition of the Montane Forest in the Almadina-Barro Preto axis, Southern Bahia, Brazil
Prescrições geriátricas inapropriadas e polifarmacoterapia em enfermarias de clÃnica médica de um Hospital-Escola
Occurrence of Ancylostoma in dogs, cats and public places from Andradina city, São Paulo state, Brazil
Metabolism within the tumor microenvironment and its implication on cancer progression: an ongoing therapeutic target
Since reprogramming energy metabolism is considered a new hallmark of cancer, tumor metabolism is again in the spotlight of cancer research. Many studies have been carried out and many possible therapies have been developed in the last years. However, tumor cells are not alone. A series of extracellular components and stromal cells, such as endothelial cells, cancer-associated fibroblasts, tumor-associated macrophages and tumor-infiltrating T cells, surround tumor cells in the so-called tumor microenvironment. Metabolic features of these cells are being studied in deep in order to find relationships between metabolism within the tumor microenvironment and tumor progression. Moreover, it cannot be forgotten that tumor growth is able to modulate host metabolism and homeostasis, so that tumor microenvironment is not the whole story. Importantly, the metabolic switch in cancer is just a consequence of the flexibility and adaptability of metabolism and should not be surprising. Treatments of cancer patients with combined therapies including anti-tumor agents with those targeting stromal cell metabolism, anti-angiogenic drugs and/or immunotherapy are being developed as promising therapeutics.Mª Carmen Ocaña is recipient of a predoctoral FPU grant from the Spanish Ministry of Education, Culture and Sport. Supported by grants BIO2014-56092-R (MINECO and FEDER), P12-CTS-1507 (Andalusian Government and FEDER) and funds from group BIO-267 (Andalusian Government). The "CIBER de Enfermedades Raras" is an initiative from the ISCIII (Spain). The funders had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript
Studies of distribution and recurrence of Helicobacter spp. gastric mucosa of dogs after triple therapy
Utilização de medicamentos por idosos brasileiros, de acordo com a faixa etária: um inquérito postal
Detection of schistosomiasis in an area directly affected by the São Francisco River large-scale water transposition project in the Northeast of Brazil
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