ContextD: An algorithm to identify contextual properties of medical terms in a dutch clinical corpus

Background: In order to extract meaningful information from electronic medical records, such as signs and symptoms, diagnoses, and treatments, it is important to take into account the contextual properties of the identified information: negation, temporality, and experiencer. Most work on automatic identification of these contextual properties has been done on English clinical text. This study presents ContextD, an adaptation of the English ConText algorithm to the Dutch language, and a Dutch clinical corpus. Results: The ContextD algorithm utilized 41 unique triggers to identify the contextual properties in the clinical corpus. For the negation property, the algorithm obtained an F-score from 87% to 93% for the different document types. For the experiencer property, the F-score was 99% to 100%. For the historical and hypothetical values of the temporality property, F-scores ranged from 26% to 54% and from 13% to 44%, respectively. Conclusions: The ContextD showed good performance in identifying negation and experiencer property values across all Dutch clinical document types. Accurate identification of the temporality property proved to be difficult and requires further work. The anonymized and annotated Dutch clinical corpus can serve as a useful resource for further algorithm development

Evaluación de la mama contralateral mediante resonancia magnética en pacientes con diagnóstico reciente de cáncer mamario unilateral

Breast Magnetic Resonance (BMR) imaging is a useful tool in the evaluation of breast cancer before surgical treatment. BMR imaging plays an important role in the evaluation of the extension of the malignant lesions, and the study of multifocality and multicentricity. BMR may have a role in the detection of synchronous contralateral breast cancer that is occult to conventional imaging methods (mammography and ultrasonography). In this study we review 13 series of different authors in which they have used BMR in the evaluation of the contralateral breast in patients with newly diagnosed breast cancer. Two thousand five hundred and eleven patients were evaluated with BMR and 123 contralateral cancers, that were occult to conventional methods, were detected with this technique (4,9 %). Therefore, BMR imaging of the breast is useful as a complementary tool because of its high sensitivity in local staging of a breast cancer and its ability in the detection of synchronous contralateral breast cancer in patients with newly diagnosed breast cance

Polycyclic aromatic hydrocarbons in freshwater isopods and field-partitioning between abiotic phases

An assessment was made of the in situ bioaccumulation of 13 polycyclic aromatic hydrocarbons (PAHs) in freshwater isopods in relation to their partitioning between sediments, particulate matter (>0.7 μm), and dissolved phases in eight different water systems of The Netherlands. Large differences in total (F PAHs) concentrations and in relative abundance of individual PAHs were observed between organisms and abiotic compartments and among sampling stations. Principal component analysis revealed distinct differences between PAH profiles in sediments and water. High molecular weight PAHs dominated in the sediments, fluoranthene and pyrene in the isopods, and naphthalene in water. Apparent lipid-based bioconcentration factors (BCFs) increased with increasing hydrophobicity (n-octanol/water partition coefficient; K(ow)). The total range of the BCFs varied only one order of magnitude, ranging from 1

Evaluation of different bowel preparations for small bowel capsule endoscopy: a prospective, randomized, controlled study

To obtain an adequate view of the whole small intestine during capsule endoscopy (CE) a clear liquid diet and overnight fasting is recommended. However, intestinal content can hamper vision in spite of these measures. Our aim was to evaluate tolerance and degree of intestinal cleanliness during CE following three types of bowel preparation. PATIENTS AND METHODS: This was a prospective, multicenter, randomized, controlled study. Two-hundred ninety-one patients underwent one of the following preparations: 4 L of clear liquids (CL) (group A; 92 patients); 90 mL of aqueous sodium phosphate (group B; 89 patients); or 4 L of a polyethylene glycol electrolyte solution (group C; 92 patients). The degree of cleanliness of the small bowel was classified by blinded examiners according to four categories (excellent, good, fair or poor). The degree of patient satisfaction, gastric and small bowel transit times, and diagnostic yield were measured. RESULTS: The degree of cleanliness did not differ significantly between the groups (P = 0.496). Interobserver concordance was fair (k = 0.38). No significant differences were detected between the diagnostic yields of the CE (P = 0.601). Gastric transit time was 35.7 +/- 3.7 min (group A), 46.1 +/- 8.6 min (group B) and 34.6 +/- 5.0 min (group C) (P = 0.417). Small-intestinal transit time was 276.9 +/- 10.7 min (group A), 249.7 +/- 13.1 min (group B) and 245.6 +/- 11.6 min (group C) (P = 0.120). CL was the best tolerated preparation. Compliance with the bowel preparation regimen was lowest in group C (P = 0.008). CONCLUSIONS: A clear liquid diet and overnight fasting is sufficient to achieve an adequate level of cleanliness and is better tolerated by patients than other forms of preparation

Polyfuran Conducting Polymers: Synthesis, Properties, and Applications.

In this review, polyfuran (PFu) synthesis methods and the nucleation mechanism; the electrochemical, structural, morphological, and magnetic properties of PFu; thermal behavior; theoretical calculations on PFu, as well as its applications reported to date, have been compiled. Not only PFu homopolymers have been reviewed, but also PFu co-polymers, PFu bipolymers, and PFu composites. The results are listed, discussed, and compared. It is hoped that this assembly of all the relevant data might enhance knowledge about this conducting polymer and lead to new research fields

Magnetic Braking in Differentially Rotating, Relativistic Stars

We study the magnetic braking and viscous damping of differential rotation in incompressible, uniform density stars in general relativity. Differentially rotating stars can support significantly more mass in equilibrium than nonrotating or uniformly rotating stars. The remnant of a binary neutron star merger or supernova core collapse may produce such a "hypermassive" neutron star. Although a hypermassive neutron star may be stable on a dynamical timescale, magnetic braking and viscous damping of differential rotation will ultimately alter the equilibrium structure, possibly leading to delayed catastrophic collapse. Here we consider the slow-rotation, weak-magnetic field limit in which E_rot << E_mag << W, where E_rot is the rotational kinetic energy, E_mag is the magnetic energy, and W is the gravitational binding energy of the star. We assume the system to be axisymmetric and solve the MHD equations in both Newtonian gravitation and general relativity. Toroidal magnetic fields are generated whenever the angular velocity varies along the initial poloidal field lines. We find that the toroidal fields and angular velocities oscillate independently along each poloidal field line, which enables us to transform the original 2+1 equations into 1+1 form and solve them along each field line independently. The incoherent oscillations on different field lines stir up turbulent-like motion in tens of Alfven timescales ("phase mixing"). In the presence of viscosity, the stars eventually are driven to uniform rotation, with the energy contained in the initial differential rotation going into heat. Our evolution calculations serve as qualitative guides and benchmarks for future, more realistic MHD simulations in full 3+1 general relativity.Comment: 26 pages, 27 graphs, 1 table, accepted for publication by Phys. Rev.