Fabrication of ZnS Zigzag Sculptured Nanostructured thin Films

AbstractIn This work, the design, manufacture and implementation of new attached equipment to the physical vapor deposition system was reported. Using this system ZnS films were prepared under glancing angle deposition (GLAD) technique with the help of varying polar and azimuthal angles of substrate simultaneously without vacuum drop during deposition process. In addition, the designed system will help to control substrate temperature which makes the growth of sculpture thin films possible. The whole system is controlled by a programmable microcontroller. The formation of ZnS zigzag sculptured nanostructured thin films was confirmed by Field Emission Scanning Electron Microscopy (FESEM) and Atomic Force Microscopy (AFM) analyses

Comparison evaluation of Curcumin(Curcuma longa extract)with the application of expressed breast milk in the treatment of nipple cracks in lactating primiparous women: A randomized clinical trial

زمینه و هدف: شقاق پستان مشکل شایعی در زنان شیرده می باشد که می تواند باعث قطع زودهنگام شیردهی گردد. زردچوبه یکی از قدیمی ترین گیاهان دارویی است که به دلیل دارا بودن کورکومین، اثر ترمیم کننده روی زخم ها دارد. این مطالعه با هدف تعیین تأثیر عصاره آبی الکلی کورکومین و مقایسه آن با باقی گذاردن قطره شیر مادر در درمان شقاق پستان انجام گردید. روش بررسی: پژوهش حاضر به صورت کارآزمایی بالینی تصادفی در سال 1392 بر روی زنان نخست زای مراجعه کننده به مراکز بهداشتی غرب اهواز انجام گردید. 88 مادر شیرده مبتلا به شقاق پستان، به شکل تصادفی به دو گروه مساوی درمان با کورکومین و گروه باقی گذاردن قطره شیر مادر تقسیم شدند. به منظور بررسی روند بهبود زخم و عوارض جانبی کورکومین، قبل ازدرمان، روز سوم و روز هفتم پس از شروع درمان، مقیاس استور توسط پژوهشگر تکمیل گردید. یافته ها: قبل از مطالعه و همچنین در روز هفتم تفاوت معنی دار بین میانگین نمره شقاق پستان در دو گروه مشاهده نشد؛ اما در روز سوم میانگین نمره شقاق در گروه کورکومین (267/0±761/)0 در مقایسه با گروه باقی گذاردن قطره شیر مادر (426/0±23/1) به طور معنی داری کمتر بود. همچنین اختلاف میانگین نمره شقاق قبل از درمان با روز سوم و همچنین با روز هفتم پس از شروع درمان، در هر دو گروه، معنی دار بود. نتیجه گیری: کورکومین و شیر مادر هر دو در درمان شقاق پستان موثر هستند؛ ولی باتوجه به عوارض جانبی محدود، فعالیت ضد میکروبی و اثر بیشتر کورکومین در کوتاه مدت، پیشنهاد می گردد از این دارو برای درمان شقاق پستان استفاده شود

Tracking development assistance for health and for COVID-19 : a review of development assistance, government, out-of-pocket, and other private spending on health for 204 countries and territories, 1990-2050

Background The rapid spread of COVID-19 renewed the focus on how health systems across the globe are financed, especially during public health emergencies. Development assistance is an important source of health financing in many low-income countries, yet little is known about how much of this funding was disbursed for COVID-19. We aimed to put development assistance for health for COVID-19 in the context of broader trends in global health financing, and to estimate total health spending from 1995 to 2050 and development assistance for COVID-19 in 2020. Methods We estimated domestic health spending and development assistance for health to generate total health-sector spending estimates for 204 countries and territories. We leveraged data from the WHO Global Health Expenditure Database to produce estimates of domestic health spending. To generate estimates for development assistance for health, we relied on project-level disbursement data from the major international development agencies' online databases and annual financial statements and reports for information on income sources. To adjust our estimates for 2020 to include disbursements related to COVID-19, we extracted project data on commitments and disbursements from a broader set of databases (because not all of the data sources used to estimate the historical series extend to 2020), including the UN Office of Humanitarian Assistance Financial Tracking Service and the International Aid Transparency Initiative. We reported all the historic and future spending estimates in inflation-adjusted 2020 US$, 2020 US$ per capita, purchasing-power parity-adjusted US$per capita, and as a proportion of gross domestic product. We used various models to generate future health spending to 2050. Findings In 2019, health spending globally reached$8. 8 trillion (95% uncertainty interval [UI] 8.7-8.8) or $1132 (1119-1143) per person. Spending on health varied within and across income groups and geographical regions. Of this total,$40.4 billion (0.5%, 95% UI 0.5-0.5) was development assistance for health provided to low-income and middle-income countries, which made up 24.6% (UI 24.0-25.1) of total spending in low-income countries. We estimate that $54.8 billion in development assistance for health was disbursed in 2020. Of this,$13.7 billion was targeted toward the COVID-19 health response. $12.3 billion was newly committed and$1.4 billion was repurposed from existing health projects. $3.1 billion (22.4$2.4 billion (17.9%) was for supply chain and logistics. Only $714.4 million (7.7$1519 (1448-1591) per person in 2050, although spending across countries is expected to remain varied. Interpretation Global health spending is expected to continue to grow, but remain unequally distributed between countries. We estimate that development organisations substantially increased the amount of development assistance for health provided in 2020. Continued efforts are needed to raise sufficient resources to mitigate the pandemic for the most vulnerable, and to help curtail the pandemic for all. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe

The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019

BACKGROUND: Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. METHODS: The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk–outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. FINDINGS: Globally, in 2019, the risk factors included in this analysis accounted for 4·45 million (95% uncertainty interval 4·01–4·94) deaths and 105 million (95·0–116) DALYs for both sexes combined, representing 44·4% (41·3–48·4) of all cancer deaths and 42·0% (39·1–45·6) of all DALYs. There were 2·88 million (2·60–3·18) risk-attributable cancer deaths in males (50·6% [47·8–54·1] of all male cancer deaths) and 1·58 million (1·36–1·84) risk-attributable cancer deaths in females (36·3% [32·5–41·3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20·4% (12·6–28·4) and DALYs by 16·8% (8·8–25·0), with the greatest percentage increase in metabolic risks (34·7% [27·9–42·8] and 33·3% [25·8–42·0]). INTERPRETATION: The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden

Thickness Dependence of Structural and Optical Properties of CdTe Films

In this work, Cadmium Telluride (CdTe) thin films were deposited on glass substrates at room temperature by vacuum evaporation technique. The deposited CdTe thin films were characterized by X-ray diffraction, UV-Visible spectroscopy and Field emission scanning electron microscope (FESEM) techniques. Structural studies revealed that the CdTe films deposited at various thicknesses are crystallized in cubic structure. The results showed the improvement of the film crystallinity upon grain size increment. Optical constants such as refractive index (n), extinction coefficient (k), real and imaginary parts of dielectric constant, volume energy loss function (VELF), and surface energy loss function (SELF) were calculated using UV-Vis spectra. In addition, band gap and Urbach energies were calculated by Tauc and ASF methods. The band gap energy of the specimens was found to decrease from 1.8 to 1.4eV with increasing the thickness of films. The absorption coefficient, computed and plotted versus the photon energy (hν) and tailing in the optical band gap, was observed which is understood based on Urbach law. Urbach energy variation from 0.125 to 0.620 eV in the samples with higher thicknesses is concluded. &nbsp

Investigating availability and distribution trend of human resources affiliated to the Ministry of Health and Medical Education in Iran from 2009 to 2015

Background and Objectives: Quantitative and qualitative improvement of human resources inequality have a significant effect on achievement to health system goals. The purpose of this study was to investigate the trend of geographic, supply, and gender distribution inequality of human resources of the Ministry of Health and Medical Education (MOHME) in Iran. Methods: In this descriptive study, the trend of human resources of the Ministry of Health during the years 2009-2015 was investigated based on gender, level of education, and type of employment. In order to study the inequality, Lorenz curve and Gini coefficient index were used. Data were collected from the Human Resources Office of the Deputy of Management Development and Resources of the MOHME and analyzed by Excel 2013 and Stata-14 software. Results: In the present study, women had the highest portion with a growth rate of 6.66% in 2015 and a Gini coefficient of 0.29 except in 2011. The highest and lowest growth rate compared to the base year in 2010 was related to specialist doctors (83.12) and general practitioners (-19.61), respectively. The lowest and highest Gini coefficient was related to the associate degree (0.26) and subspecialty (0.45), respectively. Conclusion: The present study was the first study to investigate the trend of changes in the human resources characteristics of the MOHME at a national level. Since this study only considered the quantity of the trend of human resources changes, it is recommended that the quality of human resources be investigated in the future studies

Erythrocyte membrane saturated fatty acids profile in newly diagnosed Basal Cell Carcinoma patients

Background: Skin cancers are the most prevalent malignancy worldwide and Basal Cell Carcinoma (BCC) include the major type of nonmelanoma skin cancers. Fatty acids (FA) have a structural role in cell membranes and play an important role for many physiological and pathological immunologic pathways. Several prospective studies have been conducted on circulating fatty acids and the risk of prostate, breast and other cancers. The present study aimed to determine the saturated fatty acid composition differences of red blood cells (RBCs) in BCC patients and healthy control. Methods: A hospital-based case-control study was conducted on new cases diagnosed of BCC patients. All subjects completed dietary recalls for dietary assessment. After fatty acids extraction, purification and preparation, gas chromatography was performed. The results were expressed in relative values (percent). Results: Cases had lower RBC levels of Caproic acid (6:0) (P < 0.001), Caprylic acid (8:0) (P = 0.01), Capric acid (10:0) (P = 0.01), Palmitic acid (16:0) (P = 0.02) and higher RBC level of Pentadecanoic acid (15:0) (P = 0.04) and Stearic acid (18:0) (P = 0.01) compared with controls but did not differ in the level of the other primary saturated fatty acids. Saturation Index as defined by Stearic to Oleic acid ratio was significantly lower in BCC patients in comparison with Control group (P = 0.02). Conclusion: Here we showed that BCC patient had considerable differences in the SFA profiles in comparison with healthy subjects. © 2017 European Society for Clinical Nutrition and Metabolis

Erythrocyte membrane saturated fatty acids profile in newly diagnosed Basal Cell Carcinoma patients

Background: Skin cancers are the most prevalent malignancy worldwide and Basal Cell Carcinoma (BCC) include the major type of nonmelanoma skin cancers. Fatty acids (FA) have a structural role in cell membranes and play an important role for many physiological and pathological immunologic pathways. Several prospective studies have been conducted on circulating fatty acids and the risk of prostate, breast and other cancers. The present study aimed to determine the saturated fatty acid composition differences of red blood cells (RBCs) in BCC patients and healthy control. Methods: A hospital-based case-control study was conducted on new cases diagnosed of BCC patients. All subjects completed dietary recalls for dietary assessment. After fatty acids extraction, purification and preparation, gas chromatography was performed. The results were expressed in relative values (percent). Results: Cases had lower RBC levels of Caproic acid (6:0) (P < 0.001), Caprylic acid (8:0) (P = 0.01), Capric acid (10:0) (P = 0.01), Palmitic acid (16:0) (P = 0.02) and higher RBC level of Pentadecanoic acid (15:0) (P = 0.04) and Stearic acid (18:0) (P = 0.01) compared with controls but did not differ in the level of the other primary saturated fatty acids. Saturation Index as defined by Stearic to Oleic acid ratio was significantly lower in BCC patients in comparison with Control group (P = 0.02). Conclusion: Here we showed that BCC patient had considerable differences in the SFA profiles in comparison with healthy subjects. © 2017 European Society for Clinical Nutrition and Metabolis