Enabling self-identity revisioning through portraiture, for people living with life threatening and chronic illnesses: paint me this way!

Arguably life threatening and chronic illness is not just an attack on the body, it is an attack on a person s sense of self-identity, shattering the means by which a person experiences the world, and by which they also are experienced, contributing to a person s sense of powerlessness and distress. People living with a life threatening or chronic illness, often describe the impact of their diagnosis, treatment and illness as having changed their sense of self-identity beyond all recognition. Seven participants, purposefully selected from those attending a weekly day-hospice session in Wiltshire, took part in the study. This qualitative, practice-based research project challenges the power dynamics in art therapy and attempts to equalise the relationship between researcher and participant through the development of a collaborative intersubjective relationship, within which the participants are recognised as experts on their lived experience, and in a series of negotiations , co-design their own portraits directing how they wish to be portrayed. Through this process the participants become patient/researchers (PRs) and the artist/therapist/researcher (ATR), by creating the portraits, also becomes a reflexive participant . This project utilises an in-depth multiple case-study design and multiple creative data generation methods as well as a phenomenological approach to data analysis. This project reverses the terms of engagement within art therapy and uses the art therapist s artistic practice or third hand to create portraits for patients. (This is based upon the assumption that most art therapy theories terms of engagement include patients producing art within the therapeutic encounter, however some psychodynamic and psychoanalytic art therapists may use client art generation selectively or not at all). This raises important questions around who makes the artwork in art therapy interventions . The use of portraiture as a third hand intervention enables the art therapist to develop a sense of positive focussed attention and mirroring and attunement through the art object, enabling the addition of coherence through aesthetic resonance and the holding of dualities through metaphor and symbolism. The results of this study demonstrate the power of portraiture as an intersubjective way of knowing, being and relating, enabling the revisioning of identities disrupted by illness, characterised by increases in participants creative capacity to adapt to illness and feelings of home-like-being-in-the-world, developing a stronger, more coherent lived experience of self-identity, effecting closure to difficult life experiences, and improving their overall quality of life

First evidence for onshore marine isotope stage 3 aeolianite formation on the southern Cape coastline of South Africa

The southern Cape coast of South Africa boasts an impressive suite of Plio-Pleistocene aeolian dune deposits (aeolianite). Previous research has shown that in this region onshore dune accumulation was generally focused around interglacial sea level highstands, with the locus of coastal dune accumulation shifting onto the adjacent continental shelf during glacial sea level lowstands. Here, using new luminescence dating results, we present the first evidence for preserved onshore glacial age dunes. Specifically, on the Robberg Peninsula, a rocky headland 28 km east of Knysna, two phases of aeolianite formation are identified, corresponding to early (45–60 ka) and late (35–30 ka) marine isotope stage (MIS) 3. Subsequently, during the Holocene, all substantive dune accumulation occurred between 10.2 and 7.0 ka, forming cliff-fronting dunes and filling the limited accommodation space on the headland, including an archaeological rock-shelter. Combining these ages with bathymetric data, we infer that this distinct onshore glacial age aeolianite record reflects: 1) restricted accommodation space during sea level highstands; 2) a regional narrowing of the continental shelf, and 3) liberation of sediments lying on a prominent −45 to −60 m offshore terrace, which would have been exposed during MIS 3. This demonstrates that despite broad regional-scale trends in the timing of coastal aeolian activity - driven by commonalities in relative sea level trends and climate - distinct local variations in late Quaternary coastal evolution can be identified. This is ascribed to local controls on preservation (accommodation space) and sediment supply (shoreline position and antecedent offshore sediment supplies). Such findings may have wider implications for interpretations of site context/resource availability at several notable coastal archaeological sites, and more broadly suggest that local offshore or onshore geologic contexts can at times assume greater influence on a preserved coastal aeolianite record than the regional-scale trends in sea level and climate

Understanding Late Quaternary change at the land ocean interface: a synthesis of the evolution of the Wilderness coastline, South Africa

Coastal barrier systems have been widely used to understand the responses of coastal margins to fluctuating Pleistocene sea levels. What has become apparent, particularly with the development of robust chronological frameworks, is that gaps in terrestrial barrier sedimentary records are not uncommon and that they most likely reflect phases of barrier construction on the now submerged continental shelf. Thus, understanding the land–ocean interface through time is critical to fully appreciate the Quaternary archives contained within the barriers and their associated back-barrier deposits. This study uses offshore and lakefloor (back-barrier) seismic profiling from the South African south coast at Wilderness to link the sub-aerially exposed barrier stratigraphy to the currently submerged geological and sedimentological record. A total of eight separate submerged aeolian units are identified at water depths of up to 130 m below mean sea level. Their approximate ages are constrained with reference to the eustatic sea-level record and the deepest units are consistent with the estimated magnitude of sea-level lowering during the Last Glacial Maximum (LGM) on the South African coastline. As previously assumed, aeolian sedimentation tracked the shoreline onto the continental shelf during the Late Pleistocene. During sea-level regressions, both the incision of fluvial channels and the deposition of back-barrier systems occurred across the continental shelf. During late low stand/early transgression periods, landward shoreface migration occurred, pre-existing channel incisions were infilled and pre-existing barriers were truncated. Rapid transgression, however, allowed the preservation of some back-barrier deposits, possibly aided by protection from antecedent topography. As sea level neared the present-day elevation, erosion of the mid-shelf sediments resulted in the development of a Holocene sediment wedge, which was augmented by Holocene fluvial sediment supply. The Holocene sand wedge is preserved in the back-barrier lakes and was deposited during the Holocene highstand inundation. Overlying middle to late Holocene terrestrial muds reflect the deposition of river-borne mud onto the shelf. These results clearly demonstrate that within transgressive–regressive sea-level cycles, accommodation space for barriers is controlled by antecedent drainage systems and gradients on the adjacent inner continental shelf

Preserving the palaeoenvironmental record in Drylands: Bioturbation and its significance for luminescence-derived chronologies

Luminescence (OSL) dating has revolutionised the understanding of Late Pleistocene dryland activity. However, one of the key assumptions for this sort of palaeoenvironmental work is that sedimentary sequences have been preserved intact, enabling their use as proxy indicators of past changes. This relies on stabilisation or burial soon after deposition and a mechanism to prevent any subsequent re-mobilisation. As well as a dating technique OSL, especially at the single grain level, can be used to gain an insight into post-depositional processes that may distort or invalidate the palaeoenvironmental record of geological sediment sequences. This paper explores the possible impact of bioturbation (the movement of sediment by flora and fauna) on luminescence derived chronologies from Quaternary sedimentary deposits in Texas and Florida (USA) which have both independent radiocarbon chronologies and archaeological evidence. These sites clearly illustrate the ability of bioturbation to rejuvenate ancient weathered sandy bedrock and/or to alter depositional stratigraphies through the processes of exhumation and sub-surface mixing of sediment. The use of multiple OSL replicate measurements is advocated as a strategy for checking for bioturbated sediment. Where significant OSL heterogeneity is found, caution should be taken with the derived OSL ages and further measurements at the single grain level are recommended. Observations from the linear dunes of the Kalahari show them to have no bedding structure and to have OSL heterogeneity similar to that shown from the bioturbated Texan and Florida sites. The Kalahari linear dunes could have therefore undergone hitherto undetected post-depositional sediment disturbance which would have implications for the established OSL chronology for the region

The Similarity Hypothesis in General Relativity

Self-similar models are important in general relativity and other fundamental theories. In this paper we shall discuss the ``similarity hypothesis'', which asserts that under a variety of physical circumstances solutions of these theories will naturally evolve to a self-similar form. We will find there is good evidence for this in the context of both spatially homogenous and inhomogeneous cosmological models, although in some cases the self-similar model is only an intermediate attractor. There are also a wide variety of situations, including critical pheneomena, in which spherically symmetric models tend towards self-similarity. However, this does not happen in all cases and it is it is important to understand the prerequisites for the conjecture.Comment: to be submitted to Gen. Rel. Gra

Semiclassical Instability of the Cauchy Horizon in Self-Similar Collapse

Generic spherically symmetric self-similar collapse results in strong naked-singularity formation. In this paper we are concerned with particle creation during a naked-singularity formation in spherically symmetric self-similar collapse without specifying the collapsing matter. In the generic case, the power of particle emission is found to be proportional to the inverse square of the remaining time to the Cauchy horizon (CH). The constant of proportion can be arbitrarily large in the limit to marginally naked singularity. Therefore, the unbounded power is especially striking in the case that an event horizon is very close to the CH because the emitted energy can be arbitrarily large in spite of a cutoff expected from quantum gravity. Above results suggest the instability of the CH in spherically symmetric self-similar spacetime from quantum field theory and seem to support the existence of a semiclassical cosmic censor. The divergence of redshifts and blueshifts of emitted particles is found to cause the divergence of power to positive or negative infinity, depending on the coupling manner of scalar fields to gravity. On the other hand, it is found that there is a special class of self-similar spacetimes in which the semiclassical instability of the CH is not efficient. The analyses in this paper are based on the geometric optics approximation, which is justified in two dimensions but needs justification in four dimensions.Comment: 14 pages, 4 figures, minor errors corrected and some sentences added in the introduction, accepted for publication in Physical Review

Remarkable euryhalinity of a marine fish Lutjanus novemfasciatus in mangrove nurseries

Abiotic environmental stress is a fundamental driver of population and community dynamics across diverse ecosystems (Menge and Sutherland 1987). In this context, specialist species persisting at great altitudes or depths, in near-boiling or subfreezing temperatures, through droughts or monsoons, and over prolonged bouts of resource deprivation highlight the adaptability of life on Earth. Notably, environmental stress, or harshness, incorporates ″extremeness″ along gradients such as oxygen or temperature, but it is also defined by the magnitude and tempo of variability in these environmental conditions (Peck et al. 2006). Even, extreme-tolerant species may require stable conditions to maintain fitness, while species capable of physiological plasticity are better adapted to niches characterized by environmental variability (Chevin and Hoffmann 2017)

Molecular velocity auto-correlation of simple liquids observed by NMR MGSE method

The velocity auto-correlation spectra of simple liquids obtained by the NMR method of modulated gradient spin echo show features in the low frequency range up to a few kHz, which can be explained reasonably well by a $t^{-3/2}$ long time tail decay only for non-polar liquid toluene, while the spectra of polar liquids, such as ethanol, water and glycerol, are more congruent with the model of diffusion of particles temporarily trapped in potential wells created by their neighbors. As the method provides the spectrum averaged over ensemble of particle trajectories, the initial non-exponential decay of spin echoes is attributed to a spatial heterogeneity of molecular motion in a bulk of liquid, reflected in distribution of the echo decays for short trajectories. While at longer time intervals, and thus with longer trajectories, heterogeneity is averaged out, giving rise to a spectrum which is explained as a combination of molecular self-diffusion and eddy diffusion within the vortexes of hydrodynamic fluctuations.Comment: 8 pages, 6 figur

Adaptive and reversible resistance to Kras inhibition in pancreatic cancer cells

Activating mutations in KRAS are the hallmark genetic alterations in pancreatic ductal adenocarcinoma (PDAC) and the key drivers of its initiation and progression. Longstanding efforts to develop novel KRAS inhibitors have been based on the assumption that PDAC cells are addicted to activated KRAS, but this assumption remains controversial. In this study, we analyzed the requirement of endogenous Kras to maintain survival of murine PDAC cells, using an inducible shRNA-based system that enables temporal control of Kras expression. We found that the majority of murine PDAC cells analyzed tolerated acute and sustained Kras silencing by adapting to a reversible cell state characterized by differences in cell morphology, proliferative kinetics, and tumor-initiating capacity. While we observed no significant mutational or transcriptional changes in the Kras-inhibited state, global phosphoproteomic profiling revealed significant alterations in cell signaling, including increased phosphorylation of focal adhesion pathway components. Accordingly, Kras-inhibited cells displayed prominent focal adhesion plaque structures, enhanced adherence properties, and increased dependency on adhesion for viability in vitro. Overall, our results call into question the degree to which PDAC cells are addicted to activated KRAS, by illustrating adaptive non-genetic and non-transcriptional mechanisms of resistance to Kras blockade. However, by identifying these mechanisms, our work also provides mechanistic directions to develop combination strategies that can help enforce the efficacy of KRAS inhibitors

Bi-allelic JAM2 Variants Lead to Early-Onset Recessive Primary Familial Brain Calcification.

Primary familial brain calcification (PFBC) is a rare neurodegenerative disorder characterized by a combination of neurological, psychiatric, and cognitive decline associated with calcium deposition on brain imaging. To date, mutations in five genes have been linked to PFBC. However, more than 50% of individuals affected by PFBC have no molecular diagnosis. We report four unrelated families presenting with initial learning difficulties and seizures and later psychiatric symptoms, cerebellar ataxia, extrapyramidal signs, and extensive calcifications on brain imaging. Through a combination of homozygosity mapping and exome sequencing, we mapped this phenotype to chromosome 21q21.3 and identified bi-allelic variants in JAM2. JAM2 encodes for the junctional-adhesion-molecule-2, a key tight-junction protein in blood-brain-barrier permeability. We show that JAM2 variants lead to reduction of JAM2 mRNA expression and absence of JAM2 protein in patient's fibroblasts, consistent with a loss-of-function mechanism. We show that the human phenotype is replicated in the jam2 complete knockout mouse (jam2 KO). Furthermore, neuropathology of jam2 KO mouse showed prominent vacuolation in the cerebral cortex, thalamus, and cerebellum and particularly widespread vacuolation in the midbrain with reactive astrogliosis and neuronal density reduction. The regions of the human brain affected on neuroimaging are similar to the affected brain areas in the myorg PFBC null mouse. Along with JAM3 and OCLN, JAM2 is the third tight-junction gene in which bi-allelic variants are associated with brain calcification, suggesting that defective cell-to-cell adhesion and dysfunction of the movement of solutes through the paracellular spaces in the neurovascular unit is a key mechanism in CNS calcification