The effects of amisulpride on five dimensions of psychopathology in patients with schizophrenia: a prospective open- label study

BACKGROUND: The efficacy of antipsychotics can be evaluated using the dimensional models of schizophrenic symptoms. The D(2)/D(3)-selective antagonist amisulpride has shown similar efficacy and tolerability to other atypical antipsychotics. The aim of the present study was to determine the efficacy of amisulpride on the dimensional model of schizophrenic symptoms and tolerability in latin schizophrenic patients. METHOD: Eighty schizophrenic patients were enrolled and 70 completed a prospective open-label 3-month study with amisulpride. The schizophrenic symptoms, psychosocial functioning and side-effects were evaluated with standardized scales. RESULTS: The patients showed significant improvement in the five dimensions evaluated. Amisulpride (median final dose 357.1 mg/d) was well-tolerated without treatment-emergent extrapyramidal side-effects. CONCLUSION: Amisulpride showed efficacy on different psychopathological dimensions and was well tolerated, leading to consider this drug a first line choice for the treatment of schizophrenia

Internal capsule size associated with outcome in first-episode schizophrenia

Subtle structural brain abnormalities are an established finding in first-episode psychosis. Nevertheless their relationship to the clinical course of schizophrenia is controversially discussed. In a multicentre study 45 first-episode schizophrenia patients (FE-SZ) underwent standardized MRI scanning and were followed up to 1 year. In 32 FE-SZ volumetric measurement of three regions of interests (ROIs) potentially associated with disease course, hippocampus, lateral ventricle and the anterior limb of the internal capsule (ALIC) could be performed. The subgroups of FE-SZ with good (12 patients) and poor outcome (11 patients), defined by a clinically relevant change of the PANSS score, were compared with regard to these volumetric measures. Multivariate analysis of covariance revealed a significant reduced maximal cross sectional area of the left ALIC in FE-SZ with clinically relevant deterioration compared to those with stable psychopathology. There were no differences in the other selected ROIs between the two subgroups. In conclusion, reduced maximal area of ALIC, which can be interpreted as a disturbance of fronto-thalamic connectivity, is associated with poor outcome during the 1 year course of first-episode schizophrenia

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex.

Bipolar disorder has been associated with anatomical as well as functional abnormalities in a brain network that mediates normal and impaired emotion regulation. Previous brain imaging studies have highlighted the subgenual cingulate (SC) and the amygdalo-hippocampal (AH) complex as core regions of this network. Thus we investigated white matter (WM) fiber tracts between the SC and the AH region, the uncinate fasciculus, as well as between two control regions (pons and cerebellum), using diffusion tensor imaging tractography in 16 euthymic bipolar patients (BP) and 16 sex-, age- and handedness-matched controls. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of the reconstructed fiber bundle and the number of virtual reconstructed fibers were compared between groups. The tractography results revealed a significantly increased number of reconstructed fibers between the left SC and left AH in BP as compared to healthy controls. FA and ADC of the reconstructed fiber tract did not differ significantly between the groups. Furthermore, no significant group differences were observed neither for reconstructed fiber tracts between the right SC and right AH nor between the control regions. The present results suggest an altered WM pathway between the left SC and AH region and thus extend previous findings of anatomical and functional modifications in these structures in BP

Radiative Transfer Simulations Using Mesoscale Cloud Model Outputs: Comparisons with Passive Microwave and Infrared Satellite Observations for Midlatitudes

Real midlatitude meteorological cases are simulated over western Europe with the cloud mesoscale model Méso-NH, and the outputs are used to calculate brightness temperatures at microwave frequencies with the Atmospheric Transmission at Microwave (ATM) radiative transfer model. Satellite-observed brightness temperatures (TBs) from the Advanced Microwave Scanning Unit B (AMSU-B) and the Special Sensor Microwave Imager (SSM/I) are compared to the simulated ones. In this paper, one specific situation is examined in detail. The infrared responses have also been calculated and compared to the Meteosat coincident observations. Overall agreement is obtained between the simulated and the observed brightness temperatures in the microwave and in the infrared. The large-scale dynamical structure of the cloud system is well captured by Méso-NH. However, in regions with large quantities of frozen hydrometeors, the comparison shows that the simulated microwave TBs are higher than the measured ones in the window channels at high frequencies, indicating that the calculation does not predict enough scattering. The factors responsible for the scattering (frozen particle distribution, calculation of particle dielectric properties, and nonsphericity of the particles) are analyzed. To assess the quality of the cloud and precipitation simulations by Méso-NH, the microphysical fields predicted by the German Lokal-Modell are also considered. Results show that in these midlatitude situations, the treatment of the snow category has a high impact on the simulated brightness temperatures. The snow scattering parameters are tuned to match the discrete dipole approximation calculations and to obtain a good agreement between simulations and observations even in the areas with significant frozen particles. Analysis of the other meteorological simulations confirms these results. Comparing simulations and observations in the microwave provides a powerful evaluation of resolved clouds in mesoscale models, especially the precipitating ice phase.[Completion of this field awaiting access to full-text paper]Peer reviewe