199 research outputs found
The Budget Impact of Oral Nutritional Supplements for Disease Related Malnutrition in Elderly in the Community Setting
A health economic analysis was performed to assess the economic impact on the national health care budget of using oral nutritional supplements (ONS), being a food for special medical purposes also known as medical nutrition, for the treatment of disease related malnutrition (DRM) in the community in the Netherlands. An economic model was developed to calculate the budget impact of using ONS in community dwelling elderly (>5âyears) with DRM in the Netherlands. The model reflects the costs of DRM and the cost reductions resulting from improvement in DRM due to treatment with ONS. Using ONS for the treatment of DRM in community dwelling elderly, leads to a total annual cost savings of ⏠13 million (18.9% savings), when all eligible patients are treated. The additional costs of ONS (⏠57 million) are more than balanced by a reduction of other health care costs, e.g., re-/hospitalization (⏠70 million). Sensitivity analyses were performed on all parameters, including duration of treatment with ONS and the prevalence of DRM. This budget impact analysis shows that the use of ONS for treatment of DRM in elderly patients in the community may lead to cost savings in the Netherlands
The CFHT Legacy Survey: The Morphology-Density Relation of Galaxies out to Z~1
We study the relationships between galaxy total luminosity (M_g), morphology,
color and environment as a function of redshift. We use a magnitude-limited
sample of 65,624 galaxies in the redshift range 0<z<1.3 taken from one of the
Canada-France-Hawaii Telescope Legacy Survey Deep Fields. We parametrize galaxy
morphology according to the Sersic index n. Our n>2 number fractions at z=0.1
agree well with those based on SDSS galaxies. We find that the n>2 galaxy
number fraction is constant with redshift in the field. However, for overdense
environments this fraction is larger and increases towards lower redshifts,
higher densities and higher luminosities. Rest-frame color-magnitude diagrams
show that the color distribution is bimodal out to our redshift limit of z~1
with a prominent red-sequence of galaxies at 0.2<z<0.4 and a large blue-peak
dominance at 0.8<z<1. We use this bimodality to define a red galaxy fraction
(rest-frame u-g>1). For all environments, this fraction increases towards lower
redshifts and higher luminosities. The red fraction within cluster-like regions
changes 60% faster with redshift as compared to the field for M_g<-19.5. Using,
for the first time, observations across many cluster-field interfaces
distributed over a single, large volume, we trace the large-scale
morphology-density relation and the Butcher-Oemler effect over a period of
almost 8 Gyr.Comment: Accepted by Ap
A unique bacteriohopanetetrol stereoisomer of marine anammox
Anaerobic ammonium oxidation (anammox) is a major process of bioavailable nitrogen removal from marine systems. Previously, a bacteriohopanetetrol (BHT) isomer, with unknown stereochemistry, eluting later than BHT using high performance liquid chromatography (HPLC), was detected in âCa. Scalindua profundaâ and proposed as a biomarker for anammox in marine paleo-environments. However, the utility of this BHT isomer as an anammox biomarker is hindered by the fact that four other, non-anammox bacteria are also known to produce a late-eluting BHT stereoisomer. The stereochemistry in Acetobacter pasteurianus, Komagataeibacter xylinus and Frankia sp. was known to be 17ÎČ, 21ÎČ(H), 22R, 32R, 33R, 34R (BHT-34R). The stereochemistry of the late-eluting BHT in Methylocella palustris was unknown. To determine if marine anammox bacteria produce a unique BHT isomer, we studied the BHT distributions and stereochemistry of known BHT isomer producers and of previously unscreened marine (âCa. Scalindua brodeaeâ) and freshwater (âCa. Brocadia sp.â) anammox bacteria using HPLC and gas chromatographic (GC) analysis of acetylated BHTs and ultra high performance liquid chromatography (UHPLC)-high resolution mass spectrometry (HRMS) analysis of non-acetylated BHTs. The 34R stereochemistry was confirmed for the BHT isomers in Ca. Brocadia sp. and Methylocella palustris. However, âCa. Scalindua sp.â synthesise a stereochemically distinct BHT isomer, with still unconfirmed stereochemistry (BHT-x). Only GC analysis of acetylated BHT and UHPLC analysis of non-acetylated BHT distinguished between late-eluting BHT isomers. Acetylated BHT-x and BHT-34R co-elute by HPLC. As BHT-x is currently only known to be produced by âCa. Scalindua spp.â, it may be a biomarker for marine anammox
Nutrition economics â characterising the economic and health impact of nutrition
There is a new merging of health economics and nutrition disciplines to assess the impact of diet on health and disease prevention and to characterise the health and economic aspects of specific changes in nutritional behaviour and nutrition recommendations. A rationale exists for developing the field of nutrition economics which could offer a better understanding of both nutrition, in the context of having a significant influence on health outcomes, and economics, in order to estimate the absolute and relative monetary impact of health measures. For this purpose, an expert meeting assessed questions aimed at clarifying the scope and identifying the key issues that should be taken into consideration in developing nutrition economics as a discipline that could potentially address important questions. We propose a first multidisciplinary outline for understanding the principles and particular characteristics of this emerging field. We summarise here the concepts and the observations of workshop participants and propose a basic setting for nutrition economics and health outcomes research as a novel discipline to support nutrition, health economics and health policy development in an evidence and health-benefit-based manner
Evidence for the Emergence of New Rice Types of Interspecific Hybrid Origin in West African Farmers' Fields
In West Africa two rice species (Oryza glaberrima Steud. and Oryza sativa L.) co-exist. Although originally it was thought that interspecific hybridization is impossible without biotechnological methods, progenies of hybridization appear to occur in farmer fields
The LAGUNA design study- towards giant liquid based underground detectors for neutrino physics and astrophysics and proton decay searches
The feasibility of a next generation neutrino observatory in Europe is being
considered within the LAGUNA design study. To accommodate giant neutrino
detectors and shield them from cosmic rays, a new very large underground
infrastructure is required. Seven potential candidate sites in different parts
of Europe and at several distances from CERN are being studied: Boulby (UK),
Canfranc (Spain), Fr\'ejus (France/Italy), Pyh\"asalmi (Finland),
Polkowice-Sieroszowice (Poland), Slanic (Romania) and Umbria (Italy). The
design study aims at the comprehensive and coordinated technical assessment of
each site, at a coherent cost estimation, and at a prioritization of the sites
within the summer 2010.Comment: 5 pages, contribution to the Workshop "European Strategy for Future
Neutrino Physics", CERN, Oct. 200
Living Law, Legal Pluralism, and Corruption in Post-Soviet Uzbekistan
This paper aims to explore the multifaceted meaning, logic, and morality of informal transactions in order to better understand the social context that informs the meaning of corruption and bribery in post-Soviet Uzbekistan. It will be argued that the informal transactions in Uzbek society reflect different cultural and functional meanings from those in most of the Western world, and hence transactions that from a Western-centric perspective would be labelled as bribes can be morally accepted transactions in the Uzbek cultural context. If this is true, there may be reasons to re-evaluate the relevance of the Western-centric interpretations of corruption in the context of Uzbekistan, and possibly other Central Asian countries. These issues will be investigated with reference to observations and informal interviews from post-Soviet Uzbekistan. This study is based on three periods of ethnographic field research between 2009 and 2012 in the Ferghana Province of Uzbekistan. It draws on concepts of âliving lawâ and legal pluralism to provide a theoretical framework
The VIMOS VLT Deep Survey: The build-up of the colour-density relation
We investigate the redshift and luminosity evolution of the galaxy
colour-density relation using the data from the First Epoch VIMOS-VLT Deep
Survey (VVDS). The size (6582 galaxies), depth (I_AB<=24) and redshift sampling
rate of the survey enable us to reconstruct the 3D galaxy environment on
relatively local scales (R=5 Mpc) up to z~1.5. Particular attention has been
devoted to calibrate a density reconstruction scheme, which factors out survey
selection effects and reproduces in an unbiased way the underlying `real'
galaxy environment. While at lower redshift we confirm the existence of a steep
colour-density relation, with the fraction of the reddest(/bluest) galaxies of
the same luminosity increasing(/decreasing) as a function of density, this
trend progressively disappears in the highest redshift bins investigated. The
rest frame u*-g' colour-magnitude diagram shows a bimodal pattern in both low
and high density environments up to z~1.5. We find that the bimodal
distribution is not universal but strongly depends upon environment: at lower
redshifts the colour-magnitude diagrams in low and high density regions are
significantly different while the progressive weakening of the colour-density
relation causes the two bimodal distributions to nearly mirror each other in
the highest redshift bin investigated. Both the colour-density and the
colour-magnitude-density relations appear to be a transient, cumulative product
of genetic and environmental factors operating over at least a period of 9 Gyr.
These findings support an evolutionary scenario in which star formation/gas
depletion processes are accelerated in more luminous objects and in high
density environments: star formation activity is shifting with cosmic time
towards lower luminosity (downsizing), and out of high density environments.Comment: 17 pages, 10 figures, figures added, accepted by A&
The Prevalence of Errors in Machine Learning Experiments
Context: Conducting experiments is central to research machine learning research to benchmark, evaluate and compare learning algorithms. Consequently it is important we conduct reliable, trustworthy experiments. Objective: We investigate the incidence of errors in a sample of machine learning experiments in the domain of software defect prediction. Our focus is simple arithmetical and statistical errors. Method: We analyse 49 papers describing 2456 individual experimental results from a previously undertaken systematic review comparing supervised and unsupervised defect prediction classifiers. We extract the confusion matrices and test for relevant constraints, e.g., the marginal probabilities must sum to one. We also check for multiple statistical significance testing errors. Results: We find that a total of 22 out of 49 papers contain demonstrable errors. Of these 7 were statistical and 16 related to confusion matrix inconsistency (one paper contained both classes of error). Conclusions: Whilst some errors may be of a relatively trivial nature, e.g., transcription errors their presence does not engender confidence. We strongly urge researchers to follow open science principles so errors can be more easily be detected and corrected, thus as a community reduce this worryingly high error rate with our computational experiments
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