Model-Independent Comparisons of Pulsar Timings to Scalar-Tensor Gravity

Observations of pulsar timing provide strong constraints on scalar-tensor theories of gravity, but these constraints are traditionally quoted as limits on the microscopic parameters (like the Brans-Dicke coupling, for example) that govern the strength of scalar-matter couplings at the particle level in particular models. Here we present fits to timing data for several pulsars directly in terms of the phenomenological couplings (masses, scalar charges, moment of inertia sensitivities and so on) of the stars involved, rather than to the more microscopic parameters of a specific model. For instance, for the double pulsar PSR J0737-3039A/B we find at the 68% confidence level that the masses are bounded by 1.28 < m_A/m_sun < 1.34 and 1.19 < m_B/m_sun < 1.25, while the scalar-charge to mass ratios satisfy |a_A| < 0.21, |a_B| < 0.21 and |a_B - a_A| < 0.002$. These constraints are independent of the details of the scalar tensor model involved, and of assumptions about the stellar equations of state. Our fits can be used to constrain a broad class of scalar tensor theories by computing the fit quantities as functions of the microscopic parameters in any particular model. For the Brans-Dicke and quasi-Brans-Dicke models, the constraints obtained in this manner are consistent with those quoted in the literature.Comment: 19 pages, 7 figure

The Abnormally Weighting Energy Hypothesis: the Missing Link between Dark Matter and Dark Energy

We generalize tensor-scalar theories of gravitation by the introduction of an abnormally weighting type of energy. This theory of tensor-scalar anomalous gravity is based on a relaxation of the weak equivalence principle that is now restricted to ordinary visible matter only. As a consequence, the convergence mechanism toward general relativity is modified and produces naturally cosmic acceleration as an inescapable gravitational feedback induced by the mass-variation of some invisible sector. The cosmological implications of this new theoretical framework are studied. From the Hubble diagram cosmological test \textit{alone}, this theory provides an estimation of the amount of baryons and dark matter in the Universe that is consistent with the independent cosmological tests of Cosmic Microwave Background (CMB) and Big Bang Nucleosynthesis (BBN). Cosmic coincidence is naturally achieved from a equally natural assumption on the amplitude of the scalar coupling strength. Finally, from the adequacy to supernovae data, we derive a new intriguing relation between the space-time dependences of the gravitational coupling and the dark matter mass, providing an example of crucial constraint on microphysics from cosmology. This glimpses at an enticing new symmetry between the visible and invisible sectors, namely that the scalar charges of visible and invisible matter are exactly opposite.Comment: 24 pages, 6 figures, new version with extended discussions and added references. Accepted for publication in JCAP (sept. 2008

Generating G2G_2--cosmologies with perfect fluid in dilaton gravity

We present a method for generating exact diagonal $G_2$-cosmological solutions in dilaton gravity coupled to a radiation perfect fluid and with a cosmological potential of a special type. The method is based on the symmetry group of the system of $G_2$-field equations. Several new classes of explicit exact inhomogeneous perfect fluid scalar-tensor cosmologies are presented.Comment: 10 pages, LaTe

On compatibility of string effective action with an accelerating universe

In this paper, we fully investigate the cosmological effects of the moduli dependent one-loop corrections to the gravitational couplings of the string effective action to explain the cosmic acceleration problem in early (and/or late) universe. These corrections comprise a Gauss-Bonnet (GB) invariant multiplied by universal non-trivial functions of the common modulus $\sigma$ and the dilaton $\phi$. The model exhibits several features of cosmological interest, including the transition between deceleration and acceleration phases. By considering some phenomenologically motivated ansatzs for one of the scalars and/or the scale factor (of the universe), we also construct a number of interesting inflationary potentials. In all examples under consideration, we find that the model leads only to a standard inflation ($w \geq -1$) when the numerical coefficient $\delta$ associated with modulus-GB coupling is positive, while the model can lead also to a non-standard inflation ($w<-1$), if $\delta$ is negative. In the absence of (or trivial) coupling between the GB term and the scalars, there is no crossing between the $w -1$ phases, while this is possible with non-trivial GB couplings, even for constant dilaton phase of the standard picture. Within our model, after a sufficient amount of e-folds of expansion, the rolling of both fields $\phi$ and $\sigma$ can be small. In turn, any possible violation of equivalence principle or deviations from the standard general relativity may be small enough to easily satisfy all astrophysical and cosmological constraints.Comment: 30 pages, 8 figures; v2 significant changes in notations, appendix and refs added; v3 significant revisions, refs added; v4 appendix extended, new refs, published versio

Cosmological models in scalar tensor theories of gravity and observations: a class of general solutions

We consider cosmological models in scalar tensor theories of gravity that describe an accelerating universe, and we study a family of inverse power law potentials, for which exact solutions of the Einstein equations are known. We also compare theoretical predictions of our models with observations. For this we use the following data: the publicly available catalogs of type Ia supernovae and high redshift Gamma Ray Bursts, the parameters of large scale structure determined by the 2-degree Field Galaxy Redshift Survey (2dFGRS), and measurements of cosmological distances based on the Sunyaev-Zel'dovich effect, among others.Comment: 26 pages,23 figures, accepted for publication in A&

Constraining the dark energy dynamics with the cosmic microwave background bispectrum

We consider the influence of the dark energy dynamics at the onset of cosmic acceleration on the Cosmic Microwave Background (CMB) bispectrum, through the weak lensing effect induced by structure formation. We study the line of sight behavior of the contribution to the bispectrum signal at a given angular multipole $l$: we show that it is non-zero in a narrow interval centered at a redshift $z$ satisfying the relation $l/r(z)\simeq k_{NL}(z)$, where the wavenumber corresponds to the scale entering the non-linear phase, and $r$ is the cosmological comoving distance. The relevant redshift interval is in the range 0.1\lsim z\lsim 2 for multipoles 1000\gsim\ell\gsim 100; the signal amplitude, reflecting the perturbation dynamics, is a function of the cosmological expansion rate at those epochs, probing the dark energy equation of state redshift dependence independently on its present value. We provide a worked example by considering tracking inverse power law and SUGRA Quintessence scenarios, having sensibly different redshift dynamics and respecting all the present observational constraints. For scenarios having the same present equation of state, we find that the effect described above induces a projection feature which makes the bispectra shifted by several tens of multipoles, about 10 times more than the corresponding effect on the ordinary CMB angular power spectrum.Comment: 15 pages, 7 figures, matching version accepted by Physical Review D, one figure improve

The s ---> d gamma decay in and beyond the Standard Model

The New Physics sensitivity of the s ---> d gamma transition and its accessibility through hadronic processes are thoroughly investigated. Firstly, the Standard Model predictions for the direct CP-violating observables in radiative K decays are systematically improved. Besides, the magnetic contribution to epsilon prime is estimated and found subleading, even in the presence of New Physics, and a new strategy to resolve its electroweak versus QCD penguin fraction is identified. Secondly, the signatures of a series of New Physics scenarios, characterized as model-independently as possible in terms of their underlying dynamics, are investigated by combining the information from all the FCNC transitions in the s ---> d sector.Comment: 54 pages, 14 eps figure

Estimating epsilon'/epsilon. A Review

The real part of epsilon'/epsilon measures direct CP violation in the decays of the neutral kaons in two pions. It is a fundamental quantity which has justly attracted a great deal of theoretical as well as experimental work. Its determination may answer the question of whether CP violation is present only in the mass matrix of neutral kaons (the superweak scenario) or also at work directly in the decays. After a brief historical summary, we discuss the present and expected experimental sensitivities. In the light of these, we come to the problem of estimating epsilon'/epsilon in the standard model. We review the present (circa 1998) status of the theoretical predictions of epsilon'/epsilon. The short-distance part of the computation is now known to the next-to-leading order in QCD and QED and therefore well under control. On the other hand, the evaluation of the hadronic matrix element of the relevant operators is where most of the theoretical uncertainty still resides. We analyze the results of the currently most developed calculations. The values of the B_i parameters in the various approaches are discussed, together with the allowed range of the relevant combination of the Cabibbo-Kobayashi-Maskawa entries Im V_{td}V^*_{ts}. We conclude by summarizing and comparing all up-to-date predictions of epsilon'/epsilon. Because of the intrinsic uncertainties of the long-distance computations, values ranging from 10^{-4} to a few times 10^{-3} can be accounted for in the standard model. Since this range covers most of the present experimental uncertainty, it is unlikely that new physics effects can be disentangled from the standard model prediction. For updates on the review and additional material see http://www.he.sissa.it/review/.Comment: 42 pages, 13 figures. To appear in Reviews of Modern Physic

Phase II study of mTORC1 inhibition by everolimus in neurofibromatosis type 2 patients with growing vestibular schwannomas

Neurofibromatosis type 2 (NF2) is a genetic disorder with bilateral vestibular schwannomas (VS) as the most frequent manifestation. Merlin, the NF2 tumor suppressor, was identified as a negative regulator of mammalian target of rapamycin complex 1. Pre-clinical data in mice showed that mTORC1 inhibition delayed growth of NF2-schwannomas. We conducted a prospective single-institution open-label phase II study to evaluate the effects of everolimus in ten NF2 patients with progressive VS. Drug activity was monitored every 3 months. Everolimus was administered orally for 12 months and, if the decrease in tumor volume was &gt;20 % from baseline, treatment was continued for 12 additional months. Other patients stopped when completed 12 months of everolimus but were allowed to resume treatment when VS volume was &gt;20 % during 1 year follow-up. Nine patients were evaluable. Safety was evaluated using CTCAE 3.0 criteria. After 12 months of everolimus, no reduction in volume ≥20 % was observed. Four patients had progressive disease, and five patients had stable disease with a median annual growth rate decreasing from 67 %/year before treatment to 0.5 %/year during treatment. In these patients, tumor growth resumed within 3-6 months after treatment discontinuation. Everolimus was then reintroduced and VS decreased by a median 6.8 % at 24 months. Time to tumor progression increased threefold from 4.2 months before treatment to &gt; 12 months. Hearing was stable under treatment. The safety of everolimus was manageable. Although the primary endpoint was not reached, further studies are required to confirm the potential for stabilization of everolimus

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men