Determination of the spatial and temporal variation of tropospheric water vapour using CGPS networks

Tropospheric water vapour is the main limiting factor in using GPS to determine crustal deformation at highest accuracy. On the other hand, it is an important variable to monitor meteorological and climatic processes. This paper discusses both aspects: the modelling of tropospheric water vapour using meteorological data as well as the determination of the integrated amount of water vapour and its spatiotemporal variation using GPS data. Switzerland has been chosen as experiment area. The Swiss continuous GPS (CGPS) network AGNES is used as a reference network, which represents a realistic scenario for GPS-based water vapour determination. Data of the Swiss numerical weather model aLMo are used for systematic comparison and validation. For the first aspect, integrated tropospheric wet refractivity values are determined from meteorological measurements and compared with GPS path delays. An overall agreement of 1 cm of zenith wet path delay was achieved. For the second aspect a tomographic approach has been developed. A total of 6720 GPS-determined profiles are compared with data of the numerical weather model and radio soundings. The results are statistically evaluated and systematically compared with each other. A correlation between the accuracy and the weather situation was found. Overall, an agreement of 5-7 ppm (refractivity unit) was obtained compared to aLMo. The use of GPS-determined path delays from a permanent GPS network is the recommended method to correct GPS measurements. In all other cases, the two methods presented (COITROPA, COMEDIE) are a feasible alternative to determine path delays accurately. Furthermore, GPS is a convenient application to determine the amount of water vapour in the troposphere. It is demonstrated that the vertical distribution of water vapour can be deduced by applying the tomographic approac

Determination of the spatial and temporal variation of tropospheric water vapour using CGPS networks

Tropospheric water vapour is the main limiting factor in using GPS to determine crustal deformation at highest accuracy. On the other hand, it is an important variable to monitor meteorological and climatic processes. This paper discusses both aspects: the modelling of tropospheric water vapour using meteorological data as well as the determination of the integrated amount of water vapour and its spatiotemporal variation using GPS data. Switzerland has been chosen as experiment area. The Swiss continuous GPS (CGPS) network AGNES is used as a reference network, which represents a realistic scenario for GPS-based water vapour determination. Data of the Swiss numerical weather model aLMo are used for systematic comparison and validation. For the first aspect, integrated tropospheric wet refractivity values are determined from meteorological measurements and compared with GPS path delays. An overall agreement of 1 cm of zenith wet path delay was achieved. For the second aspect a tomographic approach has been developed. A total of 6720 GPS-determined profiles are compared with data of the numerical weather model and radio soundings. The results are statistically evaluated and systematically compared with each other. A correlation between the accuracy and the weather situation was found. Overall, an agreement of 5-7 ppm (refractivity unit) was obtained compared to aLMo. The use of GPS-determined path delays from a permanent GPS network is the recommended method to correct GPS measurements. In all other cases, the two methods presented (COITROPA, COMEDIE) are a feasible alternative to determine path delays accurately. Furthermore, GPS is a convenient application to determine the amount of water vapour in the troposphere. It is demonstrated that the vertical distribution of water vapour can be deduced by applying the tomographic approac

Mutations, Clinical Findings and Survival Estimates in South American Patients with X-Linked Adrenoleukodystrophy

In this study, we analyzed the ABCD1 gene in X-linked adrenoleukodystrophy (X-ALD) patients and relatives from 38 unrelated families from South America, as well as phenotypic proportions, survival estimates, and the potential effect of geographical origin in clinical characteristics

Apoptose de neutrófilos na Sepse e na Síndrome da Angústia Respiratória Aguda secundária à Sepse

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Is healthy neuroticism associated with health behaviors? A coordinated integrative data analysis

Current literature suggests that neuroticism is positively associated with maladaptive life choices, likelihood of disease, and mortality. However, recent research has identified circumstances under which neuroticism is associated with positive outcomes. The current project examined whether “healthy neuroticism”, defined as the interaction of neuroticism and conscientiousness, was associated with the following health behaviors: smoking, alcohol consumption, and physical activity. Using a pre-registered multi-study coordinated integrative data analysis (IDA) approach, we investigated whether “healthy neuroticism” predicted the odds of engaging in each of the aforementioned activities. Each study estimated identical models, using the same covariates and data transformations, enabling optimal comparability of results. These results were then meta-analyzed in order to estimate an average (N-weighted) effect and to ascertain the extent of heterogeneity in the effects. Overall, these results suggest that neuroticism alone was not related to health behaviors, while individuals higher in conscientiousness were less likely to be smokers or drinkers, and more likely to engage in physical activity. In terms of the healthy neuroticism interaction of neuroticism and conscientiousness, significant interactions for smoking and physical activity suggest that the association between neuroticism and health behaviors was smaller among those high in conscientiousness. These findings lend credence to the idea that healthy neuroticism may be linked to certain health behaviors and that these effects are generalizable across several heterogeneous samples

Down-regulation of porin M35 in Moraxella catarrhalis by aminopenicillins and environmental factors and its potential contribution to the mechanism of resistance to aminopenicillins

The outer membrane protein M35 of Moraxella catarrhalis is an antigenically conserved porin. Knocking out M35 significantly increases the MICs of aminopenicillins. The aim of this study was to determine the biological mechanism of this potentially new antimicrobial resistance mechanism of M. catarrhalis and the behaviour of M35 in general stress situations

Intraperitoneal drain placement and outcomes after elective colorectal surgery: international matched, prospective, cohort study

Despite current guidelines, intraperitoneal drain placement after elective colorectal surgery remains widespread. Drains were not associated with earlier detection of intraperitoneal collections, but were associated with prolonged hospital stay and increased risk of surgical-site infections.Background Many surgeons routinely place intraperitoneal drains after elective colorectal surgery. However, enhanced recovery after surgery guidelines recommend against their routine use owing to a lack of clear clinical benefit. This study aimed to describe international variation in intraperitoneal drain placement and the safety of this practice. Methods COMPASS (COMPlicAted intra-abdominal collectionS after colorectal Surgery) was a prospective, international, cohort study which enrolled consecutive adults undergoing elective colorectal surgery (February to March 2020). The primary outcome was the rate of intraperitoneal drain placement. Secondary outcomes included: rate and time to diagnosis of postoperative intraperitoneal collections; rate of surgical site infections (SSIs); time to discharge; and 30-day major postoperative complications (Clavien-Dindo grade at least III). After propensity score matching, multivariable logistic regression and Cox proportional hazards regression were used to estimate the independent association of the secondary outcomes with drain placement. Results Overall, 1805 patients from 22 countries were included (798 women, 44.2 per cent; median age 67.0 years). The drain insertion rate was 51.9 per cent (937 patients). After matching, drains were not associated with reduced rates (odds ratio (OR) 1.33, 95 per cent c.i. 0.79 to 2.23; P = 0.287) or earlier detection (hazard ratio (HR) 0.87, 0.33 to 2.31; P = 0.780) of collections. Although not associated with worse major postoperative complications (OR 1.09, 0.68 to 1.75; P = 0.709), drains were associated with delayed hospital discharge (HR 0.58, 0.52 to 0.66; P < 0.001) and an increased risk of SSIs (OR 2.47, 1.50 to 4.05; P < 0.001). Conclusion Intraperitoneal drain placement after elective colorectal surgery is not associated with earlier detection of postoperative collections, but prolongs hospital stay and increases SSI risk