146 research outputs found
Ice chemistry in massive Young Stellar Objects: the role of metallicity
We present the comparison of the three most important ice constituents
(water, CO and CO2) in the envelopes of massive Young Stellar Objects (YSOs),
in environments of different metallicities: the Galaxy, the Large Magellanic
Cloud (LMC) and, for the first time, the Small Magellanic Cloud (SMC). We
present observations of water, CO and CO2 ice in 4 SMC and 3 LMC YSOs (obtained
with Spitzer-IRS and VLT/ISAAC). While water and CO2 ice are detected in all
Magellanic YSOs, CO ice is not detected in the SMC objects. Both CO and CO2 ice
abundances are enhanced in the LMC when compared to high-luminosity Galactic
YSOs. Based on the fact that both species appear to be enhanced in a consistent
way, this effect is unlikely to be the result of enhanced CO2 production in
hotter YSO envelopes as previously thought. Instead we propose that this
results from a reduced water column density in the envelopes of LMC YSOs, a
direct consequence of both the stronger UV radiation field and the reduced
dust-to-gas ratio at lower metallicity. In the SMC the environmental conditions
are harsher, and we observe a reduction in CO2 column density. Furthermore, the
low gas-phase CO density and higher dust temperature in YSO envelopes in the
SMC seem to inhibit CO freeze-out. The scenario we propose can be tested with
further observations.Comment: accepted by MNRAS Letters; 5 pages, 3 figures, 1 tabl
The youngest massive protostars in the Large Magellanic Cloud
We demonstrate the unique capabilities of Herschel to study very young
luminous extragalactic young stellar objects (YSOs) by analyzing a central
strip of the Large Magellanic Cloud obtained through the HERITAGE Science
Demonstration Program. We combine PACS 100 and 160, and SPIRE 250, 350, and 500
microns photometry with 2MASS (1.25-2.17 microns) and Spitzer IRAC and MIPS
(3.6-70 microns) to construct complete spectral energy distributions (SEDs) of
compact sources. From these, we identify 207 candidate embedded YSOs in the
observed region, ~40% never-before identified. We discuss their position in
far-infrared color-magnitude space, comparing with previously studied,
spectroscopically confirmed YSOs and maser emission. All have red colors
indicating massive cool envelopes and great youth. We analyze four example
YSOs, determining their physical properties by fitting their SEDs with
radiative transfer models. Fitting full SEDs including the Herschel data
requires us to increase the size and mass of envelopes included in the models.
This implies higher accretion rates (greater than or equal to 0.0001 M_sun/yr),
in agreement with previous outflow studies of high-mass protostars. Our results
show that Herschel provides reliable longwave SEDs of large samples of
high-mass YSOs; discovers the youngest YSOs whose SEDs peak in Herschel bands;
and constrains the physical properties and evolutionary stages of YSOs more
precisely than was previously possible.Comment: Main text: 4 pages, 3 figures, 1 table; Online material: 3 figures, 1
table; to appear in the A&A Herschel Special Issu
Ice chemistry in embedded young stellar objects in the Large Magellanic Cloud
We present spectroscopic observations of a sample of 15 embedded young
stellar objects (YSOs) in the Large Magellanic Cloud (LMC). These observations
were obtained with the Spitzer Infrared Spectrograph (IRS) as part of the
SAGE-Spec Legacy program. We analyze the two prominent ice bands in the IRS
spectral range: the bending mode of CO_2 ice at 15.2 micron and the ice band
between 5 and 7 micron that includes contributions from the bending mode of
water ice at 6 micron amongst other ice species. The 5-7 micron band is
difficult to identify in our LMC sample due to the conspicuous presence of PAH
emission superimposed onto the ice spectra. We identify water ice in the
spectra of two sources; the spectrum of one of those sources also exhibits the
6.8 micron ice feature attributed to ammonium and methanol. We model the CO_2
band in detail, using the combination of laboratory ice profiles available in
the literature. We find that a significant fraction (> 50%) of CO_2 ice is
locked in a water-rich component, consistent with what is observed for Galactic
sources. The majority of the sources in the LMC also require a pure-CO_2
contribution to the ice profile, evidence of thermal processing. There is a
suggestion that CO_2 production might be enhanced in the LMC, but the size of
the available sample precludes firmer conclusions. We place our results in the
context of the star formation environment in the LMC.Comment: Minor corrections to Table 2. Accepted for publication in ApJ, 66
pages, 9 figures (some in color), 4 table
Infrared composition of the Large Magellanic Cloud
The evolution of galaxies and the history of star formation in the Universe
are among the most important topics in today's astrophysics. Especially, the
role of small, irregular galaxies in the star-formation history of the Universe
is not yet clear. Using the data from the AKARI IRC survey of the Large
Magellanic Cloud at 3.2, 7, 11, 15, and 24 {\mu}m wavelengths, i.e., at the
mid- and near-infrared, we have constructed a multiwavelength catalog
containing data from a cross-correlation with a number of other databases at
different wavelengths. We present the separation of different classes of stars
in the LMC in color-color, and color-magnitude, diagrams, and analyze their
contribution to the total LMC flux, related to point sources at different
infrared wavelengths
Primary and malignant cholangiocytes undergo CD40 mediated Fas dependent Apoptosis, but are insensitive to direct activation with exogenous fas ligand
Introduction
Cholangiocarcinoma is a rare malignancy of the biliary tract, the incidence of which is rising, but the pathogenesis of which remains uncertain. No common genetic defects have been described but it is accepted that chronic inflammation is an important contributing factor. We have shown that primary human cholangiocyte and hepatocyte survival is tightly regulated via co-operative interactions between two tumour necrosis family (TNF) receptor family members; CD40 and Fas (CD95). Functional deficiency of CD154, the ligand for CD40, leads to a failure of clearance of biliary tract infections and a predisposition to cholangiocarcinoma implying a direct link between TNF receptor-mediated apoptosis and the development of cholangiocarcinoma.
Aims
To determine whether malignant cholangiocytes display defects in CD40 mediated apoptosis. By comparing CD40 and Fas-mediated apoptosis and intracellular signalling in primary human cholangiocytes and three cholangiocyte cell lines.
Results
Primary cholangiocytes and cholangiocyte cell lines were relatively insensitive to direct Fas-mediated killing with exogenous FasL when compared with Jurkat cells, which readily underwent Fas-mediated apoptosis, but were extremely sensitive to CD154 stimulation. The sensitivity of cells to CD40 activation was similar in magnitude in both primary and malignant cells and was STAT-3 and AP-1 dependent in both.
Conclusions
1) Both primary and malignant cholangiocytes are relatively resistant to Fas–mediated killing but show exquisite sensitivity to CD154, suggesting that the CD40 pathway is intact and fully functional in both primary and malignant cholangiocytes 2) The relative insensitivity of cholangiocytes to Fas activation demonstrates the importance of CD40 augmentation of Fas dependent death in these cells. Agonistic therapies which target CD40 and associated intracellular signalling pathways may be effective in promoting apoptosis of malignant cholangiocytes
Malignant potential of intrahepatic biliary papillomatosis: a case report and review of the literature
BACKGROUND: Biliary papillomatosis (BP) is a rare disease entity with a strong malignant potential. It is characterized by multiple papillary adenomas involving both the intrahepatic and extrahepatic biliary tree. BP was considered in the past to be a disease with low malignant potential. However, a current review of the English literature revealed a high rate of malignant occurrence of approximately 41% and histological analysis along with the expression pattern of mucin core proteins (MUC) and mucin carbohydrate antigens suggests that BP is a borderline or low grade malignant neoplasm with a high malignant potential. CASE PRESENTATION: A 68 year-old male patient was referred to our hospital due to the presence of sudden right upper quadrant abdominal pain, nausea and dark urine. Imaging workup demonstrated dilatation of the left hepatic duct without the presence of a space-occupying lesion. A left hepatectomy and cholecystectomy were carried out and histological analysis revealed a moderately to poorly differentiated carcinoma of the left hepatic duct in the background of biliary papillomatosis. Postoperative course was uneventful. Unfortunately, two years after initial diagnosis the patient rapidly deteriorated and died from multiple pulmonary secondary deposits. CONCLUSION: BP should not be considered to be a benign disease. The clinical behavior, the high recurrence rate and the even higher malignant transformation occurrence, as well as the presence of carcinogenetic indicators (K-ras mutation, overexpression of p53, MUC and Tn antigens) strongly support that BP is a low-grade neoplasm with high malignant potential
A huge intraductal papillary mucinous carcinoma of the bile duct treated by right trisectionectomy with caudate lobectomy
<p>Abstract</p> <p>Background</p> <p>Because intraductal papillary mucinous neoplasm of the bile duct (IPMN-B) is believed to show a better clinical course than non-papillary biliary neoplasms, it is important to make a precise diagnosis and to perform complete surgical resection.</p> <p>Case presentation</p> <p>We herein report a case of malignant IPMN-B treated by right trisectionectomy with caudate lobectomy and extrahepatic bile duct resection. Radiologic images showed marked dilatation of the left medial sectional bile duct (B4) resulting in a bulky cystic mass with multiple internal papillary projections. Duodenal endoscopic examination demonstrated very patulous ampullary orifice with mucin expulsion and endoscopic retrograde cholangiogram confirmed marked cystic dilatation of B4 with luminal filling defects. These findings suggested IPMN-B with malignancy potential. The functional volume of the left lateral section was estimated to be 45%. A planned extensive surgery was successfully performed. The remnant bile ducts were also dilated but had no macroscopic intraluminal tumorous lesion. The histopathological examination yielded the diagnosis of mucin-producing oncocytic intraductal papillary carcinoma of the bile duct with poorly differentiated carcinomas showing neuroendocrine differentiation. The tumor was 14.0 × 13.0 cm-sized and revealed no stromal invasiveness. Resection margins of the proximal bile duct and hepatic parenchyma were free of tumor cell. The patient showed no postoperative complication and was discharged on 10<sup>th </sup>postoperative date. He has been regularly followed at outpatient department with no evidence of recurrence.</p> <p>Conclusion</p> <p>Considering a favorable prognosis of IPMN-B compared to non-papillary biliary neoplasms, this tumor can be a good indication for aggressive surgical resection regardless of its tumor size.</p
An Ice Age JWST inventory of dense molecular cloud ices
Icy grain mantles are the main reservoir of the volatile elements that link
chemical processes in dark, interstellar clouds with the formation of planets
and composition of their atmospheres. The initial ice composition is set in the
cold, dense parts of molecular clouds, prior to the onset of star formation.
With the exquisite sensitivity of JWST, this critical stage of ice evolution is
now accessible for detailed study. Here we show the first results of the Early
Release Science program "Ice Age" that reveal the rich composition of these
dense cloud ices. Weak ices, including, CO, OCN, CO, OCS,
and COMs functional groups are now detected along two pre-stellar lines of
sight. The CO ice profile indicates modest growth of the icy grains.
Column densities of the major and minor ice species indicate that ices
contribute between 2 and 19% of the bulk budgets of the key C, O, N, and S
elements. Our results suggest that the formation of simple and complex
molecules could begin early in a water-ice rich environment.Comment: To appear in Nature Astronomy on January 23rd, 2023. 33 pages, 16
figures, 3 tables; includes extended and supplemental data sections. Part of
the JWST Ice Age Early Release Science program's science enabling products.
Enhanced spectra downloadable on Zenodo at the following DOI:
10.5281/zenodo.750123
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