Simulation Speedup Techniques for Computationally Demanding Tasks

The computational cost for the repeated evaluation of zonal-type building simulation models can be prohibitive especially in contexts, such as Building Optimization and Control Design, where repeated evaluation of the models — for different initial and boundary conditions — is required. In the present paper, two techniques to reduce simulation time are investigated: (i) geometry simplification for periodic geometries; and, (ii) the use of co-simulation to split a building into simpler sub-buildings, that can be evaluated in parallel, exploiting the resources of multi-core computational architectures. These simulation speed-up approaches are evaluated, with respect to accuracy and computational effort, against the validated full-scale models of two real buildings

Simulation Speedup Techniques for Computationally Demanding Tasks

The computational cost for the repeated evaluation of zonal-type building simulation models can be prohibitive especially in contexts, such as Building Optimization and Control Design, where repeated evaluation of the models — for different initial and boundary conditions — is required. In the present paper, two techniques to reduce simulation time are investigated: (i) geometry simplification for periodic geometries; and, (ii) the use of co-simulation to split a building into simpler sub-buildings, that can be evaluated in parallel, exploiting the resources of multi-core computational architectures. These simulation speed-up approaches are evaluated, with respect to accuracy and computational effort, against the validated full-scale models of two real buildings

CleanET: enabling timing validation for complex automotive systems

Timing validation for automotive systems occurs in late integration stages when it is hard to control how the instances of software tasks overlap in time. To make things worse, in complex software systems, like those for autonomous driving, tasks schedule has a strong event-driven nature, which further complicates relating those task-overlapping scenarios (TOS) captured during the software timing budgeting and those observed during validation phases. This paper proposes CleanET, an approach to derive the dilation factor r caused due to the simultaneous execution of multiple tasks. To that end, CleanET builds on the captured TOS during testing and predicts how tasks execution time react under untested TOS (e.g. full overlap), hence acting as a mean of robust testing. CleanET also provides additional evidence for certification about the derived timing budgets for every task. We apply CleanET to a commercial autonomous driving framework, Apollo, where task measurements can only be reasonably collected under 'arbitrary' TOS. Our results show that CleanET successfully derives the dilation factor and allows assessing whether execution times for the different tasks adhere to their respective deadlines for unobserved scenarios.This work has been partially supported by the Spanish Ministry of Economy and Competitiveness (MINECO) under grant TIN2015- 65316-P, the SuPerCom European Research Council (ERC) project under the European Union’s Horizon 2020 research and innovation programme (grant agreement No. 772773), and the HiPEAC Network of Excellence. MINECO partially supported Jaume Abella under Ramon y Cajal postdoctoral fellowship (RYC-2013-14717).Peer ReviewedPostprint (author's final draft

IEA SHC Task 42 / ECES Annex 29 WG A1: Engineering and Processing of PCMs, TCMs and Sorption Materials

An overview on the recent results on the engineering and characterization of sorption materials, PCMs and TCMs investigated in the working group WG A1 "Engineering and processing of TES materials" of IEA SHC Task 42 / ECES Annex 29 (Task 4229) entitled "Compact Thermal Energy Storage" is presented

Multi-criteria Resource Allocation in Modal Hard Real-Time Systems

In this paper, a novel resource allocation approach dedicated to hard real-time systems with distinctive operational modes is proposed. The aim of this approach is to reduce the energy dissipation of the computing cores by either powering them off or switching them into energy-saving states while still guaranteeing to meet all timing constraints. The approach is illustrated with two industrial applications, an engine control management and an engine control unit. Moreover, the amount of data to be migrated during the mode change is minimised. Since the number of processing cores and their energy dissipation are often negatively correlated with the amount of data to be migrated during the mode change, there is some trade-off between these values, which is also analysed in this paper

Body iron metabolism and pathophysiology of iron overload

Iron is an essential metal for the body, while excess iron accumulation causes organ dysfunction through the production of reactive oxygen species. There is a sophisticated balance of body iron metabolism of storage and transport, which is regulated by several factors including the newly identified peptide hepcidin. As there is no passive excretory mechanism of iron, iron is easily accumulated when exogenous iron is loaded by hereditary factors, repeated transfusions, and other diseased conditions. The free irons, non-transferrin-bound iron, and labile plasma iron in the circulation, and the labile iron pool within the cells, are responsible for iron toxicity. The characteristic features of advanced iron overload are failure of vital organs such as liver and heart in addition to endocrine dysfunctions. For the estimation of body iron, there are direct and indirect methods available. Serum ferritin is the most convenient and widely available modality, even though its specificity is sometimes problematic. Recently, new physical detection methods using magnetic resonance imaging and superconducting quantum interference devices have become available to estimate iron concentration in liver and myocardium. The widely used application of iron chelators with high compliance will resolve the problems of organ dysfunction by excess iron and improve patient outcomes

Heme-Oxygenases during Erythropoiesis in K562 and Human Bone Marrow Cells

In mammalian cells, heme can be degraded by heme-oxygenases (HO). Heme-oxygenase 1 (HO-1) is known to be the heme inducible isoform, whereas heme-oxygenase 2 (HO-2) is the constitutive enzyme. Here we investigated the presence of HO during erythroid differentiation in human bone marrow erythroid precursors and K562 cells. HO-1 mRNA and protein expression levels were below limits of detection in K562 cells. Moreover, heme was unable to induce HO-1, at the protein and mRNA profiles. Surprisingly, HO-2 expression was inhibited upon incubation with heme. To evaluate the physiological relevance of these findings, we analyzed HO expression during normal erythropoiesis in human bone marrow. Erythroid precursors were characterized by lack of significant expression of HO-1 and by progressive reduction of HO-2 during differentiation. FLVCR expression, a recently described heme exporter found in erythroid precursors, was also analyzed. Interestingly, the disruption in the HO detoxification system was accompanied by a transient induction of FLVCR. It will be interesting to verify if the inhibition of HO expression, that we found, is preventing a futile cycle of concomitant heme synthesis and catabolism. We believe that a significant feature of erythropoiesis could be the replacement of heme breakdown by heme exportation, as a mechanism to prevent heme toxicity

Snx3 Regulates Recycling of the Transferrin Receptor and Iron Assimilation

Sorting of endocytic ligands and receptors is critical for diverse cellular processes. The physiological significance of endosomal sorting proteins in vertebrates, however, remains largely unknown. Here we report that sorting nexin 3 (Snx3) facilitates the recycling of transferrin receptor (Tfrc) and thus is required for the proper delivery of iron to erythroid progenitors. Snx3 is highly expressed in vertebrate hematopoietic tissues. Silencing of Snx3 results in anemia and hemoglobin defects in vertebrates due to impaired transferrin (Tf)-mediated iron uptake and its accumulation in early endosomes. This impaired iron assimilation can be complemented with non-Tf iron chelates. We show that Snx3 and Vps35, a component of the retromer, interact with Tfrc to sort it to the recycling endosomes. Our findings uncover a role of Snx3 in regulating Tfrc recycling, iron homeostasis, and erythropoiesis. Thus, the identification of Snx3 provides a genetic tool for exploring erythropoiesis and disorders of iron metabolism.National Institutes of Health (U.S.) (P01 HL032262

IEA SHC Task 42 / ECES Annex 29 WG A1: Engineering and Processing of PCMs, TCMs and Sorption Materials

4th International Conference on Solar Heating and Cooling for Buildings and Industry, SHC 2015 --2 December 2015 through 4 December 2015 -- --An overview on the recent results on the engineering and characterization of sorption materials, PCMs and TCMs investigated in the working group WG A1 "Engineering and processing of TES materials" of IEA SHC Task 42 / ECES Annex 29 (Task 4229) entitled "Compact Thermal Energy Storage" is presented. © 2016 The Authors.Javna Agencija za Raziskovalno Dejavnost RS: BI-FR/14-15-Proteus-008, P1-0021-0104The financial supports of the European Commission for subsidizing SAM.SSA, COMTES, MERITS projects within the 7th framework program for research are acknowledged. The Slovenian Research Agency (research program P1-0021-0104 and bilateral project BI-FR/14-15-Proteus-008) is thanked for the support