10 research outputs found
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
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- Abrams J.
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- Al-Saadi Z.
- Al-Shahi Salman R.
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- Central Coordinating Office (for the RECOVERY Collaborative Group)
- Century H.
- Chadwick J.
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- Chakraborty A.
- Chamberlain S.
- Chambers E.
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- Chawla V.
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- Chiswick C.
- Chivima B.
- Chmiel C.
- Chrisopoulou A.
- Christian P.
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- Church E.
- Cianci N.
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- Clark E.
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- Clifford S.
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- Coker O.
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- Collini Paul
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- Data Monitoring Committee of the RECOVERY Collaborative Group
- Daunt A.
- Dave V.
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- Fairbairn I.
- Fairclough A.
- Falconer E.
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- Fancois V.
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- Farzana S.
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- Health records (for the RECOVERY Collaborative Group)
- Hector G.
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- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
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Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Wunderbares in der Dichtung der Aufklärung
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No full textOn beasts and monsters
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No full textAustralia and New Zealand
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No full textApproaches that Address Social Inclusion for Children with Disabilities: A Critical Review
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- A Ben-Sasson
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No full textDigital Colonialism: South Africa’s Education Transformation in the Shadow of Silicon Valley
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
No full textMapping the human genetic architecture of COVID-19
- Author
- Abdelrazik M
- Abdullah T
- Abe R
- Abe S
- Abecasis GR
- Abel L
- Abernathy C
- Abraheem A
- Abul-Husn NS
- Acosta-Herrera M
- Acquilini D
- Acquilini D
- Adachi T
- Adachi Y
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- Adeleye O
- Adeniji K
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- Afrasiabi Z
- Afset JE
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- Costantino G
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- zu Bentrup FM
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- Publication venue
- Publication date
- 01/01/2021
- Field of study
Get PDFThe genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease
Electrophysiology of Hippocampal Neurons
- Author
- A Björklund
- A Djørup
- A Dolphin
- A Hjorth-Simonsen
- A Wieraszko
- AL Hodgkin
- AL Mueller
- AL Mueller
- AL Mueller
- AL Mueller
- AL Mueller
- AM Rose
- B Gustafsson
- B Scatton
- BA MacVicar
- BA MacVicar
- BA MacVicar
- BA MacVicar
- BB Fredholm
- BD Fantie
- BE Alger
- BE Alger
- BE Alger
- BE Alger
- BE Alger
- BE Alger
- BE Alger
- BE Alger
- BE Jones
- BG Vickery
- BH Bland
- BH Bland
- BH Gähwiler
- BH Gähwiler
- BJ Hoffer
- BL McNaughton
- BL McNaughton
- BL McNaughton
- BL McNaughton
- BL McNaughton
- BR Sastry
- BW Connors
- BW Connors
- C Gall
- C Yamamoto
- C Yamamoto
- C Yamamoto
- C Yamamoto
- C Yamamoto
- CA Barnes
- CA Barnes
- CE Ribak
- CE Stafstrom
- CH Vanderwolf
- CM Smith
- CP Taylor
- CP Taylor
- CW Cotman
- D Baxter
- D Dahl
- D Durand
- D Gaffan
- D Johnston
- D Johnston
- D Johnston
- D Johnston
- D Johnston
- D Taylor
- DA Brown
- DA Brown
- DA Brown
- DA Brown
- DA Brown
- DA Prince
- DA Turner
- DA Turner
- DD Kunkel
- DD Kunkel
- DI Gottlieb
- DJ Woodward
- DP Purpura
- DP Purpura
- DR Curtis
- DR Hill
- DS Olton
- DV Madison
- DV Madison
- E Fifkova
- EC Azmitia
- ER Kandel
- ER Kandel
- ER Lewis
- FE Dudek
- FH Gage
- FJ Alvarez-Leefmans
- FJ Alvarez-Leefmans
- G Barbin
- G Buzsaki
- G Lynch
- G Raisman
- GC Salmoiraghi
- GE Handelmann
- GI Allen
- GK Kostopoulos
- GL Collingridge
- GL Collingridge
- GR Siggins
- GS Lynch
- GS Lynch
- H Jahnsen
- H Petsche
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- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1987
- Field of study
No full textLiteraturverzeichnis
- Author
- Aaronian Daisy A
- Abb
- Abel Fritz
- Abendroth-Timmer Dagmar
- Adam Wolfgang
- Aehle Wilhelm
- Ahlers Holtus
- Ahrbeck-Wothge Hirsch
- Aris Chartier
- Aris Philippe
- Asbach Olaf
- Asch Ronald G
- Asche Matthias
- Asche Matthias
- Assmann Aleida
- Audisio Gabriel
- Auerbach Erich
- Auroux Wiegand
- Austermann Simone
- Babel Paravicini
- Bachtin Michail M
- Badinter Elisabeth
- Baldassarri Stefano Ugo
- Baldzuhn Michael
- Bandelier AndrØ
- Bandelier AndrØ
- Barthold Friedrich Wilhelm
- BascuÇana
- BascuÇana
- Batkin Leonid M
- Baum Richard
- Bausch Karl-Richard
- Bausch Karl-Richard
- Bechstedt Christian Wilhelm
- Beck Heinrich
- Beck-Busse Gabriele
- Beck-Busse Zollna
- Becker Holtus
- Becker Monika
- Beetz Manfred
- Behrens Dietrich
- Behrens Rudolf
- Bel Jacqueline
- Benasse Strauß
- Bender Eva
- Benner Kemper
- Benner Oelkers
- Berding FranÅois
- Berec Laurent
- Berg Christa
- Bergeest Michael
- Berger Lüsebrink
- Berger Sick
- Berner E.
- Berriot-Salvadore Evelyne
- Berthault E. A.
- Besse Henri
- Besse Henri
- Besse Henri
- Besse Henri
- Besse Henri
- Besse Suso López
- Beyer Hildegard
- Bierbach
- Bierbach Mechtild
- Bierbach Mechtild
- Bircher Herz
- Biresch Hanna
- Bleeck Klaus
- Boaistuau Simonin
- Boerner Stiehler
- Bohse
- Bolte Johannes
- Bolte Johannes
- Borggrefe Lüpkes
- Born Joachim
- Borst
- Bosse Ghanbari
- Bossong Georg
- Bourdieu
- Bourdieu Pierre
- Bouton Charles P
- Braun Guido
- Bredella Christ
- Bredella Christ
- Bredella Meißner
- Breitkreuz Hartmut
- Briesemeister Dietrich
- Brohm Heike
- Bruchhäuser Hanns-Peter
- Bruckmayer
- Bruning Jens
- Brunner Conze
- Brunner Friedrich
- Brunner Otto
- Brunot
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- Brüning Gleixner
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- Bumke Joachim
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- Burke Peter
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- Bödeker Hans Erich
- Büsch Johann
- Cachedenier
- Cachedenier Jacquetin-Gaudet
- CalviØ Lucien
- Campe Joachim
- Campe Joachim
- Campe Joachim
- Caravolas Jean Antoine
- Caravolas Jean-Antoine
- Caravolas Jean-Antoine
- Caravolas Jean-Antoine
- Carorguy Jacques
- Casale Rita
- Castiglione
- Catach Nina
- Cato Marcus
- Cave Terence
- Cerman Ivo
- Chapuset Johann
- Chatelain Jean-Marc
- Chervel AndrØ
- Choffin David
- Christ Coste
- Christ Haßler
- Christ Herbert
- Christ Herbert
- Christ Herbert
- Christ Herbert
- Christ Herbert
- Christ Herbert
- Christ Herbert
- Christ Herbert
- Christ Herbert
- Christ Herbert
- Christ Herbert
- Christ Herbert
- Christ Herbert
- Christ Herbert
- Christ Rang
- Chudzińska Yasmine
- Cipriani Fernando
- Clark Christopher
- Clercq Lioce
- Collum Wolfgang H
- Colombat Fournier
- Comenius Johann A
- Commynes
- ComØnius Jan
- Condillac Étienne
- Cordier
- Coring Gustav
- Coseriu Eugenio
- Costadura Daum
- Coste Daniel
- Coste Daniel
- Coste Daniel
- Coudert Allison P
- Courtin
- Crome
- Cullire Alain
- Cunradi Johann Gottlieb
- Curas
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- ür Landesgeschichte
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