A functional variant of the myeloperoxidase gene is associated with cardiovascular disease in end-stage renal disease patients

A functional variant of the myeloperoxidase gene is associated with cardiovascular disease in end-stage renal disease patients. Cardiovascular disease (CVD) is the leading cause of mortality in end-stage renal disease (ESRD) patients and there is emerging evidence that genetic factors may contribute to the development of atherosclerosis. Myeloperoxidase (MPO) is an abundant enzyme involved in the production of free radicals. A functional G→A single nucleotide polymorphism (SNP) has been identified at position -463, where the A allele is associated with lower MPO expression. To analyze the association between this SNP and inflammation, oxidative stress, and CVD, we studied a cohort of 155 ESRD patients (52 ± 1 years, 62% males, 22% diabetics) shortly before the initiation of dialysis treatment. CVD was defined by medical history criteria; plasma interleukin-6 (IL-6) was used as a marker of inflammation, and plasma pentosidine as an estimation of oxidative protein damage. DNA from leukocytes was used for genotyping, performed by the pyrosequencing reaction. Only five patients (3%) had the genotype AA at the -463 position, whereas 38 (25%) had the GA and 112 (72%) had the GG genotype. No differences were noted in plasma IL-6 levels between the genotype groups, whereas the pentosidine levels were higher in the GG group (28.4 pmol/mg albumin [range, 8.5 to 123 pmol/mg albumin]) compared to the other two groups (21.4 pmol/mg albumin [range, 7.6 to 384 pmol/mg albumin; P < 0.05]). Patients with the GG genotype had a higher prevalence of positive serology for Chlamydia pneumoniae (51%) when compared to the carriers of the A allele (24%) (P < 0.05). The prevalence of CVD was lower in the AA (0%) and GA genotypes (18%), compared to the GG genotype (35%). The GG genotype was still associated with CVD after correction for age, diabetes, smoking, malnutrition, and inflammation. Our findings suggest that the -463 G→A SNP, which supposedly results in lower MPO activity, is associated with a lower prevalence of CVD in ESRD patients. It could be speculated that this effect is mediated by a decreased oxidative stress due to lower production of free radicals

Collective narcissism as a framework for understanding populism

Research on national collective narcissism, the belief and resentment that a nation's exceptionality is not sufficiently recognized by others, provides a theoretical framework for understanding the psychological motivations behind the support for right-wing populism. It bridges the findings regarding the economic and sociocultural conditions implicated in the rise of right-wing populism and the findings regarding leadership processes necessary for it to find its political expression. The conditions are interpreted as producing violations to established expectations regarding self-importance via the gradual repeal of the traditional criteria by which members of hegemonic groups evaluated their self-worth. Populist leaders propagate a social identity organized around the collective narcissistic resentment, enhance it, and propose external explanations for frustration of self and in-group-importance. This garners them a committed followership. Research on collective narcissism indicates that distress resulting from violated expectations regarding self-importance stands behind collective narcissism and its narrow vision of “true” national identity (the people), rejection and hostility toward stigmatized in-group members and out-groups as well as the association between collective narcissism and conspiratorial thinking

Species Specificity in Major Urinary Proteins by Parallel Evolution

Species-specific chemosignals, pheromones, regulate social behaviors such as aggression, mating, pup-suckling, territory establishment, and dominance. The identity of these cues remains mostly undetermined and few mammalian pheromones have been identified. Genetically-encoded pheromones are expected to exhibit several different mechanisms for coding 1) diversity, to enable the signaling of multiple behaviors, 2) dynamic regulation, to indicate age and dominance, and 3) species-specificity. Recently, the major urinary proteins (Mups) have been shown to function themselves as genetically-encoded pheromones to regulate species-specific behavior. Mups are multiple highly related proteins expressed in combinatorial patterns that differ between individuals, gender, and age; which are sufficient to fulfill the first two criteria. We have now characterized and fully annotated the mouse Mup gene content in detail. This has enabled us to further analyze the extent of Mup coding diversity and determine their potential to encode species-specific cues

Male, National, and Religious Collective Narcissism Predict Sexism

Results of three cross-sectional studies indicate that sexism in Poland is associated with collective narcissism—a belief that one’s own group’s (the in-group’s) exaggerated exceptionality is not sufficiently recognized by others—with reference to three social identities: male, religious, and national. In Study 1 (n = 329), male collective narcissism was associated with sexism. This relationship was sequentially mediated by precarious manhood and traditional gender beliefs. In Study 2 (n = 877), Catholic collective narcissism predicted tolerance of violence against women (among men and women) over and above religious fundamentalism and in contrast to intrinsic religiosity. In Study 3 (n = 1070), national collective narcissism was associated with hostile sexism among men and women and with benevolent sexism more strongly among women than among men. In contrast, national in-group satisfaction—a belief that the nation is of a high value—predicted rejection of benevolent and hostile sexism among women but was positively associated with hostile and benevolent sexism among men. Among men and women collective narcissism was associated with tolerance of domestic violence against women, whereas national in-group satisfaction was associated with rejection of violence against women

Using social and behavioural science to support COVID-19 pandemic response

The COVID-19 pandemic represents a massive global health crisis. Because the crisis requires large-scale behaviour change and places significant psychological burdens on individuals, insights from the social and behavioural sciences can be used to help align human behavior with the recommendations of epidemiologists and public health experts. Here we discuss evidence from a selection of research topics relevant to pandemics, including work on navigating threats, social and cultural influences on behaviour, science communication, moral decision-making, leadership, and stress and coping. In each section, we note the nature and quality of prior research, including uncertainty and unsettled issues. We identify several insights for effective response to the COVID-19 pandemic, and also highlight important gaps researchers should move quickly to fill in the coming weeks and months

Personal control decreases narcissistic but increases non-narcissistic in-group positivity

Objective: We examined the effects of control motivation on in-group positivity. Past research suggests that people compensate for low personal control by increasing support for social ingroups. We predicted that the effect of personal control on in-group positivity would depend on the type of in-group positivity. Low personal control should increase compensatory, narcissistic in-group positivity, while high personal control should increase secure, non-narcissistic in-group positivity. Method: These hypotheses were tested in a cross-sectional survey (Study 1, n= 1083,54% female, Mage= 47.68), two experiments (Study 2, n= 105, 50% female, Mage = 32.05; Study 3, n=154, 40% female, Mage= 29.93) and a longitudinal survey (Study 4, n= 398, 51% female,Mage= 32.05). Results: In all studies personal control was negatively associated with narcissistic in-group positivity but positively associated with non-narcissistic in-group positivity. The longitudinal survey additionally showed that the positive relationship between personal controland non-narcissistic in-group positivity was reciprocal. Moreover, both types of in-group positivity differentially mediated between personal control and out-group attitudes:narcissistic in-group positivity predicted negative attitudes and non-narcissistic positivity predicted positive attitudes. Conclusions: These findings highlight the role of individual motivation in fostering different types of in-group positivity and intergroup outcomes