Is all of the endoplasmic reticulum created equal? The effects of the heterogeneous distribution of endoplasmic reticulum Ca2+-handling proteins

The endoplasmic reticulum is a heterogeneous compartment with respect to the distribution of its Ca2+-handling proteins, namely the Ca2+-binding proteins, the Ca2+ pumps and the Ca2+ release channels. The nonuniform distribution of these proteins may explain the functional heterogeneity of the endoplasmic reticulum, such as the generation of spatially complex Ca2+ signals, Ca2+ homeostasis, and protein folding and quality control

Trends Among U.S. High School Seniors in Recent Marijuana Use and Associations With Other Substances: 1976–2013

To describe historical trends in rates of recent substance use, and associations between marijuana and other substances, among United States high school seniors by race and gender

Seismic tremor at the 9°50′N East Pacific Rise eruption site

Ocean bottom seismic observations within the 9°50′N region of the East Pacific Rise indicate persistent, low-amplitude tremor activity throughout the October 2003 through February 2007 period of monitoring. These signals exhibit either monochromatic or polychromatic spectral characteristics, with a ∼6 Hz fundamental frequency and up to two harmonics. Individual events cannot be correlated between nearby (<1 km) stations, implying the presence of multiple, small-amplitude sources positioned within the shallow crust. Tremor exhibits a semidiurnal periodicity, with some stations recording activity during times of increasing tidal extension and others detecting tremor signals during times of increasing compression. The amplitude, duration, and rate of activity also correlate positively with fortnightly changes in the amplitude of the tides. These spatiotemporal patterns are consistent with tremor generation in response to tidally modulated fluid flow within a network of shallow cracks. Tremor energy flux is spatially and temporally heterogeneous; however, there are extended periods of greater and lesser activity that can be tracked across portions of the array. Despite their shallow crustal origin, changes in tremor amplitude and spectral character occur in the months prior to a major microearthquake swarm and inferred seafloor spreading event on 22 January 2006, with an increase in the degree of correlation between tremor activity and tidal strain in the weeks leading up to this event. After the spreading event, two eruption-surviving stations near the axis continue to show high rates of tremor activity, whereas these signals are suppressed at the single station recovered from the near-axis flanks. This off-axis quiescence may result from the dike-induced closing of cracks or perhaps from the emplacement of impermeable flows near the station

Spatiotemporal distribution of the seismicity along the Mid-Atlantic Ridge north of the Azores from hydroacoustic data: Insights into seismogenic processes in a ridge-hot spot context

The seismicity of the North Atlantic was monitored from May 2002 to September 2003 by the 'SIRENA array' of autonomous hydrophones. The hydroacoustic signals provide a unique data set documenting numerous low-magnitude earthquakes along the section of the Mid-Atlantic Ridge (MAR) located in a ridge-hot spot interaction context. During the experiment, 1696 events were detected along the MAR axis between 40 degrees N and 51 degrees N, with a magnitude of completeness level of m(b) approximate to 2.4. Inside the array, location errors are in the order of 2 km, and errors in the origin time are less than 1 s. From this catalog, 15 clusters were detected. The distribution of source level (SL) versus time within each cluster is used to discriminate clusters occurring in a tectonic context from those attributed to non-tectonic (i.e. volcanic or hydrothermal) processes. The location of tectonic and non-tectonic sequences correlates well with regions with positive and negative Mantle Bouguer Anomalies (MBAs), indicating the presence of thinner/colder and thicker/warmer crust respectively. At the scale of the entire array, both the complete and declustered catalogs derived from the hydroacoustic signals show an increase of the seismicity rate from the Azores up to 43 degrees 30'N suggesting a diminishing influence of the Azores hot spot on the ridge-axis temperature, and well correlated with a similar increase in the along-axis MBAs. The comparison of the MAR seismicity with the Residual MBA (RMBA) at different scales leads us to think that the low-magnitude seismicity rates are directly related to along-axis variations in lithosphere rheology and temperatures.info:eu-repo/semantics/publishedVersio

Use of measurement theory for operationalization and quantification of psychological constructs in systems dynamics modelling

The analytical tools available to social scientists have traditionally been adapted from tools originally designed for analysis of natural science phenomena. This article discusses the applicability of systems dynamics - a qualitative based modelling approach, as a possible analysis and simulation tool that bridges the gap between social and natural sciences. After a brief overview of the systems dynamics modelling methodology, the advantages as well as limiting factors of systems dynamics to the potential applications in the field of social sciences and human interactions are discussed. The issues arise with regards to operationalization and quantification of latent constructs at the simulation building stage of the systems dynamics methodology and measurement theory is proposed as a ready and waiting solution to the problem of dynamic model calibration, with a view of improving simulation model reliability and validity and encouraging the development of standardised, modular system dynamics models that can be used in social science research

Temperature variations at diffuse and focused flow hydrothermal vent sites along the northern East Pacific Rise

Author Posting. © American Geophysical Union, 2006. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geochemistry Geophysics Geosystems 7 (2006): Q03002, doi:10.1029/2005GC001094.In the decade following documented volcanic activity on the East Pacific Rise near 9°50′N, we monitored hydrothermal vent fluid temperature variations in conjunction with approximately yearly vent fluid sampling to better understand the processes and physical conditions that govern the evolution of seafloor hydrothermal systems. The temperature of both diffuse flow (low-temperature) and focused flow (high-temperature) vent fluids decreased significantly within several years of eruptions in 1991 and 1992. After mid-1994, focused flow vents generally exhibited periods of relatively stable, slowly varying temperatures, with occasional high- and low-temperature excursions lasting days to weeks. One such positive temperature excursion was associated with a crustal cracking event. Another with both positive and negative excursions demonstrated a subsurface connection between adjacent focused flow and diffuse flow vents. Diffuse flow vents exhibit much greater temperature variability than adjacent higher-temperature vents. On timescales of a week or less, temperatures at a given position within a diffuse flow field often varied by 5°–10°C, synchronous with near-bottom currents dominated by tidal and inertial forcing. On timescales of a week and longer, diffuse flow temperatures varied slowly and incoherently among different vent fields. At diffuse flow vent sites, the conceptual model of a thermal boundary layer immediately above the seafloor explains many of the temporal and spatial temperature variations observed within a single vent field. The thermal boundary layer is a lens of warm water injected from beneath the seafloor that is mixed and distended by lateral near-bottom currents. The volume of the boundary layer is delineated by the position of mature communities of sessile (e.g., tubeworms) and relatively slow-moving organisms (e.g., mussels). Vertical flow rates of hydrothermal fluids exiting the seafloor at diffuse vents are less than lateral flow rates of near-bottom currents (5–10 cm/s). The presence of a subsurface, shallow reservoir of warm hydrothermal fluids can explain differing temperature behaviors of adjacent diffuse flow and focused flow vents at 9°50′N. Different average temperatures and daily temperature ranges are explained by variable amounts of mixing of hydrothermal fluids with ambient seawater through subsurface conduits that have varying lateral permeability.Field and shore-based analyses have been supported by the National Science Foundation (OCE-0096468, OCE-8917311, OCE-9217026, OCE-9302205, OCE-0327261), the Woods Hole Oceanographic Institution's Vetlesen Fund and W. A. Clark Senior Scientist Chair (DJF), and the Devonshire Foundation (TMS)

Faulting and hydration of the Juan de Fuca plate system

Author Posting. © Elsevier B.V., 2009. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Earth and Planetary Science Letters 284 (2009): 94-102, doi:10.1016/j.epsl.2009.04.013.Multichannel seismic observations provide the first direct images of crustal scale normal faults within the Juan de Fuca plate system and indicate that brittle deformation extends up to ~200 km seaward of the Cascadia trench. Within the sedimentary layering steeply dipping faults are identified by stratigraphic offsets, with maximum throws of 110±10 m found near the trench. Fault throws diminish both upsection and seaward from the trench. Long-term throw rates are estimated to be 13±2 mm/kyr. Faulted offsets within the sedimentary layering are typically linked to larger offset scarps in the basement topography, suggesting reactivation of the normal fault systems formed at the spreading center. Imaged reflections within the gabbroic igneous crust indicate swallowing fault dips at depth. These reflections require local alteration to produce an impedance contrast, indicating that the imaged fault structures provide pathways for fluid transport and hydration. As the depth extent of imaged faulting within this young and sediment insulated oceanic plate is primarily limited to approximately Moho depths, fault- controlled hydration appears to be largely restricted to crustal levels. If dehydration embrittlement is an important mechanism for triggering intermediate-depth earthquakes within the subducting slab, then the limited occurrence rate and magnitude of intraslab seismicity at the Cascadia margin may in part be explained by the limited amount of water imbedded into the uppermost oceanic mantle prior to subduction. The distribution of submarine earthquakes within the Juan de Fuca plate system indicates that propagator wake areas are likely to be more faulted and therefore more hydrated than other parts of his plate system. However, being largely restricted to crustal levels, this localized increase in hydration generally does not appear to have a measurable effect on the intraslab seismicity along most of the subducted propagator wakes at the Cascadia margin.Supported by the Doherty Foundation and the National Science 449 Foundation under grants OCE002488 and OCE0648303 to SMC and MR

Flux measurements of explosive degassing using a yearlong hydroacoustic record at an erupting submarine volcano

Author Posting. © American Geophysical Union, 2012. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geochemistry Geophysics Geosystems 13 (2012): Q0AF07, doi:10.1029/2012GC004211.The output of gas and tephra from volcanoes is an inherently disorganized process that makes reliable flux estimates challenging to obtain. Continuous monitoring of gas flux has been achieved in only a few instances at subaerial volcanoes, but never for submarine volcanoes. Here we use the first sustained (yearlong) hydroacoustic monitoring of an erupting submarine volcano (NW Rota-1, Mariana arc) to make calculations of explosive gas flux from a volcano into the ocean. Bursts of Strombolian explosive degassing at the volcano summit (520 m deep) occurred at 1–2 min intervals during the entire 12-month hydrophone record and commonly exhibited cyclic step-function changes between high and low intensity. Total gas flux calculated from the hydroacoustic record is 5.4 ± 0.6 Tg a−1, where the magmatic gases driving eruptions at NW Rota-1 are primarily H2O, SO2, and CO2. Instantaneous fluxes varied by a factor of ∼100 over the deployment. Using melt inclusion information to estimate the concentration of CO2 in the explosive gases as 6.9 ± 0.7 wt %, we calculate an annual CO2 eruption flux of 0.4 ± 0.1 Tg a−1. This result is within the range of measured CO2 fluxes at continuously erupting subaerial volcanoes, and represents ∼0.2–0.6% of the annual estimated output of CO2from all subaerial arc volcanoes, and ∼0.4–0.6% of the mid-ocean ridge flux. The multiyear eruptive history of NW Rota-1 demonstrates that submarine volcanoes can be significant and sustained sources of CO2 to the shallow ocean.The National Oceanic and Atmospheric Administration Office of Ocean Exploration and Research, the NOAA Vents Program, and the National Science Foundation (OCE-0751776) for support.2013-05-2

The Recent Volcanic History of Axial Seamount: Geophysical Insights into Past Eruption Dynamics with an Eye Toward Enhanced Observations of Future Eruptions

To understand the processes that form oceanic crust as well as the role of submarine volcanoes in exchanging heat and chemicals with the ocean and in supporting chemosynthetic biological communities, it is essential to study underwater eruptions. The world’s most advanced underwater volcano observatory—the Ocean Observatories Initiative Cabled Array at Axial Seamount—builds upon ~30 years of sustained geophysical monitoring at this site with autonomous and remote systems. In April 2015, only months after the Cabled Array’s installation, it recorded an eruption at Axial Seamount, adding to the records of two prior eruptions in 1998 and 2011. Between eruptions, magma recharge is focused beneath the southeast part of the summit caldera, leading to steady inflation and increasing rates of seismicity. During each eruption, the volcano deflates over days to weeks, coincident with high levels of seismicity as a dike is emplaced along one of the volcano’s rifts and lava erupts on the seafloor. Cabled Array seismic data show that motions on an outward-dipping ring fault beneath the caldera accommodate the inflation and deflation. Eruptions appear to occur at a predictable level of inflation; hence, it should be possible to time deployments of additional cabled and autonomous instrumentation to further enhance observations of the next eruption

Eruptive modes and hiatus of volcanism at West Mata seamount, NE Lau basin : 1996–2012

Author Posting. © American Geophysical Union, 2014. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geochemistry, Geophysics, Geosystems 15 (2014): 4093–4115, doi:10.1002/2014GC005387.We present multiple lines of evidence for years to decade-long changes in the location and character of volcanic activity at West Mata seamount in the NE Lau basin over a 16 year period, and a hiatus in summit eruptions from early 2011 to at least September 2012. Boninite lava and pyroclasts were observed erupting from its summit in 2009, and hydroacoustic data from a succession of hydrophones moored nearby show near-continuous eruptive activity from January 2009 to early 2011. Successive differencing of seven multibeam bathymetric surveys of the volcano made in the 1996–2012 period reveals a pattern of extended constructional volcanism on the summit and northwest flank punctuated by eruptions along the volcano's WSW rift zone (WSWRZ). Away from the summit, the volumetrically largest eruption during the observational period occurred between May 2010 and November 2011 at ∼2920 m depth near the base of the WSWRZ. The (nearly) equally long ENE rift zone did not experience any volcanic activity during the 1996–2012 period. The cessation of summit volcanism recorded on the moored hydrophone was accompanied or followed by the formation of a small summit crater and a landslide on the eastern flank. Water column sensors, analysis of gas samples in the overlying hydrothermal plume and dives with a remotely operated vehicle in September 2012 confirmed that the summit eruption had ceased. Based on the historical eruption rates calculated using the bathymetric differencing technique, the volcano could be as young as several thousand years.Support for R.W.E. during this study was by internal NOAA funding to the NOAA Vents Program (now Earth-Ocean Interactions Program). The NSF Ridge 2000 and MARGINS programs played a major role in the planning and justification for the 2009 rapid response proposal that funded the May 2009 expedition. MBARI provided support and outstanding postprocessing of the multibeam bathymetry from the D. Allan B. AUV multibeam sonar used in this study. NSF also provided major funding for the 2009 expedition (OCE930025 and OCE-0934660 to JAR) and for the 210Po-210Pb radiometric dating (OCE-0929881 and for the 210Po-210Pb radiometric dating (OCE-0929881 to KHR)). The NOAA Office of Exploration and Research provided major funding for the 2009 and 2012 field programs.2015-04-3