The impact of a deep convection on sulfate transport and redistribution

International audienceA three-dimensional compressible cloud model was used to simulate the processes related to dynamics, microphysics and chemistry of continental non-polluted and continental polluted clouds. The chemical components are formulated in terms of continuity equations for different chemical species in the aqueous phase within the cloud. Their evolution in this model came from not only by the processes of advection and turbulence transport, but also the chemical reactions and microphysical transfers. The model includes a method of kinetic uptake limitations. Gases with low solubility H* 3 mol dm-3 atm-1 are in Henry's law equilibrium with temperature dependence of Henry's law coefficients. Seven pollutant groups are currently included in the chemistry parameterization scheme: S(IV), S(VI), (H2O2), (O3), N(V), (NH3), (CO2). The present model contains explicit treatment of SO2 and O3, a kinetic method of gas uptake as well as an improved microphysical parameterization scheme. The primary objective of this model is to study the impact of the deep convection on the pollutant transport, redistribution and deposition. It is done through chemical reactions, oxidation, scavenging of aerosol particles and transfer via microphysical transitions among water categories. Two base run simulation parameters are used to initialize the model. The first model run is for the 6 July 1995 event, characterized by intensive convective cloud activity and a large amount of precipitation, manifested as a flashflood. The second one is related to transboundary dust transport and sulfate wet deposition. The chemical field initialization is based on the vertical distribution profiles of gases and aerosols for continental non-polluted and continental polluted background. The study has revealed the importance of considering interactions between dynamics, microphysics and cloud chemistry. Deep convection in the first analyzed case generates rapid upward and downward transport of pollutants. It stimulates the impact of scavenging processes and microphysical conversions, pollutant redistribution and wet deposition. We find good agreement between calculated and observed rainfall, pH, sulfate concentration and wet deposition, in the second simulated case. Aerosol particles partially dissolved in precipitation changed their qualitative and quantitative features, acidity and increment of all chemical components. A lot of sensitivity tests of the terms included in the chemistry parameterization scheme indicate that assumption of Henry's law equilibrium leads to a factor 2 to 3 underestimate of a soluble gas in cloud water and 3 to 5 in rainwater, respectively. Our calculations demonstrate that assumption of Henry's law leads to a factor of about 1.0 to 1.3 overestimation of the integrated sulfur mass removed by wet deposition. Analysis of the relative contribution of some parameters implies that 20% - 24% of total sulfur mass deposited belongs to both nucleation and impact scavenging. Liquid phase oxidation contributed 22% and 28% of the total sulfur mass deposited for continental non-polluted and continental polluted background, respectively. Neglecting liquid-ice phase chemical reactions leads to underestimation of the total sulfur mass deposited by about a factor of 1.0 to 1.2 for continental non-polluted and continental polluted distributions, relative to the base run

Magnetic resonance imaging diagnosis of causes of cerebral palsy in a developing country: A database of South African children

Background. Cerebral palsy (CP) is a common worldwide disabling disorder. However, data about prevalence and causes of CP in developing countries are deficient because of high cost and limited availability of magnetic resonance imaging (MRI), the gold standard neuro-imaging modality for evaluation and management of CP in neonates. Objectives. To determine the frequency of CP causes in children with suspected hypoxic ischaemic injury (HII) involved in medicolegal litigation in South Africa based on MRI report findings. Methods. A total of 1 620 MRI reports were categorised into HII, non-HII and normal MRI. None of the patients had prior neuro-imaging records. HII reports were sub-classified according to pattern of brain injury into basal ganglia-thalamus (BGT), watershed (WS), combined BGT-WS, periventricular leukomalacia (PVL) and multicystic encephalomalacia. Non-HII diagnoses were sub-classified into strokes, congenital malformations, kernicterus, hydrocephalus, haemorrhages, atrophies, metabolic causes and infections. Results. The median age was 6 years. HII reports (n=1 233; 76.1%) showed BGT in 447 (27.6%), WS in 266 (16.4%), combined BGT-WS in 335 (20.7%), PVL in 58 (3.6%) and multicystic in 127 (7.8%). Non-HII diagnoses (n=255; 15.7%) showed 78 (4.8%) congenital malformations, 50 (3.1%) atrophies, 35 (2.1%) kernicterus, 23 (1.4%) strokes, 12 (0.8%) haemorrhages, 14 (0.9%) hydrocephalus, 36 (2.1%) metabolic and 7 (0.5%) infections. Normal exams were 132 (8.2%). Conclusions. Despite being performed a relatively long time – median of 6 years – after the suspected perinatal HII, MRI yielded a diagnosis in 92% and showed that only 76% were due to HII, and more importantly, that there was a preterm HII pattern of injury in 15%, which when added to the 16% of non-HII cases, could potentially save on litigation in a total of 31% of cases that are unlikely to be related to malpractice. MRI should be performed wherever possible in CP cases, even if no imaging exam was performed in the perinatal period

A Three-Dimensional Simulation of Supercell Convective Storm

A supercell convective storm is simulated by using a cloud-resolving model. Numerical experiments have been performed in 3D by using the same domain size, with a different spatial and temporal resolution of the model. High-resolution cloud model has been shown to represent convective processing quite well. Running the model in a high-resolution mode gives a more realistic view of the life cycle of convective storm, internal structure, and storm behavior. The storm structure and evolutionary properties are evaluated by comparing the modeled radar reflectivity to the observed radar reflectivity. The comparative analysis between physical parameters shows good agreement among both model runs and compares well with observations, especially using a fine spatial resolution. The lack of measurements of these species in the convective outflow region does not allow us to evaluate the model results with observations. A three-dimensional simulation using higher grid resolution mode exhibits interesting features which include a double vortex circulation, cell splitting, and secondary cell formation

A heuristic to minimize the cardinality of a real-time task set by automated task clustering

International audienceWe propose in this paper a method to automatically map functionalities (blocks of code corresponding to high-level features) with real-time constraints to tasks (or threads). We aim at reducing the number of tasks functions are mapped to, while preserving the schedulability of the initial system. We consider independent tasks running on a single processor. Our approach has been applied with fixed-task or fixed-job priorities assigned in a Deadline Monotonic (DM) or a Earliest Deadline First (EDF) manner

The attitudes of European consumers toward innovation in bread; interest of the consumers toward selected quality attributes

16 pages, 7 tables, 4 figures.-- The definitive version is available at www3.interscience.wiley.comThe present survey is integrated in the European project entitled EU-FRESHBAKE. This three years project started in October 2006. It aims at developing innovative processes and innovative formulations for the Bake Off technology taking into consideration, energy demand of the process, nutrition parameters and overall quality of the bread. To help and to advise the project on the expectations of the European consumers toward innovation, a consumer survey has been carried out taking into consideration 1050 consumers from 5 countries (Belgium, Croatia, Spain, France and Poland). The global objectives are (i) to better understand the attitudes of the European innovations in bread and (ii) to understand the main determinants of it. Globally the key points that arose from the survey were the environmental concern and the concern regarding health; these two aspects seem to steer the attitudes of the consumer. Basically, two categories of consumers were observed; (i) frequent (daily) buyers with a focus on quality and pleasure and (ii) less frequent buyers (once a week) with a more pronounced interest in nutrition and energy (process). The first group was named the crust group and the second one the crumb group. The crumb family seems to be the one that is the most interested in the outcomes of the EU-FRESHBAKE project. This group is concerned by nutrition quality and would prefer a bread which has been done with a less energy demanding process. The “crust” group is schematically less interested in the nutrition, in the shelf life and in the energy demand of the process used to prepare the bread. The results from this survey should be handled with care due to the relative small size of the sample and to the fact that the average age of the sample was rather young.This study (report, paper, workshop…) has been carried out with financial support from the Commission of the European Communities, FP6, Thematic Area “Food quality and safety”, FOOD-2006-36302 EU-FRESH BAKE.Peer reviewe

Use of solid dispersions to increase stability of dithranol in topical formulations

The present study was planned to improve the stability of dithranol using solid dispersions (SD). Two different SD at a 1:9 ratio of dithranol/excipient were prepared: one of them using glyceryl behenate as excipient and the other using a mixture of argan oil with stearic acid (1:8 ratio) as excipient. Pure dithranol and SD of dithranol were incorporated in an oil-in-water cream and in a hydrophobic ointment in a drug/dermatological base ratio of 1:10. The physical and mechanical properties of semisolid formulations incorporating the pure drug and the developed SD were evaluated through rheological and textural analysis. To evaluate the stability, L*a*b* color space parameters of SD and semisolid formulations, and pH of hydrophilic formulations were determined at defined times, during one month. Each sample was stored at different conditions namely, light exposure (room temperature), high temperature exposition (37 °C) (protected from light) and protected from light (room temperature). Despite higher values of firmness and adhesiveness, hydrophobic ointment exhibited the best rheological features compared to the oil-in-water cream, namely a shear-thinning behavior and high thixotropy. These formulations have also presented more stability, with minor changes in L*a*b* color space parameters. The results of this study indicate that is possible to conclude that the developed SD contributed to the increased stability of dithranol

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat