Measuring plume-related exhumation of the British Isles in Early Cenozoic times

Mantle plumes have been proposed to exert a first-order control on the morphology of Earth's surface. However, there is little consensus on the lifespan of the convectively supported topography. Here, we focus on the Cenozoic uplift and exhumation history of the British Isles. While uplift in the absence of major regional tectonic activity has long been documented, the causative mechanism is highly controversial, and direct exhumation estimates are hindered by the near-complete absence of onshore post-Cretaceous sediments (outside Northern Ireland) and the truncated stratigraphic record of many offshore basins. Two main hypotheses have been developed by previous studies: epeirogenic exhumation driven by the proto-Iceland plume, or multiple phases of Cenozoic compression driven by far-field stresses. Here, we present a new thermochronological dataset comprising 43 apatite fission track (AFT) and 102 (U–Th–Sm)/He (AHe) dates from the onshore British Isles. Inverse modelling of vertical sample profiles allows us to define well-constrained regional cooling histories. Crucially, during the Paleocene, the thermal history models show that a rapid exhumation pulse (1–2.5 km) occurred, focused on the Irish Sea. Exhumation is greatest in the north of the Irish Sea region, and decreases in intensity to the south and west. The spatial pattern of Paleocene exhumation is in agreement with the extent of magmatic underplating inferred from geophysical studies, and the timing of uplift and exhumation is synchronous with emplacement of the plume-related British and Irish Paleogene Igneous Province (BIPIP). Prior to the Paleocene exhumation pulse, the Mesozoic onshore exhumation pulse is mainly linked to the uplift and erosion of the hinterland during the complex and long-lived rifting history of the neighbouring offshore basins. The extent of Neogene exhumation is difficult to constrain due to the poor sensitivity of the AHe and AFT systems at low temperatures. We conclude that the Cenozoic topographic evolution of the British Isles is the result of plume-driven uplift and exhumation, with inversion under compressive stress playing a secondary role

Publisher Correction: An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence.

An amendment to this paper has been published and can be accessed via a link at the top of the paper

La cognition sociale au-delà du cerveau : une cognition inclusive

National audienc

Early Cenozoic denudation of central west Britain in response to transient and permanent uplift above a mantle plume

Upwelling mantle plumes beneath continental crust are predicted to produce difficult to quantify, modest uplift and denudation. The contribution of permanent and transient components to the uplift is also difficult to distinguish. A pulse of denudation in Britain in the Early Paleogene has been linked, although with some controversy, with the arrival of the proto-Iceland mantle plume. In this contribution we show that combining apatite and zircon (U-Th-Sm)/He and apatite fission track analyses from central west Britain with numerical modeling clearly identifies a pulse of early Cenozoic denudation. The data indicate that rock uplift and denudation were centered on the northern East Irish Sea Basin and 1.0–2.4 km of rocks were removed during the latest Cretaceous-early Paleogene. Uplift and erosion appears to have started a few million years before the earliest magmatism in the region. The regional denudation pattern mirrors the distribution of low-density magmatic rocks that has been imaged in the deep crust. However, the injection of the underplating melt is not enough to account for the total denudation. An additional regional uplift of at least 300 m is required, which is consistent with a transient thermal effect from the hot mantle plume. The rapid exhumation event ceased by ~40 Ma and the data do not require significant Neogene exhumation

Functional and clinical studies reveal pathophysiological complexity of CLCN4-related neurodevelopmental condition

Missense and truncating variants in the X-chromosome-linked CLCN4 gene, resulting in reduced or complete loss-of-function (LOF) of the encoded chloride/proton exchanger ClC-4, were recently demonstrated to cause a neurocognitive phenotype in both males and females. Through international clinical matchmaking and interrogation of public variant databases we assembled a database of 90 rare CLCN4 missense variants in 90 families: 41 unique and 18 recurrent variants in 49 families. For 43 families, including 22 males and 33 females, we collated detailed clinical and segregation data. To confirm causality of variants and to obtain insight into disease mechanisms, we investigated the effect on electrophysiological properties of 59 of the variants in Xenopus oocytes using extended voltage and pH ranges. Detailed analyses revealed new pathophysiological mechanisms: 25% (15/59) of variants demonstrated LOF, characterized by a “shift” of the voltage-dependent activation to more positive voltages, and nine variants resulted in a toxic gain-of-function, associated with a disrupted gate allowing inward transport at negative voltages. Functional results were not always in line with in silico pathogenicity scores, highlighting the complexity of pathogenicity assessment for accurate genetic counselling. The complex neurocognitive and psychiatric manifestations of this condition, and hitherto under-recognized impacts on growth, gastrointestinal function, and motor control are discussed. Including published cases, we summarize features in 122 individuals from 67 families with CLCN4-related neurodevelopmental condition and suggest future research directions with the aim of improving the integrated care for individuals with this diagnosis

Care transitions in the first 6 months following traumatic brain injury: Lessons from the CENTER-TBI study

Background: No large international studies have investigated care transitions during or after acute hospitalisations for traumatic brain injury (TBI).Objectives: To characterise various TBI-care pathways and the number of associated transitions during the first 6 months after TBI and to assess the impact of these on functional TBI outcome controlled for demographic and injury-related factors.Methods: This was a cohort study of patients with TBI admitted to various trauma centres enrolled in the Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) study. Number of transitions and specific care pathways were identified. Multiple logistic regression analyses were used to assess the impact of number of transitions and care pathways on functional outcome at 6 months post-injury as assessed by the Glasgow Outcome Scale-Extended (GOSE).Results: In total, 3133 patients survived the acute TBI-care pathway and had at least one documented in-hospital transition at 6-month follow-up. The median number of transitions was 3 (interquartile range 2-3). The number of transitions did not predict functional outcome at 6 months (odds ratio 1.08, 95% confidence interval 1.09-1.18; p = 0.063). A total of 378 different care pathways were identified; 8 were identical for at least 100 patients and characterized as "common pathways". Five of these common care pathways predicted better functional outcomes at 6 months, and the remaining 3 pathways were unrelated to outcome. In both models, increased age, violence as the cause of injury, pre-injury presence of systemic disease, both intracranial and overall injury severity, and regions of Southern/Eastern Europe were associated with unfavourable functional outcomes at 6 months.Conclusions: A high number of different and complex care pathways was found for patients with TBI, particularly those with severe injuries. This high number and variety of care pathway possibilities indicates a need for standardisation and development of "common data elements for TBI care pathways" for future studies.Study registration: ClinicalTrials.gov NCT02210221.</div

A Film of Ones Own: The Animated Self-Portraits of Young Contemporary Female Animators

This article analyses animated self-portraits created by contemporary young and emerging women in animation, and elucidates significant differences between this new generation of women animators and previous ones. Through their animated self-portraits, the earlier animatrices explored their own identity as women and artists, developing new discourses and models for a subgenre that existed from the early days of cinema animation. But the animated female self-portrayal of the new generation comes closer to documentary and has more universal concerns, appealing to a wider audience and reaching theatrical distribution; Marjane Satrapi’s feature-length animation film Persepolis (2007) exemplifies this and is a focus of the article.Lorenzo Hernández, MC. (2010). A Film of Ones Own: The Animated Self-Portraits of Young Contemporary Female Animators. Animation. 5(1):73-90. doi:10.1177/1746847709358638S739051Satrapi, M. ( 2008) ‘ Persepolis: A State of Mind’, Literal. Latin American Voices, February: 44-7