59 research outputs found

    AI for Explaining Decisions in Multi-Agent Environments

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    Explanation is necessary for humans to understand and accept decisions made by an AI system when the system's goal is known. It is even more important when the AI system makes decisions in multi-agent environments where the human does not know the systems' goals since they may depend on other agents' preferences. In such situations, explanations should aim to increase user satisfaction, taking into account the system's decision, the user's and the other agents' preferences, the environment settings and properties such as fairness, envy and privacy. Generating explanations that will increase user satisfaction is very challenging; to this end, we propose a new research direction: xMASE. We then review the state of the art and discuss research directions towards efficient methodologies and algorithms for generating explanations that will increase users' satisfaction from AI system's decisions in multi-agent environments.Comment: This paper has been submitted to the Blue Sky Track of the AAAI 2020 conference. At the time of submission, it is under review. The tentative notification date will be November 10, 2019. Current version: Name of first author had been added in metadat

    A Fluorescent Thermometer Based on a Pyrene-Labeled Thermoresponsive Polymer

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    Thermoresponsive polymers that undergo a solubility transition by variation of the temperature are important materials for the development of ‘smart’ materials. In this contribution we exploit the solubility phase transition of poly(methoxy diethylene glycol methacrylate), which is accompanied by a transition from hydrophilic to hydrophobic, for the development of a fluorescent thermometer. To translate the polymer phase transition into a fluorescent response, the polymer was functionalized with pyrene resulting in a change of the emission based on the microenvironment. This approach led to a soluble polymeric fluorescent thermometer with a temperature range from 11 °C to 21 °C. The polymer phase transition that occurs during sensing is studied in detail by dynamic light scattering

    Active zone proteins are dynamically associated with synaptic ribbons in rat pinealocytes

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    Synaptic ribbons (SRs) are prominent organelles that are abundant in the ribbon synapses of sensory neurons where they represent a specialization of the cytomatrix at the active zone (CAZ). SRs occur not only in neurons, but also in neuroendocrine pinealocytes where their function is still obscure. In this study, we report that pinealocyte SRs are associated with CAZ proteins such as Bassoon, Piccolo, CtBP1, Munc13–1, and the motorprotein KIF3A and, therefore, consist of a protein complex that resembles the ribbon complex of retinal and other sensory ribbon synapses. The pinealocyte ribbon complex is biochemically dynamic. Its protein composition changes in favor of Bassoon, Piccolo, and Munc13–1 at night and in favor of KIF3A during the day, whereas CtBP1 is equally present during the night and day. The diurnal dynamics of the ribbon complex persist under constant darkness and decrease after stimulus deprivation of the pineal gland by constant light. Our findings indicate that neuroendocrine pinealocytes possess a protein complex that resembles the CAZ of ribbon synapses in sensory organs and whose dynamics are under circadian regulation

    Measurement of the mass difference m(D-s(+))-m(D+) at CDF II

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    We present a measurement of the mass difference m(D-s(+))-m(D+), where both the D-s(+) and D+ are reconstructed in the phipi(+) decay channel. This measurement uses 11.6 pb(-1) of data collected by CDF II using the new displaced-track trigger. The mass difference is found to be m(D-s(+))-m(D+)=99.41+/-0.38(stat)+/-0.21(syst) MeV/c(2)

    Search for the rare decay B-0 ->tau(+)tau(-) at BABAR

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    We present the results of a search for the decay B-0 ->tau(+)tau(-) in a data sample of (232 +/- 3)x10(6) Upsilon(4S)-> BB decays using the BABAR detector. Certain extensions of the standard model predict measurable levels of this otherwise rare decay. We reconstruct fully one neutral B meson and seek evidence for the signal decay in the rest of the event. We find no evidence for signal events and obtain B(B-0 ->tau(+)tau(-))< 4.1x10(-3) at the 90% confidence level

    Adaptation of the disector method to rare small organelles in TEM sections exemplified by counting synaptic bodies in the rat pineal gland

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    The disector is the only objective method for quantifying particles of variable size in a given volume. With this method, cell organelles are identified on adjacent sections, but only those present in one section are counted. When counting extremely rare structures in transmission electron microscope sections (physical disector), the usual procedure of counting on electron micrographs is limited for economic reasons (e.g. micrographs highly outnumbering the investigated structures). Hence, to apply this unbiased stereological method, a modification of the physical disector concerning 3 aspects has been developed. (1) The prerequisite of screening large corresponding tissue areas (here ∌65000 ÎŒm(2)) was fulfilled by examining tissue areas along the edges of ultrathin sections. (2) The size of the counting frame was determined by measuring the lengths of the section margins (minus a guard area) by means of a Morphomat. This value was multiplied by the width of the investigated tissue zone, corresponding to the diameter of the electron microscope viewing screen. (3) Disector counting was carried out simultaneously on both sections (bidirectional disector) to improve efficiency. In the present study tiny synaptic bodies (SBs) were quantitated by disector in a rat pineal gland, yielding ∌30 SBs/1000 ÎŒm(3). By contrast, single section profile counts of SBs amounted to 90 SBs/20000 ÎŒm(2). Since the presently described adaptation of the disector is time-consuming, it is proposed to determine a proportion factor allowing to estimate number of structures per volume based on single section profile counts. This would decrease the evaluation time by more than 50%

    One millisecond of light suffices to suppress nighttime pineal melatonin synthesis in rats

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    The effcct of a single high-intensity light pulse with a duration of 1 ms on nighttime pineal activity of male Sprague-Dawley rats was investigated. 10 minutes after light exposure pineal N-actyltransferase activity and melatonin content were significantly reduced. These results show that the rat pineal is capable of responding to very short light flashes of high intensity
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