He 2-104: A link between symbiotic stars and planetary nebulae

Ultraviolet, optical and infrared observations of He 2-104 are presented, and estimates for some of the physical properties of the nebular shell are made. It is argued that He 2-104 is in transition between the D-type symbiotic star and bipolar planetary nebula phases and, as such, represents a link between subclasses of these two types of objects. The model includes a binary system with a Mira variable and a hot, evolved star. Previous mass loss has resulted in the formation of a disk of gas and dust around the whole system, while the hot star has an accretion disk which produces the observed highly ionized emission line spectrum. Emission lines from cooler, lower density gas is also observed to come from the nebula. In addition, matter is flowing out of the system in a direction perpendicular to the disk with a high velocity and is impacting upon the previously-ejected red giant wind and/or the ambient interstellar medium

Криптовалюта: особенности и риски монетарного использования в экономике России

В данной статье рассматриваются ключевые особенности криптовалют, а также реакция со стороны различных участников экономических отношений на их появление и стремительное развитие. Особое внимание уделяются оценке возможности полномасштабного внедрения криптовалют на территории РФ и открывающимся перспективам. Кроме того, рассматриваются риски, как экономического, так и социально- политического характера

Perceived Burdensomeness in Older and Younger Adults: Evaluation of the Psychometric Properties of the Interpersonal Needs Questionnaire

Perceived burdensomeness is a major risk factor in the Interpersonal Theory of Suicide, and may be particularly relevant in the older population, in which suicide rates are relatively high. However, there is currently only one widely-used measure of perceived burdensomeness, and there is currently little information on the validity of this measure for older adults. The aims were to 1) evaluate measurement invariance of the INQ-15 Perceived Burdensomeness subscale across younger and older adult age groups, and 2) evaluate the construct validity of the Perceived Burdensomeness subscale in younger and older adult age groups by comparing nomological networks in both age groups. Nested multi-group confirmatory factor analyses (CFA) were used to address measurement invariance, whereas Fisher\u27s r-to-z transformations were used to compare correlations between perceived burdensomeness and other constructs in younger and older samples. The results of the measurement invariance analysis generally supported invariance, but signals of differences in fit in older adults were present. Correlations between perceived burdensomeness and other constructs were mostly similar. However, the INQ-15 Perceived Burdensomeness subscale exhibited a significantly lower correlation with depressive symptoms in older adults compared to younger adults. This study suggests that there may be some conceptual or measurement differences in perceived burdensomeness between younger and older adults

Longitudinal associations between functional disability, depression, and suicide in middle-aged and older adults

Suicide is a significant public health problem among older adults in the United States and around the world. There has been little research to date on longitudinal change in functional disability and depressive symptoms, both of which have been posited to be associated with suicide risk among middle-aged and older adults, and their association with death by suicide. The aims of this study were to 1) characterize longitudinal change in functional disability and depressive symptoms separately; 2) characterize the directional associations between functional disability and depressive symptoms in bivariate models; and 3) determine how different patterns of change among these variables are associated with risk for death by suicide. The study used two larger population-based longitudinal datasets, the Health and Retirement Study (HRS) in the United States, and the Swedish Twin Registry (STR). Results from HRS indicated that change in functional disability and depressive symptoms is characterized by a complex system of effects, including both systematic, linear change effects and proportional change based on the level of each variable at each wave. Functional disability generally increased across time and depressive symptoms remained relatively stable, with some slight increases. A bivariate model where level of disability was associated with subsequent change in depressive symptoms was supported by the data, and latent class membership representing group differences in patterns of change within this model predicted risk for death by suicide. Cognitive impairment was significantly associated with lower risk for death by suicide, and appeared to have a suppressor effect on the association of class membership with death by suicide. In STR, functional disability did not predict risk for death by suicide. Further research is needed to characterize the complex longitudinal associations between disability and depression and their effects on suicide risk, taking into account cognitive status

Coronary artery disease severity and aortic stenosis: clinical outcomes according to SYNTAX score in patients undergoing transcatheter aortic valve implantation

Aim The aim of this study was to evaluate whether coronary artery disease (CAD) severity exerts a gradient of risk in patients with aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI). Methods and results A total of 445 patients with severe AS undergoing TAVI were included into a prospective registry between 2007 and 2012. The preoperative SYNTAX score (SS) was determined from baseline coronary angiograms. In case of revascularization prior to TAVI, residual SS (rSS) was also determined. Clinical outcomes were compared between patients without CAD (n = 158), patients with low SS (0-22, n = 207), and patients with high SS (SS >22, n = 80). The pre-specified primary endpoint was the composite of cardiovascular death, stroke, or myocardial infarction (MI). At 1 year, CAD severity was associated with higher rates of the primary endpoint (no CAD: 12.5%, low SS: 16.1%, high SS: 29.6%; P = 0.016). This was driven by differences in cardiovascular mortality (no CAD: 8.6%, low SS: 13.6%, high SS: 20.4%; P = 0.029), whereas the risk of stroke (no CAD: 5.1%, low SS: 3.3%, high SS: 6.7%; P = 0.79) and MI (no CAD: 1.5%, low SS: 1.1%, high SS: 4.0%; P = 0.54) was similar across the three groups. Patients with high SS received less complete revascularization as indicated by a higher rSS (21.2 ± 12.0 vs. 4.0 ± 4.4, P 14) was associated with higher rates of the primary endpoint at 1 year (no CAD: 12.5%, low rSS: 16.5%, high rSS: 26.3%, P = 0.043). Conclusions Severity of CAD appears to be associated with impaired clinical outcomes at 1 year after TAVI. Patients with SS >22 receive less complete revascularization and have a higher risk of cardiovascular death, stroke, or MI than patients without CAD or low S

LSST Science Book, Version 2.0

A survey that can cover the sky in optical bands over wide fields to faint magnitudes with a fast cadence will enable many of the exciting science opportunities of the next decade. The Large Synoptic Survey Telescope (LSST) will have an effective aperture of 6.7 meters and an imaging camera with field of view of 9.6 deg^2, and will be devoted to a ten-year imaging survey over 20,000 deg^2 south of +15 deg. Each pointing will be imaged 2000 times with fifteen second exposures in six broad bands from 0.35 to 1.1 microns, to a total point-source depth of r~27.5. The LSST Science Book describes the basic parameters of the LSST hardware, software, and observing plans. The book discusses educational and outreach opportunities, then goes on to describe a broad range of science that LSST will revolutionize: mapping the inner and outer Solar System, stellar populations in the Milky Way and nearby galaxies, the structure of the Milky Way disk and halo and other objects in the Local Volume, transient and variable objects both at low and high redshift, and the properties of normal and active galaxies at low and high redshift. It then turns to far-field cosmological topics, exploring properties of supernovae to z~1, strong and weak lensing, the large-scale distribution of galaxies and baryon oscillations, and how these different probes may be combined to constrain cosmological models and the physics of dark energy.Comment: 596 pages. Also available at full resolution at http://www.lsst.org/lsst/sciboo

Sensing Danger: Innate Immunology for Intrusion Detection

The immune system provides an ideal metaphor for anomaly detection in general and computer security in particular. Based on this idea, artificial immune systems have been used for a number of years for intrusion detection, unfortunately so far with little success. However, these previous systems were largely based on immunological theory from the 1970s and 1980s and over the last decade our understanding of immunological processes has vastly improved. In this paper we present two new immune inspired algorithms based on the latest immunological discoveries, such as the behaviour of Dendritic Cells. The resultant algorithms are applied to real world intrusion problems and show encouraging results. Overall, we believe there is a bright future for these next generation artificial immune algorithms

Impact of Spatial Soil and Climate Input Data Aggregation on Regional Yield Simulations

This work was financially supported by the German Federal Ministry of Food and Agriculture (BMEL) through the Federal Office for Agriculture and Food (BLE), (2851ERA01J). FT and RPR were supported by FACCE MACSUR (3200009600) through the Finnish Ministry of Agriculture and Forestry (MMM). EC, HE and EL were supported by The Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (220-2007-1218) and by the strategic funding ‘Soil-Water-Landscape’ from the faculty of Natural Resources and Agricultural Sciences (Swedish University of Agricultural Sciences) and thank professor P-E Jansson (Royal Institute of Technology, Stockholm) for support. JC, HR and DW thank the INRA ACCAF metaprogramm for funding and Eric Casellas from UR MIAT INRA for support. CB was funded by the Helmholtz project “REKLIM—Regional Climate Change”. CK was funded by the HGF Alliance “Remote Sensing and Earth System Dynamics” (EDA). FH was funded by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) under the Grant FOR1695. FE and SS acknowledge support by the German Science Foundation (project EW 119/5-1). HH, GZ, SS, TG and FE thank Andreas Enders and Gunther Krauss (INRES, University of Bonn) for support. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

An 18-month meditation training selectively improves psychological well-being in older adults: A secondary analysis of a randomised controlled trial

Objectives As the world population is ageing, it is vital to understand how older adults can maintain and deepen their psychological well-being as they are confronted with the unique challenges of ageing in a complex world. Theoretical work has highlighted the promising role of intentional mental training such as meditation practice for enhancing human flourishing. However, meditation-based randomised controlled trials in older adults are lacking. We aimed to investigate the effects of meditation training on psychological well-being in older adults. Methods This study presents a secondary analysis of the Age-Well trial (ClinicalTrials.gov: NCT02977819), which randomised 137 healthy older adults (age range: 65 to 84 years) to an 18-month meditation training, an active comparator (English language training), or a passive control. Well-being was measured at baseline, mid-intervention, and 18-month post-randomisation using the Psychological Well-being Scale (PWBS), the World Health Organisation’s Quality of Life (QoL) Assessment psychological subscale, and composite scores reflecting the meditation-based well-being dimensions of awareness, connection, insight, and a global score comprising the average of these meditation-based dimensions. Results The 18-month meditation training was superior to English training on changes in the global score (0.54 [95% CI: 0.26, 0.82], p = 0.0002) and the subscales of awareness, connection, insight, and superior to no-intervention only on changes in the global score (0.54 [95% CI: 0.26, 0.82], p = 0.0002) and awareness. Between-group differences in psychological QoL in favour of meditation did not remain significant after adjusting for multiple comparisons. There were no between-group differences in PWBS total score. Within the meditation group, psychological QoL, awareness, insight, and the global score increased significantly from baseline to 18-month post-randomisation. Conclusion The longest randomised meditation training conducted to date enhanced a global composite score reflecting the meditation-based well-being dimensions of awareness, connection, and insight in older adults. Future research is needed to delineate the cognitive, affective, and behavioural factors that predict responsiveness to meditation and thus help refine the development of tailored meditation training

Impact of mindfulness-based and health self-management interventions on mindfulness, self-compassion, and physical activity in older adults with subjective cognitive decline: A secondary analysis of the SCD-Well randomized controlled trial

INTRODUCTION: Older adults experiencing subjective cognitive decline (SCD) have a higher risk of dementia. Reducing this risk through behavioral interventions, which can increase emotional well-being (mindfulness and compassion) and physical activity, is crucial in SCD. METHODS: SCD-Well is a multicenter, observer-blind, randomized, controlled, superiority trial. Three hundred forty-seven participants (mean [standard deviation] age: 72.7 [6.9] years; 64.6% women) were recruited from memory clinics in four European sites to assess the impact of an 8-week caring mindfulness-based approach for seniors (CMBAS) and a health self-management program (HSMP) on mindfulness, self-compassion, and physical activity. RESULTS: CMBAS showed a significant within-group increase in self-compassion from baseline to post-intervention and both a within- and between-group increase to follow-up visit (24 weeks). HSMP showed a significant within- and between-group increase in physical activity from baseline to post-intervention and to follow-up visit. DISCUSSION: Non-pharmacological interventions can differentially promote modifiable factors linked to healthy aging in older adults with SCD