Towards low-latency real-time detection of gravitational waves from compact binary coalescences in the era of advanced detectors

Electromagnetic (EM) follow-up observations of gravitational wave (GW) events will help shed light on the nature of the sources, and more can be learned if the EM follow-ups can start as soon as the GW event becomes observable. In this paper, we propose a computationally efficient time-domain algorithm capable of detecting gravitational waves (GWs) from coalescing binaries of compact objects with nearly zero time delay. In case when the signal is strong enough, our algorithm also has the flexibility to trigger EM observation before the merger. The key to the efficiency of our algorithm arises from the use of chains of so-called Infinite Impulse Response (IIR) filters, which filter time-series data recursively. Computational cost is further reduced by a template interpolation technique that requires filtering to be done only for a much coarser template bank than otherwise required to sufficiently recover optimal signal-to-noise ratio. Towards future detectors with sensitivity extending to lower frequencies, our algorithm's computational cost is shown to increase rather insignificantly compared to the conventional time-domain correlation method. Moreover, at latencies of less than hundreds to thousands of seconds, this method is expected to be computationally more efficient than the straightforward frequency-domain method.Comment: 19 pages, 6 figures, for PR

GNC University: A Case Study in Partnering Business and Education through Distance Learning

In 2002, General Nutrition Corporation, Inc. contacted the Department of Food Science and Human Nutrition at the University of Florida to collaborate in offering a series of courses in introductory nutrition for GNC employees in order to equip them with basic nutrition knowledge. The purpose of this case study was to describe the GNC University program as a model for business-education partnerships via distance education, to describe student expectations for the GNC University experience, to describe student reactions to the GNC University experience, and to describe the reaction of teaching assistants to their experience with GNC University. There were several key findings in this study. Students’ expectations are to increase in nutrition knowledge, professionally and personally, and to increase in their technological skills. There is a need, in future evaluation of this program, to measure whether students feel their expectations of increased knowledge and technological skills are being met. Additionally, focus groups with teaching assistants revealed a need for greater preparation for assisting students with technical difficulties. Overall, this program shows promise for business-education partnerships through distance education

Can Anyone Hear Us? An Exploration of Echo Chambers at a Land-Grant University

Faculty at land-grant universities are expected to engage in some form of Extension, or science communication, as part of the land-grant mission. However, critics have claimed these institutions are out of touch with their stakeholders’ needs and faculty mainly communicate with others in academia. This engagement with a homogenous group reflects the concepts of echo chambers, where people are only exposed to information that aligns with their beliefs and current knowledge and discredit opposing information. An explanatory mixed-methods design was used to understand land-grant faculty’s engagement in echo chambers. A survey was distributed to a census of tenure-track faculty in the University of Florida’s Institute of Food and Agricultural Sciences to understand respondents’ engagement in echo chambers. Follow-up interviews were conducted with 13 of the survey respondents to further explore their audiences and channels used in science communication to understand their engagement in echo chambers. Survey results indicated faculty did not necessarily participate in echo chambers, but they also did not contribute to an open communication network. However, the interviews found participants were interested in reaching new audiences yet struggled to communicate with stakeholders. The participants also reported wanting to find alternative channels to peer reviewed journals to help disseminate their work. The findings from this study indicated faculty contributed to a type of echo chamber, but rather than viewing their stakeholders’ opinions as false, they simply did not hear the opinions. Agricultural communicators should work with land-grant faculty administrators to identify appropriate audiences and channels for science communication

A Study to Validate a Self-Reported Version of the ONS Drug Dependence Questionnaire

Aim: A prospective study to establish the reliability of a self-completion version of the Office for National Statistics (ONS) questionnaire for assessing drug dependence of substance misuse clients. Method: A total of 47 treatment seeking opioid-dependent clients completed the self-complete version of the ONS questionnaire (ONS-sc) followed by the interviewer-administered ONS questionnaire (ONS-ia) at a single clinic appointment. Scores for four Class A drugs (heroin, methadone, speed and crack/cocaine) from both formats were compared. Results: The observed agreement was 87% or more and Cohen's kappa was 0.7 (p < 0.001) or more for all four Class A drugs. Sensitivity for each Class A drugs was 56% or higher and specificity was 87% or higher. Sensitivity for severe heroin dependency was 98% (CI 89–100%). There was a 100% correlation between the ONS-sc and positive urine analysis for heroin use. However, methadone and crack/cocaine drug use appeared under reported. Conclusion: ONS-sc is a feasible, practical and time-saving alternative to a detailed interview on drug dependence. Further research with a larger sample size and non-opiate-dependent clients are needed, as this could prove a useful tool for monitoring clients in everyday practice, or for survey purposes where interviews are impractical

INFLUENCE OF MULTI-STAKEHOLDER INNOVATION PLATFORM APPROACH ON SMALLHOLDER FARMERS MARKETING DECISIONS

One of the very numerous decisions that smallholder farmers face world wide relates to market participation in agricultural markets and, consequently choosing the appropriate marketing channel for their agricultural produce. Such decisions impact on their incomes and subsequently on their welfare. The objective of this study was to determine how a multi-stakeholder innovation platform approach influences pigeon pea ( Cajanus Cajan L.) marketing decisions in smallholder farming in Malawi. The study relied on primary data collected from 115 households in Balaka District in Malawi during an impact survey done in November 2014. Results confirmed that the multi-stakeholder innovation platform approach improves decision making in pigeon pea marketing. Variables such as access to transport services and market information, improved extension, capacity building through farmer training, adoption of conservation agriculture and membership to farmer groups influenced marketing decisions.L\u2019une des plus nombreuses d\ue9cisions auxquelles les petits agriculteurs font face g\ue9n\ue9ralement est relative \ue0 la participation aux march\ue9s entre les march\ue9s agricoles et, par cons\ue9quent choisir les canaux appropri\ue9s de commercialisation pour leur produits agricoles. De telles d\ue9cisions impactent sur leurs revenus et ult\ue9rieurement sur leur bien-\ueatre. L\u2019objectif de cette \ue9tude \ue9tait de determiner comment l\u2019approche de la plate-forme d\u2019innovation multipartite influence les d\ue9cisions de commercialisation du pois d\u2019angole ( Cajanus Cajan L.) chez les petits exploitants agricoles au Malawi. L\u2019\ue9tude s\u2019est bas\ue9e sur des donn\ue9es primaires collect\ue9es sur 115 m\ue9nages dans le district de Balaka au Malawi au cours d\u2019une enqu\ueate d\u2019impact conduit en Novembre 2014. Les r\ue9sultats ont confirm\ue9 que l\u2019approche de la plate-forme d\u2019innovation multipartite am\ue9liore la prise de d\ue9cision de la commercilisation du pois d\u2019angole. Les variables tells que l\u2019acc\ue8s aux services de transport et au march\ue9 d\u2019information, am\ue9liorent la vulgaristaion, le renforcement des capacit\ue9s \ue0 travers la formation des producteurs, l\u2019adoption de l\u2019agriculture de conservation et les groupements de producteurs ont influenc\ue9 les d\ue9cisions de commercilalisation

COLLECTIVE MARKET PARTICIPATION FOR IMPROVED INCOME AMONG SMALLHOLDER FARMING HOUSEHOLDS: A CASE OF BALAKA INNOVATION PLATFORM IN MALAWI

Collective market participation can reduce transaction costs and information asymmetries, which can build up market power. The objective of this study was to evaluate decisions to participate in collective marketing and its effect on household income among smallholder farmers in an Innovation Platform (IP). This study targeted the Balaka IP in Malawi. Collective marketing identified as critical for improving households\u2019 incomes, is one of the activities that Balaka Innovation Platform has been addressing since its formation in 2009. The study involved a sample of 115 randomly selected households from Balaka Innovation Platform. The odds of participating in collective marketing by smallholder farm households in Balaka was significantly influenced by gender, education level, access to social capital through membership in farmer groups that form the Innovation Platform, farming experience, adoption/practice of conservation agriculture and possession of assets e.g. cellphone and bicycle. Moreover, results indicate that functions of IPs such as organising farmers to market collectively, promoting crop diversification, improved extension service, credit access through linkages to microfinance, communication and market linkages, positively influence income. Thus participation in multi-stakeholder IP activities highly influences collective marketing, which in turn impacts positively on smallholder farming households\u2019 income.La participation collective au march\ue9 peut r\ue9duire les co\ufbts de transaction et les assym\ue9tries d\u2019information; lesquelles peuvent constituer un pouvoir du march\ue9. L\u2019objectif de cette \ue9tude \ue9tait d\u2019\ue9valuer les d\ue9cisions \ue0 participer \ue0 la commercialisation collective et leur effet sur le revenu des m\ue9nages entre les petits exploitants agricoles dans une Plate-forme d\u2019Innovation (IP). Cette \ue9tude s\u2019est focalis\ue9e sur le Balaka IP au Malawi. La commercialisation collective identifi\ue9e comme essentielle pour l\u2019am\ue9lioration des revenus de m\ue9nages, est une des activit\ue9s que la Plate-forme d\u2019Innovation de Balaka a toujours abord\ue9 depuis sa mise en place en 2009. Cette \ue9tude a utilis\ue9 un \ue9chantillon de 115 m\ue9nages al\ue9atoirement select\ue9s dans la Plate-forme d\u2019Innovation de Balaka. Les chances de participation des petits exploitants agricoles \ue0 la commercialisation collective au Balaka \ue9tait significativement influenc\ue9es par le genre, le niveau d\u2019\ue9ducation, l\u2019acc\ue8s au capital social \ue0 travers les groupements de producteurs qui forment la Plate-forme d\u2019Innovation, l\u2019exp\ue9rience agricole, l\u2019adoption/la pratique de l\u2019agriculture conservative et la possession d\u2019actifs eg. t\ue9l\ue9phone cellulaire et bicyclette. De plus, les r\ue9sultats montrent que les fonctions des IPs telles que: organiser les agricultures \ue0 commercialiser collectivement, promouvoir la diversification de culture, le service am\ue9lior\ue9 de vulgarisation, l\u2019acc\ue8s au credit en liaison avec la microfinance, la communication et les liens commerciaux, influencent posistivement le revenu. Ainsi, la participation multipartite aux activit\ue9s de l\u2019IP influence la commercialisation collective, qui en cons\ue9quence impacte positvement sur le revenu des petits exploitants agricoles

Effect of the exercise programme on the quality of life of prostate cancer survivors: A randomized controlled trial

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Detection of SARS-CoV-2 RNA in the Danube river in Serbia associated with the discharge of untreated wastewaters

In Serbia less than 13 % of collected municipal wastewaters is being treated before their release in the environment. This includes all municipal wastewater discharges from Belgrade (capital city of Serbia; population 1,700,000). Previous research has identified the impacts of raw wastewater discharges from Belgrade on the Danube River, and this study investigated if such discharges also provided a pathway for SARS-CoV-2 RNA material. Samples were collected during the most critical circumstances that occurred so far within the COVID-19 pandemics in Serbia. Grab and composite samples were collected in December 2020, during the peak of the third wave (in terms of reported cases) at the site which receives the wastewater loads in Belgrade. Grab samples collected upstream and downstream of Belgrade were also analyzed. RNA was quantified using RT-qPCR with primer sets targeting nucleocapsid (N1 and N2) and envelope (E) protein genes. SARS-CoV-2 RNA (5.97×103 to 1.32×104 copies/L) was detected only in samples collected at the site strongly impacted by the wastewaters where all three applied primer sets gave positive signals. Determined concentrations correspond to those reported in wastewater influents sampled at treatment plants in other countries indicating an epidemiological indicator function of used approach for rivers with high pollution loads in countries with poor wastewater treatment

Design, synthesis, and antimicrobial evaluation of a novel bone-targeting bisphosphonate-ciprofloxacin conjugate for the treatment of osteomyelitis biofilms

Osteomyelitis is a major problem worldwide and is devastating due to the potential for limb-threatening sequelae and mortality. Osteomyelitis pathogens are bone-attached biofilms, making antibiotic delivery challenging. Here we describe a novel osteoadsorptive bisphosphonate-ciprofloxacin conjugate (BV600022), utilizing a “target and release” chemical strategy, which demonstrated a significantly enhanced therapeutic index versus ciprofloxacin for the treatment of osteomyelitis in vivo. In vitro antimicrobial susceptibility testing of the conjugate against common osteomyelitis pathogens revealed an effective bactericidal profile and sustained release of the parent antibiotic over time. Efficacy and safety were demonstrated in an animal model of periprosthetic osteomyelitis, where a single dose of 10 mg/kg (15.6 μmol/kg) conjugate reduced the bacterial load by 99% and demonstrated nearly an order of magnitude greater activity than the parent antibiotic ciprofloxacin (30 mg/kg, 90.6 μmol/kg) given in multiple doses. Conjugates incorporating a bisphosphonate and an antibiotic for bone-targeted delivery to treat osteomyelitis biofilm pathogens constitute a promising approach to providing high bone-antimicrobial potency while minimizing systemic exposure

To sit or stand? A preliminary, cross sectional study to investigate if there is a difference in glenohumeral subluxation in sitting or standing in people following stroke

Background: Glenohumeral subluxation (GHS) is a common symptom following stroke. Many therapists postulate that GHS may be reduced if the base of support (BOS) is reduced and the centre of mass (COM) is raised as this requires greater postural muscle activity. However, there is little empirical evidence to support this practice. Objective: The aim of this preliminary study was to investigate if the amount of GHS alters from sitting to standing. Study design: A cross sectional, within-subject design in a convenience sample of 15 stroke patients with GHS was utilised. Methods: A prospective design was used with a single blinded tester who assessed GHS using the calliper method in sitting, standing and on return to sitting. Friedman and post hoc Wilcoxon tests showed that GHS was significantly reduced in standing compared to sitting (p <0.05) but this reduction was not maintained on return to sitting (p = 0.25). Conclusions: The results of this study are limited by its small size. However, these results indicate that reducing BOS during rehabilitation may improve GHS after stroke. Whilst the maintenance of benefit is not established, these findings suggest that reducing BOS as part of treatment may help patients with GHS. Further research is now required to replicate these results in a larger sample and to directly examine shoulder muscle activity to investigate which muscles may influence GHS in response to changing BOS. Future work could also aim to determine whether the reduction in GHS was directly attributable to a reduced BOS or the effort associated with moving from sitting to standing