Evaluación de la tendencia en el diseño de espacios de trabajo flexibles y su impacto en la productividad y el bienestar de los empleados

La investigación, basada en una revisión sistemática de literatura, tiene la necesidad de verificar casos de estudios previos, situaciones donde se involucre al usuario, encuestas ya realizadas, a fin de identificar momentos que marcaron una evolución en el esquema laboral tradicional. Se hace énfasis en la experiencia, productividad y bienestar de los empleados, situándolos en una línea de tiempo; siendo la COVID-19 un punto de inflexión, el mundo experimenta nuevos retos y sale del paradigma laboral presencial, se toma nuevos lineamientos para cuantificar la productividad, surgen los cuestionamientos de la empresa con los empleados, logrando realizar un equilibrio entre las partes

High frequencies of telomeric associations, chromosome aberrations, and sister chromatid exchanges in ulcerative colitis

Chromosome instability provides a predisposing background to malignancy, contributing to the crucial genetic changes in multistep carcinogenesis. The aim of this work was to analyze chromosome instability in patients with ulcerative colitis (UC) to achieve a better understanding of the increased risk for colorectal cancer. METHODS: Peripheral blood lymphocyte cultures from 20 untreated UC patients and 24 controls were used to study chromosome instability by assessing telomeric associations (TAS), chromosome aberrations (CA), and sister chromatid exchanges (SCE). RESULTS: Mean frequencies of TAS and CA were significantly increased in UC patients compared to controls (p < 0.001). Chromosomes 10, 11, 21, 16, and 19 were the most frequently involved in TAS. A total of 104 CA clustered in 66 breakpoints could be exactly localized. Seven nonrandom bands significantly affected in UC patients were found (p < 0.004), showing a significant correlation with the location of cancer breakpoints (p < 0.003), particularly with colorectal carcinoma rearrangements. SCE analysis showed higher levels in patients compared to controls (p < 0.006), but no differences were observed in cell cycle kinetics. CONCLUSIONS: Our results demonstrate the presence of an unstable genome in UC patients that could be related to the cancer development observed in this disease.Fil: Cottliar, Alejandra. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; ArgentinaFil: Fundia, Ariela Freya. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; ArgentinaFil: Boerr, Luis. Hospital de Gastroenterología “Bonorino Udaondo,; ArgentinaFil: Sambuelli, Alicia. Hospital de Gastroenterología “Bonorino Udaondo,; ArgentinaFil: Negreira, Silvia. Hospital de Gastroenterología “Bonorino Udaondo,; ArgentinaFil: Gil, Anibal. Hospital de Gastroenterología “Bonorino Udaondo,; ArgentinaFil: Gomez, Juan Carlos. Provincia de Buenos Aires. Hospital Interzonal General de Agudos Gral. San Martin; ArgentinaFil: Chopita, Nestor. Provincia de Buenos Aires. Hospital Interzonal General de Agudos Gral. San Martin; ArgentinaFil: Bernedo, Alberto. Provincia de Buenos Aires. Hospital Interzonal General de Agudos Gral. San Martin; ArgentinaFil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentin

Temperatura neutral y rangos de confort térmico para exteriores, período cálido en clima cálido seco

El estimar las temperaturas de confort térmico en espacios exteriores permite obtener información que sirve de base para generar propuestas de diseño, cuyas condiciones ambientales propicien el confort térmico de los usuarios. Se presenta la estimación de temperatura neutral y rangos de confort térmico para espacios exteriores de un parque recreativo, en el período cálido en un clima desértico. El estudio fue desarrollado en Mexicali, Baja California, México. Se diseñó un cuestionario basado en la escala de sensaciones térmicas de ISO 10551, se midieron temperatura de bulbo seco, temperatura de globo gris, humedad relativa y velocidad de viento. Se aplicaron 822 encuestas en julio y agosto del 2008. Se estimaron temperatura neutra y rangos de confort con el método de medias por intervalo de sensación térmica. El análisis se hizo para tres niveles de actividad: pasiva, moderada e intensa y uno combinado con los tres niveles. Los valores de temperatura neutra obtenidos son aproximadamente simétricos con respecto a sus rangos de confort térmico. Las temperaturas neutras obtenidas muestran que los sujetos en actividad intensa, con práctica periódica de ejercicio y hábitos apropiados a las condiciones de clima, tienen una temperatura de confort térmico similar a aquellos con actividad pasiva

La imagen y la narrativa como herramientas para el abordaje psicosocial en escenarios de violencia. Tunja, Cucaita y Soatá.

La imagen y la narrativa como herramientas para el abordaje psicosocial en escenarios de violencia. Tunja, Cucaita y Soatá.Este trabajo da a conocer la realidad que se ha vivido tras el conflicto armado en Colombia, reconociéndolo por medio del enfoque narrativo como instrumento de trabajo para realizar una intervención desde el campo psicosocial como futuros profesionales de la psicología. En un primer paso se realiza el análisis del relato de Carlos, un sujeto que desde su construcción subjetiva busca romper con la cadena de la victimización y en el cual se identifica cómo su discurso intenta escaparse de las imágenes de violencia para convertirlo en un sobreviviente; siguiendo el mismo relato se formulan interrogantes que desde la entrevista buscan reconocer impactos psicosociales y símbolos que sirvan de apoyo para la intervención. Luego se profundiza en la revisión del caso Pandurí y desde una postura de acompañamiento se logran estrategias psicosociales para el uso de recursos de afrontamiento superando la estigmatización y brindando apoyo para la reconstrucción de la memoria histórica dejando atrás la violencia. Finalmente apoyándose en la herramienta foto voz se logra la sistematización de experiencias en diferentes contextos cercanos logrando imágenes que por medio de la metáfora acercan al observador a la realidad del postconflicto y la percepción de violencia. En este sentido desde el diplomado de acompañamiento psicosocial en escenarios de violencia se dan los primero pasos y acercamientos a los futuros profesionales de psicología en el contexto actual de los actores que deja el conflicto armado y se generan sus primeras impresiones, análisis y búsqueda de estrategias para su acompañamiento.This work unveils the reality that has been experienced after the armed conflict in Colombia, recognizing by means of the narrative approach as a work tool to carry out an intervention from the psychosocial field as future professionals of the psychology. In A first step is carried out the analysis of the story of Carlos Arturo, a subject from his subjective construction seeks to break the chain of victimization and in which identifies how his speech tries to escape the images of violence to turn it into a Survivor Following the same story, questions are asked that from the interview seek to recognize psychosocial impacts and symbols that serve as support for intervention. Then deepened in the review of the case Pandurí and from an accompanying posture are achieved psychosocial strategies for the use of coping resources overcoming stigmatization and providing support for the reconstruction of historical memory leaving Behind the violence. Finally supported in the tool photo voice is achieved the systematization of experiences in different contexts close by achieving images that by means of the metaphor bring the observer to the reality of post-conflict and the perception of violence. In this sense, since the Diploma of psychosocial accompaniment in scenarios of violence, the first steps and approaches to future psychology professionals are given in the current context of the actors who leave the armed conflict and generate their first Impressions, analysis and search of strategies for their accompaniment

A View from the Past Into our Collective Future: The Oncofertility Consortium Vision Statement

Today, male and female adult and pediatric cancer patients, individuals transitioning between gender identities, and other individuals facing health extending but fertility limiting treatments can look forward to a fertile future. This is, in part, due to the work of members associated with the Oncofertility Consortium. The Oncofertility Consortium is an international, interdisciplinary initiative originally designed to explore the urgent unmet need associated with the reproductive future of cancer survivors. As the strategies for fertility management were invented, developed or applied, the individuals for who the program offered hope, similarly expanded. As a community of practice, Consortium participants share information in an open and rapid manner to addresses the complex health care and quality-of-life issues of cancer, transgender and other patients. To ensure that the organization remains contemporary to the needs of the community, the field designed a fully inclusive mechanism for strategic planning and here present the findings of this process. This interprofessional network of medical specialists, scientists, and scholars in the law, medical ethics, religious studies and other disciplines associated with human interventions, explore the relationships between health, disease, survivorship, treatment, gender and reproductive longevity. The goals are to continually integrate the best science in the service of the needs of patients and build a community of care that is ready for the challenges of the field in the future

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to &lt;90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], &gt;300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of &lt;15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P&lt;0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P&lt;0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

PENSAMIENTO CRÍTICO EN LA INVESTIGACIÓN CIENTÍFICA Y ACADÉMICA COLECCIÓN CIENTÍFICA EDUCACIÓN, EMPRESA Y SOCIEDAD

PENSAMIENTO CRÍTICO EN LA INVESTIGACIÓN CIENTÍFICA Y ACADÉMICA COLECCIÓN CIENTÍFICA EDUCACIÓN, EMPRESA Y SOCIEDAD Primera Edición 2023 Vol. 21 Editorial EIDEC Sello Editorial EIDEC (978-958-53018) NIT 900583173-1 ISBN: 978-628-95884-1-5 Formato: Digital PDF (Portable Document Format) DOI: https://doi.org/10.34893/e1150-3660-8721-s Publicación: Colombia Fecha Publicación: 13/09/2023 Coordinación Editorial Escuela Internacional de Negocios y Desarrollo Empresarial de Colombia – EIDEC Centro de Investigación Científica, Empresarial y Tecnológica de Colombia – CEINCET Red de Investigación en Educación, Empresa y Sociedad – REDIEES Revisión y pares evaluadores Centro de Investigación Científica, Empresarial y Tecnológica de Colombia – CEINCET Red de Investigación en Educación, Empresa y Sociedad – REDIEE