Young People in the Labour Market

Bakalářská práce se zabývá mladými lidmi na trhu práce. Mladí lidé jsou často spojování s nedostatkem zkušeností, dovedností či kvalifikace, a proto jsou také řazeni mezi rizikové skupiny trhu práce. Jejím cílem je na základě teoretických znalostí identifikovat problémy mladých lidí na trhu práce v České republice se zaměřením na Moravskoslezský kraj a navrhnout opatření politiky zaměstnanosti, které mohou přispět k podpoře zaměstnatelnosti a zaměstnanosti mladých lidí v ČR a Moravskoslezském kraji. Vytyčený cíl se podařilo v průběhu jednotlivých kapitol naplnit. Bakalářská práce je rozčleněna do 6 kapitol. První kapitola je úvod. Druhá kapitola na základě teoretických znalostí popisuje mladé lidi jako znevýhodněnou skupinu na trhu práce. Třetí kapitola je zaměřena na podporu zaměstnávaní mladých osob v Evropské unii, České republice a Moravskoslezském kraji. Ve čtvrté kapitole je provedena analýza nezaměstnanosti mladých lidí v Moravskoslezském kraji. Také jsou zde popsány vybrané problémy trhu práce. Návrhy a doporučení ke zlepšení postavení mladých osob na trhu práce jsou součástí páté kapitoly. Poslední kapitolu tvoří závěr.The bachelor thesis deals with young people at the labour market. Young people are often associated with a lack of experience, skills or qualifications and are therefore also ranked among risky groups of the labour market. The aim of the thesis is to identify on the basis of theoretical knowledge the problems of young people at the labour market in the Czech Republic focusing on the Moravian-Silesian Region and to propose employment policy measures that can contribute to supporting the ability employment and employment of young people in the CR and the Moravian-Silesian Region. The goal has been fulfilled in the individual chapters. The bachelor thesis is divided into 6 chapters. The first chapter is an introduction. The second chapter based on theoretical knowledge describes young people as a disadvantaged group at the labour market. The third chapter focuses on supporting the employment of young people in the European Union, the Czech Republic and the Moravian-Silesian Region. The fourth chapter analyzes the unemployment of young people in the Moravian-Silesian Region. There are also described selected problems of the labour market. Suggestions and recommendations for improving the position of young people in the labour market are part of the fifth chapter. The last chapter is the conclusion.153 - Katedra veřejné ekonomikyvýborn

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

To nap or not to nap: is the wujiao a healthy habit?

Circadian clocks in health and diseas

Interacting epidemics? Sleep curtailment, insulin resistance, and obesity

Circadian clocks in health and diseas

Different subsets of newborn granule cells: a possible role in epileptogenesis?

Several factors, including epileptic seizures, can strongly stimulate ongoing neurogenesis in the adult hippocampus. Although adult-born granule cells generated after seizure activity have different physiological properties from their normal counterparts, they integrate into the existing, mature network of the adult hippocampal dentate gyrus. However, the exact role of the neurogenic response during epilepsy and its possible involvement in epileptogenesis have remained elusive. Here, we discuss recent studies shedding new light on the interplay between epilepsy and neurogenesis, and try to explain discrepancies in this literature by proposing seizure severity-dependent induction of two subsets of newborn cells with different properties. We hypothesise that a low seizure intensity would stimulate neurogenesis to a 'physiological plasticity' level and have few pathological consequences. In contrast, a high initial seizure intensity may induce a specific subset of altered and/or ectopically located new granule cells with different electrophysiological properties that could initiate hyperexcitatory recurrent networks that could, in turn, contribute to chronic epilepsy. This hypothesis may clarify previously contradictory data in the literature, and could thereby aid in our understanding of the role of neurogenesis in epileptogenesis, and open up promising avenues for therapeutic intervention