Full modal analysis of the Brillouin gain spectrum of an optical fiber

We present a numerical study of stimulated Brillouin scattering in optical fibers based on a full modal analysis of the acoustic and optical properties. The computation of each acoustic mode supported by the fiber structure allows us a deep and detailed investigation of the characteristics of the Brillouin gain spectrum. We focus our attention on optical fibers acting as acoustic antiwaveguides where the biggest contribution to the Brillouin response often comes from very high-order modes but it is sometimes overlooked because of computational issues. Our analysis clearly highlights their role and their dependence on the physical and geometrical structure of the fiber

The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression

Mutations in the gene autoimmune regulator (AIRE) cause autoimmune polyendocrinopathy candidiasis ectodermal dystrophy. AIRE is expressed in thymic medullary epithelial cells, where it promotes the expression of tissue-restricted antigens. By the combined use of biochemical and biophysical methods, we show that AIRE selectively interacts with histone H3 through its first plant homeodomain (PHD) finger (AIRE–PHD1) and preferentially binds to non-methylated H3K4 (H3K4me0). Accordingly, in vivo AIRE binds to and activates promoters containing low levels of H3K4me3 in human embryonic kidney 293 cells. We conclude that AIRE–PHD1 is an important member of a newly identified class of PHD fingers that specifically recognize H3K4me0, thus providing a new link between the status of histone modifications and the regulation of tissue-restricted antigen expression in thymus

Excitation function shape and neutron spectrum of the Li 7 ( p , n ) Be 7 reaction near threshold

The forward-emitted low energy tail of the neutron spectrum generated by the $^{7}\mathrm{Li}(p,n)^{7}\mathrm{Be}$ reaction on a thick target at a proton energy of 1893.6 keV was measured by time-of-flight spectroscopy. The measurement was performed at BELINA (Beam Line for Nuclear Astrophysics) of the Laboratori Nazionali di Legnaro. Using the reaction kinematics and the proton on lithium stopping power the shape of the excitation function is calculated from the measured neutron spectrum. Good agreement with two reported measurements was found. Our data, along with the previous measurements, are well reproduced by the Breit-Wigner single-resonance formula for $s$-wave particles. The differential yield of the reaction is calculated and the widely used neutron spectrum at a proton energy of 1912 keV was reproduced. Possible causes regarding part of the 6.5% discrepancy between the ^{197}\mathrm{Au}(n,\ensuremath{\gamma}) cross section measured at this energy by Ratynski and Kappeler [Phys. Rev. C 37, 595 (1988)] and the one obtained using the Evaluated Nuclear Data File version B-VII.1 are given

Optical observations of the young supernova remnant SNR 0540-69.3 and its pulsar

We have used the ESO NTT/EMMI and VLT/FORS1 instruments to examine the LMC supernova remnant 0540-69.3 as well as its pulsar (PSR B0540-69) and pulsar-powered nebula in the optical range.Spectroscopic observations of the remnant covering the range of 3600-7350 A centered on the pulsar produced results consistent with those of Kirshner et al. (1989), but also revealed many new emission lines. The most important are [Ne III] 3869, 3967 and Balmer lines of hydrogen. In both the central part of the remnant, as well as in nearby H II regions, the [O III] temperature is higher than about 20 000 K, but lower than previously estimated. For PSR B0540-69, previous optical data are mutually inconsistent: HST/FOS spectra indicate a significantly higher absolute flux and steeper spectral index than suggested by early time-resolved groundbased UBVRI photometry. We show that the HST and VLT spectroscopic data for the pulsar have more then about 50% nebular contamination, and that this is the reason for the previous difference. Using HST/WFPC2 archival images obtained in various bands from the red part of the optical to the NUV range we have performed an accurate photometric study of the pulsar, and find that the spectral energy distribution of the pulsar emission has a negative slope with 1.07 +/- 0.2. This is steeper than derived from previous UBVRI photometry, and also different from the almost flat spectrum of the Crab pulsar. We also estimate that the proper motion of the pulsar is 4.9 +/- 2.3 mas/yr, corresponding to a transverse velocity of 1190 +/- 560 km/s, projected along the southern jet of the pulsar nebula.Comment: To appear in the conference proceedings '35th COSPAR Scientific Assembly. E1.4-0058-04, Paris, France, 18 - 25 July 2004'. Paper with full resolution images can be found at ftp://ftp.astro.su.se/pub/supernova/natalia/0540psr_snr_fin.pd

New approach to privacy-preserving clinical decision support systems for HIV treatment

Background: HIV treatment prescription is a complex process. Clinical decision support systems (CDSS) are a category of health information technologies that can assist clinicians to choose optimal treatments based on clinical trials and expert knowledge. The usability of some CDSSs for HIV treatment would be significantly improved by using the knowledge obtained by treating other patients. This knowledge, however, is mainly contained in patient records, whose usage is restricted due to privacy and confidentiality constraints. Methods: A treatment effectiveness measure, containing valuable information for HIV treatment prescription, was defined and a method to extract this measure from patient records was developed. This method uses an advanced cryptographic technology, known as secure Multiparty Computation (henceforth referred to as MPC), to preserve the privacy of the patient records and the confidentiality of the clinicians’ decisions. Findings: Our solution enables to compute an effectiveness measure of an HIV treatment, the average time-to-treatment-failure, while preserving privacy. Experimental results show that our solution, although at proof-of-concept stage, has good efficiency and provides a result to a query within 24 min for a dataset of realistic size. Interpretation: This paper presents a novel and efficient approach HIV clinical decision support systems, that harnesses the potential and insights acquired from treatment data, while preserving the privacy of patient records and the confidentiality of clinician decisions

Impulsiveness, postprandial blood glucose and glucoregulation affect measures of behavioral flexibility

Behavioral flexibility (BF) performance is influenced by both psychological and physiological factors. Recent evidence suggests that impulsivity and blood glucose can affect executive function, of which BF is a subdomain. Here, we hypothesized that impulsivity, fasting blood glucose (FBG), glucose changes (i.e. glucoregulation) from postprandial blood glucose (PBG) following the intake of a 15g glucose beverage could account for variability in BF performance. The Stroop Color-Word Test and the Wisconsin Card Sorting Test (WCST) were used as measures of BF, and the Barratt Impulsiveness Scale (BIS-11) to quantify participants’ impulsivity. In Study 1, neither impulsivity nor FBG could predict performance on the Stroop or the WCST. In Study 2, we tested whether blood glucose levels following the intake of a sugary drink, and absolute changes in glucose levels following the intake of the glucose beverage could better predict BF. Results showed that impulsivity and the difference in blood glucose between time 1 (postprandial) and time 2, but not blood glucose levels at time 2 per se could account for variation in performance on the WCST but not on the Stroop task. More specifically, lower impulsivity scores on the BIS-11, and smaller differences in blood glucose levels from time 1 to time 2 predicted a decrease in the number of total and perseverative errors on the WCST. Our results show that measures of impulsivity and glucoregulation can be used to predict BF. Importantly our data extend the work on glucose and cognition to a clinically relevant domain of cognition

Association of kidney disease measures with risk of renal function worsening in patients with type 1 diabetes

Background: Albuminuria has been classically considered a marker of kidney damage progression in diabetic patients and it is routinely assessed to monitor kidney function. However, the role of a mild GFR reduction on the development of stage 653 CKD has been less explored in type 1 diabetes mellitus (T1DM) patients. Aim of the present study was to evaluate the prognostic role of kidney disease measures, namely albuminuria and reduced GFR, on the development of stage 653 CKD in a large cohort of patients affected by T1DM. Methods: A total of 4284 patients affected by T1DM followed-up at 76 diabetes centers participating to the Italian Association of Clinical Diabetologists (Associazione Medici Diabetologi, AMD) initiative constitutes the study population. Urinary albumin excretion (ACR) and estimated GFR (eGFR) were retrieved and analyzed. The incidence of stage 653 CKD (eGFR < 60 mL/min/1.73 m2) or eGFR reduction > 30% from baseline was evaluated. Results: The mean estimated GFR was 98 \ub1 17 mL/min/1.73m2 and the proportion of patients with albuminuria was 15.3% (n = 654) at baseline. About 8% (n = 337) of patients developed one of the two renal endpoints during the 4-year follow-up period. Age, albuminuria (micro or macro) and baseline eGFR < 90 ml/min/m2 were independent risk factors for stage 653 CKD and renal function worsening. When compared to patients with eGFR > 90 ml/min/1.73m2 and normoalbuminuria, those with albuminuria at baseline had a 1.69 greater risk of reaching stage 3 CKD, while patients with mild eGFR reduction (i.e. eGFR between 90 and 60 mL/min/1.73 m2) show a 3.81 greater risk that rose to 8.24 for those patients with albuminuria and mild eGFR reduction at baseline. Conclusions: Albuminuria and eGFR reduction represent independent risk factors for incident stage 653 CKD in T1DM patients. The simultaneous occurrence of reduced eGFR and albuminuria have a synergistic effect on renal function worsening

Full modal analysis of the Brillouin gain spectrum of an optical fiber

We present a numerical study of stimulated Brillouin scattering in optical fibers based on a full modal analysis of the acoustic and optical properties. The computation of each acoustic mode supported by the fiber structure allows us a deep and detailed investigation of the characteristics of the Brillouin gain spectrum. We focus our attention on optical fibers acting as acoustic antiwaveguides where the biggest contribution to the Brillouin response often comes from very high-order modes but it is sometimes overlooked because of computational issues. Our analysis clearly highlights their role and their dependence on the physical and geometrical structure of the fiber

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