A survey of techniques for reducing interference in real-time applications on multicore platforms

This survey reviews the scientific literature on techniques for reducing interference in real-time multicore systems, focusing on the approaches proposed between 2015 and 2020. It also presents proposals that use interference reduction techniques without considering the predictability issue. The survey highlights interference sources and categorizes proposals from the perspective of the shared resource. It covers techniques for reducing contentions in main memory, cache memory, a memory bus, and the integration of interference effects into schedulability analysis. Every section contains an overview of each proposal and an assessment of its advantages and disadvantages.This work was supported in part by the Comunidad de Madrid Government "Nuevas Técnicas de Desarrollo de Software de Tiempo Real Embarcado Para Plataformas. MPSoC de Próxima Generación" under Grant IND2019/TIC-17261

Revisão sistemática sobre a resiliência como fator influente durante o estágio adolescente

Introducción: La resiliencia se identifica como el proceso por el cual se produce una mejora y crecimiento personal debido a la superación de situaciones y dificultades estresantes. Se desarrolla y se adquiere en base al desarrollo personal, fruto de procesos sociales, psicológicos, externos e internos. Objetivos: El presente estudio se plantea como objetivo realizar una revisión sistemática sobre la resiliencia, su conceptualización, tratamiento y su alcance en la etapa adolescente. Material y métodos: Se utilizaron las bases de datos Web of Science y Scopus. Como descriptores de búsqueda de incluyeron tanto en castellano como en inglés siendo“resiliencia”, “adolescentes” y “educación”, y estableciéndose un rango desde 2007 hasta 2017. Resultados y discusión: Se encontraron un total de 347 documentos, repartidos en 231 en Web of Science y 116 en Scopus, resultando la muestra de esta revisión 20 artículos científicos como aquellos afines a la finalidad planteada. Tras la revisión analizada se plantea la necesidad de llevar el trabajo y concienciación de la importancia de la resiliencia para el correcto desarrollo y resolución de problemas y situaciones planteadas en la vida diaria, de forma que las familias y la escuela presentan un papel fundamental para este objetivo. Conclusiones: Es esencial el conocimiento de los factores señalados con anterioridad para promover la resiliencia entre los más jóvenes.Introduction: Resilience is identified as the process by which personal improvement and growth occurs due to the overcoming of stressful situations and difficulties. It is developed and acquired based on personal development, the result of social, psychological, external and internal processes. Objectives: This study aims to conduct a systematic review of resilience, its conceptualization, treatment and its scope in the adolescent stage. Material and methods: The bibliographic search was carried out through the Web of Science and Scopus. As search descriptors, they included both Spanish and English being "resilience", "adolescents" and "education", and establishing a range from 2007 to 2017. Results: A total of 347 documents were found, distributed in 231 in Web of Science and 116 in Scopus, resulting in the sample of this review 20 scientific articles as those related to the proposed purpose. Discussion and conclusions: After the review analyzed, the need to carry out the work and awareness of the importance of resilience for the correct development and resolution of problems and situations raised in daily life, so that families and the school present a fundamental role for this objective, being essential the knowledge of the factors indicated previously to promote resilience among the youngest.Introdução: Introdução: a resiliência é identificada como o processo pelo qual a melhoria e o crescimento pessoal ocorrem devido à superação de situações e dificuldades estressantes. É desenvolvido e adquirido com base no desenvolvimento pessoal, resultado de processos sociais, psicológicos, externos e internos. Objetivos: Este estudo tem como objetivo realizar uma revisão sistemática da resiliência, sua conceituação, tratamento e seu escopo na fase adolescente. Material e métodos: a busca bibliográfica foi realizada através dos portais Web of Science e Scopus. Como descritores de pesquisa, eles incluíam espanhol e inglês como "resiliência", "adolescentes" e "educação", e estabelecendo um intervalo de 2007 a 2017. Resultados: Foram encontrados 347 documentos, distribuídos em 231 na Web de Ciência e 116 em Scopus, resultando na amostra desta revisão 20 artigos científicos como aqueles relacionados ao propósito proposto. Discussão e conclusões: após a análise analisada, a necessidade de realizar o trabalho e a conscientização sobre a importância da resiliência para o desenvolvimento correto e resolução de problemas e situações levantadas no cotidiano, para que as famílias e a escola apresentem um papel fundamental para este objetivo, sendo essencial o conhecimento dos fatores indicados anteriormente para promover a resiliência entre os mais jovens

Improving quality in nanoparticle-induced cytotoxicity testing by a tiered inter-laboratory comparison study

The quality and relevance of nanosafety studies constitute major challenges to ensure their key role as a supporting tool in sustainable innovation, and subsequent competitive economic advantage. However, the number of apparently contradictory and inconclusive research results has increased in the past few years, indicating the need to introduce harmonized protocols and good practices in the nanosafety research community. Therefore, we aimed to evaluate if best-practice training and inter-laboratory comparison (ILC) of performance of the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay for the cytotoxicity assessment of nanomaterials among 15 European laboratories can improve quality in nanosafety testing. We used two well-described model nanoparticles, 40-nm carboxylated polystyrene (PS-COOH) and 50-nm amino-modified polystyrene (PS-NH2). We followed a tiered approach using well-developed standard operating procedures (SOPs) and sharing the same cells, serum and nanoparticles. We started with determination of the cell growth rate (tier 1), followed by a method transfer phase, in which all laboratories performed the first ILC on the MTS assay (tier 2). Based on the outcome of tier 2 and a survey of laboratory practices, specific training was organized, and the MTS assay SOP was refined. This led to largely improved intra- and inter-laboratory reproducibility in tier 3. In addition, we confirmed that PS-COOH and PS-NH2 are suitable negative and positive control nanoparticles, respectively, to evaluate impact of nanomaterials on cell viability using the MTS assay. Overall, we have demonstrated that the tiered process followed here, with the use of SOPs and representative control nanomaterials, is necessary and makes it possible to achieve good inter-laboratory reproducibility, and therefore high-quality nanotoxicological data.Web of Science108art. no. 143

Rationale and design of the Concordance study between FFR and iFR for the assessment of lesions in the left main coronary artery. The ILITRO-EPIC-07 Trial

Introduction and objectives: Patients with left main coronary artery (LMCA) stenosis have been excluded from the trials that support the non-inferiority of the instantaneous wave-free ratio (iFR) compared to the fractional flow reserve (FFR) in the decision-making process of coronary revascularization. This study proposes to prospectively assess the concordance between the two indices in LMCA lesions and to validate the iFR cut-off value of 0.89 for clinical use. Methods: National, prospective, and observational multicenter registry of 300 consecutive patients with intermediate lesions in the LMCA (angiographic stenosis, 25% to 60%. A pressure gudiewire study and determination of the RFF and the iFR will be performed: in the event of a negative concordant result (FFR > 0.80/iFR > 0.89), no treatment will be performed; in case of a positive concordant result (FFR 0.80/iFR 0.89), an intravascular echocardiography will be performed and revascularization will be delayed if the minimum lumen area is > 6 mm(2). The primary clinical endpoint will be a composite of cardiovascular death, LMCA lesion-related non-fatal infarction or need for revascularization of the LMCA lesion at 12 months. Conclusions: Confirm that an iFR-guided decision-making process in patients with intermediate LMCA stenosis is clinically safe and would have a significant clinical impact. Also, justify its systematic use when prescribing treatment in these potentially high-risk patients

Usos del e‐learning en las Universidades Andaluzas: estado de la situación y análisis de buenas prácticas. (Resumen ejecutivo).

Secretaría General de Universidades, Investigación y Tecnología P07-SE-J.0267

Usos del e-learning en las Universidades Andaluzas: Estado de la situación y análisis de buenas prácticas. (Versión completa)

Secretaría General de Universidades, Investigación y Tecnología P07-SE-J.0267

Early-Career Coordinated Distributed Experiments: Empowerment Through Collaboration

Este artículo contiene 7 páginas, 1 tabla, 3 figuras.Coordinated distributed experiments (CDEs) enable the study of large-scale ecological patterns in geographically dispersed areas, while simultaneously providing broad academic and personal benefits for the participants. However, the effective involvement of early-career researchers (ECRs) presents major challenges. Here, we analyze the benefits and challenges of the first CDE exclusively led and conducted by ECRs (i.e. ECR-CDE), which sets a baseline for similar CDEs, and we provide recommendations for successful CDE execution. ECR-CDEs achieve most of the outcomes identified in conventional CDEs as well as extensive benefits for the young cohort of researchers, including: (i) receiving scientific credit, (ii) peer-training in new concepts and methods, (iii) developing leadership and communication skills, (iv) promoting a peer network among ECRs, and (v) building on individual engagement and independence. We also discuss the challenges of ECR-CDEs, which are mainly derived from the lack of independence and instability of the participants, and we suggest mechanisms to address them, such as resource re-allocation and communication strategies. We conclude that ECR-CDEs can be a relevant tool to empower ECRs across disciplines by fostering their training, networking and personal well-being.The authors were supported by the following founding: NC the support of the Beatriu de Pinós postdoctoral program of the Government of Catalonia’s Secretariat for Universities and Research of the Ministry of Economy and Knowledge (BP2016- 00215), EE by a predoctoral grant from the Basque Government (2014-2017), AB by a Generalitat de Catalunya—Beatriu de Pinós (BP-00385-2016), AMG-F by a predoctoral research grant (BES-2013-065770) from the Spanish Ministry of Economy and Competitiveness, MAr by a postdoctoral grant from the Basque Government, MIA by a Juan de la Cierva postdoctoral grant (FJCI-2015-26192), PR-L by a Margalida Comas postdoctoral contract (PD/031/2018) funded by the Government of the Balearic Islands and the European Social Fund, AP by a Ramón Areces Foundation Postdoctoral Scholarship, and AL by a Kempe Foundation stipend. DOMIPEX project was founded by the First Call of Collaborative Projects among Young Researchers of the Iberian Association of Limnology (AIL; 2013-2015).Peer reviewe

Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial

Previous studies suggested that dietary polyphenols could reduce the incidence and complications of type-2 diabetes (T2D); although the evidence is still limited and inconsistent. This work analyzes whether changing to a diet with a higher polyphenolic content is associated with an improved glucose profile. At baseline, and at 1 year of follow-up visits, 5921 participants (mean age 65.0 ± 4.9, 48.2% women) who had overweight/obesity and metabolic syndrome filled out a validated 143-item semi-quantitative food frequency questionnaire (FFQ), from which polyphenol intakes were calculated. Energy-adjusted total polyphenols and subclasses were categorized in tertiles of changes. Linear mixed-effect models with random intercepts (the recruitment centers) were used to assess associations between changes in polyphenol subclasses intake and 1-year plasma glucose or glycosylated hemoglobin (HbA1c) levels. Increments in total polyphenol intake and some classes were inversely associated with better glucose levels and HbA1c after one year of follow-up. These associations were modified when the analyses were run considering diabetes status separately. To our knowledge, this is the first study to assess the relationship between changes in the intake of all polyphenolic groups and T2D-related parameters in a senior population with T2D or at high-risk of developing T2

Impact of interstitial lung disease on the survival of systemic sclerosis with pulmonary arterial hypertension

To assess severity markers and outcomes of patients with systemic sclerosis (SSc) with or without pulmonary arterial hypertension (PAH-SSc/non-PAH-SSc), and the impact of interstitial lung disease (ILD) on PAH-SSc. Non-PAH-SSc patients from the Spanish SSc registry and PAH-SSc patients from the Spanish PAH registry were included. A total of 364 PAH-SSc and 1589 non-PAH-SSc patients were included. PAH-SSc patients had worse NYHA-functional class (NYHA-FC), worse forced vital capacity (FVC) (81.2 +/- 20.6% vs 93.6 +/- 20.6%, P < 0.001), worse tricuspid annular plane systolic excursion (TAPSE) (17.4 +/- 5.2 mm vs 19.9 +/- 6.7 mm, P < 0.001), higher incidence of pericardial effusion (30% vs 5.2%, P < 0.001) and similar prevalence of ILD (41.8% vs. 44.9%). In individuals with PAH-SSc, ILD was associated with worse hemodynamics and pulmonary function tests (PFT). Up-front combination therapy was used in 59.8% and 61.7% of patients with and without ILD, respectively. Five-year transplant-free survival rate was 41.1% in PAH-SSc patients and 93.9% in non-PAH-SSc patients (P < 0.001). Global survival of PAH-SSc patients was not affected by ILD regardless its severity. The multivariate survival analysis in PAH-SSc patients confirmed age at diagnosis, worse NYHA-FC, increased PVR, reduced DLCO, and lower management with up-front combination therapy as major risk factors. In conclusion, in PAH-SSc cohort risk of death was greatly increased by clinical, PFT, and hemodynamic factors, whereas it was decreased by up-front combination therapy. Concomitant ILD worsened hemodynamics and PFT in PAH-SSc but not survival regardless of FVC impairment