Determinación de la capacidad de regulación hídrica de un Typic Hapludands mediante las curvas de retención de humedad y la modelación de sus propiedades hidrofísicas.

(Eng) In the watershed Centella , located in the upper river basin of the Dagua - Valle del Cauca, in nine farms with association coffee - banana, coffee - guamo, cane panelera and pastures, the water regulation capacity of the soil was studied by means of humidity retention curves obtained in the laboratory and by modeling its hydrophysical properties in Hydrus 2D. Properties such as texture, bulk density, porosity, organic matter, hydraulic conductivity, infiltration and humidity were determined. Subsequently, moisture retention curves were simulated using the hydraulic models of Van Genuchten, Brooks and Corey, Van Genuchten modified and Kosugi, evaluating the average errors and the dispersion of the data. Agreed to the results it is possible to point out that the soil under study has a high capacity for moisture retention ( > 18%), consequence of the high content of clays ( > 41%) and organic matter ( > 5%), characteristics of the Andisols of the Valle del Cauca. Finally, the best fitting model was compared statistically with the data of the curves obtained in the laboratory, finding that Van Genuchten and Van Genuchten models modified, are the most appropriate for obtaining the retention curves from the hydrophysical properties since they presented a lower mean error (ME) with a value not higher than -0.11 cm 3 / cm 3 and a value of the square root of the mean square error (RMSE) less than 0.11 cm 3 / cm 3 .(Spa) En la microcuenca Centella, ubicada en la cuenca alta del río Dagua - Valle del Cauca, en nueve fincas con asociación café – pláta - no, café - guamo, caña panelera y pastos, se estudió la capacidad de regulación hídrica del suelo mediante curvas de retención de humedad obtenidas en laboratorio y por modelación de sus propiedades hidrofísicas, en Hydrus 2D. Se determin ó textura, densidad aparente, porosidad, materia orgánica, conductividad hidr áulica, infiltración y humedad del suelo . Posteriormente, se simularon las curvas de retención de humedad mediante los modelos hidráulicos de Van Genuchten, Brooks y Corey, Van Genuchten modificado y Kosugi, evaluando los errores medios y la dispersión de los datos. De acuerdo a los resultados es posible señalar que el suelo en estudio tiene una alta capacidad de retención de humedad ( > 18 % ), debido a los altos contenidos de arcilla ( > 41 %) y materia or - gánica ( > 5%) , característico de los Andisoles presentes en el Valle del Cauca. Finalmente, se comparó estadísticamente el modelo de mejor ajuste con los datos de las curvas obtenidas en laboratorio, encontrando que los modelos Van Genuchten y Van Genuchten modificado, son los más apropiados para la obtención de las curvas de retención a partir de propiedades hidrofísicas dado que pre - sentaron un menor error medio (ME) con un valor no superior a -0.11 cm 3 /cm 3 y un valor de la raíz cuadrada del error cuadrático medio (RMSE) menor de 0.11 cm 3 /cm 3

Determination of the water regulation capacity of a typic hapludands by means of humidity retention curves and the modeling of its hydrophysical properties

In the watershed Centella , located in the upper river basin of the Dagua - Valle del Cauca, in nine farms with association coffee - banana, coffee - guamo, cane panelera and pastures, the water regulation capacity of the soil was studied by means of humidity retention curves obtained in the laboratory and by modeling its hydrophysical properties in Hydrus 2D. Properties such as texture, bulk density, porosity, organic matter, hydraulic conductivity, infiltration and humidity were determined. Subsequently, moistureretention curves were simulated using the hydraulic models of Van Genuchten, Brooks and Corey, Van Genuchten modified and Kosugi, evaluating the average errors and the dispersion of the data. Agreed to the results it is possible to point out that the soil under study has a high capacity for moisture retention ( > 18%), consequence of the high content of clays ( > 41%) and organic matter ( > 5%), characteristics of the Andisols of the Valle del Cauca. Finally, the best fitting model was compared statistically with the data of the curves obtained in the laboratory, finding that Van Genuchten and Van Genuchten models modified, are the most appropriate for obtaining the retention curves from the hydrophysical properties since they presented a lower mean error (ME) with a value not higher than -0.11 cm3 / cm3 and a value of the square root of the mean square error (RMSE) less than 0.11 cm3 / cm3.En la microcuenca Centella, ubicada en la cuenca alta del río Dagua - Valle del Cauca, en nueve fincas con asociación café – plátano, café - guamo, caña panelera y pastos, se estudió la capacidad de regulación hídrica del suelo mediante curvas de retención de humedad obtenidas en laboratorio y por modelación de sus propiedades hidrofísicas, en Hydrus 2D. Se determinó textura, densidad aparente, porosidad, materia orgánica, conductividad hidráulica, infiltración y humedad del suelo. Posteriormente, se simularon lascurvas de retención de humedad mediante los modelos hidráulicos de Van Genuchten, Brooks y Corey, Van Genuchten modificado y Kosugi, evaluando los errores medios y la dispersión de los datos. De acuerdo a los resultados es posible señalar que el suelo en estudio tiene una alta capacidad de retención de humedad ( > 18 % ), debido a los altos contenidos de arcilla ( > 41 %) y materia orgánica( > 5%) , característico de los Andisoles presentes en el Valle del Cauca. Finalmente, se comparó estadísticamente el modelo de mejor ajuste con los datos de las curvas obtenidas en laboratorio, encontrando que los modelos Van Genuchten y Van Genuchten modificado, son los más apropiados para la obtención de las curvas de retención a partir de propiedades hidrofísicas dado que presentaronun menor error medio (ME) con un valor no superior a -0.11 cm3/cm3 y un valor de la raíz cuadrada del error cuadrático medio (RMSE) menor de 0.11 cm3/cm3

Reduced Cancer Incidence in Huntington's Disease: Analysis in the Registry Study

Background: People with Huntington's disease (HD) have been observed to have lower rates of cancers. Objective: To investigate the relationship between age of onset of HD, CAG repeat length, and cancer diagnosis. Methods: Data were obtained from the European Huntington's disease network REGISTRY study for 6540 subjects. Population cancer incidence was ascertained from the GLOBOCAN database to obtain standardised incidence ratios of cancers in the REGISTRY subjects. Results: 173/6528 HD REGISTRY subjects had had a cancer diagnosis. The age-standardised incidence rate of all cancers in the REGISTRY HD population was 0.26 (CI 0.22-0.30). Individual cancers showed a lower age-standardised incidence rate compared with the control population with prostate and colorectal cancers showing the lowest rates. There was no effect of CAG length on the likelihood of cancer, but a cancer diagnosis within the last year was associated with a greatly increased rate of HD onset (Hazard Ratio 18.94, p < 0.001). Conclusions: Cancer is less common than expected in the HD population, confirming previous reports. However, this does not appear to be related to CAG length in HTT. A recent diagnosis of cancer increases the risk of HD onset at any age, likely due to increased investigation following a cancer diagnosis

Clinical and genetic characteristics of late-onset Huntington's disease

Background: The frequency of late-onset Huntington's disease (&gt;59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30–50 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of ≤35 or a UHDRS motor score of ≤5 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P &lt;.001). Overall motor and cognitive performance (P &lt;.001) were worse, however only disease motor progression was slower (coefficient, −0.58; SE 0.16; P &lt;.001) compared to the common-onset group. Repeat size was significantly lower in the late-onset (n = 40.8; SD 1.6) compared to common-onset (n = 44.4; SD 2.8) (P &lt;.001). Fewer late-onset patients (n = 451) had a positive family history compared to common-onset (n = 2940) (P &lt;.001). Conclusions: Late-onset patients present more frequently with gait and balance problems as first symptom, and disease progression is not milder compared to common-onset HD patients apart from motor progression. The family history is likely to be negative, which might make diagnosing HD more difficult in this population. However, the balance and gait problems might be helpful in diagnosing HD in elderly patients

The surgical safety checklist and patient outcomes after surgery: a prospective observational cohort study, systematic review and meta-analysis

© 2017 British Journal of Anaesthesia Background: The surgical safety checklist is widely used to improve the quality of perioperative care. However, clinicians continue to debate the clinical effectiveness of this tool. Methods: Prospective analysis of data from the International Surgical Outcomes Study (ISOS), an international observational study of elective in-patient surgery, accompanied by a systematic review and meta-analysis of published literature. The exposure was surgical safety checklist use. The primary outcome was in-hospital mortality and the secondary outcome was postoperative complications. In the ISOS cohort, a multivariable multi-level generalized linear model was used to test associations. To further contextualise these findings, we included the results from the ISOS cohort in a meta-analysis. Results are reported as odds ratios (OR) with 95% confidence intervals. Results: We included 44 814 patients from 497 hospitals in 27 countries in the ISOS analysis. There were 40 245 (89.8%) patients exposed to the checklist, whilst 7508 (16.8%) sustained ≥1 postoperative complications and 207 (0.5%) died before hospital discharge. Checklist exposure was associated with reduced mortality [odds ratio (OR) 0.49 (0.32–0.77); P\u3c0.01], but no difference in complication rates [OR 1.02 (0.88–1.19); P=0.75]. In a systematic review, we screened 3732 records and identified 11 eligible studies of 453 292 patients including the ISOS cohort. Checklist exposure was associated with both reduced postoperative mortality [OR 0.75 (0.62–0.92); P\u3c0.01; I2=87%] and reduced complication rates [OR 0.73 (0.61–0.88); P\u3c0.01; I2=89%). Conclusions: Patients exposed to a surgical safety checklist experience better postoperative outcomes, but this could simply reflect wider quality of care in hospitals where checklist use is routine

Prospective observational cohort study on grading the severity of postoperative complications in global surgery research

Background The Clavien–Dindo classification is perhaps the most widely used approach for reporting postoperative complications in clinical trials. This system classifies complication severity by the treatment provided. However, it is unclear whether the Clavien–Dindo system can be used internationally in studies across differing healthcare systems in high- (HICs) and low- and middle-income countries (LMICs). Methods This was a secondary analysis of the International Surgical Outcomes Study (ISOS), a prospective observational cohort study of elective surgery in adults. Data collection occurred over a 7-day period. Severity of complications was graded using Clavien–Dindo and the simpler ISOS grading (mild, moderate or severe, based on guided investigator judgement). Severity grading was compared using the intraclass correlation coefficient (ICC). Data are presented as frequencies and ICC values (with 95 per cent c.i.). The analysis was stratified by income status of the country, comparing HICs with LMICs. Results A total of 44 814 patients were recruited from 474 hospitals in 27 countries (19 HICs and 8 LMICs). Some 7508 patients (16·8 per cent) experienced at least one postoperative complication, equivalent to 11 664 complications in total. Using the ISOS classification, 5504 of 11 664 complications (47·2 per cent) were graded as mild, 4244 (36·4 per cent) as moderate and 1916 (16·4 per cent) as severe. Using Clavien–Dindo, 6781 of 11 664 complications (58·1 per cent) were graded as I or II, 1740 (14·9 per cent) as III, 2408 (20·6 per cent) as IV and 735 (6·3 per cent) as V. Agreement between classification systems was poor overall (ICC 0·41, 95 per cent c.i. 0·20 to 0·55), and in LMICs (ICC 0·23, 0·05 to 0·38) and HICs (ICC 0·46, 0·25 to 0·59). Conclusion Caution is recommended when using a treatment approach to grade complications in global surgery studies, as this may introduce bias unintentionally

Critical care admission following elective surgery was not associated with survival benefit: prospective analysis of data from 27 countries

This was an investigator initiated study funded by Nestle Health Sciences through an unrestricted research grant, and by a National Institute for Health Research (UK) Professorship held by RP. The study was sponsored by Queen Mary University of London