DOCUMENTATION OF COMPLEX ENVIRONMENTS IN CULTURAL HERITAGE SITES. A SLAM-BASED SURVEY IN THE CASTELLO DEL VALENTINO BASEMENT

Underground Built Heritage (UBH) stands out among the existing Cultural Heritage sites as a peculiar scenario. The assets belonging to this type of heritage are typically difficult to manage, exploit, and promote because of a lack of knowledge and documentation. The challenges in documenting built heritage are many and wide-ranging, and the main need must be to provide an accurate and appropriate representation of the surveyed area and its geometric features without employing time-consuming processes. Mobile Mapping Systems (MMSs) are nowadays trending technologies for the geomatics community, proving to be a useful alternative to traditional surveying techniques when taking time and cost constraints into account. The paper focuses on the use of an MMS, the STONEX® X120GO SLAM Laser Scanner system, in documenting a portion of the Castello del Valentino, an articulated and complex architecture located in Turin (Italy). The underground floor of the castle, due to its complexity in terms of accessibility and the challenge it poses for the documentation approach, was chosen as a case study to assess the STONEX® X120GO's capabilities in terms of portability of the instrument, speed of acquisition, as well as completeness and accuracy of the acquired dataset. The results obtained using the MMS technique have been compared to and validated using data from a TLS (Terrestrial Laser Scanner) survey used as a ground reference. The results and considerations reported in this paper demonstrate that MMSs can accurately and completely depict built spaces and their main characteristics and have substantial potential in mapping complex assets

THE IPAD PRO BUILT-IN LIDAR SENSOR: 3D RAPID MAPPING TESTS AND QUALITY ASSESSMENT

The main goal of this ongoing research is the evaluation of the iPad Pro built-in LiDAR sensor for large scale 3D rapid mapping. Different aspects have been considered from the architectural surveying perspective and several analyses were carried out focusing on the acquisition phase and the definition of best practices for data collection, the quantitative analysis on the acquired data and their 3D positional accuracy assessment, and the qualitative analysis of the achievable metric products. Despite this paper is a preliminary analysis and deeper studies in various application environment are necessary, the availability of a LiDAR sensor embedded in a tablet or mobile phone, appears promising for rapid surveying purposes. According to test outcomes, the sensor is able to rapidly acquire reliable 3D point clouds suitable for 1:200 architectural rapid mapping; the iPad Pro could represent an interesting novelty also thanks to its price (compared to standard surveying instruments), portability and limited time required both for data acquisition and processing

GEOMATIC CONTRIBUTION FOR THE RESTORATION PROJECT OF THE VALENTINO CASTLE GREEN ROOM. FROM DATA ACQUISITION TO INTEGRATED DOCUMENTATION

In the framework of restoration operations, valuable assistance can be supplied from innovative techniques and methods developed in the field of Geomatics. Over the years, this continuous collaboration has produced synergistic and interdisciplinary results that have been successfully contributing to heritage conservation and valorisation. In the case of the current research, thorough multisensory investigations have been performed in order to provide a deeper knowledge of the Green Room of the Valentino Castle in Turin and to support the planning of the future restoration works that will involve this valuable asset. In the framework of this experience, four LiDAR systems have been employed in order to evaluate the different results obtainable from the sensors. Additionally, a complete photogrammetric close-range survey has been carried out, and some tests were completed using a hyperspectral camera. The workflow followed during the current research is described in this paper, and a comparison between the obtained outputs is proposed, focusing on the characteristics of these metric products, useful and sometimes necessary in the framework of the restoration project. Besides, some considerations on the advantages and the issues connected with the use of these reality-based data as a starting point for HBIM (Heritage Building Information Modeling) model generation are proposed, along with some observations about the potentialities of a photogrammetric co-registration approach using spectrum technologies for deterioration/decay detection and monitoring of heritage

Challenging multi-sensor data models and use of 360 images. The Twelve Months Fountain of Valentino park in Turin

The cultural heritage and the ways in which it is today studied and analysed as well as disseminated and enhanced for the purposes of conservation, requires high attention in the choice of 3D survey and modelling methods. This manuscript investigates the possible integrations and fusion of methods and data, among the vast availability of image and range based systems, especially in the sphere of low cost techniques, which in the context of heritage documentation makes the whole and complex process of conservation more sustainable. The investigation is carried out on a historical fountain that includes a quantity of cultural values and the need to document its context: its location in the historical Valentino of Turin park, its architectural values and the geometry of the complex typically related to the tastes of the late XIX century that consist in the extreme refinement of the statuary complexes and the underground portion with the technological equipment for the activation of the water games. Basically, it will be possible to appreciate solved issues and permanent criticalities derived from the integration of close range and UAV photogrammetry techniques in addition to the LiDAR survey, both classic from a fixed position, and in the portable scanner mode, based on SLAM technology

Применение информационных технологий и этические нюансы в управлении массовым сознанием

This paper discusses the current value of information technology in our lives, as well as their application to control the mass consciousness

Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk.

Common variants in the hepatocyte nuclear factor 1 homeobox B (HNF1B) gene are associated with the risk of Type II diabetes and multiple cancers. Evidence to date indicates that cancer risk may be mediated via genetic or epigenetic effects on HNF1B gene expression. We previously found single-nucleotide polymorphisms (SNPs) at the HNF1B locus to be associated with endometrial cancer, and now report extensive fine-mapping and in silico and laboratory analyses of this locus. Analysis of 1184 genotyped and imputed SNPs in 6608 Caucasian cases and 37 925 controls, and 895 Asian cases and 1968 controls, revealed the best signal of association for SNP rs11263763 (P = 8.4 × 10(-14), odds ratio = 0.86, 95% confidence interval = 0.82-0.89), located within HNF1B intron 1. Haplotype analysis and conditional analyses provide no evidence of further independent endometrial cancer risk variants at this locus. SNP rs11263763 genotype was associated with HNF1B mRNA expression but not with HNF1B methylation in endometrial tumor samples from The Cancer Genome Atlas. Genetic analyses prioritized rs11263763 and four other SNPs in high-to-moderate linkage disequilibrium as the most likely causal SNPs. Three of these SNPs map to the extended HNF1B promoter based on chromatin marks extending from the minimal promoter region. Reporter assays demonstrated that this extended region reduces activity in combination with the minimal HNF1B promoter, and that the minor alleles of rs11263763 or rs8064454 are associated with decreased HNF1B promoter activity. Our findings provide evidence for a single signal associated with endometrial cancer risk at the HNF1B locus, and that risk is likely mediated via altered HNF1B gene expression

The handling of urinary incontinence in Danish general practices after distribution of guidelines and voiding diary reimbursement: an observational study

BACKGROUND: Though urinary incontinence (UI) is a bothersome condition for the individual patient, the patients tend not to inform their physician about UI and the physician tend not to ask the patient. Recently different initiatives have been established in Danish general practices to improve the management of UI. The aim of this study was to identify the handling of urinary incontinence (UI) in Danish general practices after distribution of clinical guidelines and reimbursement for using a UI diary. METHODS: In October 2001, a questionnaire was sent to 243 general practitioners (GPs) in Frederiksborg County following distribution of clinical guidelines in July 1999 (UI in general practice) and September 2001 (UI in female, geriatric, or neurological patients). A policy for a small reimbursement to GPs for use of a fluid intake/voiding diary in the assessment of UI in general practice was implemented in October 2001. Information concerning monthly reimbursement for using a voiding diary, prescribed drugs (presumably used for treating UI), UI consultations in outpatient clinics, and patient reimbursement for pads was obtained from the National Health Service County Registry. RESULTS: Of the 132 (54%) GPs who replied, 87% had read the guidelines distributed 2 years before, but only 47% used them daily. The majority (69%) of the responding GPs had read and appreciated 1–3 other UI guidelines distributed before the study took place. Eighty-three percent of the responding GPs sometimes or often actively asked their patients about UI, and 92% sometimes or often included a voiding diary in the UI assessment. The available registry data concerning voiding diary reimbursement, prescribed UI drugs, UI consultations in outpatient clinics, and patient reimbursement for pads were insufficient or too variable to determine significant trends. CONCLUSION: GPs management of UI in a Danish county may be reasonable, but low response rate to the questionnaire and insufficient registry data made it difficult to evaluate the impact of different UI initiatives

Genetic variation in TIMP1 but not MMPs predict excess FEV1 decline in two general population-based cohorts

BACKGROUND: An imbalance in matrix metalloproteases (MMPs) and tissue inhibitors of MMPs (TIMPs) contributes to chronic obstructive pulmonary disease (COPD) development. Longitudinal studies investigating Single Nucleotide Polymorphisms (SNPs) in MMPs and TIMPs with respect to COPD development and lung function decline in the general population are lacking. METHODS: We genotyped SNPs in MMP1 (G-1607GG), MMP2 (-1306 C/T), MMP9 (3 tagging SNPs), MMP12 (A-82G and Asn357Ser) and TIMP1 (Phe124Phe and Ile158Ile) in 1390 Caucasians with multiple FEV1 measurements from a prospective cohort study in the general population. FEV1 decline was analyzed using linear mixed effect models adjusted for confounders. Analyses of the X-chromosomal TIMP1 gene were stratified according to sex. All significant associations were repeated in an independent general population cohort (n=1152). RESULTS: MMP2 -1306 TT genotype carriers had excess FEV1 decline (-4.0 ml/yr, p=0.03) compared to wild type carriers. TIMP1 Ile158Ile predicted significant excess FEV1 decline in both males and females. TIMP1 Phe124Phe predicted significant excess FEV1 decline in males only, which was replicated (p=0.10) in the second cohort. The MMP2 and TIMP1 Ile158Ile associations were not replicated. Although power was limited, we did not find associations with COPD development. CONCLUSIONS: We for the first time show that TIMP1 Phe124Phe contributes to excess FEV1 decline in two independent prospective cohorts, albeit not quite reaching conventional statistical significance in the replication cohort. SNPs in MMPs evidently do not contribute to FEV1 decline in the general population