Non-linear instability of slowly rotating Kerr-AdS black holes

Generic scalar perturbations on a fixed slowly rotating Kerr-AdS black hole background exhibit stable trapping, that is, the scalar field remains in a region between the exterior of the black hole and the AdS boundary for a very long time, decaying only inverse logarithmically in time. We study this effect employing fully general simulations that take into account the non-linear backreaction of the scalar field on the geometry. We find that the stable trapping of generic perturbations of Kerr-AdS persists at the non-linear level. Furthermore, the spacetime settles into a time-dependant and non-axisymmetric black hole which differs from Kerr-AdS. Since our perturbations are generic, our results indicate that slowly rotating Kerr-AdS black holes are non-linearly unstable.Comment: v2: Major revision; includes new sections with new result

The "Square Box" : Therapeutic Equivalence as a Foundation of the WHO Model List of Essential Medicines

Every two years, the World Health Organization (WHO) updates its Model List of Essential Medicines, intended as a guide for countries to adopt or adapt in accordance with local priorities and treatment guidelines, for the development of national essential medicines lists. When more than one therapeutic option is available for a given indication, the WHO Model List often includes a single medicine as representative of a group of equivalent and interchangeable medicines. The representative medicine of that group is listed with an accompanying 'square box' symbol. The intended purpose of the square box is to highlight pharmacological classes or groups of medicines for which countries, institutions and health professionals can assume homogeneous therapeutic efficacy and safety and select the most appropriate single medicine based on price, local availability, and acceptability. Though this concept of therapeutic equivalence within a therapeutic class has been endorsed by most authoritative textbooks of pharmacology since Goodman & Gilman's The Pharmacological Basis of Therapeutics and evidence-based guidelines, marketing forces have often made claims on individual drugs to distinguish them beyond relevant differences shown by reliable evidence: this has generated the concept of "me-too drugs" with its double meaning- i.e., market latecomers differing minimally from products preceding them and whose marketing budgets have significant opportunity costs, or medicines which may be useful to substitute for equivalent products in the event of shortages. The square box concept is applied in the context of a comprehensive list: therapeutic equivalence or interchangeability cannot always be easily established. Different interpretations have been applied to different groups of medicines over the 40+ year history of the Model List. This paper presents the concept of the square box, provides key examples and guidance on how square box listings should be practically interpreted in the development and implementation of national essential medicine lists, considers the applicability of a square box listing concept to biologic medicines and proposes that an updated review of the square box concept and listings is warranted

Heteroscedastic Gaussian processes and random features: scalable motion primitives with guarantees

Heteroscedastic Gaussian processes (HGPs) are kernel-based, non-parametric models that can be used to infer nonlinear functions with time-varying noise. In robotics, they can be employed for learning from demonstration as motion primitives, i.e. as a model of the trajectories to be executed by the robot. HGPs provide variance estimates around the reference signal modeling the trajectory, capturing both the predictive uncertainty and the motion variability. However, similarly to standard Gaussian processes they suffer from a cubic complexity in the number of training points, due to the inversion of the kernel matrix. The uncertainty can be leveraged for more complex learning tasks, such as inferring the variable impedance profile required from a robotic manipulator. However, suitable approximations are needed to make HGPs scalable, at the price of potentially worsening the posterior mean and variance profiles. Motivated by these observations, we study the combination of HGPs and random features, which are a popular, data-independent approximation strategy of kernel functions. In a theoretical analysis, we provide novel guarantees on the approximation error of the HGP posterior due to random features. Moreover, we validate this scalable motion primitive on real robot data, related to the problem of variable impedance learning. In this way, we show that random features offer a viable and theoretically sound alternative for speeding up the trajectory processing, without sacrificing accuracy.Peer ReviewedPostprint (published version

GRFolres: A code for modified gravity simulations in strong gravity

GRFolres is an open-source code for performing simulations in modified theories of gravity, based on the publicly available 3+1D numerical relativity code GRChombo. Note: Submitted for review in the Journal of Open Source Software; Comments welcome; The code can be found at https://github.com/GRChombo/GRFolre

Effect of Porcine circovirus 2 (PCV-2) maternally derived antibodies on performance and PCV-2 viremia in vaccinated piglets under field conditions

Background: Nowadays, the most common presentation of PCV-2 is the subclinical infection in piglets after weaning. The success of PCV-2 vaccination is associated with the control of the clinical disease as well as the improvement of production parameters. In consequence, the objective of the present study was to analyse the effect of PCV-2 maternally derived antibody (MDA) levels on vaccine efficacy in piglets vaccinated at three weeks of age with a commercial PCV-2 subunit vaccine. The study was performed analysing a database with 6112 wean-to-slaughter piglets from 4 different European regions. Results: Results showed that the use of the vaccine was able to decrease the PCV-2 viremia calculated as area under the curve (AUC = 60.29 ± 3.73), increase average daily weight gain (ADWG = 0.65 ± 0.01 kg/day) and reduce mortality (7%) in vaccinated piglets compared to non-vaccinated ones (AUC of 198.27 ± 6.14, 0.62 ± 0.01 kg/day and 11% respectively). The overall difference of ADWG between both groups was close to 30 g per day (p < 0.05), also when they were split for low and high levels of MDA titres. Moreover, the animals with the highest ADWG were observed in the group of piglets vaccinated with high or extremely high antibody titres (0.66 and 0.65 kg/day respectively). Considering only animals with extremely high antibody titres, both study groups performed similar, however there was a numerical difference of 10 g/day in favour of vaccinated piglets. Likewise, lack of correlation between ADWG and MDA was observed suggesting that no maternal antibody interference was present with the tested vaccine because the vaccinated animals grew faster compared to unvaccinated control animals, regardless of the level of maternal antibodies present at the time of vaccination. Conclusions: The results of the present study demonstrated that the MDA against PCV-2 transferred through the colostrum intake has a protective effect against this viral infection. The vaccine used in the present study (Ingelvac CircoFLEX®) was effective when applied at three weeks of age and was not affected by the level of MDA at the time of vaccination

Comportamiento de los estudiantes de Ciencias Médicas ante la pesquisa activa durante la COVID-19

Introducción: ante la situación epidemiológica existente, los estudiantes de las Ciencias Médicas desempeñan labores de pesquisa activa. Objetivo: describir el comportamiento de los estudiantes de Ciencias Médicas ante la pesquisa activa durante la COVID-19. Material y método: se realizó un estudio observacional, descriptivo y transversal en los meses de marzo a mayo de 2020, en el Policlínico Norte de Ciego de Ávila. Se estudió a los 320 estudiantes de las Ciencias Médicas asignados a la pesquisa del área de salud, que constituyeron el universo de la investigación. Las variables en estudio fueron: fuentes de información sobre COVID-19, conocimientos de la enfermedad, emociones, conductas de los estudiantes. Resultados: las principales fuentes de información de los estudiantes y profesores de Ciencias Médicas sobre la COVID-19 fueron la recibida en la capacitación (100 %), y el asesoramiento por los profesores (100 %). El 100 % de los estudiantes conocían adecuadamente el lugar de origen, los síntomas y las medidas preventivas. En la esfera emocional, el miedo al contagio prevaleció en el 100%, así como las conductas higiénicas sanitarias del uso de la mascarilla y el distanciamiento físico entre los propios estudiantes y con la población.  Conclusiones: esta investigación aportó un conocimiento nuevo sobre el comportamiento de los estudiantes de las Ciencias Médicas ante la pesquisa de la pandemia COVID-19, de elevada letalidad y contagio

High intake of sugars and starch, low number of meals and low roughage intake are associated with equine gastric ulcer syndrome in a Belgian cohort

Equine gastric ulcer syndrome (EGUS) is a pathological condition affecting the glandular and squamous regions of the stomach. It is characterized by non-specific clinical signs, behavioural changes or can also be found without any overt clinical manifestations. Nutritional factors such as intermittent feeding, high sugars and starch intake, large amounts of straw as forage and prolonged time without access to forage have all been associated with an increased risk of equine squamous gastric disease (ESGD). The aim of this study was to investigate which nutritional practices are commonly seen in clinical ESGD cases in Belgium. Medical records of 27 horses referred to the equine nutritional service at Ghent University (2013-2018) due to equine gastric ulcer lesions were reviewed. Twenty-one healthy horses referred for dietary evaluation during the same period were selected as control cases (CC). Dietary evaluation was performed on an individual basis. Forage/concentrate ratio on dry matter basis, forage content in the diet, total dietary sugars and starch intake per day and per meal were analysed. Retrospective descriptive and statistical analyses were performed. Significantly, higher amounts of forage intake (%DM per BW) in the CC vs. ESGD group were noted (p <= .05) with average values of 1.39 (SD +/- 0.27) and 1.27 (SD +/- 0.70) respectively. There were no significant differences for sugars and starch intake in g/kg BW/day (p = .18). However, the sugars and starch intake per meal (g/kg BW/meal) in the CC group (average value 1.06, SD +/- 0.56) was significantly (p < .001) lower than in the EGUS group (average value 1.85 SD +/- 0.78). Forage intake below the recommended absolute minimum value as well as high sugars and starch intake were most commonly associated with EGUS in the present case series. An adequate diet formulation taking into account these main nutritional factors is therefore essential to avoid gastric problems in horses

Risk factors for Equine Gastric Glandular Disease: A case-control study in a Finnish referral hospital population

BackgroundEquine gastric glandular disease (EGGD) is a term used to classify erosive and ulcerative diseases of the glandular mucosa of the equine stomach. Epidemiologic studies of risk factors for EGGD have not been reported. ObjectiveTo determine risk factors for EGGD. AnimalsCases (n=83) had endoscopic evidence of EGGD; controls (n=34) included healthy horses and horses with equine squamous gastric disease (ESGD) without EGGD. MethodsRetrospective case-control study. The data were analyzed by multivariable logistic regression modeling. Analysis was performed on the full dataset. An additional analysis compared horses with glandular lesions (n=43) against healthy horses (n=22). ResultsOn first analysis, Warmblood breed (OR=13.9, 95% CI 2.2-90.9, P=.005) and an increasing number of caretakers (OR=7.3, 95% CI 0.98-55.6, P=.053) were associated with an increased risk of EGGD. On analysis of the subset of data, Warmblood breed (OR=28.6, 95% CI 2.96-250.0, P=.004) and increasing number of riders (OR=12.99, 95% CI 0.94-166.7, P=.056) were risk factors. The presence of sand in the colon appeared to have a protective effect against EGGD (OR=0.195, 95% CI 0.04-1.0, P=.051 for sand versus not having sand). Conclusions and clinical importanceThis study suggests that Warmbloods are predisposed to EGGD and multiple handlers/riders might increase the risk of EGGD. Identification of risk factors allows speculation on potential pathophysiological mechanisms of EGGD.Peer reviewe

Mytilus galloprovincialis Myticin C: A Chemotactic Molecule with Antiviral Activity and Immunoregulatory Properties

Previous research has shown that an antimicrobial peptide (AMP) of the myticin class C (Myt C) is the most abundantly expressed gene in cDNA and suppressive subtractive hybridization (SSH) libraries after immune stimulation of mussel Mytilus galloprovincialis. However, to date, the expression pattern, the antimicrobial activities and the immunomodulatory properties of the Myt C peptide have not been determined. In contrast, it is known that Myt C mRNA presents an unusual and high level of polymorphism of unidentified biological significance. Therefore, to provide a better understanding of the features of this interesting molecule, we have investigated its function using four different cloned and expressed variants of Myt C cDNA and polyclonal anti-Myt C sera. The in vivo results suggest that this AMP, mainly present in hemocytes, could be acting as an immune system modulator molecule because its overexpression was able to alter the expression of mussel immune-related genes (as the antimicrobial peptides Myticin B and Mytilin B, the C1q domain-containing protein MgC1q, and lysozyme). Moreover, the in vitro results indicate that Myt C peptides have antimicrobial and chemotactic properties. Their recombinant expression in a fish cell line conferred protection against two different fish viruses (enveloped and non-enveloped). Cell extracts from Myt C expressing fish cells were also able to attract hemocytes. All together, these results suggest that Myt C should be considered not only as an AMP but also as the first chemokine/cytokine-like molecule identified in bivalves and one of the few examples in all of the invertebrates