Designing deck-point of fixity connections

RESUMEN: En este artículo se describen las soluciones tipológicas adoptadas en diversos proyectos realizados en SILGA para el diseño de la conexión del tablero al punto fijo al que se transmiten fundamentalmente las acciones debidas al frenado y arranque y, en su caso, también el sismo. Se realizan reflexiones sobre su cálculo, dimensionamiento y diseño orientado a la durabilidad y el mantenimiento

Cardiorenal benefits of finerenone: protecting kidney and heart

Albuminuria; Enfermedad renal crónica; FinerenonaAlbuminúria; Malaltia renal crònica; FinerenonaAlbuminuria; Chronic kidney disease; FinerenonePersons with diabetes and chronic kidney disease (CKD) have a high residual risk of developing cardiovascular (CV) complications despite treatment with renin-angiotensin system blockers and sodium-glucose cotransporter type 2 inhibitors. Overactivation of mineralocorticoid receptors plays a key role in the progression of renal and CV disease, mainly by promoting inflammation and fibrosis. Finerenone is a nonsteroidal selective mineralocorticoid antagonist. Recent clinical trials, such as FIDELIO-DKD and FIGARO-DKD and the combined analysis FIDELITY have demonstrated that finerenone decreases albuminuria, risk of CKD progression, and CV risk in subjects with type 2 diabetes (T2D) and CKD. As a result, finerenone should thus be considered as part of a holistic approach to kidney and CV risk in persons with T2D and CKD. In this narrative review, the impact of finerenone treatment on the CV system in persons with type 2 diabetes and CKD is analyzed from a practical point of view

Newborn screening for Fabry disease in the north-west of Spain

Fabry disease is an X-linked lysosomal storage disorder caused by the impairment of α-galactosidase A. Enzyme replacement therapy is available to treat patients, who often experience delayed diagnosis. A newborn screening for Fabry disease was performed to study the prevalence of the pathology and to evaluate the possibility to implement the test in systematic screenings. We collected 14,600 dried blood spot samples (7575 males and 7025 females) and carried out a diagnostic study by fluorometric measurement of α-galactosidase A enzymatic activity and GLA gene sequencing. We detected one patient with a mutation in GLA associated with classical Fabry Disease (M290I), ten subjects carrying genetic variants of uncertain diagnosis (S126G, R118C, A143T), and a girl with the non-characterized variant F18Y, which was not previously described. Additional 25 samples presented nucleotide substitutions described as polymorphisms (D313Y, rs2071225, and rs2071397). The estimated prevalence for Fabry disease in north-western Spanish males is of 0.013%. Conclusion: These results confirm that the prevalence of Fabry disease is underestimated and systematic screening is feasible; however, further characterization of variants of uncertain clinical significance is necessary to establish protocols of patients’ managementThis studied was founded by the Spanish National Institute of Health-Instituto Carlos III/EU-FEDER, grant no. PI11-00842, to Ortolano S. and FEEL Foundation to Cristobal ColónS

Contribution to the channel path loss and time-dispersion characterization in an office environment at 26 GHz

In this paper, path loss and time-dispersion results of the propagation channel in a typical office environment are reported. The results were derived from a channel measurement campaign carried out at 26 GHz in line-of-sight (LOS) and obstructed-LOS (OLOS) conditions. The parameters of both the floating-intercept (FI) and close-in (CI) free space reference distance path loss models were derived using the minimum-mean-squared-error (MMSE). The time-dispersion characteristics of the propagation channel were analyzed through the root-mean-squared (rms) delay-spread and the coherence bandwidth. The results reported here provide better knowledge of the propagation channel features and can be also used to design and evaluate the performance of the next fifth-generation (5G) networks in indoor office environments at the potential 26 GHz frequency band.This work was funded in part by the Spanish Ministerio de Economía, Industria y Competitividad under the research projects TEC2016-78028-C3-2-P, TEC2017-86779C1-2-R, and TEC2017-86779-C2-2-R, and by COLCIENCIAS in Colombia

CSCI 2017

Producción CientíficaElastic Optical Networks (EON) are seen as an essential technology to implement the backhaul of Future Internet allowing the deployment of emerging paradigms like the Internet of Things (IoT), Tactile Internet, or Industry 4.0. When designing those Elastic Optical Networks (EONs), the Routing and Spectrum Assignment (RSA) problem has to be solved. In this paper, we analyse the effect of using two types of flexibility in a well‑known RSA method. A simulation study will be presented with the main results of this comparison.Ministerio de Economía, Industria y Competitividad (Projects TEC2014-53071-C3-2-P, TEC2015-71932-REDT)Ministerio de Educación, Cultura y Deporte (Proyect BES-2015-074514

Variations in platelet proteins associated with st-elevation myocardial infarction: Novel clues on pathways underlying platelet activation in acute coronary syndromes

OBJECTIVE: Our aim in this study was to provide novel information on the molecular mechanisms playing a major role in the unwanted platelet activation associated with ST-elevation myocardial infarction (STEMI). METHODS AND RESULTS: We compared the platelet proteome of 11 STEMI patients to a matched control group of 15 stable chronic ischemic cardiopathy patients. In addition, we did a prospective study to follow the STEMI patients over time. Proteins were separated by high-resolution 2D gel electrophoresis, identified by mass spectrometry, and validated by Western blotting. Platelets from STEMI patients on admission displayed 56 protein spot differences (corresponding to 42 unique genes) compared with the control group. The number of differences decreased with time during the patients' follow-up. Interestingly, the adapter protein CrkL and the active form of Src (phosphorylated in Tyr418) were found to be upregulated in platelets from STEMI patients. Major signaling pathways related to the proteins identified include integrin, integrin-linked kinase, and glycoprotein VI (GPVI) signaling. Interestingly, a study on an independent cohort of patients showed a higher degree of activation of GPVI signaling in STEMI patients. CONCLUSIONS: CrkL, the active form of Src, and GPVI signaling are upregulated in platelets from STEMI patients

A comparative study of platelet-rich plasma, hydroxyapatite, demineralized bone matrix and autologous bone to promote bone regeneration after mandibular impacted third molar extraction.

Objectives: 1) to compare mandibular bone regeneration by applying autologous bone, platelet-rich plasma and two biomaterials (synthetic calcium hydroxyapatite, and demineralized bone matrix), and thus establish the potential benefits of these biomaterials in the regeneration of postextraction alveolar bone, 2) to identify wich of them accelerates more bone regeneration and 3) to determine whether there are differences in the postoperative period (pain, swelling, trismus, infection) depending on the material used. Study Design: It consists in a prospective, controlled (with a split- mouth design) and double blinded study. We use as a model an easily reproducible non-critical bone defect: the defect that remains after extraction of mandibular impacted third molar. The study design is based on the extraction of two mandibular impacted third molars in a patient during the same surgical procedure by the same surgeon. We assessed postoperative clinical data, and short, medium and long term neoformation of alveolar bone after extraction. We compared the two sockets (right and left), which had been grafted in a different way with the various elements mentioned above. In addition, we compared the postoperative inflammatory symptoms between groups. Results: The highest acceleration in bone formation was observed in groups in which we used autologous bone and demineralized bone matrix. There were no statistically significant differences between groups regarding pain, swelling, trismus and infection throughout the postoperative period. Conclusions: According to the results of our study, autologous bone persists as the gold standard material for bone regeneration. Among the assessed biomaterials, demineralized bone matrix has yielded the best results obtained. No significant differences in the postoperative (pain, swelling, trismus and infectious events) were observed, depending on the type of material used as a graft

2022 32nd International Telecommunication Networks and Applications Conference (ITNAC)

Producción CientíficaMulti-band elastic optical network (MB-EON) is a promising technology to extend the bandwidth of the current elastic optical networks in the middle term. The migration from current networks to MB-EONs should be made carefully taking into account both the required cost and the bandwidth requirements. This paper focuses on the necessity of looking for a trade-off between the links to be upgraded during the migration from the standard C-band to the L-band and the acceptable level of capacity increase. Therefore, it makes two contributions to efficiently upgrade current elastic optical networks: firstly, a planning method to decide which fibers should be upgraded to exploit C+L band; and second, one heuristic for solving the routing, band, modulation level, and spectrum assignment (RBMLSA) problem during network operation. Simulation results demonstrate that, thanks to use of these proposals, the upgrade of a set of the fibers could be viewed as a fully convincing middle term solution by the network operators to get around the huge cost of the whole network migration to C+L line system.EU H2020 MSCA ITN-ETN IoTalentum (grant no. 953442);Ministerio de Ciencia e Innovación y Agencia Estatal de Investigación (Proyecto PID2020-112675RB-C42 financiado por MCIN/AEI/10.13039/501100011033)EU H2020 B5G-OPEN (GA 101016663

2023 26th Conference on Innovation in Clouds, Internet and Networks and Workshops (ICIN)

Network Slicing (NS) is a key enabler of the 5G network ecosystem due to its potential to provide distinct services over the same physical infrastructure. However, the necessity to optimally orchestrate resources for heterogeneous demands is crucial when dealing with resource constraints and Quality-of-Service (QoS) requirements. We consider a radio access network scenario providing NS over multiple base stations (BS) with limited resources, and we design an efficient resource orchestration technique, based on reinforcement learning, which optimizes resource utilization among different services while satisfying the constraints and complying with Service Level Agreement (SLA) and QoS requirements. The proposed technique makes use of the Trust Region Method to formulate the orchestration objective function and satisfy the constraints and is then optimized via Kronecker Factored Approximate Curvature (K-FAC). Extensive simulations demonstrate that the proposed technique outperforms other Reinforcement Learning (RL) algorithms, reaching 99% of QoS and SLA satisfaction while assuring bandwidth constraints.EU H2020 MSCA ITN-ETN IoTalentum (grant no. 953442)Consejería de Educación de la Junta de Castilla y León y FEDER (VA231P20)Ministerio de Ciencia e Innovación y Agencia Estatal de Investigación (Proyecto PID2020-112675RB-C42 financiado por MCIN/AEI/10.13039/501100011033

Cardiac protein changes in ischaemic and dilated cardiomyopathy: A proteomic study of human left ventricular tissue

The development of heart failure (HF) is characterized by progressive alteration of left ventricle structure and function. Previous works on proteomic analysis in cardiac tissue from patients with HF remain scant. The purpose of our study was to use a proteomic approach to investigate variations in protein expression of left ventricle tissue from patients with ischaemic (ICM) and dilated cardiomyopathy (DCM). Twenty-four explanted human hearts, 12 from patients with ICM and 12 with DCM undergoing cardiac transplantation and six non-diseased donor hearts (CNT) were analysed by 2DE. Proteins of interest were identified by mass spectrometry and validated by Western blotting and immunofluorescence. We encountered 35 differentially regulated spots in the comparison CNT versus ICM, 33 in CNT versus DCM, and 34 in ICM versus DCM. We identified glyceraldehyde 3-phophate dehydrogenase up-regulation in both ICM and DCM, and alpha-crystallin B down-regulation in both ICM and DCM. Heat shock 70 protein 1 was up-regulated only in ICM. Ten of the eleven differentially regulated proteins common to both aetiologies are interconnected as a part of a same network. In summary, we have shown by proteomics analysis that HF is associated with changes in proteins involved in the cellular stress response, respiratory chain and cardiac metabolism. Although we found altered expression of eleven proteins common to both ischaemic and dilated aetiology, we also observed different proteins altered in both groups. Furthermore, we obtained that seven of these eleven proteins are involved in cell death and apoptosis processes, and therefore in HF progression