Delivery of Health Education in Adolescents with Behavioral Health Challenges

BACKGROUND Adolescents with behavioral health issues tend to have inadequate access to health education, and are thus less aware of the importance of personal and dental hygiene, exercise, and healthy diet and lifestyle habits. Due to this disparity, this population has been known to harbor a higher prevalence of STI’s, drug and alcohol abuse, physical altercations, juvenile detention, and suicide attempts. PURPOSE The overall objective of this study was to examine the effect of integrating a health science curriculum in this population. METHODS Participants aged 5-17 years old were recruited and assigned to either control or science groups by Family and Children’s Services (FCS). We created an 8-week health science curriculum to teach everyday life skills. A questionnaire was utilized to assess participants’ comprehension of health information. The effect of the curriculum on participants’ behaviors was examined using a pre/post “Behavioral Insight” questionnaire. Non-parametric Mann-Whitney U test was utilized to determine whether there was a significant difference in behavioral goals and science based knowledge between the control and science groups. RESULTS We examined two measurements to evaluate the efficacy of delivering health science information to 23 participants in two science groups, compared to 20 participants in two control groups who did not receive the curriculum. The health knowledge assessment results demonstrated a marginally significant improvement of understanding and retaining health science, which was delivered to the science group in 8 independent sessions on a weekly basis (p=0.0669). We observed a statistically significant difference in participants’ understanding of their behavioral deficits and how to improve primary behavior (p=0.01). There was no significant difference in either group regarding the extent to which participants understand the particular behavior to improve (p\u3e0.05). CONCLUSION Findings from our study demonstrate that integration of an 8-week science curriculum into life skill training did not negatively affect participants’ understanding of their own behaviors. Compared to the control group, we observed a marginally significant improvement in health knowledge assessment scores among students in the science group. Finally, the 8-week science curriculum, both active and passive learning components, was determined to be an effective delivery method for the content involved. Further study in a larger sample may be necessary to detect significant effects of the curriculum

A Polyextreme Hydrothermal System Controlled by Iron: The Case of Dallol at the Afar Triangle

One of the latest volcanic features of the Erta Ale range at the Afar Triangle (NE Ethiopia) has created a polyextreme hydrothermal system located at the Danakil depression on top of a protovolcano known as the dome of Dallol. The interaction of the underlying basaltic magma with the evaporitic salts of the Danakil depression has generated a unique, high-temperature (108 °C), hypersaline (NaCl supersaturated), hyperacidic (pH values from 0.1 to −1.7), oxygen-free hydrothermal site containing up to 150 g/L of iron. We find that the colorful brine pools and mineral patterns of Dallol derive from the slow oxygen diffusion and progressive oxidation of the dissolved ferrous iron, the iron-chlorine/-sulfate complexation, and the evaporation. These inorganic processes induce the precipitation of nanoscale jarosite-group minerals and iron(III)- oxyhydroxides over a vast deposition of halite displaying complex architectures. Our results suggest that life, if present under such conditions, does not play a dominant role in the geochemical cycling and mineral precipitation at Dallol as opposed to other hydrothermal sites. Dallol, a hydrothermal system controlled by iron, is a present-day laboratory for studying the precipitation and progressive oxidation of iron minerals, relevant for geochemical processes occurring at early Earth and Martian environmentsThis work received funding from the European Research Council under the Programme (FP7/2007-2013)/ERC Grant Agreement 340863 (Prometheus) and from MINECO, ref CGL2016-78971-P, AEI/FEDER, UE”

Use of surgical bone cement to increase the projection of the nasomaxillary buttress in a case of orthognathic surgery. Technical note

The soft tissue outcome of the projection at the level of the nasomaxillary buttress is difficult to manage in cases of severe hypoprojection, being orthognathic surgery resolutive at the occlusal level but sometimes insufficient at the level of esthetic outcome. The literature describes the use of alloplastic prostheses and autologous bone grafts, but there are few documented cases of the use of premolded surgical cement for this purpose. The main advantage of the use of bone cement over the alternatives described is its ability to be premolded for customization, low cost, easy availability, speed of preparation and minimal comorbidity. This technical note describes the surgical steps and outcome of the use of surgical bone cement for projection augmentation at this level, including notes on preparation, premolding and fixation. Key words:Orthognathic surgery, maxillary surgery, surgical bone cement, nasomaxillary buttress

biofábricas y biorreactores de inmersión temporal: propagación in vitro de Anthurium andreanum L., y su viabilidad económica

Objective: To evaluate technical and financial feasibility for implementation of a biofactory for in vitro propagation of anthuriums. Design/methodology/approach: The experiment had a completely random distribution. Data were subjected to a one-way analysis of variance (ANOVA), means were compared using Duncan's test (P ? 0.05). In order to calculate the economic viability of the Biofactory, the indicators Equilibrium Point, Benefit/Cost Ratio, Net Present Value (VAV) and Internal Rate of Return (IRR) were determined. Results: Commercial SIT Automated Temporary Immersion Vessel (RITA®) was used in this study. An average multiplication rate of 26.4 shoots per explant was obtained using liquid medium supplemented with 2 mg L-1 of 6-bencylaminopurine. For the establishment of the biofactory 210 RITA® were used, with an installed capacity to obtain approximately 400,000 seedlings per year. When performing the financial analysis of this technique, it yielded an Internal Rate of Return of 73.64% and a Cost Benefit Ratio of 1.67 and a Net Present Value of MEX $2, 513,056.14 Mexican pesos (US$ 131230.08), over a period of 5 years. These results demonstrated the economic and technical feasibility for the implementation of a biofactory producing anthuriums. Limitations on study/implications: The use of semi-solid culture media in the multiplication stage reduces the production capacity and significantly reduces the profitability of the Biofactory. Findings/conclusions: The profitability of a biofactory for the production of anthuriums depends on the multiplication rate, achieved in this case through the use of RITA®, currently has the complete and proven technology to be transferred to any interested entrepreneur.Objetivo: Evaluar la viabilidad técnica y financiera para la implementación de una biofábrica para la propagación in vitro de Anthurium andreanum L. Diseño/metodología/aproximación: El experimento tuvo una distribución completamente al azar. Los datos se sometieron a un análisis unidireccional de varianza (ANOVA), las medias se compararon mediante la prueba de Duncan (P ? 0,05). Con el fin de calcular la viabilidad económica de la Biofábrica, se determinaron los indicadores de Punto de Equilibrio, Relación Beneficio/Costo, el Valor Actual Neto (VAV) y la Tasa Interna de Retorno (TIR). Resultados: En este estudio se utilizó el SIT comercial Recipiente de Inmersión Temporal Automatizado (RITA®). Se obtuvo una tasa promedio de multiplicación de 26.4 brotes por explante utilizando medio líquido suplementado con 2 mg L-1 de 6-bencilaminopurina. Para el establecimiento de la biofábrica se utilizaron 210 RITA®, con una capacidad instalada para obtener aproximadamente 400,000 plántulas al año. Al realizar el análisis financiero de esta técnica, arrojó una Tasa Interna de Retorno de 73.64% y una Relación Beneficio Costo de 1.67 y un Valor Actual Neto de MEX $2, 513,056.14 pesos mexicanos (US$ 131230.08), en un periodo de 5 años. Con estos resultados se demostró la viabilidad económica y técnica para la implementación de una biofábrica productora de anturios. Limitaciones del estudio/implicaciones: Utilizar medios de cultivo semisólidos en la etapa de multiplicación, disminuye la capacidad de producción y baja de manera significativa la rentabilidad de la biofábrica. Hallazgos/conclusiones: La rentabilidad de una biofábrica para la producción de anturios depende de la tasa de multiplicación, alcanzada en este caso a través del uso del RITA®, actualmente se cuenta con la tecnología completa y comprobada para ser transferida a algún emprendedor interesado

Gestión ejecutiva del medio digital especializado en gastronomía peruana Leche de Tigre entre los meses setiembre y noviembre del año 2022

El presente trabajo expone la construcción de un medio digital periodístico especializado en gastronomía, Leche de Tigre, con el objetivo de abordarla desde diferentes ámbitos de la sociedad, tales como la salud, la política, la cultura o el entretenimiento. Este medio nacido en septiembre del 2022 busca convertirse en un referente sobre la industria gastronómica peruana. De igual manera, este trabajo aborda teóricamente el periodismo gastronómico, el uso de las redes sociales y el financiamiento de un medio nativo digital tomando como ejemplo el desarrollo de Leche de Tigre en el periodo de septiembre a octubre de 2022. Asimismo, en la presente investigación se explora el plan de marketing digital y los métodos de financiamiento utilizados en dicho medio para su sostenibilidad.This paper presents the construction of a digital journalistic medium specialized in gastronomy, Leche de Tigre, with the aim of approaching it from different areas of society, such as health, politics, culture or entertainment. This media, born in September 2022, seeks to become a reference on the Peruvian gastronomic industry. Similarly, this work theoretically addresses gastronomic journalism, the use of social networks and the financing of a digital native media, taking as an example the development of Leche de Tigre in the period from September to October 2022. Likewise, this research explores the digital marketing plan and the financing methods used in said medium for its sustainability

Agranulocitosis en paciente en tratamiento con oxcarbazepina que tras su retirada se evidenció recuperación de neutrófilos

INTRODUCCIÓN La oxcarbacepina es un derivado estructural de la carbacepina que rápidamente pasa a su metabolito activo MHD (monohidroxiderivado). Su estructura particular ayuda a reducir el impacto sobre el metabolismo del hígado asociado con la carbamacepina y, por lo tanto, también a la aparición de menor número de efectos secundarios, como la agranulocitosis. CASO CLÍNICO Mujer de setenta y nueve años con antecedentes de espondiloartrosis y neuralgia del trigémino, en tratamiento habitual con oxcarbacepina. Acude a urgencias remitida por su médico de atención primaria tras cuadro confusional de unos días de evolución, y fiebre de 38° C junto con cuadro diarreico de veinticuatro horas de evolución. En analítica general se evidencian leucocitos 0,5 x 109/l con un 87 % de linfocitos, resto de parámetros normales. Se revisan ana-líticas anteriores de los últimos cinco años, objetivándose parámetros dentro de la normalidad..

NeuroBoricuas: a novel approach for incorporating neuroscience education in schools of Puerto Rico

[EN] Puerto Rico is in dire need of transforming its education system to counter the current economic recession and ensure a future with talented Puerto Ricans at the forefront of scientific research and technology development.  Here we present a group of neuroscientists and educators, the NeuroBoricuas, committed to revolutionize the scientific culture of Puerto Rico by incorporating neuroscience research training and inquiry-based activities in public and private schools. We carry out our vision through diverse methods, such as community outreach activities, where we promote neuroscience literacy using diverse learning activities. In parallel, we are designing a neuroscience course and textbook with educators to be implemented in schools. We also established neuroscience laboratories in K-12 schools and trained science teachers to manage such laboratories, using equipment from the company “Backyard Brains”. These laboratory experiences are integrated into the academic curriculum in high schools and the equipment is also available for students interested in designing their independent research projects. Lastly, we are expanding a network of committed scientists who partner with educators to help nurture future neuroscientists early in their academic endeavors. Here, we describe our trajectory and our approach to transform scientific education in Puerto Rico.We thank Dr. Gregory J. Quirk, Dr. Daniel Colon-Ramos and Dr. Mark Miller for their support. We thank Tim Marzullo, from Backyard Brains, for supporting NeuroBoricuas. We also thank Palabreria, Digi-Serv and Puerto Rico 4.0 for their constant support. We thank all the NeuroBoricuas that selflessly work hard for a better Puerto Rico. This work has been supported by generous donations from the Puerto Rican people, a grant from the University of Puerto Rico Medical Sciences Campus’ Chancellor’s office, and the Grass Foundation.http://ocs.editorial.upv.es/index.php/HEAD/HEAD18Bravo-Rivera, C.; Díaz-Ríos, M.; Aldarondo-Hernández, A.; Santos-Vera, B.; Ramos-Medina, L.; De Jesús-Burgos, M.; Bravo-Rivera, H.... (2018). NeuroBoricuas: a novel approach for incorporating neuroscience education in schools of Puerto Rico. Editorial Universitat Politècnica de València. 1447-1455. https://doi.org/10.4995/HEAD18.2018.8223OCS1447145

A randomized phase II clinical trial of dendritic cell vaccination following complete resection of colon cancer liver metastasis

Surgically resectable synchronic and metachronic liver metastases of colon cancer have high risk of relapse in spite of standard-of-care neoadjuvant and adjuvant chemotherapy regimens. Dendritic cell vaccines loaded with autologous tumor lysates were tested for their potential to avoid or delay disease relapses (NCT01348256). Patients with surgically amenable liver metastasis of colon adenocarcinoma (n = 19) were included and underwent neoadjuvant chemotherapy, surgery and adjuvant chemotherapy. Fifteen patients with disease-free resection margins were randomized 1:1 to receive two courses of four daily doses of dendritic cell intradermal vaccinations versus observation. The trial had been originally designed to include 56 patients but was curtailed due to budgetary restrictions. Follow-up of the patients indicates a clear tendency to fewer and later relapses in the vaccine arm (median disease free survival –DFS-) 25.26 months, 95% CI 8. 74-n.r) versus observation arm (median DFS 9.53 months, 95% CI 5.32–18.88)

Parenteral Nutrition: Current Use, Complications, and Nutrition Delivery in Critically Ill Patients

Background: Parenteral nutrition (PN) is needed to avoid the development of malnutrition when enteral nutrition (EN) is not possible. Our main aim was to assess the current use, complications, and nutrition delivery associated with PN administration in adult critically ill patients, especially when used early and as the initial route. We also assessed the differences between patients who received only PN and those in whom EN was initiated after PN (PN-EN). Methods: A multicenter (n = 37) prospective observational study was performed. Patient clinical characteristics, outcomes, and nutrition-related variables were recorded. Statistical differences between subgroups were analyzed accordingly. Results: From the entire population (n = 629), 186 (29.6%) patients received PN as initial nutrition therapy. Of these, 74 patients (11.7%) also received EN during their ICU stay (i.e., PNEN subgroup). PN was administered early (<48 h) in the majority of patients (75.3%; n = 140) and the mean caloric (19.94 +/- 6.72 Kcal/kg/day) and protein (1.01 +/- 0.41 g/kg/day) delivery was similar to other contemporary studies. PN showed similar nutritional delivery when compared with the enteral route. No significant complications were associated with the use of PN. Thirty-two patients (43.3%) presented with EN-related complications in the PN-EN subgroup but received a higher mean protein delivery (0.95 +/- 0.43 vs 1.17 +/- 0.36 g/kg/day; p = 0.03) compared with PN alone. Once adjusted for confounding factors, patients who received PN alone had a lower mean protein intake (hazard ratio (HR): 0.29; 95% confidence interval (CI): 0.18-0.47; p = 0.001), shorter ICU stay (HR: 0.96; 95% CI: 0.91-0.99; p = 0.008), and fewer days on mechanical ventilation (HR: 0.85; 95% CI: 0.81-0.89; p = 0.001) compared with the PN-EN subgroup. Conclusion: The parenteral route may be safe, even when administered early, and may provide adequate nutrition delivery. Additional EN, when possible, may optimize protein requirements, especially in more severe patients who received initial PN and are expected to have longer ICU stays. NCT Registry: 03634943

Contribución de la producción animal en pequeña escala al desarrollo rural

La producción y el consumo de productos de origen animal han experimentado un rápido crecimiento en todo el mundo, y se prevé que continuarán aumentando. Se considera que la mayor parte del incremento en la producción provendrá de sistemas de producción en pequeña escala, que representan el medio de vida de hasta un 70% de la población rural pobre del mundo.1 La producción animal en pequeña escala se reconoce en todo el mundo como un elemento que contribuye al alivio de la pobreza en el medio rural, mediante generación de ingresos, oportunidades de ocupación y dinamismo del uso de los recursos disponibles. Por lo tanto, es de suma importancia conocer las dinámicas de estos sistemas de producción animal y su contribución al desarrollo rural en México. Investigadores y extensionistas deben priorizar las demandas de la producción animal en las comunidades rurales, ya que la producción animal en pequeña escala ha contribuido a mejorar la calidad de vida y a disminuir la vulnerabilidad de las familias productoras. En el México prehispánico la población sólo criaba xoloitzcuintle y guajolotes como animales domésticos, y complementaba en proteínas su dieta con la caza y la pesca. Sin embargo, con la llegada de los españoles en 1521 llegaron también los primeros bovinos a la Nueva España, que se reprodujeron con suma rapidez. La carne de bovino llegó a constituir una parte sustancial de la dieta alimenticia de toda la población.2 A pesar de que al inicio la producción animal era casi nula, ésta empezó a desarrollarse rápidamente y en la actualidad representa un pilar importante para el desarrollo rural en las familias campesinas de nuestro país, pues es vista como una fuente de ingreso