3,440 research outputs found
Patient-reported outcomes and therapeutic affordances of social media findings from a global online survey of people with chronic pain
BACKGROUND: Patient-reported outcomes (PROs) from social media use in chronic disease management continue to emerge. While many published articles suggest the potential for social media is positive, there is a lack of robust examination into mediating mechanisms that might help explain social media’s therapeutic value. This study presents findings from a global online survey of people with chronic pain (PWCP) to better understand how they use social media as part of self-management. OBJECTIVE: Our aim is to improve understanding of the various health outcomes reported by PWCP by paying close attention to therapeutic affordances of social media. We wish to examine if demographics of participants underpin health outcomes and whether the concept of therapeutic affordances explains links between social media use and PROs. The goal is for this to help tailor future recommendations for use of social media to meet individuals’ health needs and improve clinical practice of social media use. METHODS: A total of 231 PWCP took part in a global online survey investigating PROs from social media use. Recruited through various chronic disease entities and social networks, participants provided information on demographics, health/pain status, social media use, therapeutic affordances, and PROs from use. Quantitative analysis was performed on the data using descriptive statistics, cross-tabulation, and cluster analysis. RESULTS: The total dataset represented 218 completed surveys. The majority of participants were university educated (67.0%, 146/218) and female (83.9%, 183/218). More than half (58.7%, 128/218) were married/partnered and not working for pay (75.9%, 88/116 of these due to ill health). Fibromyalgia (46.6%, 55/118) and arthritis (27.1%, 32/118) were the most commonly reported conditions causing pain. Participants showed a clear affinity for social network site use (90.0%, 189/210), followed by discussion forums and blogs. PROs were consistent, suggesting that social media positively impact psychological, social, and cognitive health. Analysis also highlighted two strong correlations linking platform used and health outcomes (particularly psychological, social, and cognitive) to (1) the narrative affordance of social media and (2) frequency of use of the platforms. CONCLUSIONS: Results did not uncover definitive demographics or characteristics of PWCP for which health outcomes are impacted. However, findings corroborate literature within this domain suggesting that there is a typical profile of people who use social media for health and that social media are more suited to particular health outcomes. Exploration of the relationship between social media’s therapeutic affordances and health outcomes, in particular the narration affordance, warrants further attention by patients and clinicians
La calidad del servicio de las empresas ferroviarias de Cusco y el nivel de satisfacción de los turistas en el año 2023
En el presente estudio titulado “La calidad del servicio de las empresas ferroviarias
de Cusco y el nivel de satisfacción de los turistas en el año 2023”, se buscó
comprender la relación entre estos dos aspectos clave, teniendo como objetivo
determinar la relación que existe entre la calidad del servicio de las empresas
ferroviarias de Cusco y el nivel de satisfacción de los turistas en el año 2023, siendo
la metodología de investigación tipo básica, con un nivel descriptivo y correlacional
no experimental. Este enfoque permitió comprender la relación entre la calidad del
servicio y la satisfacción de los turistas sin introducir variables de intervención.
Como población del estudio se tuvo en cuenta a los turistas que usaron los servicios
de transporte ferroviario en Cusco durante el presente año, teniendo como muestra
un grupo de 100 encuestados extranjeros para lo que fue de utilidad como
instrumento de recolección de datos el cuestionario. El análisis de datos del
presente estudio se realizó con la ayuda del software SPSS 25, teniendo como
resultado que el 34% de los turistas experimentan una regular calidad de servicio y
nivel de satisfacción, este hallazgo subraya la necesidad de abordar y mejorar
específicamente los aspectos relacionados con la calidad de servicio para elevar la
satisfacción del cliente en este segmento. Identificar las áreas específicas de
mejora dentro de la calidad de servicio será esencial para elevar el nivel general de
satisfacción de estos turistas y, por ende, fortalecer la reputación y la retención del
cliente. El presente estudio concluyó que la calidad de servicio y el nivel de
satisfacción tienen una correlación de Rho = 0,510 y un nivel de significancia de =
0,001 < 0,05
Associations between sexual activity and weight status: Findings from the English Longitudinal Study of Ageing.
OBJECTIVE: To investigate the association between weight status and sexual activity in middle-aged and older adults. METHODS: Cross-sectional analysis on Wave 6 (2012/13) of the English Longitudinal Study of Ageing. Data were from 2,200 men and 2,737 women aged ≥50 years (mean 68.2 years). The explanatory variable was weight status, defined as normal-weight (BMI: ≤24.9), overweight (BMI: 25.0-29.9) or obese (BMI: ≥30) based on objective measurements of height and weight. Outcome variables were any self-reported sexual activity in the last year (yes/no) and, if yes, frequency of sexual intercourse in the last month. Covariates included a range of sociodemographic, lifestyle, and health-related variables. Associations were analysed using binary (past-year sexual activity) and ordinal (frequency of past-month sexual intercourse) logistic regression models. RESULTS: The majority (73.3%) of men and half (50.0%) of women reported any sexual activity in the last year. The odds of reporting any sexual activity in the last year did not differ significantly by weight status in either men or women. However, among those who were sexually active, men with overweight (OR = 1.45, 95% CI 1.15-1.81, p = 0.002) or obesity (OR = 1.38, 95% CI 1.07-1.77, p = 0.015), and women with overweight (OR = 1.34, 95% CI 1.05-1.71, p = 0.017) reported significantly more frequent sexual intercourse in the last month compared with those who had a BMI in the normal-weight range, after adjustment for covariates. CONCLUSION: Older adults with overweight or obesity who are sexually active engage in more frequent sexual activity than those who are normal weight
A method for automatically extracting infectious disease-related primers and probes from the literature
BACKGROUND: Primer and probe sequences are the main components of nucleic acid-based detection systems. Biologists use primers and probes for different tasks, some related to the diagnosis and prescription of infectious diseases. The biological literature is the main information source for empirically validated primer and probe sequences. Therefore, it is becoming increasingly important for researchers to navigate this important information. In this paper, we present a four-phase method for extracting and annotating primer/probe sequences from the literature. These phases are: (1) convert each document into a tree of paper sections, (2) detect the candidate sequences using a set of finite state machine-based recognizers, (3) refine problem sequences using a rule-based expert system, and (4) annotate the extracted sequences with their related organism/gene information. RESULTS: We tested our approach using a test set composed of 297 manuscripts. The extracted sequences and their organism/gene annotations were manually evaluated by a panel of molecular biologists. The results of the evaluation show that our approach is suitable for automatically extracting DNA sequences, achieving precision/recall rates of 97.98% and 95.77%, respectively. In addition, 76.66% of the detected sequences were correctly annotated with their organism name. The system also provided correct gene-related information for 46.18% of the sequences assigned a correct organism name. CONCLUSIONS: We believe that the proposed method can facilitate routine tasks for biomedical researchers using molecular methods to diagnose and prescribe different infectious diseases. In addition, the proposed method can be expanded to detect and extract other biological sequences from the literature. The extracted information can also be used to readily update available primer/probe databases or to create new databases from scratch.The present work has been funded, in part, by the European Commission through the ACGT integrated project (FP6-2005-IST-026996) and the ACTION-Grid support action (FP7-ICT-2007-2-224176), the Spanish Ministry of Science and Innovation through the OntoMineBase project (ref. TSI2006-13021-C02-01), the ImGraSec project (ref. TIN2007-61768), FIS/AES PS09/00069 and COMBIOMED-RETICS, and the Comunidad de Madrid, Spain.S
Real-world evidence of tisagenlecleucel for the treatment of relapsed or refractory large B-cell lymphoma
Recerca clínica del càncer; Càncer hematològic; Limfoma no HodgkinInvestigación clínica del cáncer; Cáncer hematológico; Linfoma no HodgkinClinical cancer research; Hematological cancer; Non-Hodgkin's lymphomaTisagenlecleucel (tisa-cel) is a second-generation autologous CD19-targeted chimeric antigen receptor (CAR) T-cell therapy approved for relapsed/refractory (R/R) large B-cell lymphoma (LBCL). The approval was based on the results of phase II JULIET trial, with a best overall response rate (ORR) and complete response (CR) rate in infused patients of 52% and 40%, respectively. We report outcomes with tisa-cel in the standard-of-care (SOC) setting for R/R LBCL. Data from all patients with R/R LBCL who underwent leukapheresis from December 2018 until June 2020 with the intent to receive SOC tisa-cel were retrospectively collected at 10 Spanish institutions. Toxicities were graded according to ASTCT criteria and responses were assessed as per Lugano 2014 classification. Of 91 patients who underwent leukapheresis, 75 (82%) received tisa-cel therapy. Grade 3 or higher cytokine release syndrome and neurotoxicity occurred in 5% and 1%, respectively; non-relapse mortality was 4%. Among the infused patients, best ORR and CR were 60% and 32%, respectively, with a median duration of response of 8.9 months. With a median follow-up of 14.1 months from CAR T-cell infusion, median progression-free survival and overall survival were 3 months and 10.7 months, respectively. At 12 months, patients in CR at first disease evaluation had a PFS of 87% and OS of 93%. Patients with an elevated lactate dehydrogenase showed a shorter PFS and OS on multivariate analysis. Treatment with tisa-cel for patients with relapsed/refractory LBCL in a European SOC setting showed a manageable safety profile and durable complete responses
The Prevalence and Indications of Intravenous Rehydration Therapy in Hospital Settings: A Systematic Review
(1) Objective: We performed a systematic review to explore the prevalence of intravenous (IV) rehydration therapy in hospital settings, and we assessed it by patient groups and populations. (2) Methods: A systematic review of major databases and grey literature was undertaken from inception to 28 March 2022. Studies reporting prevalence of IV rehydration therapy in a hospital setting were identified. The data were synthesised in a narrative approach. (3) Results: Overall, 29 papers met the inclusion criteria. The prevalence of IV rehydration therapy in paediatric patients ranged from 4.5% (hospitalised with diarrhoea and dehydration) to 100% (admitted to the emergency department with mild to moderate dehydration caused by viral gastroenteritis), and in adults this ranged from 1.5% (had single substance ingestion of modafinil) to 100% (hospitalised with hypercalcemia). The most common indication for IV rehydration therapy in paediatric patients was dehydration due to fluid loss from the gastrointestinal tract. Other causes included malnutrition, neuromuscular disease, bronchiolitis, and influenza. In adults, indications for IV rehydration therapy were much more diverse: fever, diarrhoea, drug intoxication, hypercalcemia, cancer, and postural tachycardia syndrome; (4) Conclusions: This systematic review showed that IV rehydration therapy in paediatric patients is often used to treat dehydration and diarrhoea, while in adults it has a broader spectrum of use. While IV rehydration therapy is important in correcting fluid problems and electrolyte status, the maintenance fluid prescribing practices vary considerably, and guidelines are scarce
Nanoinformatics: developing new computing applications for nanomedicine
Nanoinformatics has recently emerged to address the need of computing applications at the nano level. In this regard, the authors have participated in various initiatives to identify its concepts, foundations and challenges. While nanomaterials open up the possibility for developing new devices in many industrial and scientific areas, they also offer breakthrough perspectives for the prevention, diagnosis and treatment of diseases. In this paper, we analyze the different aspects of nanoinformatics and suggest five research topics to help catalyze new research and development in the area, particularly focused on nanomedicine. We also encompass the use of informatics to further the biological and clinical applications of basic research in nanoscience and nanotechnology, and the related concept of an extended ?nanotype? to coalesce information related to nanoparticles. We suggest how nanoinformatics could accelerate developments in nanomedicine, similarly to what happened with the Human Genome and other -omics projects, on issues like exchanging modeling and simulation methods and tools, linking toxicity information to clinical and personal databases or developing new approaches for scientific ontologies, among many others
Propuesta de intervención frente a la desnutrición infantil de 0 a 5 años del municipio de Puerto Carreño - Vichada
No aplicaLa población infantil de 0 a 5 años del municipio de Puerto Carreño – Vichada, continúa afrontando el grave problema de la desnutrición a pesar de los esfuerzos que las entidades estatales vienen realizando para mejorar esta situación. Uno de los vacíos que se han presentado al evaluar el impacto de las acciones de complementariedad alimentaria ha sido la carencia de un diagnóstico del estado nutricional que permita conocer la situación inicial de la intervención y facilite la determinación de un sistema de vigilancia nutricional. Una de las problemáticas más grandes que enfrenta el municipio de Puerto Carreño es el acceso a una alimentación adecuada, lo cual se ve reflejado en el consumo y el estado nutricional de su población en especial la que se encuentra entre 0 a 5 años, según los indicadores económicos y sociales, la tasa de pobreza del municipio es de 29,3% y la de pobreza extrema de 8,4% (DNP, 2016).
Esta propuesta está orientada a disminuir las tasas desnutrición de la población infantil de 0 a 5 años en el municipio de Puerto Carreño, bajo un enfoque interinstitucional e intersectorial que implique los actores responsables de brindar una respuesta integral a la problemática de desnutrición en la población de 0 a 5 años del municipio. Desde el sector salud, las acciones orientadas deben ser transversales cuya base se encuentra en una atención sanitaria que permita la identificación de un diagnóstico y tratamiento temprano además de promover estrategias de promoción y prevención.The child population from 0 to 5 years of age in the municipality of Puerto Carreño - Vichada continues to face the serious problem of malnutrition despite the efforts that state entities have been making to improve this situation. One of the gaps that have arisen when evaluating the impact of food complementarity actions has been the lack of a nutritional status diagnosis that allows knowing the initial situation of the intervention and facilitates the determination of a nutritional surveillance system. One of the biggest problems facing the municipality of Puerto Carreño is access to adequate food, which is reflected in the consumption and nutritional status of its population, especially those between 0 to 5 years of age. According to economic and social indicators, the municipality's poverty rate is 29.3% and the extreme poverty rate is 8.4% (DNP, 2016).
This proposal is aimed at reducing the malnutrition rates of the child population from 0 to 5 years of age in the municipality of Puerto Carreño, under an inter-institutional and intersectoral approach that involves the actors responsible for providing a comprehensive response to the problem of malnutrition in the population of 0 to 5 years of the municipality. From the health sector, the oriented actions must be transversal, based on health care that allows the identification of early diagnosis and treatment, as well as promoting promotion and prevention strategies
Response-adapted treatment with rituximab, bendamustine, mitoxantrone, and dexamethasone followed by rituximab maintenance in patients with relapsed or refractory follicular lymphoma after first-line immunochemotherapy: Results of the RBMDGELTAMO08 phase II trial
Background Consensus is lacking regarding the optimal salvage therapy for patients with follicular lymphoma who relapse after or are refractory to immunochemotherapy. Methods This phase II trial evaluated the efficacy and safety of response-adapted therapy with rituximab, bendamustine, mitoxantrone, and dexamethasone (RBMD) in follicular lymphoma patients who relapsed after or were refractory to first-line immunochemotherapy. Sixty patients received three treatment cycles, and depending on their response received an additional one (complete/unconfirmed complete response) or three (partial response) cycles. Patients who responded to induction received rituximab maintenance therapy for 2 years. Results Thirty-three (55%) and 42 (70%) patients achieved complete/unconfirmed complete response after three cycles and on completing induction therapy (4-6 cycles), respectively (final overall response rate, 88.3%). Median progression-free survival was 56.4 months (median follow-up, 28.3 months; 95% CI, 15.6-51.2). Overall survival was not reached. Progression-free survival did not differ between patients who received four vs six cycles (P = .6665), nor between patients who did/did not receive rituximab maintenance after first-line therapy (P = .5790). Median progression-free survival in the 10 refractory patients was 25.5 months (95% CI, 0.6-N/A) and was longer in patients who had shown progression of disease after 24 months of first-line therapy (median, 56.4 months; 95% CI, 19.8-56.4) than in those who showed early progression (median, 42.31 months; 95% CI, 24.41-NA) (P = .4258). Thirty-six (60%) patients had grade 3/4 neutropenia. Grade 3/4 febrile neutropenia and infection were recorded during induction (4/60 [6.7%] and 5/60 [8.3%] patients, respectively) and maintenance (2/43 [4.5%] and 4/43 [9.1%] patients, respectively). Conclusions This response-adapted treatment with RBMD followed by rituximab maintenance is an effective and well-tolerated salvage treatment for relapsed/refractory follicular lymphoma following first-line immunochemotherapy
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