Looking for the left sneutrino LSP with displaced-vertex searches

We analyze a displaced dilepton signal expected at the LHC for a tau left sneutrino as the lightest supersymmetric particle with a mass in the range $45$-$100$ GeV. The sneutrinos are pair produced via a virtual $W$, $Z$ or $\gamma$ in the $s$ channel and, given the large value of the tau Yukawa coupling, their decays into two dileptons or a dilepton plus missing transverse energy from neutrinos can be significant. The discussion is carried out in the $\mu \nu$SSM, where the presence of $R$-parity violating couplings involving right-handed neutrinos solves the $\mu$ problem and can reproduce the neutrino data. To probe the tau left sneutrinos we compare the predictions of the $\mu \nu$SSM with the ATLAS search for long-lived particles using displaced lepton pairs in $pp$ collisions at $\sqrt s= 8$ TeV, allowing us to constrain the parameter space of the model. We also consider an optimization of the trigger requirements used in existing displaced-vertex searches by means of a High Level Trigger that exploits tracker information. This optimization is generically useful for a light metastable particle decaying into soft charged leptons. The constraints on the sneutrino turn out to be more stringent. We finally discuss the prospects for the $13$ TeV LHC searches as well as further potential optimizations.Comment: Version published in PRD, discussions expanded, references added, LEP and LHC constraints discussed in more detail, 29 pages, 9 figures, 9 table

Professor Avatar Holographic Telepresence Model

Introduced into theaters in the 1860s, Pepper’s Ghost startled theatergoers with an effect that allowed live people or objects to materialize into the scene. The illusion of a ghost is an actor located forward of and below the stage floor. The glass illustrates the reflection of the offstage “ghost,” while the leftmost “ghost” simulates what the audiences see. Modern versions of this effect consist of a completely new way of projecting video to create the illusion of life-size, full-color, moving images but projected as 2D images into a set. The mind of the audience creates the 3D illusion. This technology enables a new line of communication, which is called “holographic telepresence” that delivers a life-sized holographic experience in real time, enabling to connect more effectively and make an impact on audiences. The technology reduces expenses and saves on time travel. This project identified the parameters for correct setup of holographic telepresence, so that future users will be able to replicate and use with ease. The project used action research, which provides fast and effective solutions. The results demonstrated that it was possible that by defining the parameters and a guide for setting up a holographic telepresence

Four International Factors for Democratic Change in Mexico (1990-2006)

Durante la mayor parte del siglo XX, México se mantuvo aislado de la influencia externa a causa del sesgo estatista y nacionalista de su política exterior. Debido a un sistema político autoritario presidencialista, de partido hegemónico y pluralismo limitado. Durante los años 1990 se fueron implementando reformas económicas y políticas, influenciadas por cuatro actores externos: Estados Unidos, ONU, OEA y Unión Europea. Aquí se revisan momentos históricos clave que incidieron para la apertura democrática en México. La influencia se centró en dos áreas principales: 1) Derechos humanos, donde se aceptó la observación internacional y 2) en los procesos electorales, que generaron reformas que dieron paso al proceso de transición a la democracia en México.For the most part of the twentieth century, Mexico remained isolated from outside influence because of its nationalist and statist bias of its foreign policy, this because of a presidential authoritarian political system, of hegemonic party, and limited pluralism. During the 1990s were implemented economic and political reforms, influenced by four external actors: United States, United Nations, OAS, and European Union. Here, key historical moments that induced the democratic opening in Mexico are reviewed. Their influence focused on two main areas: 1) human rights, where international observation was accepted, and 2) electoral processes, which generate reforms that led to the transition to democracy in Mexico

Sampling the μν SSM for displaced decays of the tau left sneutrino LSP at the LHC

Within the framework of the μνSSM , a displaced dilepton signal is expected at the LHC from the decay of a tau left sneutrino as the lightest supersymmetric particle (LSP) with a mass in the range 45–100 GeV. We compare the predictions of this scenario with the ATLAS search for long-lived particles using displaced lepton pairs in pp collisions, considering an optimization of the trigger requirements by means of a high level trigger that exploits tracker information. The analysis is carried out in the general case of three families of right-handed neutrino superfields, where all the neutrinos get contributions to their masses at tree level. To analyze the parameter space, we sample the μνSSM for a tau left sneutrino LSP with proper decay length cτ>0.1mm using a likelihood data-driven method, and paying special attention to reproduce the current experimental data on neutrino and Higgs physics, as well as flavor observables. The sneutrino is special in the μνSSM since its couplings have to be chosen so that the neutrino oscillation data are reproduced. We find that important regions of the parameter space can be probed at the LHC run 3.Fil: Kpatcha, Essodjolo. Universidad Autónoma de Madrid; EspañaFil: Lara, Iñaki. Universidad Autónoma de Madrid; España. Institute for Basic Science. Center for Theoretical Physics of the Universe; Corea del NorteFil: Lopez, Daniel Elbio. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Muñoz, Carlos. Universidad Autónoma de Madrid; EspañaFil: Nagata, Natsumi. University Of Tokyo; JapónFil: Otono, Hidetoshi. Kyushu University; JapónFil: de Austri, Roberto Ruiz. Instituto de Física Corpuscular; Españ

Obtención de Jabón de Tocador a partir de Glicerina, por el método de Saponificación con NaOH, usando como agente espumante saponinas, provenientes del fruto del árbol de Guanacaste (Enterolobium cyclocarpum) y determinación de los parámetros de calidad del jabón tocador al jabón de glicerina terminado, en los laboratorios del Departamento de Química de la UNAN-Managua. Abril 2014

En el presente estudio se obtuvo jabón de tocador a pariir de glicerina con el objetivo de compararlo con un jabón de tocador PROTEX a través de la aplicación de los parámetros de calidad, tales como: pH, índice de espumosidad y porcentaje de humedad, buscando con ello dar una respuesta a las personas alérgicas que utjlizan jabones comerciales irritando sus pieles sensibles. Para obtener el jabón de tocador a partir de glicerina, se utilizó el método de saponificación con NaoH por medio de tres pasos, los cuales son: separación, saponificación y secado, conjuntamente utilizando el programa estadístico Minitab para las condiciones operacionales para la elaboración del jabón de tocador

Cbfa-1 mediates nitric oxide regulation of MMP-13 in osteoblasts.

During bone development, osteoblast differentiation requires remodeling of the extracellular matrix. Although underlying mechanisms have not been elucidated, evidence points to the participation of the nitric oxide (NO) and cyclic guanosine 3',5'-monophosphate (cGMP) system. Here, we detected increased matrix metalloproteinase (MMP)-13 mRNA, protein and activity, as well as increased inducible NO synthase (iNOS) and NO production during the differentiation of MC3T3-E1 osteoblasts. Transcriptional activity of the MMP-13 promoter was augmented by NO, 8-bromo-cGMP (8-Br-cGMP), and by a dominant-positive form of protein kinase G (PKG1-alpha). The stimulatory effect on the MMP-13 promoter was partially inhibited by mutation of the osteoblast-specific element 2 (OSE-2) binding site. Core binding factor-1 (Cbfa-1) expression peaked at 7 days of differentiation, and was phosphorylated by PKG in vitro. Cbfa-1 was localized to cell nuclei, and its translocation was inhibited by the iNOS inhibitor 1400W. Immunohistological examination revealed that MMP-13 and Cbfa-1 expression levels are both reduced in 17-day-old embryos of iNOS-deficient mice. Silencing of Cbfa-1 mRNA blocked MMP-13 expression without interfering with endogenous NO production, confirming its role in NO-induced MMP-13 expression by MC3T3-E1 cells. The results described here suggest a mechanism by which NO regulates osteogenesis.S

The results of different labour induction approaches: A Cross sectional study

Background and Purpose: To evaluate the use of prostaglandins and oxytocin in labour induction according to different indications. Perinatal outcomes, rate of vaginal delivery and complation of labour were studied and compared. Methods: Cross-sectional descriptive study from January 2012 to December 2012. 530 women who required labour induction were included. Seven groups were created according to the methods of induction. Women with twin pregnancies, induction of dead foetus, two previous caesarean sections or an incomplete clinical history were excluded. Results: The rate of vaginal deliveries in women that only received prostaglandins the first day was 84.6%; similar in women with prolonged pregnancies, 85.2%. The induction with oxytocin directly showed the highest rate of caesarean section. The rate of vaginal deliveries was 50% in women with previous caesarean section. Conclusions: A high rate of vaginal deliveries with a single dose of prostaglandin and within 24 hours of beginning induction. Administration of prostaglandins must be used when cervix is unfavorable and previous to oxytocin stymulation

The effects of detraining and retraining periods on fat-mass and fat-free mass in elite male soccer players

The aim of the study was to examine the effects of a detraining period (DTP) (i.e., offseason) with an individually prescribed training program, and a retraining period (RTP) (i.e., pre-season) combining soccer and flywheel-based strength training on fat-free mass (FFM) and fat-mass (FM) in 10 elite professional male soccer players. The present study used a controlled repeated-measures research design to investigate the changes in FFM and FM using dual-energy X-ray absorptiometry. Whole body %FM increased (effect size (ES) = 0.87 ± 0.46) and FFM reduced after DTP (ES = -0.30 ± 0.19), returning to values comparable to the end of the previous season after RTP. At regional levels, arms, legs, and trunk %FM increased (ES = from 0.42 to 1.29) while trunk-FFM was reduced (ES=-0.40±0.26) after DTP, returning to the values observed at the end of the previous season after RTP. Legs-FFM did not change after DTP, with a substantial increase after RTP in comparison with pre-season values (ES = 0.34 ± 0.29 and 0.53 ± 0.36 for the right and left leg, respectively). Despite the small sample size of the present study, the findings indicate that elite soccer players can be allowed 2 weeks of rest during a five-week DTP, since the changes in %FM and FFM were relatively small, and FM and FFM returned to the optimal initial values for competition after the proposed RTP during the pre-season

The nuclear receptor LXRα controls the functional specialization of splenic macrophages.

Macrophages are professional phagocytic cells that orchestrate innate immune responses and have considerable phenotypic diversity at different anatomical locations. However, the mechanisms that control the heterogeneity of tissue macrophages are not well characterized. Here we found that the nuclear receptor LXRα was essential for the differentiation of macrophages in the marginal zone (MZ) of the spleen. LXR-deficient mice were defective in the generation of MZ and metallophilic macrophages, which resulted in abnormal responses to blood-borne antigens. Myeloid-specific expression of LXRα or adoptive transfer of wild-type monocytes restored the MZ microenvironment in LXRα-deficient mice. Our results demonstrate that signaling via LXRα in myeloid cells is crucial for the generation of splenic MZ macrophages and identify an unprecedented role for a nuclear receptor in the generation of specialized macrophage subsets

Insomnia Disorder in Adult Attention-Deficit/Hyperactivity Disorder Patients: Clinical, Comorbidity, and Treatment Correlates

Trastorn per dèficit d'atenció i hiperactivitat; Comorbilitat; Trastorn d'insomniTrastorno por déficit de atención e hiperactividad; Comorbilidad; Trastorno de insomnioAttention deficit and hyperactivity disorder; Comorbidity; Insomnia disorderIntroduction: Several investigations have been performed on insomnia symptoms in adult attention-deficit/hyperactivity disorder (ADHD). However, the relationship between insomnia disorder and adult ADHD has been neglected in research. The main objective of the current study is to analyze the differences between adult ADHD patients with and without insomnia disorder, in terms of ADHD clinical severity, medical and psychiatric comorbidity, psychopharmacological treatment, and quality of life. Material and Methods: Two hundred and fifty-two adult patients with ADHD (mean age 37.60 ± 13.22 years; ADHD presentations—combined: 56.7%, inattentive: 39.7%, hyperactive/impulsive: 3.6%) were evaluated with an exhaustive clinical and psychological evaluation protocol including semistructured interviews (for comorbidities and ADHD assessment) and symptom rating scales for ADHD. The diagnosis of ADHD and insomnia disorder was made according to DSM-5 criteria. Furthermore, the Pittsburgh Sleep Quality Index, Insomnia Severity Index, and Epworth Sleepiness Scale were administered. Results: Insomnia disorder was found in 44.4% of adult ADHD patients and was more common in combined presentation (64.3%) and in patients with more ADHD severity. Comorbidities (both medical and psychiatric), especially mood disorders (42%), anxiety disorder (26.8%), personality disorder (39.3%), and any substance use disorder (11.6%), were associated with a higher insomnia disorder prevalence. ADHD stimulant treatment was related to lower insomnia disorder compared to patients without medication, as well as ADHD stable treatment. Additionally, worse health-related quality of life was associated with insomnia disorder. Conclusion: Insomnia disorder is highly prevalent in adult ADHD and is related to higher ADHD severity and more psychiatric and medical comorbidities. Some stimulants and stable pharmacological ADHD treatment are associated with better outcomes of insomnia disorder.The research leading to these results has received funding from the Instituto de Salud Carlos III (PI18/01788) and supported by the EU's Horizon 2020 Programme (Grant No. 667302, CoCA and Grant No. 728018 Eat2beNICE)