4,543 research outputs found

    Investigation of a novel composite sorbent for improved sorption characteristic

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    Novel composite sorbents are developed. Strontium chloride (SrCl2) is selected whereas expanded natural graphite and nanoparticle i.e. carbon coated nickel are integrated as the additive with different densities for the better heat transfer and sorption performance. Thermal properties such as thermal diffusivity and conductivity are investigated by the laser flash method. The sorption performance is tested by the unit which is especially designed. It is indicated that the highest thermal diffusivity could reach 2.242 mm2\ub7s-1 when the density is 1000 kg\ub7m-3 and testing temperature is 20oC. For different testing temperature and density, the thermal diffusivity range from 1.3 mm2\ub7s-1 to 2.242 mm2\ub7s-1. Also worth noting that the highest thermal conductivity could reach 2.5 mm2\ub7s-1 for the environmental temperature. One paramount factor i.e. the global conversion rate of the novel composite SrCl2 is compared and analyzed under different working conditions. It can be found that the higher desorption temperature results in the faster variation of the global conversion rate. In addition, It takes about 15 minutes and 40 minutes to finish the reaction SrCl2 8-1 and 1-0 when the desorption temperature is 180oC and 130oC, respectively. For sorption process, it is indicated that the global conversion rate varies faster with the increase of the sorption temperature. When the global conversion is 0.7, it takes about 14 to 28 minutes when sorption temperature range from -5oC to 15oC

    Projective simulation for artificial intelligence

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    We propose a model of a learning agent whose interaction with the environment is governed by a simulation-based projection, which allows the agent to project itself into future situations before it takes real action. Projective simulation is based on a random walk through a network of clips, which are elementary patches of episodic memory. The network of clips changes dynamically, both due to new perceptual input and due to certain compositional principles of the simulation process. During simulation, the clips are screened for specific features which trigger factual action of the agent. The scheme is different from other, computational, notions of simulation, and it provides a new element in an embodied cognitive science approach to intelligent action and learning. Our model provides a natural route for generalization to quantum-mechanical operation and connects the fields of reinforcement learning and quantum computation.Comment: 22 pages, 18 figures. Close to published version, with footnotes retaine

    Tour guiding, organisational culture and learning: lessons from an entrepreneurial company

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    This paper examines the impacts of organisational culture on the learning and development of tour guides. Drawing on a case study of a small entrepreneurial tour company, the paper considers the nature of the organisation's culture, the tours it provides, including their narrative contents and the processes of organisational learning and socialisation. The paper suggests that the development of a learning culture within such an organisation may benefit from the provision of appropriate learning opportunities among the guides and facilitators who coordinate guide development

    Efficient Bayesian-based Multi-View Deconvolution

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    Light sheet fluorescence microscopy is able to image large specimen with high resolution by imaging the sam- ples from multiple angles. Multi-view deconvolution can significantly improve the resolution and contrast of the images, but its application has been limited due to the large size of the datasets. Here we present a Bayesian- based derivation of multi-view deconvolution that drastically improves the convergence time and provide a fast implementation utilizing graphics hardware.Comment: 48 pages, 20 figures, 1 table, under review at Nature Method

    Histone deacetylase adaptation in single ventricle heart disease and a young animal model of right ventricular hypertrophy.

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    BackgroundHistone deacetylase (HDAC) inhibitors are promising therapeutics for various forms of cardiac diseases. The purpose of this study was to assess cardiac HDAC catalytic activity and expression in children with single ventricle (SV) heart disease of right ventricular morphology, as well as in a rodent model of right ventricular hypertrophy (RVH).MethodsHomogenates of right ventricle (RV) explants from non-failing controls and children born with a SV were assayed for HDAC catalytic activity and HDAC isoform expression. Postnatal 1-day-old rat pups were placed in hypoxic conditions, and echocardiographic analysis, gene expression, HDAC catalytic activity, and isoform expression studies of the RV were performed.ResultsClass I, IIa, and IIb HDAC catalytic activity and protein expression were elevated in the hearts of children born with a SV. Hypoxic neonatal rats demonstrated RVH, abnormal gene expression, elevated class I and class IIb HDAC catalytic activity, and protein expression in the RV compared with those in the control.ConclusionsThese data suggest that myocardial HDAC adaptations occur in the SV heart and could represent a novel therapeutic target. Although further characterization of the hypoxic neonatal rat is needed, this animal model may be suitable for preclinical investigations of pediatric RV disease and could serve as a useful model for future mechanistic studies
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