Forecasting The Ocean Wave Heights Using Linear Genetic Programming

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv

Clinical Study of Chakramardadi Pralepa in the management of Dadru Kushta

Background: Skin is the largest organ of human body. Its size and external location makes it susceptible to a wide variety of disorders. In recent years there has been increase in incidence of skin problem due to various reasons like Poverty, Poor sanitation, Unhygienic condition, Pollution etc. Dadru is one among Kushta Roga affecting all the age of population. It is Kapha-Pitta Pradhan Vyadhi and presents clinically with the features of Kandu, Raga, Pidika, Daha, Rookshata, Udgata Mandala etc. and can be correlated with Tinea infection. Management of Dadru includes Shodhana, Shaman and Bahiparimarjan Chikitsa. Chakramarda is a wild crop grows in most part of India and it is known as Ringworm plant. So here in this study Chakramadadi Pralepa was used to evaluate the efficacy in Dadru

Clinical efficacy of Kasakartari Gutika in the management of Kasa in Tamaka Shwasa w.s.r. to Bronchial Asthma

Background: The disease Kasa and Tamaka Shwasa mentioned by Acharya Charaka separately, both the disease are originating from Pranavaha Srotas and can damage Pranavaha Srotas permanently. Especially in Tamaka Shwasa Vyadhi, Kasa is very common as a prominent symptom. In fact patient gets more detoriated after onset of Kasa Vega and fills better when it gets subside. Though Tamaka Shwasa Vyadhi is Pitta Samudbhava, Kapha and Vata are always predominant factors. The Strotorodha made by Styana Kapha provocate Vayu excessively and result into Kasa Vega as symptom. According to Ayurveda the contain of Kasakartari Gutika is act as Kasa-shwashar property and hence for present study Kasakartari Gutika was selected as trial drug for treating the patient of Kasa in Tamaka Shwasa. Aim: To study the efficacy of ‘Kasakartari Gutika’ in the management of Kasa in Tamaka Shwasa w.s.r. to Bronchial Asthma. Material and Methods: Total 30 paients of Kasa in Tamaka Shwasa from OPD and IPD unit of Dr. M. N. Agashe Hospital, Satara, were selected and treated with Kasakartari Gutika 1gm B.D. for the duration of 2 month. Result: Maximum 81.81% relief was observed in Kshudhamandya and 80.64% relief was observed in Ayasenshwasa and 77.5% relief was observed in Kasa. Conclusion: The compound formulation ‘Kasakartari Gutika’ was found as an effective remedy for Kasa in Tamaka Shwasa. The parameters like Kasa, Ayasenshwasa and Kshudhamandya shows that they are highly significant result

Intra- and inter-operator reproducibility of automated cloud-based carotid lumen diameter ultrasound measurement

Background: Common carotid artery lumen diameter (LD) ultrasound measurement systems are either manual or semi-automated and lack reproducibility and variability studies. This pilot study presents an automated and cloud-based LD measurements software system (AtheroCloud) and evaluates its: (i) intra/inter-operator reproducibility and (ii) intra/inter-observer variability. Methods: 100 patients (83 M, mean age: 68 ± 11 years), IRB approved, consisted of L/R CCA artery (200 ultrasound images), acquired using a 7.5-MHz linear transducer. The intra/inter-operator reproducibility was verified using three operator's readings. Near-wall and far carotid wall borders were manually traced by two observers for intra/inter-observer variability analysis. Results: The mean coefficient of correlation (CC) for intra- and inter-operator reproducibility between all the three automated reading pairs were: 0.99 (P < 0.0001) and 0.97 (P < 0.0001), respectively. The mean CC for intra- and inter-observer variability between both the manual reading pairs were 0.98 (P < 0.0001) and 0.98 (P < 0.0001), respectively. The Figure-of-Merit between the mean of the three automated readings against the four manuals were 98.32%, 99.50%, 98.94% and 98.49%, respectively. Conclusions: The AtheroCloud LD measurement system showed high intra/inter-operator reproducibility hence can be adapted for vascular screening mode or pharmaceutical clinical trial mode

Synthesis and evaluation of analgesic, anti-asthmatic activity of (E)-1-(8-hydroxyquinolin-7-yl)-3-phenylprop-2-en-1 ones

Abstract Seventeen (E)-1-(8-hydroxyquinolin-7-yl)-3-phenylprop-2-en-1 one derivatives were synthesized via aldol condensation of substituted benzaldehydes with quinoline chalcones starting from 8-hydroxy quinoline. Molecular docking studies were performed on COX-2 protein for analgesic activity and PDE 4 enzyme for anti-asthmatic activity. Docking studies for analgesic activity reveal that the compounds 2 , 4 , 12 , 14 , and 15 showed significant interaction in terms of hydrogen bonding, hydrophobic attachment and van der Waal interaction with COX-2. The docking studies and pharmacological screening indicate that substitution of hydroxyl and conjugated ketone groups on the aldehyde ring and the quinoline ring accelerates analgesia with better binding to active site. Eddy's hot plate method was used to evaluate analgesic activity of the synthesized compounds. Compounds showed a substantial increase in reaction time when compared with standard pentazocin. Compounds 2 , 4 , 7 , 9 and 13 showed significant binding interactions with PDE 4 enzyme and hence were selected for evaluation of anti-asthmatic activity using the goat tracheal chain method. Studies reveal that substitution of the methoxy group at 4th & 5th positions for compounds 2 , 4 & 7 leads to significant percentage inhibition of histamine induced contraction. The synthesized compounds are thus found to be potent as analgesic and anti-asthmatic agents

Ayurvedic paradigm for COVID-19 prophylaxis and management strategies

25-36The prophylactic and therapeutic potential of traditional systems of medicine like Ayurveda has not being explored to its maximum in the search for effective solutions to the COVID-19 crisis. The present work is an attempt to strategize the strength of Ayurveda in the prophylaxis and management of COVID-19 as a standalone system or integrated with conventional medicine. The restorative protocols for COVID-19 may be planned on the line of management principles described for infectious diseases, epidemics, fever, and respiratory ailments in Ayurveda with single herb and formulations having proven immunomodulatory and anti-viral properties. The way forward is to adopt an integrative approach by taking leads from Ayurveda and incorporating it into the action strategy to fight this pandemic

Double-Stranded RNA Attenuates the Barrier Function of Human Pulmonary Artery Endothelial Cells

Circulating RNA may result from excessive cell damage or acute viral infection and can interact with vascular endothelial cells. Despite the obvious clinical implications associated with the presence of circulating RNA, its pathological effects on endothelial cells and the governing molecular mechanisms are still not fully elucidated. We analyzed the effects of double stranded RNA on primary human pulmonary artery endothelial cells (hPAECs). The effect of natural and synthetic double-stranded RNA (dsRNA) on hPAECs was investigated using trans-endothelial electric resistance, molecule trafficking, calcium (Ca2+) homeostasis, gene expression and proliferation studies. Furthermore, the morphology and mechanical changes of the cells caused by synthetic dsRNA was followed by in-situ atomic force microscopy, by vascular-endothelial cadherin and F-actin staining. Our results indicated that exposure of hPAECs to synthetic dsRNA led to functional deficits. This was reflected by morphological and mechanical changes and an increase in the permeability of the endothelial monolayer. hPAECs treated with synthetic dsRNA accumulated in the G1 phase of the cell cycle. Additionally, the proliferation rate of the cells in the presence of synthetic dsRNA was significantly decreased. Furthermore, we found that natural and synthetic dsRNA modulated Ca2+ signaling in hPAECs by inhibiting the sarco-endoplasmic Ca2+-ATPase (SERCA) which is involved in the regulation of the intracellular Ca2+ homeostasis and thus cell growth. Even upon synthetic dsRNA stimulation silencing of SERCA3 preserved the endothelial monolayer integrity. Our data identify novel mechanisms by which dsRNA can disrupt endothelial barrier function and these may be relevant in inflammatory processes

The chemokine receptor CXCR2 and coronavirus-induced neurologic disease.

Inoculation with the neurotropic JHM strain of mouse hepatitis virus (MHV) into the central nervous system (CNS) of susceptible strains of mice results in an acute encephalomyelitis in which virus preferentially replicates within glial cells while excluding neurons. Control of viral replication during acute disease is mediated by infiltrating virus-specific T cells via cytokine secretion and cytolytic activity, however sterile immunity is not achieved and virus persists resulting in chronic neuroinflammation associated with demyelination. CXCR2 is a chemokine receptor that upon binding to specific ligands promotes host defense through recruitment of myeloid cells to the CNS as well as protecting oligodendroglia from cytokine-mediated death in response to MHV infection. These findings highlight growing evidence of the diverse and important role of CXCR2 in regulating neuroinflammatory diseases