[Pharmacogenetics of depression in elderly patients]

International audienc

[Pharmacogenetics of depression in elderly patients]

International audienc

Odor perception in patients with mood disorders.

International audienceBACKGROUND: Olfaction has obvious correlates with emotional processes but little is known about the several aspects of olfaction in psychiatric disorders characterized by mood disturbance. This research aims at pointing out the specificities of olfactory perception in patients in order to identify the specific cerebral impairments involved in these disorders. METHODS: Olfactory sensitivity, detection, identification, self-evaluation of intensity and pleasantness have been recorded in a control group of healthy subjects (N = 58) and in three sample populations admitted to a Psychiatry Department: depressive patients (N = 49), anorectic patients (N = 17), and patients suffering from addiction to alcohol or drugs (N = 21). RESULTS: Depressive patients have a poor sensitivity, poor detection abilities but over-evaluate the pleasantness of odors. Anorectic patients have a high sensitivity, over-evaluate the intensities of the odors but under-evaluate their pleasantness. Alcoholic/drug addicted patients showed impairments in identification. LIMITATION: This study does not identify inter-individual differences in olfactory perception. CONCLUSION: The psychiatric diseases, here at hand although every one of them may be characterized by depressive components, show diverging impairments in olfactory perception. When variations in sensitivity are usually attributed to peripheral cues, impairments in emotional and cognitive aspects of olfaction are typically related to specific brain structures and processes which could be particularly involved in these diseases