313 research outputs found
The effect of caffeine mouth rinse on self-paced cycling performance
The aim of the study was to determine whether caffeine mouth rinse would improve 30 min self-paced cycling trial. Twelve healthy active males (age 20.5±0.7 years, mass 87.4±18.3 kg) volunteered for the study. They attended the laboratory on 3 separate occasions performing a 30 min self-paced cycling trial. On one occasion water was given as a mouth rinse for 5 s (PLA), on another occasion a 6.4% maltodextrin (CHO) solution was given for 5 s and finally a caffeine solution (containing 32 mg of caffeine dissolved in 125 ml water; CAF) was given for 5 s. Distance cycled, heart rate, ratings of perceived exertion, cadence, speed and power output were recorded throughout all trials. Distance cycled during the CAF mouth rinse trial (16.2±2.8 km) was significantly greater compared to PLA trial (14.9±2.6 km). There was no difference between CHO and CAF trials (P=0.89). Cadence, power and velocity were significantly greater during the CAF trial compared to both PLA and CHO (P0.05). Caffeine mouth rinse improves 30 min cycling performance by allowing the participant to increase cadence, power and velocity without a concurrent increase in perceived exertion and heart rate
Client data files and auditor skepticism: How do âdirtyâ files influence auditorsâ skeptical judgments and actions?
Auditors receive an abundance of client-prepared data files when performing audit work. With todayâs increasingly data-rich environment, these files are likely becoming even more challenging for auditors to cognitively process. Specifically, these data files may have characteristics (e.g., contain errors or irrelevant information; aka âdirtyâ files) that could challenge their ease of use and interpretation (i.e., processing fluency). Depending on this ease, auditors may view these files as relatively less reliable and trustworthy, resulting in skeptical judgments and actions that are sometimes excessive. This paper reports two experiments examining whether two features of the data files, the presence of minor errors (absent or present) and information load (low or high), influence auditorsâ processing fluency, skeptical judgments, and actions. While minor errors should raise auditorsâ concerns, greater information load should not. However, we find the lowest processing fluency and highest skeptical judgments and actions when minor errors are present and information load is higher. Our study contributes to the literature by presenting an alternative issue to those raised by regulators (i.e., too much skepticism rather than too little) that can occur when auditors struggle to interpret large amounts of data. From a practical perspective, while access to increased amounts of client data may have benefits, audit firms and clients need to be wary of the potential for wasted time that could create inefficiencies that may affect audit quality
Trends in Weekly Reported Net use by Children During and after Rainy Season in Central Tanzania.
The use of long-lasting insecticidal nets (LLINs) is one of the principal interventions to prevent malaria in young children, reducing episodes of malaria by 50% and child deaths by one fifth. Prioritizing young children for net use is important to achieve mortality reductions, particularly during transmission seasons. Households were followed up weekly from January through June 2009 to track net use among children under seven under as well as caretakers. Net use rates for children and caretakers in net-owning households were calculated by dividing the number of person-weeks of net use by the number of person-weeks of follow-up. Use was stratified by age of the child or caretaker status. Determinants of ownership and of use were assessed using multivariate models. Overall, 60.1% of the households reported owning a bed net at least once during the study period. Among net owners, use rates remained high during and after the rainy season. Rates of use per person-week decreased as the age of the child rose from 0 to six years old; at ages 0-23âmonths and 24-35âmonths use rates per person-week were 0.93 and 0.92 respectively during the study period, while for children ages 3 and 4 use rates per person-week were 0.86 and 0.80. For children ages 5-6 person-week ratios dropped to 0.55. This represents an incidence rate ratio of 1.67 for children ages 0-23âmonths compared to children aged 5-6. Caretakers had use rates similar to those of children age 0-35âmonths. Having fewer children under age seven in the household also appeared to positively impact net use rates for individual children. In this area of Tanzania, net use is very high among net-owning households, with no variability either at the beginning or end of the rainy season high transmission period. The youngest children are prioritized for sleeping under the net and caretakers also have high rates of use. Given the high use rates, increasing the number of nets available in the household is likely to boost use rates by older children
Variation in the organization and subunit composition of the mammalian pyruvate dehydrogenase complex E2/E3BP core assembly
The final version of this article is available at the link below.Crucial to glucose homoeostasis in humans, the hPDC (human pyruvate dehydrogenase complex) is a massive molecular machine comprising multiple copies of three distinct enzymes (E1âE3) and an accessory subunit, E3BP (E3-binding protein). Its icosahedral E2/E3BP 60-meric âcoreâ provides the central structural and mechanistic framework ensuring favourable E1 and E3 positioning and enzyme co-operativity. Current core models indicate either a 48E2+12E3BP or a 40E2+20E3BP subunit composition. In the present study, we demonstrate clear differences in subunit content and organization between the recombinant hPDC core (rhPDC; 40E2+20E3BP), generated under defined conditions where E3BP is produced in excess, and its native bovine (48E2+12E3BP) counterpart. The results of the present study provide a rational basis for resolving apparent differences between previous models, both obtained using rhE2/E3BP core assemblies where no account was taken of relative E2 and E3BP expression levels. Mathematical modelling predicts that an âaverageâ 48E2+12E3BP core arrangement allows maximum flexibility in assembly, while providing the appropriate balance of bound E1 and E3 enzymes for optimal catalytic efficiency and regulatory fine-tuning. We also show that the rhE2/E3BP and bovine E2/E3BP cores bind E3s with a 2:1 stoichiometry, and propose that mammalian PDC comprises a heterogeneous population of assemblies incorporating a network of E3 (and possibly E1) cross-bridges above the core surface.This work was partly supported by EPSRC (under grants GR/R99393/01 and EP/C015452/1)
Reconstructing the 3-D Trajectories of CMEs in the Inner Heliosphere
A method for the full three-dimensional (3-D) reconstruction of the
trajectories of coronal mass ejections (CMEs) using Solar TErrestrial RElations
Observatory (STEREO) data is presented. Four CMEs that were simultaneously
observed by the inner and outer coronagraphs (COR1 and 2) of the Ahead and
Behind STEREO satellites were analysed. These observations were used to derive
CME trajectories in 3-D out to ~15Rsun. The reconstructions using COR1/2 data
support a radial propagation model. Assuming pseudo-radial propagation at large
distances from the Sun (15-240Rsun), the CME positions were extrapolated into
the Heliospheric Imager (HI) field-of-view. We estimated the CME velocities in
the different fields-of-view. It was found that CMEs slower than the solar wind
were accelerated, while CMEs faster than the solar wind were decelerated, with
both tending to the solar wind velocity.Comment: 17 pages, 10 figures, 1 appendi
Folding and organization of a contiguous chromosome region according to the gene distribution pattern in primary genomic sequence
Specific mammalian genes functionally and dynamically associate together within the nucleus. Yet, how an array of many genes along the chromosome sequence can be spatially organized and folded together is unknown. We investigated the 3D structure of a well-annotated, highly conserved 4.3-Mb region on mouse chromosome 14 that contains four clusters of genes separated by gene âdeserts.â In nuclei, this region forms multiple, nonrandom âhigher orderâ structures. These structures are based on the gene distribution pattern in primary sequence and are marked by preferential associations among multiple gene clusters. Associating gene clusters represent expressed chromatin, but their aggregation is not simply dependent on ongoing transcription. In chromosomes with aggregated gene clusters, gene deserts preferentially align with the nuclear periphery, providing evidence for chromosomal region architecture by specific associations with functional nuclear domains. Together, these data suggest dynamic, probabilistic 3D folding states for a contiguous megabase-scale chromosomal region, supporting the diverse activities of multiple genes and their conserved primary sequence organization
Virtual environment navigation with look-around mode to explore new real spaces by people who are blind
Background. This paper examines the ability of people who are blind to construct a mental map and perform orientation tasks in real space by using Nintendo Wii technologies to explore virtual environments. The participant explores new spaces through haptic and auditory feedback triggered by pointing or walking in the virtual environments and later constructs a mental map, which can be used to navigate in real space. Methods. The study included 10 participants who were congenitally or adventitiously blind, divided into experimental and control groups. The research was implemented by using virtual environments exploration and orientation tasks in real spaces, using both qualitative and quantitative methods in its methodology.
Results. The results show that the mode of exploration afforded to the experimental group is radically new in orientation and mobility training; as a result 60% of the experimental participants constructed mental maps that were based on map model, compared to only 30% of the control group participants.
Conclusion. Using technology that enabled them to explore and to collect spatial information in a way that does not exist in real space influenced the ability of the experimental group to construct a mental map based on the map model
4pi Models of CMEs and ICMEs
Coronal mass ejections (CMEs), which dynamically connect the solar surface to
the far reaches of interplanetary space, represent a major anifestation of
solar activity. They are not only of principal interest but also play a pivotal
role in the context of space weather predictions. The steady improvement of
both numerical methods and computational resources during recent years has
allowed for the creation of increasingly realistic models of interplanetary
CMEs (ICMEs), which can now be compared to high-quality observational data from
various space-bound missions. This review discusses existing models of CMEs,
characterizing them by scientific aim and scope, CME initiation method, and
physical effects included, thereby stressing the importance of fully 3-D
('4pi') spatial coverage.Comment: 14 pages plus references. Comments welcome. Accepted for publication
in Solar Physics (SUN-360 topical issue
Cross Sections for the Reactions e+e- --> K+ K- pi+pi-, K+ K- pi0pi0, and K+ K- K+ K- Measured Using Initial-State Radiation Events
We study the processes e+e- --> K+ K- pi+pi-gamma, K+ K- pi0pi0gamma, and K+
K- K+ K-gamma, where the photon is radiated from the initial state. About
84000, 8000, and 4200 fully reconstructed events, respectively, are selected
from 454 fb-1 of BaBar data. The invariant mass of the hadronic final state
defines the \epem center-of-mass energy, so that the K+ K- pi+pi- data can be
compared with direct measurements of the e+e- --> K+ K- pi+pi- reaction. No
direct measurements exist for the e+e- --> K+ K-pi0pi0 or e+e- --> K+ K-K+ K-
reactions, and we present an update of our previous result with doubled
statistics. Studying the structure of these events, we find contributions from
a number of intermediate states, and extract their cross sections. In
particular, we perform a more detailed study of the e+e- --> phi(1020)pipigamma
reaction, and confirm the presence of the Y(2175) resonance in the phi(1020)
f0(980) and K+K-f0(980) modes. In the charmonium region, we observe the J/psi
in all three final states and in several intermediate states, as well as the
psi(2S) in some modes, and measure the corresponding product of branching
fraction and electron width.Comment: 35 pages, 42 figure
Study of Upsilon(3S,2S) -> eta Upsilon(1S) and Upsilon(3S,2S) -> pi+pi- Upsilon(1S) hadronic trasitions
We study the Upsilon(3S,2S)->eta Upsilon(1S) and Upsilon(3S,2S)->pi+pi-
Upsilon(1S) transitions with 122 million Upsilon(3S) and 100 million
Upsilon(2S) mesons collected by the BaBar detector at the PEP-II asymmetric
energy e+e- collider. We measure B[Upsilon(2S)->eta
Upsilon(1S)]=(2.39+/-0.31(stat.)+/-0.14(syst.))10^-4 and Gamma[Upsilon(2S)->eta
Upsilon(1S)]/Gamma[Upsilon(2S)-> pi+pi-
Upsilon(1S)]=(1.35+/-0.17(stat.)+/-0.08(syst.))10^-3. We find no evidence for
Upsilon(3S)->eta Upsilon(1S) and obtain B[Upsilon(3S)->eta Upsilon(1S)]<1.0
10^-4 and Gamma[Upsilon(3S)->eta Upsilon(1S)]/Gamma[Upsilon(3S)->pi+pi-
Upsilon(1S)]<2.3 10^-3 as upper limits at the 90% confidence level. We also
provide improved measurements of the Upsilon(2S) - Upsilon(1S) and Upsilon(3S)
- Upsilon(1S) mass differences, 562.170+/-0.007(stat.)+/-0.088(syst.) MeV/c^2
and 893.813+/-0.015(stat.)+/-0.107(syst.) MeV/c^2 respectively.Comment: 8 pages, 16 encapsulated postscript figures, submitted to Phys.Rev.
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