Inverse correlation between endothelin-1-induced peripheral microvascular vasoconstriction and blood pressure in glaucoma patients

• Background: The potent vasoconstrictor peptide endothelin-I has been shown to participate in the control of peripheral vascular tone and in the regulation of ocular perfusion. In glaucoma patients vasospasms and arterial hypotension have been identified as risk factors for the progression of glaucomatous damage, and the regulation of endothelin-1 release is disturbed in some of these patients. The aim of this study was to assess the relationship between resting blood pressure and cutaneous vascular responsiveness to endothelin-1 and phenylephrine in patients with glaucoma and in matched controls. • Methods: In 9 patients with primary open-angle glaucoma (POAG), 7 patient with normal tension glaucoma (NTG), and 16 age- and sex-matched controls, endothelin-1 and phenylephrine responses were assessed in the human forearm microcirculation using laser Doppler flowmetry during intra-arterial drug administration. Blood pressure was measured intra-arterially. • Results: In contrast to α1-adrenergic effects, endothelin-1 responses were inversely correlated to both systolic (r 2 = 0.27,P = 0.05) and diastolic (r 2 = 0.54,P = 0.001) blood pressure in glaucoma patients, whereas there was no such correlation in controls. Patients with lower blood pressure values were more sensitive to the vasoconstrictor effects of endothelin-1. Cutaneous responsiveness to endothelin-1 and phenylephrine was similar in glaucoma patients and in controls. • Conclusion: These results reveal that glaucoma patients appear to have peripheral microvascular abnormalities which are exhibited as altered responsiveness to endothelin-1. Thus, this study supports the hypothesis that endothelin-l-related microvascular dysfunction may be involved in the pathogenesis of glaucomatous damag

From Diagnosis to Action: An Automated Failure Advisor for Human Deep Space Missions

The major goal of current space system development at NASA is to enable human travel to deep space locations such as Mars and asteroids. At that distance, round trip communication with ground operators may take close to an hour, thus it becomes unfeasible to seek ground operator advice for problems that require immediate attention, either for crew safety or for activities that need to be performed at specific times for the attainment of scientific results. To achieve this goal, major reliance will need to be placed on automation systems capable of aiding the crew in detecting and diagnosing failures, assessing consequences of these failures, and providing guidance in repair activities that may be required. We report here on the most current step in the continuing development of such a system, and that is the addition of a Failure Response Advisor. In simple terms, we have a system in place the Advanced Caution and Warning System (ACAWS) to tell us what happened (failure diagnosis) and what happened because that happened (failure effects). The Failure Response Advisor will tell us what to do about it, how long until something must be done and why its important that something be done and will begin to approach the complex reasoning that is generally required for an optimal approach to automated system health management. This advice is based on the criticality and various timing elements, such as durations of activities and of component repairs, failure effects delay, and other factors. The failure advice is provided to operators (crew and mission controllers) together with the diagnostic and effects information. The operators also have the option to drill down for more information about the failure and the reasons for any suggested priorities

Large-eddy simulation of the lid-driven cubic cavity flow by the spectral element method

This paper presents the large-eddy simulation of the lid-driven cubic cavity flow by the spectral element method (SEM) using the dynamic model. Two spectral filtering techniques suitable for these simulations have been implemented. Numerical results for Reynolds number $\text{Re}=12'000$ are showing very good agreement with other experimental and DNS results found in the literature

Detection of Extended Polarized Ultraviolet Radiation from the z = 1.82 Radio Galaxy 3C 256

We have detected spatially extended linear polarized UV emission from the high-redshift radio galaxy 3C~256 ($z=1.82$). A spatially integrated ($7.8''$ diameter aperture) measurement of the degree of polarization of the $V-$band (rest frame 0.19 $\mu$m) emission yields a value of 16.4\% ($\pm 2.2$\%) with a position angle of $42{}\rlap{\rm .}^\circ 4$ ($\pm 3{}\rlap{\rm .}^\circ 9$), orthogonal to the position angle on the sky of the major axis of the extended emission. The peak emission measured with a $3.6''$ diameter circular aperture is 11.7\% ($\pm 1.5$\%) polarized with a position angle of $42{}\rlap{\rm .}^\circ 4$ ($\pm 3{}\rlap{\rm .}^\circ 6$). An image of the polarized flux is presented, clearly displaying that the polarized flux is extended and present over the entire extent of the object. While it has been suggested that the UV continuum of 3C~256 might be due to star formation (Elston 1988) or a protogalaxy (Eisenhardt \& Dickinson 1993) based on its extremely blue spectral energy distribution and similar morphology at UV and visible wavelengths, we are unable to reconcile the observed high degree of polarization with such a model. While the detection of polarized emission from HZRGs has been shown to be a common phenomena, 3C~256 is only the third object for which a measurement of the extended polarized UV emission has been presented. These data lend additional support to the suggestion first made by di Serego Alighieri and collaborators that the ``alignment effect'', the tendency for the extended UV continuum radiation and line emission from HZRGs to be aligned with the major axis of the extended radio emission, is in large part due to scattering of anisotropic nuclear emission.Comment: 11 pages, LaTeX (aaspp style) file. Figure available by request to [email protected]

Want Ad

pages 34-5

Baricitinib in patients with inadequate response or intolerance to conventional synthetic DMARDs: Results from the RA-BUILD study

Background Baricitinib is an oral, reversible, selective Janus kinase 1 and 2 inhibitor. Methods In this phase III, double-blind 24-week study, 684 biologic disease-modifying antirheumatic drug (DMARD)-naïve patients with rheumatoid arthritis and inadequate response or intolerance to ≥1 conventional synthetic DMARDs were randomly assigned 1:1:1 to placebo or baricitinib (2 or 4 mg) once daily, stratified by region and the presence of joint erosions. Endpoint measures included American College of Rheumatology 20% response (ACR20, primary endpoint), Disease Activity Score (DAS28) and Simplified Disease Activity Index (SDAI) score ≤3.3. Results More patients achieved ACR20 response at week 12 with baricitinib 4 mg than with placebo (62% vs 39%, p≤0.001). Compared with placebo, statistically significant improvements in DAS28, SDAI remission, Health Assessment Questionnaire-Disability Index, morning joint stiffness, worst joint pain and worst tiredness were observed. In a supportive analysis, radiographic progression of structural joint damage at week 24 was reduced with baricitinib versus placebo. Rates of adverse events during the treatment period and serious adverse events (SAEs), including serious infections, were similar among groups (SAEs: 5% for baricitinib 4 mg and placebo). One patient had an adverse event of tuberculosis (baricitinib 4 mg); one patient had an adverse event of non-melanoma skin cancer (baricitinib 4 mg). Two deaths and three major adverse cardiovascular events occurred (placebo). Baricitinib was associated with a decrease in neutrophils and increases in low-density and high-density lipoprotein. Conclusions In patients with rheumatoid arthritis and an inadequate response or intolerance to conventional synthetic DMARDs, baricitinib was associated with clinical improvement and inhibition of progression of radiographic joint damage

Regulating services

No abstract available

Team Joseph: Adaptive Aquatic Device

The scope of this project included designing and fabricating an adaptive aquatic device for Joseph, a 20 year old student in the Special Education Program at San Luis Obispo High School with a subset of cerebral palsy known as spastic quadriplegia. The project was presented at the beginning of the Fall 2013 quarter to the mechanical engineering students at Cal Poly with the aspiration that a team of engineers would construct a device that would allow Joseph, his friends and family to compete in their first triathlon on July 27, 2014. The project was humbly accepted by mechanical engineering students Lilly Hoff and Paul Sands, as well as kinesiology student Andrea Voigt. The team designed a device for Joseph that emphasizes the least restrictive environment by orienting him in a prone position that immerses the majority of his body in the water, yet provides the necessary features to satisfy all safety concerns. A PVC frame is incorporated to provide stability in the water, attached to which are floats that provide buoyancy as well as a mesh material body support for him to lay on. Buoyancy and hydrodynamics are factored into the design by attaching a fiberglassed bow that extends forward from the front of the frame. Joseph will be pulled through the water by a swimmer wearing a swimming belt attached to the device. In conclusion, all of the customer requirements were satisfied by the design, and all testing performed validated the performance of the device. This report details the project specifications, design decisions, background research on both Joseph’s disability as well as similar existing products, the manufacturing process used to construct it, a full detailed description of the final design, and the testing procedures performed to ensure that the device is fully functional and safe

Poly Drop

Poly Drop is a software interface to control an Open Drop digital micro-fluidics system. We obtained a hardware system from Gaudi labs. Our task was to create a Graphical User Interface that made the control of the device easier and more automated for better testing. We created software that had 3 parts: a control GUI, arduino code to control the hardware, and Image Analysis that gives the user information such as location and color of liquid drops as they move across the electrode grid of the Open Drop system. The GUI was developed using Java Swing. The communication between the GUI and the arduino was accomplished using the open source RXTX library. The image analysis portion was created using the open source OpenCV software

The zCOSMOS 10k-Bright Spectroscopic Sample

We present spectroscopic redshifts of a large sample of galaxies with I_(AB) < 22.5 in the COSMOS field, measured from spectra of 10,644 objects that have been obtained in the first two years of observations in the zCOSMOS-bright redshift survey. These include a statistically complete subset of 10,109 objects. The average accuracy of individual redshifts is 110 km s^(–1), independent of redshift. The reliability of individual redshifts is described by a Confidence Class that has been empirically calibrated through repeat spectroscopic observations of over 600 galaxies. There is very good agreement between spectroscopic and photometric redshifts for the most secure Confidence Classes. For the less secure Confidence Classes, there is a good correspondence between the fraction of objects with a consistent photometric redshift and the spectroscopic repeatability, suggesting that the photometric redshifts can be used to indicate which of the less secure spectroscopic redshifts are likely right and which are probably wrong, and to give an indication of the nature of objects for which we failed to determine a redshift. Using this approach, we can construct a spectroscopic sample that is 99% reliable and which is 88% complete in the sample as a whole, and 95% complete in the redshift range 0.5 < z < 0.8. The luminosity and mass completeness levels of the zCOSMOS-bright sample of galaxies is also discussed