LA TIERRA INEXPLORADA: DISEÑO DE PERSONAJES PARA NOVELA VISUAL BASADA EN HAMLET, DE WILLIAM SHAKESPEARE

[ES] Diseño de tres personajes para una novela visual basada en la obra "Hamlet" de Shakespeare, acompañado de sus dibujos conceptuales, bocetos, pruebas, etc.[EN] Character design for three characters for a visual novel based on the play "Hamlet" by William Shakespeare along with it's sketches, illustrations, etc.Azores Lillo, M. (2018). LA TIERRA INEXPLORADA: DISEÑO DE PERSONAJES PARA NOVELA VISUAL BASADA EN HAMLET, DE WILLIAM SHAKESPEARE. http://hdl.handle.net/10251/119803TFG

Bone Remodeling of Two Anatomic Stems: Densitometric Study of the Redesign of the ABG-II Stem

Background: Periprosthetic bone remodeling, which is a phenomenon observed in all femoral stems, has a multifactorial origin as it depends on factors related to the patient, the surgical technique, and the design of the implant. To determine the pattern of remodeling produced by 2 models of anatomic cementless implants, we quantified the changes in bone mineral density (BMD) in the 7 areas of Gruen observed at different moments after surgery during the first postoperative year. Methods: A prospective, comparative, controlled, 1-year follow-up densitometric study was carried out in 2 groups of patients suffering from primary unilateral hip osteoarthritis. In the first group, with 68 patients, an ABG-II stem was implanted. In the second, with 66 patients, the ANATO stem was used. The contralateral, healthy hip was taken as a control. Results: Both groups showed a decrease in BMD at 3 months in all the areas, which recovered at the end of the study, except in zone 7: there was a 17.7% decrease in the ABG-II group and a 5.9% decrease in the ANATO group. In zones 2 and 6, where more loads are transmitted, conservation of BMD is observed in response to Wolff''s law. The differences in the pattern of remodeling between groups were maintained despite the age, gender, and BMI of the patients or the size of the implants. Conclusion: The ANATO stem achieved a more efficient transmission of loads at the metaphyseal level, which promotes bone preservation at the proximal femur, than the ABG-II stem

Stress fracture of the lamina: a diagnosis of suspicion

Lumbar laminolysis, a stress fracture of the lamina, is one of the causes of chronic low back pain in adolescents. Its prevalence is very low, and it is described as an incidental fi nding in most cases. The authors report the case of a 14-year-old girl with a symptomatic stress fracture of the left lamina of the fi fth lumbar vertebra. Recent advances in diagnostic tools and techniques enable early diagnosis.Multimodal radiological examinations of the whole lumbar spine are recommended in cases of symptomatic patients with low back pain who do not respond to initial treatment with basic physiotherapy or analgesic medical treatment. Knowledge of laminolysis in adolescent patients with low back pain is necessary to prevent it from being overlooked or late diagnosis. In almost all cases, conservative treatment may be suffi cient to achieve bone healing

Adaptive Bone Remodeling With New Design of the ABG Stem. Densitometric Study

To establish the pattern of bone remodeling caused by a cementless, anatomic implant, we intend to evaluate the changes in bone mineral density observed after surgery in the Gruen zones. A controlled, prospective study was carried out, in which a group of 37 patients with primary coxarthrosis were densitrometrically analyzed over the 1 year period following the implant of an ANATO stem (Stryker). The patient's healthy hip was taken as the control. Any differences in the remodeling pattern were compared according to age, body mass index, and implant size. Decreases in bone mineral density were observed after 3 months in all of the zones studied. However, this bone mineral density loss was recovered in all zones by the end of the study, except in zone 7 where a decrease of 7.2% in bone mass was observed. In zones 2 and 6, where more loads are transmitted, bone mass preservation, in accordance with Wolff's law, can be seen. No differences were found in the remodeling pattern in relation to age and body mass index. There were also no differences related to stem size except in zones 1 and 7. The ANATO stem achieves an efficient transmission of loads between the stem and the proximal femur, providing enough mechanical loads for bone preservation. It is only in zone 7 where significant bone atrophy can be observed, attributable to the damage that this area suffers during the surgical process and the subsequent stress-shielding caused by the implant design

Resultado tras el tratamientoquirúrgico de tumores de células gigantes

Resumen: Introducción: El tumor de células gigantes se presenta en adultos jóvenes, y su capacidad metastásica obliga a realizar un tratamiento quirúrgico, aunque su tasa de recurrencias hace que no haya consenso respecto a su manejo terapéutico. Material y métodos: 23 pacientes fueron intervenidos en el periodo de 1996 a 2012 en el hospital Miguel Servet, realizándose un seguimiento medio de 8,9 años. Resultados: el resultado funcional fue satisfactorio en todos los casos, pudiendo reanudar su actividad física habitual. Se detectaron 6 recurrencias, que fueron tratadas quirúrgicamente, mostrando los pacientes una recuperación total. Un paciente falleció a causa de metástasis pulmonares. Conclusión: El tratamiento quirúrgico es el más indicado en tumores de células gigantes, habiendo demostrado buenos resultados tanto en el tratamiento del tumor primario como en el de las recidivas.</p

Homochiral Metal-Organic Frameworks for Enantioselective Separations in Liquid Chromatography

Selective separation of enantiomers is a substantial challenge for the pharmaceutical industry. Chromatography on chiral stationary phases is the standard method, but at a very high cost for industrial-scale purification owing to the high cost of the chiral stationary phases. Typically, these materials are poorly robust, expensive to manufacture and often too specific for a single desired substrate, lacking desirable versatility across different chiral analytes. Here we disclose a porous, robust homochiral metal-organic framework (MOF), TAMOF-1, built from copper(II) and an affordable linker prepared from natural L-histidine. TAMOF-1 has shown to be able to separate a variety of model racemic mixtures, including drugs, in a wide range of solvents of different polarity, outperforming several commercial chiral columns for HPLC separations. Although not exploited in the present article, it is worthy to mention that the preparation of this new material is scalable to the multikilogram scale, opening unprecedented possibilities for low-energy chiral separation at the industrial scale

Personalized monitoring of electrical remodelling during atrial fibrillation progression via remote transmissions from implantable devices

Atrial electrical remodelling (AER) is a transitional period associated with the progression and long-term maintenance of atrial fibrillation (AF). We aimed to study the progression of AER in individual patients with implantable devices and AF episodes. Observational multicentre study (51 centres) including 4618 patients with implantable cardioverter-defibrillator and results þ/resynchronization therapy (ICD/CRT-D) and 352 patients (2 centres) with pacemakers (median follow-up: 3.4 years). Atrial activation rate (AAR) was quantified as the frequency of the dominant peak in the signal spectrum of AF episodes with atrial bipolar electrograms. Patients with complete progression of AER, from paroxysmal AF episodes to electrically remodelled persistent AF, were used to depict patient-specific AER slopes. A total of 34 712 AF tracings from 830 patients (87 with pacemakers) were suitable for the study. Complete progression of AER was documented in 216 patients (16 with pacemakers). Patients with persistent AF after completion of AER showed ∼30% faster AAR than patients with paroxysmal AF. The slope of AAR changes during AF progression revealed patient-specific patterns that correlated with the time-to-completion of AER (R = 0.85). Pacemaker patients were older than patients with ICD/CRT-Ds (78.3 vs. 67.2 year olds, respectively, P < 0.001) and had a shorter median time-to-completion of AER (24.9 vs. 93.5 days, respectively, P = 0.016). Remote transmissions in patients with ICD/CRT-D devices enabled the estimation of the time-to-completion of AER using the predicted slope of AAR changes from initiation to completion of electrical remodelling (R = 0.45). The AF progression shows patient-specific patterns of AER, which can be estimated using available remote-monitoring technology

Personalized monitoring of electrical remodelling during atrial fibrillation progression via remote transmissions from implantable devices

Aims: Atrial electrical remodelling (AER) is a transitional period associated with the progression and long-term maintenance of atrial fibrillation (AF). We aimed to study the progression of AER in individual patients with implantable devices and AF episodes. Methods and results: Observational multicentre study (51 centres) including 4618 patients with implantable cardioverter-defibrillator +/-resynchronization therapy (ICD/CRT-D) and 352 patients (2 centres) with pacemakers (median follow-up: 3.4 years). Atrial activation rate (AAR) was quantified as the frequency of the dominant peak in the signal spectrum of AF episodes with atrial bipolar electrograms. Patients with complete progression of AER, from paroxysmal AF episodes to electrically remodelled persistent AF, were used to depict patient-specific AER slopes. A total of 34 712 AF tracings from 830 patients (87 with pacemakers) were suitable for the study. Complete progression of AER was documented in 216 patients (16 with pacemakers). Patients with persistent AF after completion of AER showed ∼30% faster AAR than patients with paroxysmal AF. The slope of AAR changes during AF progression revealed patient-specific patterns that correlated with the time-to-completion of AER (R2 = 0.85). Pacemaker patients were older than patients with ICD/CRT-Ds (78.3 vs. 67.2 year olds, respectively, P < 0.001) and had a shorter median time-to-completion of AER (24.9 vs. 93.5 days, respectively, P = 0.016). Remote transmissions in patients with ICD/CRT-D devices enabled the estimation of the time-to-completion of AER using the predicted slope of AAR changes from initiation to completion of electrical remodelling (R2 = 0.45). Conclusion: The AF progression shows patient-specific patterns of AER, which can be estimated using available remote-monitoring technology

Ul Mira 14, Saint Petersburg 197101, Russia 6 St. Petersburg Hospital No. 31, Pr. Dinamo 3, Saint Petersburg

The spread of carbapenemase-producing Enterobacteriaceae is a global problem; however, no exact data on the epidemiology of carbapenemase in the Baltic countries and St. Petersburg area is available. We aimed to evaluate the epidemiology of carbapenemaseproducing Escherichia coli and Klebsiella pneumoniae in the Baltic States and St. Petersburg, Russia, and to compare the different methods for carbapenemase detection. From January to May 2012, all K. pneumoniae ( = 1983) and E. coli ( = 7774) clinical isolates from 20 institutions in Estonia, Latvia, Lithuania, and St. Petersburg, Russia were screened for carbapenem susceptibility. The IMP, VIM, GIM, NDM, KPC, and OXA-48 genes were detected using real-time PCR and the ability to hydrolyze ertapenem was determined using MALDI-TOF MS. Seventy-seven strains were found to be carbapenem nonsusceptible. From these, 15 K. pneumoniae strains hydrolyzed ertapenem and carried the NDM gene. All of these strains carried integron 1 and most carried integron 3 as well as genes of the CTX-M-1 group. No carbapenemase-producing E. coli or K. pneumoniae strains were found in Estonia, Latvia, or Lithuania; however, NDM-positive K. pneumoniae was present in the hospital in St. Petersburg, Russia. A MALDI-TOF MS-based assay is a suitable and cost-effective method for the initial confirmation of carbapenemase production

A Transiting, Temperate Mini-Neptune Orbiting the M Dwarf TOI-1759 Unveiled by TESS

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.-- Full list of authors: Espinoza, Néstor; Pallé, Enric; Kemmer, Jonas; Luque, Rafael; Caballero, José A.; Cifuentes, Carlos; Herrero, Enrique; Sánchez Béjar, Víctor J.; Stock, Stephan; Molaverdikhani, Karan; Morello, Giuseppe; Kossakowski, Diana; Schlecker, Martin; Amado, Pedro J.; Bluhm, Paz; Cortés-Contreras, Miriam; Henning, Thomas; Kreidberg, Laura; Kürster, Martin; Lafarga, Marina; Lodieu, Nicolas; Morales, Juan Carlos; Oshagh, Mahmoudreza; Passegger, Vera M.; Pavlov, Alexey; Quirrenbach, Andreas; Reffert, Sabine; Reiners, Ansgar; Ribas, Ignasi; Rodríguez, Eloy; López, Cristina Rodríguez; Schweitzer, Andreas; Trifonov, Trifon; Chaturvedi, Priyanka; Dreizler, Stefan; Jeffers, Sandra V.; Kaminski, Adrian; López-González, María José; Lillo-Box, Jorge; Montes, David; Nowak, Grzegorz; Pedraz, Santos; Vanaverbeke, Siegfried; Zapatero Osorio, Maria R.; Zechmeister, Mathias; Collins, Karen A.; Girardin, Eric; Guerra, Pere; Naves, Ramon; Crossfield, Ian J. M.; Matthews, Elisabeth C.; Howell, Steve B.; Ciardi, David R.; Gonzales, Erica; Matson, Rachel A.; Beichman, Charles A.; Schlieder, Joshua E.; Barclay, Thomas; Vezie, Michael; Villaseñor, Jesus Noel; Daylan, Tansu; Mireies, Ismael; Dragomir, Diana; Twicken, Joseph D.; Jenkins, Jon; Winn, Joshua N.; Latham, David; Ricker, George; Seager, Sara.We report the discovery and characterization of TOI-1759 b, a temperate (400 K) sub-Neptune-sized exoplanet orbiting the M dwarf TOI-1759 (TIC 408636441). TOI-1759 b was observed by TESS to transit in Sectors 16, 17, and 24, with only one transit observed per sector, creating an ambiguity regarding the orbital period of the planet candidate. Ground-based photometric observations, combined with radial-velocity measurements obtained with the CARMENES spectrograph, confirm an actual period of 18.85019 ± 0.00014 days. A joint analysis of all available photometry and radial velocities reveals a radius of 3.17 ± 0.10 R⊕ and a mass of 10.8 ± 1.5 M⊕. Combining this with the stellar properties derived for TOI-1759 (R⋆ = 0.597 ± 0.015 R⊙; M⋆ = 0.606 ± 0.020 M⊙; Teff = 4065 ± 51 K), we compute a transmission spectroscopic metric (TSM) value of over 80 for the planet, making it a good target for transmission spectroscopy studies. TOI-1759 b is among the top five temperate, small exoplanets (Teq 200 days seem to be present in our radial velocities. While our data suggest both could arise from stellar activity, the later signal's source and periodicity are hard to pinpoint given the ∼200 days baseline of our radial-velocity campaign with CARMENES. Longer baseline radial-velocity campaigns should be performed in order to unveil the true nature of this long-period signal. © 2022. The Author(s). Published by the American Astronomical Society.CARMENES is an instrument at the Centro Astronómico Hispano-Alemán (CAHA) at Calar Alto (Almería, Spain), operated jointly by the Junta de Andalucía and the Instituto de Astrofísica de Andalucía (CSIC). CARMENES was funded by the Max-Planck-Gesellschaft (MPG), the Consejo Superior de Investigaciones Científicas (CSIC), the Ministerio de Economía y Competitividad (MINECO), and the European Regional Development Fund (ERDF) through projects FICTS-2011-02, ICTS-2017-07-CAHA-4, and CAHA16-CE-3978, and the members of the CARMENES Consortium (Max-Planck-Institut für Astronomie, Instituto de Astrofísica de Andalucía, Landessternwarte Königstuhl, Institut de Ciëncies de l'Espai, Institut für Astrophysik Göttingen, Universidad Complutense de Madrid, Thüringer Landessternwarte Tautenburg, Instituto de Astrofísica de Canarias, Hamburger Sternwarte, Centro de Astrobiología, and Centro Astronómico Hispano-Alemán), with additional contributions by the MINECO, the Deutsche Forschungsgemeinschaft through the Major Research Instrumentation Programme and Research Unit FOR2544 "Blue Planets around Red Stars," the Klaus Tschira Stiftung, the states of Baden-Württemberg and Niedersachsen, and by the Junta de Andalucía. This work was based on data from the CARMENES data archive at CAB (CSIC-INTA). We acknowledge financial support from the Agencia Estatal de Investigación of the Ministerio de Ciencia, Innovación y Universidades and the ERDF through projects PID2019-109522GB-C5[1:4], PGC2018-098153-B-C33, AYA2018-84089, PID2019-107061GB-C64, PID2019-110689RB-100, AYA2016-79425-C3-1/2/3-P, and BES-2017-080769, and the Centre of Excellence "Severo Ochoa" and "María de Maeztu" awards to the Instituto de Astrofísica de Canarias (CEX2019-000920-S), Instituto de Astrofísica de Andalucía (SEV-2017-0709), and Centro de Astrobiología (MDM-2017-0737), NASA (NNX17AG24G), and the Generalitat de Catalunya/CERCA program. Data were partly collected with the 90 cm telescope at the Sierra Nevada Observatory (SNO) operated by the Instituto de Astrofí fica de Andalucí a (IAA, CSIC). We acknowledge the telescope operators from the Sierra Nevada Observatory for their support. G.M. has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 895525. This research has made use of the NASA Exoplanet Archive, which is operated by the California Institute of Technology, under contract with the National Aeronautics and Space Administration under the Exoplanet Exploration Program. We acknowledge the use of public TESS data from pipelines at the TESS Science Office and at the TESS Science Processing Operations Center. Resources supporting this work were provided by the NASA High-End Computing (HEC) Program through the NASA Advanced Supercomputing (NAS) Division at Ames Research Center for the production of the SPOC data products.Peer reviewe