SÍNDROME DO ENVELHECIMENTO PRECOCE BUCAL: UMA REVISÃO BIBLIOGRÁFICA

The Premature Oral Aging Syndrome (POAS) is a major challenge in dentistry, mainly due to its multifactorial clinical characteristics that are responsible for its enormous complexity, requiring a multidisciplinary approach. Some of the etiological agents can be classified into: acid diet, psychiatric disorders, gastrointestinal diseases and sleep disorders. The clinical characteristics of the lesions are associated with the etiological factors present and with the stage of the lesion. The objective of this present study was to carry out a bibliographic review about the Premature Oral Aging Syndrome, its diagnosis, clinical manifestations, prevention and treatment. The literature review was carried out with searches in books and in the databases Pubmed, Scielo, BVS, REVodonto and other scientific annals, using the keywords: premature aging, dental wear and dental erosion. It is concluded that SEPB is the clinical manifestation of accelerated aging of the oral cavity and stomatognathic system, presenting a state of clinical non-normality of oral structures, with characteristics incompatible with the physiological (chronological) age of the individual, caused by systemic diseases of different origins, influence of new habits and/or lifestyle changes.El Síndrome de Envejecimiento Oral Prematuro (SEOP) constituye un gran desafío en odontología, principalmente por sus características clínicas multifactoriales que son responsables de su enorme complejidad, requiriendo un abordaje multidisciplinario. Algunos de los agentes etiológicos se pueden clasificar en: dieta ácida, trastornos psiquiátricos, enfermedades gastrointestinales y trastornos del sueño. Las características clínicas de las lesiones están asociadas con los factores etiológicos presentes y el estadio en el que se encuentra la lesión. El objetivo del presente estudio fue realizar una revisión bibliográfica sobre el Síndrome de Envejecimiento Oral Prematuro, su diagnóstico, manifestaciones clínicas, prevención y tratamiento. La revisión de la literatura se realizó con búsquedas en libros y bases de datos Pubmed, Scielo, BVS, REVodonto y otros anales científicos, utilizando las palabras clave: envejecimiento prematuro, desgaste dental y erosión dental. Se concluye que la SEPB es la manifestación clínica del envejecimiento acelerado de la cavidad bucal y del sistema estomatognático, presentando un estado de no normalidad clínica de las estructuras bucales, con características incompatibles con la edad fisiológica (cronológica) del individuo, causada por enfermedades sistémicas de diferente origen, influencia de nuevos hábitos y/o cambios en el estilo de vida.A Síndrome do Envelhecimento Precoce Bucal (SEPB) é um grande desafio na odontologia, principalmente pelas suas características clínicas multifatoriais que são responsáveis por sua enorme complexidade, precisando de uma abordagem multiprofissional. Alguns dos agentes etiológicos podem ser classificados em: dieta ácida, transtornos psiquiátricos, doenças gastrointestinais e distúrbios do sono. As características clínicas das lesões estão associadas aos fatores etiológicos presentes e com a etapa que a lesão se encontra. O objetivo deste presente estudo foi realizar uma revisão bibliográfica acerca da Síndrome do envelhecimento precoce bucal, seu diagnóstico, manifestações clínicas, prevenção e tratamento. A revisão de literatura foi realizada com buscas em livros e nas bases de dados Pubmed, Scielo, BVS, REVodonto e outros anais científicos, utilizando as palavras-chaves: envelhecimento precoce, desgaste dentário e erosão dentária. Conclui-se que a SEPB é a manifestação clínica do envelhecimento acelerado da cavidade bucal e do sistema estomatognático, apresentando estado de não normalidade clínica das estruturas bucais, com características incompatíveis com a idade fisiológica (cronológica) do indivíduo, provocada por doenças sistêmicas de diferentes origens, influência de novos hábitos e/ou mudança de estilo de vida

Dwellings, jabuticabas, and affections — trajectories with Sylvia Caiuby Novaes

Sylvia Caiuby Novaes é professora do Departamento de Antropologia da Universidade de São Paulo (USP) e dedica-se há cerca de 50 anos à pesquisa e ao ensino em antropologia. Entre outras realizações, ela é uma das pioneiras da antropologia visual no Brasil, é fundadora do Laboratório de Imagem e Som da Antropologia (LISA) e editora responsável pela revista Gesto, Imagem e Som. Revista de Antropologia (GIS). Nesta entrevista, realizada por mais de 30 orientandos de diferentes gerações, Sylvia fala sobre sua trajetória, projetos, visão de mundo, suas diversas viagens, o fascínio pelas pesquisas de campo e a universidade. Ao contar sobre sua trajetória acadêmica e pessoal, Sylvia traz reflexões sobre sua relação com a fotografia e a produção de imagens.  Sylvia Caiuby Novaes is a Professor in the Department of Anthropology at the University of São Paulo (USP) and has been dedicated to research and teaching in anthropology for nearly 50 years. Among other accomplishments, she is one of the pioneers of visual anthropology in Brazil, is the founder of the Laboratory of Image and Sound of Anthropology (LISA) and the editor in charge of the Gesture, Image and Sound.  Journal of Anthropology (GIS). In this interview, conducted by more than 30 advisees from different generations, Sylvia talks about her trajectory, projects, worldview, her various travels, her fascination with field research and the university. When telling about her academic and personal trajectory, Sylvia reflects on her relationship with photography and the production of images

Das considerações acerca do paciente politraumatizado com ênfase em trauma cranio encefalico: Considerations about the polytrauma patient with emphasis on head trauma

A morte decorrente do trauma é um grande problema de saúde no mundo inteiro, resultando em quase 14 mil mortes diariamente, o trauma se evidencia entre as cinco principais causas de morte. Nos últimos 10 anos, mais de 1 milhão de pessoas ficaram inválidas devido a traumas mecânicos no Brasil, sendo os acidentes de trânsito os principais responsáveis por estas taxas. Além do aumento do número de veículos em circulação, a desorganização, a deficiência geral da fiscalização, as péssimas condições de muitos veículos, o comportamento dos usuários e a impunidade dos infratores fizeram com que nas últimas décadas o Brasil se colocasse entre os campeões mundiais de acidentes de trânsito. As lesões cerebrais constituem uma causa importante de morte, especialmente em adultos jovens, e uma causa importante de incapacidade. Atualmente estão cada vez mais disseminados os agentes causais de lesões nos seres humanos, tais como: os meios de transportes, o maquinário agrícola e industrial, o aumento da agressividade das armas de fogo, entre outros. Se por um lado o aumento tecnológico tem contribuído para o aumento da qualidade de vida, por outro ameaça a sobrevivência dos cidadãos. Esta pesquisa se enquadra como revisão de literatura, do tipo sistemática de caráter exploratório e abordagem qualitativa. O grande objetivo desta pesquisa foi elaborar atualização acerca das informações acerca do trauma cranioencefálico de forma a fomentar atualização em saúde

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial

Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt

Immediate effects of an anchor system on the stability limit of individuals with chronic dizziness of peripheral vestibular origin

Abstract Introduction The symptoms associated with chronic peripheral vestibulopathy exert a negative impact on the independence and quality of life of these individuals, and many individuals continue to suffer from these symptoms even after conventional vestibular rehabilitation. Objective To evaluate the acute effect of an anchor system for balance evaluation of patients with chronic dizziness who failed to respond to traditional vestibular rehabilitation. Methods Subjects over 50 years of age, presenting with chronic dizziness and postural instability of peripheral vestibular origin, participated in the study. The limit of stability was evaluated in three positions using the Balance Master® system: Position 1, standing with the arms along the body; Position 2, standing with the elbows bent at 90º (simulating holding the anchors); and Position 3, with the elbows bent at 90º holding the anchors. The variables of movement latency, endpoint excursion and directional control of movement were evaluated. Results Using the anchor system, significant reduction of time in the response at the beginning of the movement compared to Position 1 (p < 0.05); increased endpoint excursion in the left lateral direction compared to Position 1 (p < 0.05); and more directional control of movement in the anterior and posterior directions (p < 0.05) compared to the other positions, were found. Conclusion While using the system anchor, individuals with chronic peripheral vestibulopathy showed an immediate improvement in the stability limit in relation to the movement latency, endpoint excursion, and directional control of movement variables, suggesting that the haptic information aids postural control

Genetic Predisposition to Hepatocarcinogenesis in Inbred and Outbred Mouse Lines Selected for High or Low Inflammatory Response

AIRmax and AIRmin mouse strains phenotypically selected for high and low acute inflammatory responsiveness (AIR) are, respectively, susceptible or resistant to developing hepatocellular carcinoma (HCC) induced by the chemical carcinogens urethane and diethylnitrosamine (DEN). Early production of TNF-α, IL-1β, and IL-6 in the liver after DEN treatment correlated with tumor development in AIRmax mice. Transcriptome analysis of livers from untreated AIRmax and AIRmin mice showed specific gene expression profiles in each line, which might play a role in their differential susceptibility to HCC. Linkage analysis with SNP markers in F2 (AIRmax×AIRmin) intercross mice revealed two quantitative trait loci (QTL) in chromosomes 2 and 9, which are significantly associated with the number and progression of urethane-induced liver tumors. An independent linkage analysis with an intercross population from A/J and C57BL/6J inbred mice mapped regions in chromosomes 1 and 7 associated with the progression of urethane-induced liver tumors, evidencing the heterogeneity of HCC genetic control

DataSheet_1_Altered distribution and function of NK-cell subsets lead to impaired tumor surveillance in JAK2V617F myeloproliferative neoplasms.pdf

In cancer, tumor cells and their neoplastic microenvironment can sculpt the immunogenic phenotype of a developing tumor. In this context, natural killer (NK) cells are subtypes of lymphocytes of the innate immune system recognized for their potential to eliminate neoplastic cells, not only through direct cytolytic activity but also by favoring the development of an adaptive antitumor immune response. Even though the protective effect against leukemia due to NK-cell alloreactivity mediated by the absence of the KIR-ligand has already been shown, and some data on the role of NK cells in myeloproliferative neoplasms (MPN) has been explored, their mechanisms of immune escape have not been fully investigated. It is still unclear whether NK cells can affect the biology of BCR-ABL1-negative MPN and which mechanisms are involved in the control of leukemic stem cell expansion. Aiming to investigate the potential contribution of NK cells to the pathogenesis of MPN, we characterized the frequency, receptor expression, maturation profile, and function of NK cells from a conditional Jak2V617F murine transgenic model, which faithfully resembles the main clinical and laboratory characteristics of human polycythemia vera, and MPN patients. Immunophenotypic analysis was performed to characterize NK frequency, their subtypes, and receptor expression in both mutated and wild-type samples. We observed a higher frequency of total NK cells in JAK2V617F mutated MPN and a maturation arrest that resulted in low-numbered mature CD11b+ NK cells and increased immature secretory CD27+ cells in both human and murine mutated samples. In agreement, inhibitory receptors were more expressed in MPN. NK cells from Jak2V617F mice presented a lower potential for proliferation and activation than wild-type NK cells. Colonies generated by murine hematopoietic stem cells (HSC) after mutated or wild-type NK co-culture exposure demonstrated that NK cells from Jak2V617F mice were deficient in regulating differentiation and clonogenic capacity. In conclusion, our findings suggest that NK cells have an immature profile with deficient cytotoxicity that may lead to impaired tumor surveillance in MPN. These data provide a new perspective on the behavior of NK cells in the context of myeloid malignancies and can contribute to the development of new therapeutic strategies, targeting onco-inflammatory pathways that can potentially control transformed HSCs.</p

NEOTROPICAL XENARTHRANS: a data set of occurrence of xenarthran species in the Neotropics

Xenarthrans—anteaters, sloths, and armadillos—have essential functions for ecosystem maintenance, such as insect control and nutrient cycling, playing key roles as ecosystem engineers. Because of habitat loss and fragmentation, hunting pressure, and conflicts with domestic dogs, these species have been threatened locally, regionally, or even across their full distribution ranges. The Neotropics harbor 21 species of armadillos, 10 anteaters, and 6 sloths. Our data set includes the families Chlamyphoridae (13), Dasypodidae (7), Myrmecophagidae (3), Bradypodidae (4), and Megalonychidae (2). We have no occurrence data on Dasypus pilosus (Dasypodidae). Regarding Cyclopedidae, until recently, only one species was recognized, but new genetic studies have revealed that the group is represented by seven species. In this data paper, we compiled a total of 42,528 records of 31 species, represented by occurrence and quantitative data, totaling 24,847 unique georeferenced records. The geographic range is from the southern United States, Mexico, and Caribbean countries at the northern portion of the Neotropics, to the austral distribution in Argentina, Paraguay, Chile, and Uruguay. Regarding anteaters, Myrmecophaga tridactyla has the most records (n = 5,941), and Cyclopes sp. have the fewest (n = 240). The armadillo species with the most data is Dasypus novemcinctus (n = 11,588), and the fewest data are recorded for Calyptophractus retusus (n = 33). With regard to sloth species, Bradypus variegatus has the most records (n = 962), and Bradypus pygmaeus has the fewest (n = 12). Our main objective with Neotropical Xenarthrans is to make occurrence and quantitative data available to facilitate more ecological research, particularly if we integrate the xenarthran data with other data sets of Neotropical Series that will become available very soon (i.e., Neotropical Carnivores, Neotropical Invasive Mammals, and Neotropical Hunters and Dogs). Therefore, studies on trophic cascades, hunting pressure, habitat loss, fragmentation effects, species invasion, and climate change effects will be possible with the Neotropical Xenarthrans data set. Please cite this data paper when using its data in publications. We also request that researchers and teachers inform us of how they are using these data

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial

Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.13Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt