Fobias y filias en la imagen de la historia: el caso de 245 metros cúbicos, de Santiago Sierra

In the light of the work of art of Santiago Sierra, 245 cubic meters (2006), this paper analyse the variety of reactions that the (re)creation of traumatic events in history and memory might generate. The work of Sierra recreated a gas chamber inside what used to be the Stommeln synagogue in Pulheim, a small town in Germany. The Spanish artist arranged a number of cars outside the building and pumped carbon monoxide from their exhausts through tubing into the disused synagogue. The reaction of some Jewish communities was immediate and the exhibition was closed just one week after its opening. This synagogue has not been used for worship since the Second World War, but was reopened in 1991 as a memorial place where every year artists are invited to honour the victims of the holocaust �this was the very first time that one of the artistic projects was closed so immediately. Sierra himself said that he had no intention whatsoever to offend the sensibility of the victims, but the opposite in fact. I explore here the possible origins of the controversy, which perhaps did not arise from feelings of offence since there seems to be some evidence that might point towards other hypothesis.En relación con la obra de Santiago Sierra, 245 metros cúbicos (2006), se analizan en este artículo las diversas reacciones que la (re)creación de los hechos traumáticos de la historia y de la memoria pueden llegar a provocar. Esta obra en particular, recreaba una cámara de gas en lo que había sido la sinagoga de Stommeln, en la ciudad alemana de Pulheim. Para ello, el artista español colocó una serie de coches en el exterior del edificio que transmitían al interior del mismo, mediante tubos, el monóxido de carbono producido por sus motores. Las reacciones por parte de diversas comunidades judías fueron inmediatas y la instalación se clausuró una semana después de su inauguración. Esta sinagoga, en desuso tras la Segunda Guerra Mundial, fue reabierta en 1991 como memorial con la idea de invitar anualmente a artistas para rendir homenaje a las víctimas del holocausto; nunca antes se había producido la clausura de ningún proyecto artístico. Según Sierra, su obra no quería herir la sensibilidad de las víctimas, sino todo lo contrario. En este artículo se exploran los posibles orígenes de la polémica, que quizás no surgieran tanto de dicha ofensa, ya que hay indicios que parecen apuntar a otras hipótesis

On How Fas Apoptosis-Independent Pathways Drive T Cell Hyperproliferation and Lymphadenopathy in lpr Mice

This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission.Fas induces massive apoptosis in T cells after repeated in vitro T cell receptor (TCR) stimulation and is critical for lymphocyte homeostasis in Fas-deficient (lpr) mice. Although the in vitro Fas apoptotic mechanism has been defined, there is a large conceptual gap between this in vitro phenomenon and the pathway that leads to in vivo development of lymphadenopathy and autoimmunity. A striking abnormality in lpr mice is the excessive proliferation of CD4+ and CD8+ T cells, and more so of the double-negative TCR+CD4−CD8−B220+ T cells. The basis of lpr T cell hyperproliferation remains elusive, as it cannot be explained by Fas-deficient apoptosis. T cell-directed p21 overexpression reduces hyperactivation/hyperproliferation of all lpr T cell subtypes and lymphadenopathy in lpr mice. p21 controls expansion of repeatedly stimulated T cells without affecting apoptosis. These results confirm a direct link between hyperactivation/hyperproliferation, autoreactivity, and lymphadenopathy in lpr mice and, with earlier studies, suggest that Fas apoptosis-independent pathways control lpr T cell hyperproliferation. lpr T cell hyperproliferation could be an indirect result of the defective apoptosis of repeatedly stimulated lpr T cells. Nonetheless, in this perspective, we argue for an alternative setting, in which lack of Fas would directly cause lpr T cell hyperactivation/hyperproliferation in vivo. We propose that Fas/Fas ligand (FasL) acts as an activation inhibitor of recurrently stimulated T cells, and that its disruption causes overexpansion of T cells in lpr mice. Research to define the underlying mechanism of this Fas/FasL effect could resolve the phenotype of lpr mice and lead to therapeutics for related human syndromes.This work was supported by grants from the Ministry of Economy and Competitivity (MINECO/FEDER PI11/00950 and SAF2016-80803-R to DB, and SAF2013-42289-R and SAF2016-75456-R to CM-A), from the Fundación Alfonso Martin Escudero to CM-A, and from the Community of Madrid (MITIC S2011/BMD2502 to DB and CM-A).Peer reviewe

Escenarios de guerra: paseando por Madrid a través de su memoria

La actividad "Escenarios de Guerra. Paseando por Madrid a través de su memoria" se organiza en el marco de la XV Semana de la Ciencia (2015) con el objetivo de difundir los resultados de las investigaciones llevadas a cabo por los proyectos de investigación de I+D+i "50 años de arte en el Siglo de Plata español (1931-1981)" (HAR2014-53871-P) y "Madrid 1936-1939: capital, frente, retaguardia y ciudad en guerra" (HAR2014-52065-P). En ella se proponen tres itinerarios por los lugares más significativos del impacto de la Guerra Civil española en Madrid: el centro de la ciudad (Cibeles-Museo Nacional Centro de Arte Reina Sofía), el norte (Ciudad Universitaria) y el oeste (Plaza de Oriente-Arco de la Victoria). A lo largo de estos recorridos guiados, los miembros de los mencionados proyectos comentarán aspectos de la historia, el arte, el patrimonio, la memoria y la vida cotidiana, apoyándose en las fuentes directas de quienes vivieron el conflicto, recogidas en la publicación que tiene entre sus manos.Proyectos de I+D+i: "50 años de arte en el Siglo de Plata español (1931-1981)" (HAR2014-53871-P) y "Madrid 1936-1939: capital, frente, retaguardia y ciudad en guerra" (HAR2014-52065-P).Peer reviewe

A low-power RF front-end for 2.5 GHz receivers

© 2008 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes,creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.This paper presents a low power and low cost front end for a direct conversion 2.5 GHz ISM band receiver composed of a 16 kV HBM ESD protected LNA, differential Gilbert-cell mixers, and high-pass filters for DC offset cancellation. The whole front-end is implemented in a 2P6M 0.18 µm RFCMOS process. It exhibits a voltage gain of 24dB and a SSB noise figure of 8.4dB which make it suitable for most of the 2.5 GHz wireless short-range communication transceivers. The achieved power consumption is only 1.06mW from a 1.2V power supply.Peer ReviewedPostprint (published version

International Conference on Broadband Communications, Networks and Systems

Producción CientíficaNetwork Function Virtualization (NFV) is considered to be one of the enabling technologies for 5G. NFV poses several challenges, like deciding the virtual network function (VNF) placement and chaining, and adding backup resources to guarantee the survivability of service chains. In this paper, we propose a genetic algorithm that jointly solves the VNF-placement, chaining and virtual topology design problem in WDM metro ring network, with the additional capacity of providing node protection. The simulation results show how important is to solve all of these subproblems jointly, as well as the benefits of using shared VNF and network resources between backup instances in order to reduce both the service blocking ratio and the number of active CPUs.Ministerio de Economía, Industria y Competitividad (grant TEC2017-84423-C3-1-P)Ministerio de Industria, Comercio y Turismo (grant BES 2015-074514)INTERREG V-A España-Portugal (POCTEP) (grant 0677_DISRUPTIVE_2_E)

Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns

Altres ajuts: L.M. is a recipient of an FPI fellowship. P.A. acknowledges the support of the Spanish Ministerio de Economía y Competitividad, the European Research Council (SysPharmAD: 614944), and the Generalitat de Catalunya. V.S. is a recipient of a Miguel Servet grant from ISCIII and receives funds from AGAUR (). The PDX program is supported by a GHD-Pink (FERO foundation) grant to V.S., A.G.-O. and M.P. received a FI-AGAUR and a Juan de la Cierva (MJCI-2015-25412) fellowship, respectively. M.S., P.R., and S.C. acknowledge the support of the NIH grants P30 CA008748, RO1CA190642, and the Breast Cancer Research Foundation. Additionally, P.R. receives funds from the Breast Cancer Alliance.Identification of actionable genomic vulnerabilities is key to precision oncology. Utilizing a large-scale drug screening in patient-derived xenografts, we uncover driver gene alteration connections, derive driver co-occurrence (DCO) networks, and relate these to drug sensitivity. Our collection of 53 drug-response predictors attains an average balanced accuracy of 58% in a cross-validation setting, rising to 66% for a subset of high-confidence predictions. We experimentally validated 12 out of 14 predictions in mice and adapted our strategy to obtain drug-response models from patients' progression-free survival data. Our strategy reveals links between oncogenic alterations, increasing the clinical impact of genomic profiling

2020 22nd International Conference on Transparent Optical Networks (ICTON)

Producción CientíficaNetwork Function Virtualization (NFV) is a promising networking paradigm that will ease the network manageability and increase its flexibility, while reducing costs. In this paradigm, operators must solve the Virtual Network Function (VNF) placement and chaining problems. It is also important to provide backup resources to ensure the survivability of the offered services when a node failure happens. In this paper, we compare two different protection approaches to ensure the service resilience: individual VNF protection and end-to-end protection. Results show the benefits in terms of use of computing resources and energy consumption of protecting each VNF individually, compared to the end-to-end protection approach.Ministerio de Economía, Industria y Competitividad (grant TEC2017-84423-C3-1-P)Ministerio de Industria, Comercio y Turismo (fellowship BES-2015-074514)Research network Go2Edge (grant RED2018-102585-T)Interreg V-A Spain-Portugal (POCTEP) programme 2014- 202

Optimización de Campus Virtual: archivo/repositorio en red de referencias artísticas desde 1900 hasta la actualidad

El objeto de este proyecto consiste en la realización de un espacio dentro del Campus Virtual de la UCM, que dote al estudiante de Bellas Artes de una herramienta digital de referencias artísticas desde el arte del siglo XX a nuestros días

How important professional vocation is when medical professionals are affected by Burnout syndrome

Recepción: 29 de mayo de 2016 | Revisión: 30 de mayo de 2016 | Aceptado: 1 de junio de 2016Correspondencia: [email protected]ún distintos estudios, la vocación, las expectativas excesivas y los ideales desconectados de la realidad se presentan como un factor facilitador de la aparición de Burnout. La presente investigación pretende estudiar la relación entre vocación y Burnout en el sector sanitario. Para ello se ha utilizado el cuestionario de Maslach junto con otras preguntas de carácter sociodemográfico, aplicado a una muestra de 43 participantes de diferentes características. Los resultados obtenidos muestran que, en lo que a factores constituyentes del fenómeno se refiere, se encuentra una clara correlación significativa e inversa entre vocación y cansancio emocional. Es decir, que a mayor vocación menor es el cansancio emocional. La relación entre vocación y despersonalización no produjo resultados significativos, aunque sí se observa cierta relación. Por último, se observa también una relación significativa y directa entre vocación y realización personal. Esto es, la realización personal aumenta a medida que aumenta la vocación.According to different studies, vocation, excessive expectations and ideals disconnected from reality are presented as a facilitating factor in the emergence of Burnout. This research looks for studding the relation between professional vocation and burnout syndrome in medical scope. Maslach inventory and other socio-demographic questions are given to 43 participants with different features. The obtained results show that there is an important inverse correlation between vocation and emotional exhaustion. The relation between vocation and depersonalisation did not make any significant result, but there is a relation, indeed. Finally, the direct relation between vocation and personal realisation is also important. Therefore, personal realisation increases at the same time as vocation does.Universidad de Granada. Departamento de Psicología Social. Proyecto de Innovación Docente ReiDoCre

2019 21st International Conference on Transparent Optical Networks (ICTON)

Producción Científica5G technology will provide networks with high-bandwidth, low latency and multitenancy. The integration of computing and storage resources in the edge of the fronthaul network, i.e., multi-access edge computing (MEC), will allow to instantiate some virtual network functions (VNF) in those computing resources. The backhaul of 5G networks will be based on optical technology, in particular WDM, due to its high capacity and flexibility. In this paper, we analyse the problem of VNF-provisioning in a metro ring-topology network equipped with MEC resources and with a WDM network connecting the edge nodes. In contrast to previous proposals, the method decides where VNFs must be instantiated but also the design of the virtual topology for the WDM metro network in order to reduce the service blocking ratio and the number of resources in operation.Ministerio de Economía, Industria y Competitividad (project TEC2017-84423-C3-1-P)Ministerio de Industria, Energía y Turismo (project BES-2015-074514