81 research outputs found
John Y. Templeton III: Pioneer of modern cardiothoracic surgery.
John Young Templeton III was born in 1917 in Portsmouth, Virginia, and graduated from Jefferson Medical College in 1941. He completed his residency training under Dr. John H. Gibbon, Jr., and was the first resident who worked on Gibbon\u27s heart-lung machine. After his training, he remained at Jefferson as an American Cancer Society fellow and Damon Runyon fellow and went on to become the fourth Samuel D. Gross Professor and Chair of the Department of Surgery in 1967. Dr. Templeton was the recipient of numerous grants and published over 80 papers in the field of cardiothoracic surgery. As a teacher and mentor, he was a beloved figure who placed great faith in his residents. He participated in over 60 professional societies, serving as president to many such as the Philadelphia Academy of Surgery and the Pennsylvania Association of Thoracic Surgery. He was also recognized through his many awards, in particular the John Y. Templeton III lectureship established in 1980 at Jefferson of whom Denton Cooley was the first lecturer. Dr. Templeton retired from practice in 1987. He is forever remembered as an important model of a modern surgeon evident in numerous academic achievements, the admiration and affection of his trainees, and the lives of patients that he had touched
New constraints on H_0 and Omega_M from SZE/X-RAY data and Baryon Acoustic Oscillations
The Hubble constant, , sets the scale of the size and age of the
Universe and its determination from independent methods is still worthwhile to
be investigated. In this article, by using the Sunyaev-Zel`dovich effect and
X-ray surface brightness data from 38 galaxy clusters observed by Bonamente
{\it{et al.}} (2006), we obtain a new estimate of in the context of a
flat CDM model. There is a degeneracy on the mass density parameter
() which is broken by applying a joint analysis involving the
baryon acoustic oscillations (BAO) as given by Sloan Digital Sky Survey (SDSS).
This happens because the BAO signature does not depend on . Our basic
finding is that a joint analysis involving these tests yield km s Mpc and
. Since the hypothesis of spherical geometry
assumed by Bonamente {\it {et al.}} is questionable, we have also compared the
above results to a recent work where a sample of triaxial galaxy clusters has
been considered.Comment: 8 pages, 4 figures, 1 table, accepted version in the general
relativity and gravitatio
Finite-time destruction of entanglement and non-locality by environmental influences
Entanglement and non-locality are non-classical global characteristics of
quantum states important to the foundations of quantum mechanics. Recent
investigations have shown that environmental noise, even when it is entirely
local in influence, can destroy both of these properties in finite time despite
giving rise to full quantum state decoherence only in the infinite time limit.
These investigations, which have been carried out in a range of theoretical and
experimental situations, are reviewed here.Comment: 27 pages, 6 figures, review article to appear in Foundations of
Physic
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants
Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling. © 2018 The Author(s).Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling. © 2018 The Author(s).Peer reviewe
Temperature, impurity and electromagnetic field effects on the transition of a two-level system in a triangular potential
Improved AdaBoost-based image retrieval with relevance feedback via paired feature learning
Stress and bubble pressure response of wet foam to continuous and oscillatory sinusoidal shear
Cosmological parameter estimation with future gravitational wave standard siren observation from the Einstein Telescope
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