Adipose-derived mesenchymal stem cells (AdMSC) for the treatment of secondary-progressive multiple sclerosis: A triple blinded, placebo controlled, randomized phase I/II safety and feasibility study

Background Currently available treatments for secondary progressive multiple sclerosis(SPMS) have limited efficacy and/or safety concerns. Adipose-mesenchymal derived stem cells(AdMSCs) represent a promising option and can be readily obtained using minimally invasive procedures. Go to: Patients and methods In this triple-blind, placebo-controlled study, cell samples were obtained from consenting patients by lipectomy and subsequently expanded. Patients were randomized to a single infusion of placebo, low-dose(1x106cells/kg) or high-dose(4x106cells/kg) autologous AdMSC product and followed for 12 months. Safety was monitored recording adverse events, laboratory parameters, vital signs and spirometry. Expanded disability status score (EDSS), magnetic-resonance-imaging, and other measures of possible treatment effects were also recorded. Go to: Results Thirty-four patients underwent lipectomy for AdMSCs collection, were randomized and thirty were infused (11 placebo, 10 low-dose and 9 high-dose); 4 randomized patients were not infused because of karyotype abnormalities in the cell product. Only one serious adverse event was observed in the treatment arms (urinary infection, considered not related to study treatment). No other safety parameters showed changes. Measures of treatment effect showed an inconclusive trend of efficacy. Conclusion Infusion of autologous AdMSCs is safe and feasible in patients with SPMS. Larger studies and probably treatment at earlier phases would be needed to investigate the potential therapeutic benefit of this technique

Neutrosophic Logic for Mental Model Elicitation and Analysis

Mental models are personal, internal representations of external reality that people use to interact with the world around them. They are useful in multiple situations such as muticriteria decision making, knowledge management, complex system learning and analysis. In this paper a framework for mental models elicitation and analysis based on neutrosophic Logic is presented. An illustrative example is provided to show the applicability of the proposal. The paper ends with conclusion future research directions

Metodología de establecimiento de las relaciones interdisciplinarias en el año académico en la carrera Cultura Física

This article aims to develop a methodology to contribute to the establishment of interdisciplinary relationships in the academic year in the Physical Culture career. For the systematization of the theoretical-methodological references that support the research from the philosophical, psychological, pedagogical and didactic point of view, as well as the diagnosis of the current state of the establishment of interdisciplinary relationships in the first academic year of the career Physical Culture methods and techniques were used such as analysis-synthesis, induction-deduction, systemic-structural-functional, modeling, documentary analysis, observation, survey, interview, the results of which facilitated the development of the proposed methodology.El presente artículo tiene como objetivo elaborar una metodología para contribuir al establecimiento de las relaciones interdisciplinarias en el año académico en la carrera Cultura Física. Para la sistematización de los referentes teórico-metodológicos que desde el punto de vista filosófico, psicológico, pedagógico y didáctico sustentan la investigación, así como, la realización del diagnóstico del estado actual del establecimiento de las relaciones interdisciplinarias en el primer año académico de la carrera Cultura Física se utilizaron métodos y técnicas tales como análisis-síntesis, inducción-deducción, sistémico-estructural-funcional, modelación, análisis documental, observación, encuesta, entrevista cuyos resultados facilitaron la elaboración de la metodología que se propone

De Obama a Biden: continuidad y ruptura en la estrategia de contención de EE.UU. frente a China

Synthesizing the elements of continuity and rupture present in the international projection of the United States during the administrations of B. Obama, D. Trump and J. Biden to try to contain the increasingly growing influence of China in the current world geopolitical scenario, constitutes the central purpose of our article. As a genuine expression of the transformations and sharpening of the system of contradictions intrinsic to global Capitalism, together with the result of a new correlation of international forces, the international system is gradually reconfigured in the 21st century. A complex and dynamic transition process towards a Multipolar or Apolar world order headed by a group of emerging powers led by China has put the unipolarism led by the traditional Western powers -with the US as the most visible head- in "check". since the end of the 20th century. In this sense, Washington manages the pieces of the world geopolitical board in an eclectic and erratic way in order to respond to the new demands of the historical context in order to recover the spaces of power relatively lost since the beginning of the 2000s.Sintetizar los elementos de continuidad y ruptura presentes en la proyección internacional estadounidense durante las administraciones de Barack Obama, Donald Trump y Joseph Biden para intentar contener la influencia cada vez más creciente de China en el escenario geopolítico mundial actual, constituye el propósito central de nuestro artículo. Como genuina expresión de las transformaciones y la agudización del sistema de contradicciones intrínsecas al Capitalismo global, unido a la resultante de una nueva correlación de las fuerzas internacionales se reconfigura gradualmente el sistema internacional en el siglo XXI. Un complejo y dinámico proceso de tránsito hacia un orden mundial multipolar o apolar encabezado por un conjunto de poderes emergentes liderado por China ha puesto en “jaque” al unipolarismo protagonizado por las potencias occidentales tradicionales –con los EE.UU. como cabeza más visible- desde fines del siglo XX. En este sentido, Washington maneja de manera ecléctica y errática las piezas del tablero geopolítico mundial con la finalidad de responder a las nuevas exigencias del contexto histórico, en aras de recuperar los espacios de poder relativamente perdidos desde inicios de los años 2000

Aplicación legal existente para la protección del patrimonio cultural monumental en la Ciudad de Chiclayo

El problema planteado en mi tesis sobre la “APLICACIÓN LEGAL EXISTENTE PARA LA PROTECCIÓN DEL PATRIMONIO CULTURAL MONUMENTAL EN LA CIUDAD DE CHICLAYO”, tiene por objetivo proponer el conocimiento de las normas de patrimonio monumental. Que las entidades locales tienen la función legal de proteger el patrimonio existente, abordando los efectos jurídicos y sociológicos. Por lo que propongo que el Estado sobre las leyes vigentes que amparan este patrimonio cultural; las instituciones nacionales e internacionales deben de intervenir activamente en el control de dichos monumentos y vestigios del pasado de la ciudad Chiclayo como sucede en el Cuzco. El Estado a través de los órganos de control y las instituciones públicas encargadas debieran presentar sus reclamos sobre la destrucción innecesaria del patrimonio cultural ante el Poder Judicial. Nuestra Constitución Política del Perú en su Art. 21°, señala que los yacimientos y restos arqueológicos, construcciones, monumentos…. están debidamente declarados como bienes culturales y la presunción de tales. El código Penal señala en su Art. 226, sobre “El atentada contra los monumentos arqueológicos”, con penas de cárcel no menor 3 ni mayor de 6 años y en el Art. 230, señala sobre “La destrucción alteración o extracción de bienes culturales”, con penas no menor de 2 ni mayor de 5 años y con 85 días multa. Tenemos la Ley general del Patrimonio Cultural de la Nación, que es la Ley N° 28296, que protege la variedad de patrimonios existentes en el país.Tesi

Melhoria da Atenção à Saúde dos Portadores de Hipertensão Arterial Sistêmica e Diabetes Mellitus na ESF Tainha, São Francisco de Paula, RS

PEREZ, José Luis Leyva. Melhoria da Atenção à saúde dos portadores de Hipertensão Arterial Sistêmica e Diabetes Mellitus na ESF Tainha, São Francisco de Paula/ RS. 2016. 89f. Trabalho de Conclusão de Curso (Curso de Especialização em Saúde da Família) - Departamento de Medicina Social, Faculdade de Medicina, Universidade Federal de Pelotas, Pelotas, 2016. A ausência de Prevenção e Promoção de Saúde tem desencadeado um aumento na incidência das doenças crônicas não transmissíveis, como Hipertensão Arterial Sistêmica (HAS) e Diabetes Mellitus (DM). Por isso, justifica-se a escolha do foco para intervir nesta ação, procurando propiciar um melhor atendimento e de maior qualidade para as pessoas. Trata-se de um trabalho de intervenção que tem como objetivo geral a Melhoria da Atenção à saúde dos portadores de HAS E DM na ESF Tainha, São Francisco de Paula/ RS. Esta intervenção foi desenvolvida durante 12 semanas na Estratégia de saúde da Família (ESF) Tainha, localizada no interior do município, distantes 38 km da sede, com uma população de 868 habitantes. Utilizamos o Caderno de Ações Programático (CAP) para estimar a quantidade de usuários com hipertensão e com diabetes com 20 anos ou mais, residentes na área. Foram estimados 194 e 55 usuários com os respectivos problemas. Antes de iniciar intervenção, tínhamos uma cobertura de 49% para usuários com hipertensão e 38% dos usuários com diabetes, residentes na área e acompanhados da equipe. Com a intervenção conseguimos cadastrar 178 usuários (91,8%) com HAS, das 194 pessoas estimadas, e 48 usuários (87,3%) com DM, das 55 estimadas pela CAP Realizamos exame clínico e solicitação de exames complementares, de acordo com o protocolo, a todas as pessoas cadastradas, além disso, foram oferecidas atividades educativas de forma regular e com qualidade para comunidade. Tivermos problemas para realizar na integra algumas metas, mas, de um modo geral, todas as ações foram trabalhadas e serão aprimoradas com o decorrer do tempo

Modeling and analyzing non-functional requirements interdependencies with neutrosofic logic

Nonfunctional requirements refer to global properties of software. They are an important part of the requirement engineering process and play a key role in software quality. Current approaches for modelling nonfunctional requirements interdependencies have limitations. In this work we proposed a new method to model interdependencies in nonfunctional requirements using neutrosophic logic

Electrochemical monitoring of the oxidative coupling of alkynes catalyzed by triphenylphosphine gold complexes

Electrochemical monitoring of the oxidative coupling of alkynes in the homogeneous phase through catalytic cycles involving triphenylphosphine gold complexes and selectfluor as oxidant reveals that at least two gold species in +3 and +1 oxidation states are implicated. Electrochemically driven homocoupling of terminal alkynes using molecular oxygen as the oxidant can be performed using such catalysts.Domenech Carbo, A.; Leyva Perez, A.; Al-Resayes, SI.; Corma Canós, A. (2012). Electrochemical monitoring of the oxidative coupling of alkynes catalyzed by triphenylphosphine gold complexes. Electrochemistry Communications. 19:145-148. doi:10.1016/j.elecom.2012.02.038S1451481