The duty cycle of radio galaxies revealed by LOFAR : remnant and restarted radio source populations in the Lockman Hole

14 pages, 7 figures, accepted for publication in MNRAS. Companion paper to Jurlin et al., also in today's arXiv postingFeedback from radio jets associated with Active Galactic Nuclei (AGN) plays a profound role in the evolution of galaxies. Kinetic power of these radio jets appears to show temporal variation, but the mechanism(s) responsible for this process are not yet clear. Recently, the LOw Frequency ARray (LOFAR) has uncovered large populations of active, remnant and restarted radio jet populations. By focusing on LOFAR data in the Lockman Hole, in this work we use the Radio AGN in Semi-Analytic Environments (RAiSE) dynamical model to present the first self-consistent modelling analysis of active, remnant and restarted radio source populations. Consistent with other recent work, our models predict that remnant radio lobes fade quickly. Any high (>10 percent) observed fraction of remnant and restarted sources therefore requires a dominant population of short-lived jets. We speculate that this could plausibly be provided by feedback-regulated accretion.Peer reviewe

Aggressive shadowing of a low-dimensional model of atmospheric dynamics

Predictions of the future state of the Earth's atmosphere suffer from the consequences of chaos: numerical weather forecast models quickly diverge from observations as uncertainty in the initial state is amplified by nonlinearity. One measure of the utility of a forecast is its shadowing time, informally given by the period of time for which the forecast is a reasonable description of reality. The present work uses the Lorenz 096 coupled system, a simplified nonlinear model of atmospheric dynamics, to extend a recently developed technique for lengthening the shadowing time of a dynamical system. Ensemble forecasting is used to make forecasts with and without inflation, a method whereby the ensemble is regularly expanded artificially along dimensions whose uncertainty is contracting. The first goal of this work is to compare model forecasts, with and without inflation, to a true trajectory created by integrating a modified version of the same model. The second goal is to establish whether inflation can increase the maximum shadowing time for a single optimal member of the ensemble. In the second experiment the true trajectory is known a priori, and only the closest ensemble members are retained at each time step, a technique known as stalking. Finally, a targeted inflation is introduced to both techniques to reduce the number of instances in which inflation occurs in directions likely to be incommensurate with the true trajectory. Results varied for inflation, with success dependent upon the experimental design parameters (e.g. size of state space, inflation amount). However, a more targeted inflation successfully reduced the number of forecast degradations without significantly reducing the number of forecast improvements. Utilized appropriately, inflation has the potential to improve predictions of the future state of atmospheric phenomena, as well as other physical systems.Comment: 14 pages, 16 figure

Sequential phase II Southwest Oncology Group studies (S0112 and S0301) of daunorubicin and cytarabine by continuous infusion, without and with ciclosporin, in older patients with previously untreated acute myeloid leukaemia

Attempts to overcome multi-drug resistance in acute myeloid leukaemia (AML) have been limited by toxicities. To investigate the effect of reducing peak drug levels, we performed sequential phase II studies using continuous infusion daunorubicin and cytarabine without (AD) and then with ciclosporin (ADC) in older patients with AML. Untreated patients (age 56+ years) received daunorubicin (45 mg/m 2 per day for 3 d) and cytarabine (200 mg/m 2 per day for 7 d), both by continuous infusion, without (S0112, 60 patients) and then with (S0301, 50 patients) the addition of ciclosporin. Complete response (CR) rates were 38% on S0112 and 44% on S0301. Fatal induction toxicities occurred in 17% and 12% respectively, arising primarily from infection and haemorrhage. Median overall and relapse-free survival was 7 and 8 months for AD respectively, and 6 and 14 months for ADC. Patients with phenotypic or functional P-glycoprotein had somewhat higher CR rates with ADC than AD, although confidence intervals overlapped. In these sequential trials, continuous infusion AD produced CR rates comparable to those with bolus daunorubicin. The addition of ciclosporin did not cause undue toxicities, produced a similar CR rate, and possibly improved relapse-free survival. Further correlate analyses did not identify a subpopulation specifically benefitting from the addition of ciclosporin.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78683/1/j.1365-2141.2009.07919.x.pd

On the nature and variability of the east Greenland Spill Jet : a case study in Summer 2003

Author Posting. © American Meteorological Society, 2011. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Physical Oceanography 41 (2011): 2307–2327, doi:10.1175/JPO-D-10-05004.1.Results from a high-resolution (~2 km) numerical simulation of the Irminger Basin during summer 2003 are presented. The focus is on the East Greenland Spill Jet, a recently discovered component of the circulation in the basin. The simulation compares well with observations of surface fields, the Denmark Strait overflow (DSO), and the hydrographic structure of typical sections in the basin. The model reveals new aspects of the circulation on scales of O(0.1–10) days and O(1–100) km. The model Spill Jet results from the cascade of dense waters over the East Greenland shelf. Spilling can occur in various locations southwest of the strait, and it is present throughout the simulation but exhibits large variations on periods of O(0.1–10) days. The Spill Jet sometimes cannot be distinguished in the velocity field from surface eddies or from the DSO. The vorticity structure of the jet confirms its unstable nature with peak relative and tilting vorticity terms reaching twice the planetary vorticity term. The average model Spill Jet transport is 4.9 ±1.7 Sv (1 Sv ≡ 106 m3 s−1) equatorward, about 2½ times larger than has been previously reported from a single ship transect in August 2001. Kinematic analysis of the model results suggests two different types of spilling events. In the first case (type I), a local perturbation results in dense waters descending over the shelf break into the Irminger Basin. In the second case (type II), surface cyclones associated with DSO deep domes initiate the spilling process. During summer 2003, more than half of the largest Spill Jet transport values are of type II.The research is supported by the National Science Foundation Grants OCE-0726393 and OCI-0904640 (MGM and TWNH) and OCE-0726640 (RSP).2012-06-0

Exclusive vector meson production at HERA

Exclusive vector meson production from real and virtual photons is, for the most part, described well by soft pomeron exchange. However, there are some unsolved normalisation problems, and just a hint that an additional contribution from hard pomeron exchange may be needed.Comment: 12 pages, uuencoded postscript, including 5 figure

CD34-related coexpression of MDR1 and BCRP indicates a clinically resistant phenotype in patients with acute myeloid leukemia (AML) of older age

Clinical resistance to chemotherapy in acute myeloid leukemia (AML) is associated with the expression of the multidrug resistance (MDR) proteins P-glycoprotein, encoded by the MDR1/ABCB1 gene, multidrug resistant-related protein (MRP/ABCC1), the lung resistance-related protein (LRP), or major vault protein (MVP), and the breast cancer resistance protein (BCRP/ABCG2). The clinical value of MDR1, MRP1, LRP/MVP, and BCRP messenger RNA (mRNA) expression was prospectively studied in 154 newly diagnosed AML patients ≥60 years who were treated in a multicenter, randomized phase 3 trial. Expression of MDR1 and BCRP showed a negative whereas MRP1 and LRP showed a positive correlation with high white blood cell count (respectively, p < 0.05, p < 0.001, p < 0.001 and p < 0.001). Higher BCRP mRNA was associated with secondary AML (p < 0.05). MDR1 and BCRP mRNA were highly significantly associated (p < 0.001), as were MRP1 and LRP mRNA (p < 0.001) expression. Univariate regression analyses revealed that CD34 expression, increasing MDR1 mRNA as well as MDR1/BCRP coexpression, were associated with a lower complete response (CR) rate and with worse event-free survival and overall survival. When adjusted for other prognostic actors, only CD34-related MDR1/BCRP coexpression remained significantly associated with a lower CR rate (p = 0.03), thereby identifying a clinically resistant subgroup of elderly AML patients

Some Gender Implications of the ‘Civilising Mission’ of the Anglican Church for the Acholi Peoples of Northern Uganda

Anglican missionaries arriving in Uganda’s Acholiland in 1903 saw the local peoples as in need not just of Christianisation but also of civilising. This last consisted primarily of inculcating western notions of gender identities for both men and women, with an emphasis on the wearing of gender-appropriate clothing and terminating the practices of polygyny and bride-price payment. The first missionaries considered the Acholi to have high levels of gender equality but they still believed conversion would improve women’s status through domesticating them and instilling the notion of male superiority, despite the fact that local customary rituals did not distinguish on grounds of gender. Over decades, the population gradually converted to various Christian denominations, mainly Anglicanism and Catholicism, but without abandoning their customary rituals, using them as and when required, to ward off evil or ask for rain, for instance. The most significant impact of the civilising process was arguably the institutionalisation of the notion of masculine superiority now legitimised by appeals to what happened in the Garden of Eden. The paper is based on historical documents, both published and from the missionary archives, as well as on ethnographic research into gender in the region today

A Search for Dark Higgs Bosons

Recent astrophysical and terrestrial experiments have motivated the proposal of a dark sector with GeV-scale gauge boson force carriers and new Higgs bosons. We present a search for a dark Higgs boson using 516 fb-1 of data collected with the BABAR detector. We do not observe a significant signal and we set 90% confidence level upper limits on the product of the Standard Model-dark sector mixing angle and the dark sector coupling constant.Comment: 7 pages, 5 postscript figures, published version with improved plots for b/w printin

Lung resistance-related protein as a predictor of clinical outcome in advanced testicular germ-cell tumours

This study was undertaken to investigate the expression and predictive value for outcome of multidrug resistance-associated (MDR) proteins P-glycoprotein (Pgp), MRP1, BCRP, and LRP, in advanced testicular germ-cell tumours (TGCT). Paraffin-embedded sections from 56 previously untreated patients with metastatic TGCT were immunostained for Pgp, MRP1, BCRP, and LRP. All patients received platinum-based chemotherapy after orchidectomy. Immunostaining was related to clinicopathological parameters, response to chemotherapy, and outcome. Strong and intermediate expressions of the different MDR-related proteins were: 27 and 41% (Pgp), 54 and 37% (MRP1), 86 and 7% (BCRP), and 14 and 29% (LRP). P-glycoprotein and MRP1 associated, respectively, to low AFP (P=0.026) and high LDH levels (P=0.014), whereas LRP expression associated with high beta-hCG levels (P=0.003) and stage IV tumours (P=0.029). No correlation was found between Pgp, MRP1, and BCRP expression and response to chemotherapy and survival. In contrast, patients with LRP-positive tumours (strong or intermediate expression) had shorter progression-free (P=0.0006) and overall survival (P=0.0116) than LRP-negative patients, even after individual log-rank adjustments by statistically associated variables. Our data suggest that a positive LRP immunostaining at the time of diagnosis in metastatic TGCT is associated with an adverse clinical outcome